Exploring central and peripheral diversity in antibody evolution

Molecular Immunology

Volumn 44, Issue 10, 2007, Pages 2729-2736

  Persson, Helena ^a   Ohlin, Mats ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Antibody evolution; Antibody library; Autoimmunity; Hapten; Paratope; Phage display

Indexed keywords

CARRIER PROTEIN; HAPTEN ANTIBODY;

ANTIBODY LIBRARY; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MODIFICATION;

ANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; BINDING SITES; EVOLUTION, MOLECULAR; HAPTENS; HUMANS; MODELS, MOLECULAR; PEPTIDE LIBRARY;

EID: 33846927264     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.11.024     Document Type: Article

References (34)

1. Almagro J.C. Identification of differences in the specificity-determining residues of antibodies that recognize antigens of different size: implications for the rational design of antibody repertoires. J. Mol. Recognit. 17 (2004) 132-143
2. Bigazzi P.E. Autoimmunity caused by xenobiotics. Toxicology 119 (1997) 1-21
3. Bruggraber S.F., Leung P.S., Amano K., Quan C., Kurth M.J., Nantz M.H., Benson G.D., Van de Water J., Luketic V., Roche T.E., Ansari A.A., Coppel R.L., and Gershwin M.E. Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis. Gastroenterology 125 (2003) 1705-1713
4. Charlton K., Harris W.J., and Porter A.J. The isolation of super-sensitive anti-hapten antibodies from combinatorial antibody libraries derived from sheep. Biosens. Bioelectron. 16 (2001) 639-646
5. Cicortas Gunnarsson L., Nordberg Karlsson E., Albrekt A.S., Andersson M., Holst O., and Ohlin M. A carbohydrate binding module as a diversity-carrying scaffold. Protein Eng. Des. Sel. 17 (2004) 213-221
6. Collis A.V., Brouwer A.P., and Martin A.C. Analysis of the antigen combining site: correlations between length and sequence composition of the hypervariable loops and the nature of the antigen. J. Mol. Biol. 325 (2003) 337-354
7. Davis M.M. The evolutionary and structural 'logic' of antigen receptor diversity. Semin. Immunol. 16 (2004) 239-243
8. Engberg J., Andersen P.S., Nielsen L.K., Dziegiel M., Johansen L.K., and Albrechtsen B. Phage-display libraries of murine and human antibody Fab fragments. Meth. Mol. Biol. 51 (1995) 355-376
9. Foote J., and Milstein C. Conformational isomerism and the diversity of antibodies. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 10370-10374
10. Griem P., Panthel K., Kalbacher H., and Gleichmann E. Alteration of a model antigen by Au(III) leads to T cell sensitization to cryptic peptides. Eur. J. Immunol. 26 (1996) 279-287
11. Griem P., Wulferink M., Sachs B., Gonzalez J.B., and Gleichmann E. Allergic and autoimmune reactions to xenobiotics: how do they arise?. Immunol. Today 19 (1998) 133-141
12. Holsapple M.P. Autoimmunity by pesticides: a critical review of the state of the science. Toxicol. Lett. 127 (2002) 101-109
13. Honegger A., and Plückthun A. Yet another numbering scheme for immunoglobulin variable domains: an automatic modeling and analysis tool. J. Mol. Biol. 309 (2001) 657-670
14. James L.C., Roversi P., and Tawfik D.S. Antibody multispecificity mediated by conformational diversity. Science 299 (2003) 1362-1367
15. Jang Y.S., Lim K.H., and Kim B.S. Analysis of T cell reactivities to phosphorylcholine-conjugated hen egg lysozyme in C57BL/6 mice: hapten-conjugate specificity reflects an altered expression of a major carrier epitope. Eur. J. Immunol. 21 (1991) 1303-1310
16. Kabat, E.A., Wu, T.T., Perry, H.M., Gottesman, K.S., Foeller, C., 1991. Sequences of proteins of immunological interest, vol. 5, NIH Publication no. 91-3242 U.S. Department of Health and Human Services.
17. Kang H.K., Chung Y.J., Park C.U., Jang Y.S., and Kim B.S. Induction of autoimmunity by immunization with hapten-modified hen egg lysozyme in hen egg lysozyme-transgenic mice. Immunology 117 (2006) 368-378
18. Kimber I., and Dearman R.J. Immunologic basis for autoimmunity and the potential influences of xenobiotics. Toxicol. Lett. 127 (2002) 77-81
19. Lefranc M.P., Pommie C., Ruiz M., Giudicelli V., Foulquier E., Truong L., Thouvenin-Contet V., and Lefranc G. IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains. Dev. Comp. Immunol. 27 (2003) 55-77
20. Long S.A., Quan C., Van de Water J., Nantz M.H., Kurth M.J., Barsky D., Colvin M.E., Lam K.S., Coppel R.L., Ansari A., and Gershwin M.E. Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis. J. Immunol. 167 (2001) 2956-2963
21. MacCallum R.M., Martin A.C., and Thornton J.M. Antibody-antigen interactions: contact analysis and binding site topography. J. Mol. Biol. 262 (1996) 732-745
22. Manivel V., Sahoo N.C., Salunke D.M., and Rao K.V. Maturation of an antibody response is governed by modulations in flexibility of the antigen-combining site. Immunity 13 (2000) 611-620
23. Moghaddam A., Lobersli I., Gebhardt K., Braunagel M., and Marvik O.J. Selection and characterisation of recombinant single-chain antibodies to the hapten Aflatoxin-B1 from naive recombinant antibody libraries. J. Immunol. Meth. 254 (2001) 169-181
24. Padlan E.A. Anatomy of the antibody molecule. Mol. Immunol. 31 (1994) 169-217
25. Persson H., Lantto J., and Ohlin M. A focused antibody library for improved hapten recognition. J. Mol. Biol. 357 (2006) 607-620
26. Pichler W.J. Drug-induced autoimmunity. Curr. Opin. Allergy Clin. Immunol. 3 (2003) 249-253
27. Ramirez-Benitez M.C., and Almagro J.C. Analysis of antibodies of known structure suggests a lack of correspondence between the residues in contact with the antigen and those modified by somatic hypermutation. Proteins 45 (2001) 199-206
28. Rao T., and Richardson B. Environmentally induced autoimmune diseases: potential mechanisms. Environ. Health Perspect. 107 Suppl. 5 (1999) 737-742
29. Sethi D.K., Agarwal A., Manivel V., Rao K.V., and Salunke D.M. Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response. Immunity 24 (2006) 429-438
30. Söderlind E., Strandberg L., Jirholt P., Kobayashi N., Alexeiva V., Åberg A.M., Nilsson A., Jansson B., Ohlin M., Wingren C., Danielsson L., Carlsson R., and Borrebaeck C.A.K. Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries. Nat. Biotechnol. 18 (2000) 852-856
31. Tomlinson I.M., Walter G., Jones P.T., Dear P.H., Sonnhammer E.L., and Winter G. The imprint of somatic hypermutation on the repertoire of human germline V genes. J. Mol. Biol. 256 (1996) 813-817
32. Uetrecht J. Current trends in drug-induced autoimmunity. Autoimmun. Rev. 4 (2005) 309-314
33. Vargas-Madrazo E., Lara-Ochoa F., and Almagro J.C. Canonical structure repertoire of the antigen-binding site of immunoglobulins suggests strong geometrical restrictions associated to the mechanism of immune recognition. J. Mol. Biol. 254 (1995) 497-504
34. Wedemayer G.J., Patten P.A., Wang L.H., Schultz P.G., and Stevens R.C. Structural insights into the evolution of an antibody combining site. Science 276 (1997) 1665-1669