Cardiovascular fitness is negatively associated with homocysteine levels in female adolescents

Archives of Pediatrics and Adolescent Medicine

Volumn 161, Issue 2, 2007, Pages 166-171

  Ruiz, Jonatan R ^a,f   Sola, Ricardo ^a,b   Gonzalez Gross, Marcela ^a,d   Ortega, Francisco B ^a,f   Vicente Rodriguez, German ^c   Garcia Fuentes, Miguel ^e   Gutierrez, Angel ^a   Sjöström, Michael ^f   Pietrzik, Klaus ^g   Castillo, Manuel J ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

^e UNIVERSITY OF CANTABRIA   (Spain)

^f KAROLINSKA INSTITUTE   (Sweden)

^g UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADOLESCENT; AMINO ACID BLOOD LEVEL; ARTICLE; BIRTH WEIGHT; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DNA SEQUENCE; FEMALE; FITNESS; FOLIC ACID BLOOD LEVEL; FUNCTION TEST; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MALE; MULTIPLE REGRESSION; PRIORITY JOURNAL; PUBERTY; SKINFOLD THICKNESS; SMOKING; SOCIAL STATUS; VITAMIN BLOOD LEVEL;

ADOLESCENT; CARDIOVASCULAR PHYSIOLOGY; EXERCISE TEST; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PHYSICAL FITNESS; POLYMORPHISM, GENETIC; REGRESSION ANALYSIS; SEX DISTRIBUTION; SEX FACTORS; SPAIN; VITAMIN B 12;

EID: 33846915772     PISSN: 10724710     EISSN: 15383628     Source Type: Journal    
DOI: 10.1001/archpedi.161.2.166     Document Type: Article

References (52)

