메뉴 건너뛰기




Volumn 46, Issue 6, 2007, Pages 1557-1567

Probing the mechanism of the hamster mitochondrial folate transporter by metagenesis and homology modeling

Author keywords

[No Author keywords available]

Indexed keywords

HAMSTER; HOMOLOGY MODEL; METAGENESIS; MITOCHONDRIAL MEMBRANE; MUTATIONS;

EID: 33846981149     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi062191+     Document Type: Article
Times cited : (11)

References (49)
  • 1
    • 0018351280 scopus 로고
    • The distribution and chemical nature of radioactive folates in rat liver cells and rat liver mitochondria
    • Cook, R. J., and Blair, J. A. (1979) The distribution and chemical nature of radioactive folates in rat liver cells and rat liver mitochondria, Biochem. J. 178, 651-659.
    • (1979) Biochem. J , vol.178 , pp. 651-659
    • Cook, R.J.1    Blair, J.A.2
  • 2
    • 0015460532 scopus 로고
    • Subcellular localization of folate and effect of methotrexate on the incorporation of radioactive folic acid into guinea-pig liver folate
    • Corrocher, R., and Hoffbrand, A. V. (1972) Subcellular localization of folate and effect of methotrexate on the incorporation of radioactive folic acid into guinea-pig liver folate, Clin. Sci. 43, 812-822.
    • (1972) Clin. Sci , vol.43 , pp. 812-822
    • Corrocher, R.1    Hoffbrand, A.V.2
  • 3
    • 0027501365 scopus 로고
    • Regulation of folate and one-carbon metabolism in mammalian cells. III. Role of mitochondrial folylpoly-γ-glutamate synthetase
    • Lin, B. F., Huang, R. F., and Shane, B. (1993) Regulation of folate and one-carbon metabolism in mammalian cells. III. Role of mitochondrial folylpoly-γ-glutamate synthetase, J. Biol. Chem. 268, 21674-21679.
    • (1993) J. Biol. Chem , vol.268 , pp. 21674-21679
    • Lin, B.F.1    Huang, R.F.2    Shane, B.3
  • 4
    • 0014455226 scopus 로고
    • Intracellular distribution of folic acid in mouse liver
    • Sankar, D. V., Geisler, A., and Rozsa, P. W. (1969) Intracellular distribution of folic acid in mouse liver, Experientia 25, 691-692.
    • (1969) Experientia , vol.25 , pp. 691-692
    • Sankar, D.V.1    Geisler, A.2    Rozsa, P.W.3
  • 5
    • 0017104055 scopus 로고
    • Subcellular localization of gamma-glutamyl carboxypeptidase and of folates
    • Shin, Y. S., Chan, C., Vidal, A. J., Brody, T., and Stokstad, E. L. (1976) Subcellular localization of gamma-glutamyl carboxypeptidase and of folates, Biochim. Biophys. Acta 444, 794-801.
    • (1976) Biochim. Biophys. Acta , vol.444 , pp. 794-801
    • Shin, Y.S.1    Chan, C.2    Vidal, A.J.3    Brody, T.4    Stokstad, E.L.5
  • 6
    • 0025954883 scopus 로고
    • Compartmentation of folate-mediated one-carbon metabolism in eukaryotes
    • Appling, D. R. (1991) Compartmentation of folate-mediated one-carbon metabolism in eukaryotes, FASEB J. 5, 245-251.
    • (1991) FASEB J , vol.5 , pp. 245-251
    • Appling, D.R.1
  • 7
    • 0034711259 scopus 로고    scopus 로고
    • Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria
    • Titus, S. A., and Moran, R. G. (2000) Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria, J. Biol. Chem. 275, 36811-36817.
    • (2000) J. Biol. Chem , vol.275 , pp. 36811-36817
    • Titus, S.A.1    Moran, R.G.2
  • 8
    • 0028921872 scopus 로고
    • Upstream organization of and multiple transcripts from the human folylpoly-γ-glutamate synthetase gene
    • Freemantle, S. J., Taylor, S. M., Krystal, G., and Moran, R. G. (1995) Upstream organization of and multiple transcripts from the human folylpoly-γ-glutamate synthetase gene, J. Biol. Chem. 270, 9579-9584.
    • (1995) J. Biol. Chem , vol.270 , pp. 9579-9584
    • Freemantle, S.J.1    Taylor, S.M.2    Krystal, G.3    Moran, R.G.4
  • 9
    • 4043146497 scopus 로고    scopus 로고
    • A mutation inactivating the mitochondrial inner membrane folate transporter creates a glycine requirement for survival of chinese hamster cells
    • McCarthy, E. A., Titus, S. A., Taylor, S. M., Jackson-Cook, C., and Moran, R. G. (2004) A mutation inactivating the mitochondrial inner membrane folate transporter creates a glycine requirement for survival of chinese hamster cells, J. Biol. Chem. 279, 33829-33836.
    • (2004) J. Biol. Chem , vol.279 , pp. 33829-33836
    • McCarthy, E.A.1    Titus, S.A.2    Taylor, S.M.3    Jackson-Cook, C.4    Moran, R.G.5
  • 10
    • 0032571303 scopus 로고    scopus 로고
    • Highly conserved charge-pair networks in the mitochondrial carrier family
    • Nelson, D. R., Felix, C. M., and Swanson, J. M. (1998) Highly conserved charge-pair networks in the mitochondrial carrier family, J. Mol. Biol. 277, 285-308.
    • (1998) J. Mol. Biol , vol.277 , pp. 285-308
    • Nelson, D.R.1    Felix, C.M.2    Swanson, J.M.3
  • 11
    • 23944435962 scopus 로고    scopus 로고
    • The human mitochondrial transport protein family, identification and protein regions significant for transport function and substrate specificity
    • Wohlrab, H. (2005) The human mitochondrial transport protein family, identification and protein regions significant for transport function and substrate specificity, Biochim. Biophys. Acta 1709, 157-168.
    • (2005) Biochim. Biophys. Acta , vol.1709 , pp. 157-168
    • Wohlrab, H.1
  • 12
    • 0020473533 scopus 로고
    • Internal sequence repeats and the path of polypeptide in mitochondrial ADP/ATP translocase
    • Saraste, M., and Walker, J. E. (1982) Internal sequence repeats and the path of polypeptide in mitochondrial ADP/ATP translocase, FEBS Lett. 144, 250-254.
    • (1982) FEBS Lett. 144 , pp. 250-254
    • Saraste, M.1    Walker, J.E.2
  • 13
    • 0028798146 scopus 로고
    • The N- and C-termini of the tricarboxylate carrier are exposed to the cytoplasmic side of the inner mitochondrial membrane
    • Capobianco, L., Bisaccia, F., Michel, A., Sluse, F. E., and Palmieri, F. (1995) The N- and C-termini of the tricarboxylate carrier are exposed to the cytoplasmic side of the inner mitochondrial membrane, FEBS Lett. 357, 297-300.
    • (1995) FEBS Lett , vol.357 , pp. 297-300
    • Capobianco, L.1    Bisaccia, F.2    Michel, A.3    Sluse, F.E.4    Palmieri, F.5
  • 14
    • 0025648976 scopus 로고
    • Mitochondrial proton/phosphate transporter. An antibody directed against the COOH terminus and proteolytic cleavage experiments provides new insights about its membrane topology
    • Ferreira, G. C., Pratt, R. D., and Pedersen, P. L. (1990) Mitochondrial proton/phosphate transporter. An antibody directed against the COOH terminus and proteolytic cleavage experiments provides new insights about its membrane topology, J. Biol. Chem. 265, 21202-21206.
    • (1990) J. Biol. Chem , vol.265 , pp. 21202-21206
    • Ferreira, G.C.1    Pratt, R.D.2    Pedersen, P.L.3
  • 15
    • 0025899923 scopus 로고
    • Transmembrane topography of the mitochondrial phosphate carrier explored by peptide-specific antibodies and enzymatic digestion
    • Capobianco, L., Brandolin, G., and Palmieri F. (1991) Transmembrane topography of the mitochondrial phosphate carrier explored by peptide-specific antibodies and enzymatic digestion, Biochemistry 30, 4963-4969.
    • (1991) Biochemistry , vol.30 , pp. 4963-4969
    • Capobianco, L.1    Brandolin, G.2    Palmieri, F.3
  • 16
    • 0027136160 scopus 로고
    • The mitochondrial transport protein superfamily
    • Walker, J. E., and Runswick, M. J. (1993) The mitochondrial transport protein superfamily, J. Bioenerg. Biomembr. 25, 435-446.
    • (1993) J. Bioenerg. Biomembr , vol.25 , pp. 435-446
    • Walker, J.E.1    Runswick, M.J.2
  • 19
    • 0014659237 scopus 로고
    • Genetics of somatic mammalian cells. X. Complementation analysis of glycine-requiring mutants
    • Kao, F., Chasin, L., and Puck, T. T. (1969) Genetics of somatic mammalian cells. X. Complementation analysis of glycine-requiring mutants, Proc. Natl. Acad. Sci. U.S.A. 64, 1284-1291.
    • (1969) Proc. Natl. Acad. Sci. U.S.A , vol.64 , pp. 1284-1291
    • Kao, F.1    Chasin, L.2    Puck, T.T.3
  • 22
    • 0031473847 scopus 로고    scopus 로고
    • SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
    • Guex, N., and Peitsch, M. C. (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling, Electrophoresis 18, 2714-2723.
    • (1997) Electrophoresis , vol.18 , pp. 2714-2723
    • Guex, N.1    Peitsch, M.C.2
  • 23
    • 0026610767 scopus 로고
    • Assessment of protein models with three-dimensional profiles
    • Luthy, R., Bowie, J. U., and Eisenberg, D. (1992) Assessment of protein models with three-dimensional profiles, Nature 356, 83-85.
    • (1992) Nature , vol.356 , pp. 83-85
    • Luthy, R.1    Bowie, J.U.2    Eisenberg, D.3
  • 24
    • 0027490731 scopus 로고
    • Recognition of errors in three-dimensional structures of proteins
    • Sippl, M. J. (1993) Recognition of errors in three-dimensional structures of proteins, Proteins 17, 355-362.
    • (1993) Proteins , vol.17 , pp. 355-362
    • Sippl, M.J.1
  • 25
    • 0042511005 scopus 로고    scopus 로고
    • A graph-theory algorithm for rapid protein side-chain prediction
    • Canutescu, A. A., Shelenkov, A. A., and Dunbrack, R. L. Jr. (2001) A graph-theory algorithm for rapid protein side-chain prediction, Protein Sci. 12, 2001-2014.
    • (2001) Protein Sci , vol.12 , pp. 2001-2014
    • Canutescu, A.A.1    Shelenkov, A.A.2    Dunbrack Jr., R.L.3
  • 26
    • 0020187063 scopus 로고
    • Folate-dependent enzymes in cultured Chinese hamster ovary cells: Impaired mitochondrial serine hydroxymethyltransferase activity in two additional glycine-auxotroph complementation classes
    • Taylor, R. T., and Hanna, M. L. (1982) Folate-dependent enzymes in cultured Chinese hamster ovary cells: impaired mitochondrial serine hydroxymethyltransferase activity in two additional glycine-auxotroph complementation classes, Arch. Biochem. Biophys. 217, 609-623.
    • (1982) Arch. Biochem. Biophys , vol.217 , pp. 609-623
    • Taylor, R.T.1    Hanna, M.L.2
  • 27
    • 0020606569 scopus 로고
    • Purification of VDAC (voltage-dependent anion-selective channel) from rat liver mitochondria
    • Colombini, M. (1983) Purification of VDAC (voltage-dependent anion-selective channel) from rat liver mitochondria, J. Membr. Biol. 74, 115-121.
    • (1983) J. Membr. Biol , vol.74 , pp. 115-121
    • Colombini, M.1
  • 28
    • 27144449733 scopus 로고    scopus 로고
    • Folate metabolism in plants: An Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts
    • Bedhomme, M., Hoffmann, M., McCarthy, E. A., Gambonnet, B., Moran, R. G., Rebeille, F., and Ravanel, S. (2005) Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts, J. Biol. Chem. 280, 34823-34831.
    • (2005) J. Biol. Chem , vol.280 , pp. 34823-34831
    • Bedhomme, M.1    Hoffmann, M.2    McCarthy, E.A.3    Gambonnet, B.4    Moran, R.G.5    Rebeille, F.6    Ravanel, S.7
  • 29
    • 0033537993 scopus 로고    scopus 로고
    • GenTHREADER: An efficient and reliable protein fold recognition method for genomic sequences
    • Jones, D. T. (1999) GenTHREADER: an efficient and reliable protein fold recognition method for genomic sequences, J. Mol. Biol. 287, 797-815.
    • (1999) J. Mol. Biol , vol.287 , pp. 797-815
    • Jones, D.T.1
  • 30
    • 0038634975 scopus 로고    scopus 로고
    • Improvement of the GenTHREADER method for genomic fold recognition
    • McGuffin, L. J., and Jones, D. T. (2003) Improvement of the GenTHREADER method for genomic fold recognition, Bioinformatics 19, 874-81.
    • (2003) Bioinformatics , vol.19 , pp. 874-881
    • McGuffin, L.J.1    Jones, D.T.2
  • 31
    • 4143120198 scopus 로고    scopus 로고
    • Nucleotide exchange in mitochondria: Insight at a molecular level
    • Pebay-Peyroula, E., and Brandolin, G. (2004) Nucleotide exchange in mitochondria: insight at a molecular level, Curr. Opin. Struct. Biol. 14, 420-425.
    • (2004) Curr. Opin. Struct. Biol , vol.14 , pp. 420-425
    • Pebay-Peyroula, E.1    Brandolin, G.2
  • 32
    • 0028276561 scopus 로고
    • Expression of Escherichia coli folylpolyglutamate synthetase in the Chinese hamster ovary cell mitochondria
    • Lin, B.-F., and Shane, B. (1994) Expression of Escherichia coli folylpolyglutamate synthetase in the Chinese hamster ovary cell mitochondria, J. Biol. Chem. 269, 9705-9713.
    • (1994) J. Biol. Chem , vol.269 , pp. 9705-9713
    • Lin, B.-F.1    Shane, B.2
  • 33
    • 0032879495 scopus 로고    scopus 로고
    • Folylpoly-γ-glutamate synthetase: Generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity
    • Qi, H., Atkinson, I., Xiao, S., Choi, Y.-J., Tobimatsu, T., and Shane, B. (1999) Folylpoly-γ-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity, Adv. Enzyme Regul. 39, 263-273.
    • (1999) Adv. Enzyme Regul , vol.39 , pp. 263-273
    • Qi, H.1    Atkinson, I.2    Xiao, S.3    Choi, Y.-J.4    Tobimatsu, T.5    Shane, B.6
  • 34
    • 0028241527 scopus 로고
    • Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate, an anti-purine drug
    • Kim, J. S., and Shane, B. (1994) Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate, an anti-purine drug, J. Biol. Chem. 269, 9714-9720.
    • (1994) J. Biol. Chem , vol.269 , pp. 9714-9720
    • Kim, J.S.1    Shane, B.2
  • 35
    • 0027442503 scopus 로고
    • Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-γ- glutamate synthetase in methotrexate metabolism and cytotoxicity
    • Kim, J. S., Lowe, K. E., and Shane, B. (1993) Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-γ- glutamate synthetase in methotrexate metabolism and cytotoxicity, J. Biol. Chem. 268, 21680-21685.
    • (1993) J. Biol. Chem , vol.268 , pp. 21680-21685
    • Kim, J.S.1    Lowe, K.E.2    Shane, B.3
  • 36
    • 11844249290 scopus 로고    scopus 로고
    • Cysteine labeling studies detect conformational changes in region 106-132 of the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae
    • Kihira, Y., Majima, E., Shinohara, Y, and Terada, H. (2005) Cysteine labeling studies detect conformational changes in region 106-132 of the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae, Biochemistry 44, 184-192.
    • (2005) Biochemistry , vol.44 , pp. 184-192
    • Kihira, Y.1    Majima, E.2    Shinohara, Y.3    Terada, H.4
  • 37
    • 12544249526 scopus 로고    scopus 로고
    • The yeast mitochonrial citrate transport protein. Characterization of transmembrane domain III residue involved in substrate translocation
    • Ma, C., Kotaria, R., Major, J. A., Remani, S., Walters, D. E., and Kaplan, R. S. (2005) The yeast mitochonrial citrate transport protein. Characterization of transmembrane domain III residue involved in substrate translocation, J. Biol. Chem. 280, 2331-2340.
    • (2005) J. Biol. Chem , vol.280 , pp. 2331-2340
    • Ma, C.1    Kotaria, R.2    Major, J.A.3    Remani, S.4    Walters, D.E.5    Kaplan, R.S.6
  • 38
    • 33748796367 scopus 로고    scopus 로고
    • Functional and structural role of amino acid residues in the even numbered transmembrane α-helices of the bovine mitochondrial oxoglutarate carrier
    • Cappello, A. R., Curcio, R., Miniero, D. V., Stipani, I., Robinson, A. J., Kunji, E. R. S., and Palmieri, F. (2006) Functional and structural role of amino acid residues in the even numbered transmembrane α-helices of the bovine mitochondrial oxoglutarate carrier, J. Mol. Biol. 363, 51-62.
    • (2006) J. Mol. Biol , vol.363 , pp. 51-62
    • Cappello, A.R.1    Curcio, R.2    Miniero, D.V.3    Stipani, I.4    Robinson, A.J.5    Kunji, E.R.S.6    Palmieri, F.7
  • 39
    • 0035951096 scopus 로고    scopus 로고
    • The mitochondrial oxoglutarate carrier: Cysteine-scanning mutagenesis of transmembrane domain IV and sensitivity of Cys mutants to sulfhydral reagents
    • Stipani, V., Cappello, A. R., Daddabbo, L., Natuzzi, D., Miniero, D. V., Stipani, I., and Palmieri, F. (2001) The mitochondrial oxoglutarate carrier: Cysteine-scanning mutagenesis of transmembrane domain IV and sensitivity of Cys mutants to sulfhydral reagents, Biochemistry 40, 15805-15810.
    • (2001) Biochemistry , vol.40 , pp. 15805-15810
    • Stipani, V.1    Cappello, A.R.2    Daddabbo, L.3    Natuzzi, D.4    Miniero, D.V.5    Stipani, I.6    Palmieri, F.7
  • 40
    • 0030480093 scopus 로고    scopus 로고
    • Probing the role of positive residues in the ADP/ATP carrier from yeast. The effect of six arginine mutations on transport and the four ATP versus ADP exchange modes
    • Heidkämper, D., Müller, V., Nelson, D. R., and Klingenberg, M. (1996) Probing the role of positive residues in the ADP/ATP carrier from yeast. The effect of six arginine mutations on transport and the four ATP versus ADP exchange modes, Biochemistry 35, 16144-16152.
    • (1996) Biochemistry , vol.35 , pp. 16144-16152
    • Heidkämper, D.1    Müller, V.2    Nelson, D.R.3    Klingenberg, M.4
  • 41
    • 0027207801 scopus 로고
    • Site-directed mutagenesis of the yeast motochondrial ADP/ATP translocator. Six arginines and one lysine are essential
    • Nelson, D. R., Lawson, J. E., Klingenberg, M., and Douglas, M. G. (1993) Site-directed mutagenesis of the yeast motochondrial ADP/ATP translocator. Six arginines and one lysine are essential, J. Mol. Biol. 230, 1159-1170.
    • (1993) J. Mol. Biol , vol.230 , pp. 1159-1170
    • Nelson, D.R.1    Lawson, J.E.2    Klingenberg, M.3    Douglas, M.G.4
  • 42
    • 33644555509 scopus 로고    scopus 로고
    • Mitochondrial carriers in the cytoplasmic state have a common substrate binding site
    • Robinson, A. J., and Kunji, E. R. S. (2006) Mitochondrial carriers in the cytoplasmic state have a common substrate binding site, Proc Natl. Acad. Sci. U.S.A. 106, 2617-2622.
    • (2006) Proc Natl. Acad. Sci. U.S.A , vol.106 , pp. 2617-2622
    • Robinson, A.J.1    Kunji, E.R.S.2
  • 43
    • 0030043489 scopus 로고    scopus 로고
    • Cation interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp
    • Dougherty, D. A. (1996) Cation interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp, Science 271, 163-168.
    • (1996) Science , vol.271 , pp. 163-168
    • Dougherty, D.A.1
  • 45
    • 0041624288 scopus 로고    scopus 로고
    • Min, Y., Zhang, Y., and Xu, R.-M. (2003) Structural basis for specific binding of polycomb chromodomain to histone H3 methylated at Lys 27, Genes Dev. 17, 1823-1828.
    • Min, Y., Zhang, Y., and Xu, R.-M. (2003) Structural basis for specific binding of polycomb chromodomain to histone H3 methylated at Lys 27, Genes Dev. 17, 1823-1828.
  • 47
    • 0029984499 scopus 로고    scopus 로고
    • FLX1 codes for a carrier protein involved in maintaining a proper balance of flavin nucleotides in yeast mitochondria
    • Tzagoloff, A., Jang, J., Glerum, D. M., and Wu, M. (1996) FLX1 codes for a carrier protein involved in maintaining a proper balance of flavin nucleotides in yeast mitochondria, J. Biol. Chem. 271, 7392-7397.
    • (1996) J. Biol. Chem , vol.271 , pp. 7392-7397
    • Tzagoloff, A.1    Jang, J.2    Glerum, D.M.3    Wu, M.4
  • 48
    • 30744433627 scopus 로고    scopus 로고
    • Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: Bacterial expression, reconstitution and functional characterization
    • Marobbio, C. M., Di Noia, M. A., and Palmieri, F. (2006) Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: Bacterial expression, reconstitution and functional characterization, Biochem. J. 393, 441-446.
    • (2006) Biochem. J , vol.393 , pp. 441-446
    • Marobbio, C.M.1    Di Noia, M.A.2    Palmieri, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.