1. Virtanen JK, Voutilainen S, Alfthan G, et al. Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. J Intern Med. 2005;257:255-262.
2. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015-2022.
3. Vrentzos GE, Papadakis JA, Malliaraki N, et al. Diet, serum homocysteine levels and ischaemic heart disease in a Mediterranean population. Br J Nutr. 2004;91:1013-1019.
4. Ford ES, Smith SJ, Stroup DF, Steinberg KK, Mueller PW, Thacker SB. Homocyst (e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int J Epidemiol. 2002;31:59-70.
5. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346:476-483.
6. McLean RR, Jacques PF, Selhub J, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004;350:2042-2049.
7. Hague WM. Homocysteine and pregnancy. Best Pract Res Clin Obstet Gynaecol. 2003;17:459-469.
8. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest. 1996;98:5-7.
9. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042-1050.
10. Greenlund KJ, Srinivasan SR, Xu JH, et al. Plasma homocysteine distribution and its association with parental history of coronary artery disease in black and white children: the Bogalusa Heart Study. Circulation. 1999;99:2144-2149.
11. Kark JD, Sinnreich R, Rosenberg IH, Jacques PF, Selhub J. Plasma homocysteine and parental myocardial infarction in young adults in Jerusalem. Circulation. 2002;105:2725-2729.
12. Hyanek J, Stribrny J, Sebesta P, et al. Diagnostic significance of mild hyperhomocysteinemia in a population of children with parents or grandparents who have peripheral or coronary artery disease [in Czech]. Cas Lek Cesk. 1999;138:333-336.
13. Morrison JA, Jacobsen DW, Sprecher DL, Robinson K, Khoury P, Daniels SR. Serum glutathione in adolescent males predicts parental coronary heart disease. Circulation. 1999;100:2244-2247.
14. Tonstad S, Refsum H, Sivertsen M, Christophersen B, Ose L, Ueland PM. Relation of total homocysteine and lipid levels in children to premature cardiovascular death in male relatives. Pediatr Res. 1996;40:47-52.
15. De Laet C, Wautrecht JC, Brasseur D, et al. Plasma homocysteine concentration in a Belgian school-age population. Am J Clin Nutr. 1999;69:968-972.
16. Gonzalez-Gross M, Marcos A, Pietrzik K. Nutrition and cognitive impairment in the elderly. Br J Nutr. 2001;86:313-321.
17. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-113.
18. Papoutsakis C, Yiannakouris N, Manios Y, et al. Plasma homocysteine levels in Greek children are influenced by an interaction between the methylenetetrahydrofolate reductase C677T genotype and folate status. J Nutr. 2005;135:383-388.
19. Balasa VV, Gruppo RA, Glueck CJ, et al. The relationship of mutations in the MTHFR, prothrombin, and PAI-1 genes to plasma levels of homocysteine, prothrombin, and PAI-1 in children and adults. Thromb Haemost. 1999;81:739-744.
20. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr. 2001;73:613-621.
21. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693-2698.
22. Nygard O, Refsum H, Ueland PM, Vollset SE. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr. 1998;67:263-270.
23. Silaste ML, Rantala M, Alfthan G, Aro A, Kesaniemi YA. Plasma homocysteine concentration is decreased by dietary intervention. Br J Nutr. 2003;89:295-301.
24. Chrysohoou C, Panagiotakos DB, Pitsavos C, et al. The associations between smoking, physical activity, dietary habits and plasma homocysteine levels in cardiovascular disease-free people: the "ATTICA" study. Vasc Med. 2004;9:117-123.
25. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801.
26. LaMonte MJ, Barlow CE, Jurca R, Kampert JB, Church TS, Blair SN. Cardiorespiratory fitness is inversely associated with the incidence of metabolic syndrome: a prospective study of men and women. Circulation. 2005;112:505-512.
27. Kuo HK, Yen CJ, Bean JF. Levels of homocysteine are inversely associated with cardiovascular fitness in women, but not in men: data from the National Health and Nutrition Examination Survey 1999-2002. J Intern Med. 2005;258:328-335.
28. Mesa JL, Ortega FB, Ruiz JR, Castillo MJ, Hurtig Wennlöf A, Gutiérrez A. The importance of cardiorespiratory fitness for healthy metabolic traits in children and adolescents: the AVENA Study. J Public Health. 2006;14:178-180.
29. Ruiz JR, Ortega FB, Meusel D, Harro M, Oja P, Sjöström M. Cardiorespiratory fitness is associated with features of metabolic risk factors in children: should cardiorespiratory fitness be assessed in a European health monitoring system? the European Youth Heart Study. J Public Health. 2006;14:94-102.
30. Mesa JL, Ruiz JR, Ortega FB, et al. Aerobic physical fitness in relation to blood lipids and fasting glycaemia in adolescents: Influence of weight status. Nutr Metab Cardiovasc Dis. 2006;16:285-293.
31. Gonzalez-Gross M, Castillo MJ, Moreno L, et al. Feeding and assessment of nutritional status of Spanish adolescents (AVENA Study): evaluation of risks and interventional proposal: I, methodology [in Spanish]. Nutr Hosp. 2003;18:15-28.
32. Moreno LA, Mesana MI, Fleta J, et al. Overweight, obesity and body fat composition in Spanish adolescents: The AVENA Study. Ann Nutr Metab. 2005;49:71-76.
33. Ruiz JR, Ortega FB, Moreno LA, et al. Serum lipid and lipoprotein distributions of Spanish adolescents: the AVENA Study. Soz Praventivmed. 2006;51:99-109.
34. Sociedad Española de Epidemiología. La Medición de la Clase Social en Ciencias de la Salud: Informe de un Grupo de Trabajo de la Sociedad Española de Epidemiología. Barcelona, Spain: SG Editores; 1995.
35. Moreno LA, Rodríguez G, Guillén J, Rabanaque MJ, León JF, Ariño A. Anthropometric measurements in both sides of the body in the assessment of nutritional status in prepubertal children. Eur J Clin Nutr. 2002;56:1208-1215.
36. Moreno LA, Mesana MI, González-Gross M, et al. Anthropometric body fat composition reference values in Spanish adolescents: the AVENA Study. Eur J Clin Nutr. 2006;60:191-196.
37. Moreno LA, Joyanes M, Mesana MI, et al. Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents. Nutrition. 2003;19:481-486.
38. Rodriguez G, Moreno LA, Blay MG, et al. Body fat measurement in adolescents: comparison of skinfold thickness equations with dual-energy x-ray absorptiometry. Eur J Clin Nutr. 2005;59:1158-1166.
39. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity and stages of puberty. Arch Dis Child. 1976;51:170-179.
40. Leger L, Lambert A, Goulet A, Rowan C, Dinelle Y. Aerobic capacity of 6- to 17-year-old Quebecois: 20-meter shuttle run test with 1 minute stages [in French]. Can J Appl Sport Sci. 1984;9:64-69.
41. Leger LA, Mercier D, Gadoury C, Lambert J. The multistage 20 metre shuttle run test for aerobic fitness. J Sports Sci. 1988;6:93-101.
42. Liu NYS, Plowman SA, Looney MA. The reliability and validity of the 20-meter shuttle test in American students 12 to 15 years old. Res Q Exerc Sport. 1992;63:360-365.
43. Willems HP, Bos GM, Gerrits WB, den Heijer M, Vloet S, Blom HJ. Acidic citrate stabilizes blood samples for assay of total homocysteine. Clin Chem. 1998;44:342-345.
44. Higuchi R. Simple and rapid preparation of samples for PCR. In: Erlich H, ed. PCR Technology. New York, NY: Stockton Press; 1989:31-37.
45. Taylor HL, Buskirk E, Henschel A. Maximal oxygen uptake as an objective measure of cardio-respiratory performance. J Appl Physiol. 1955;8:73-80.
46. Reed KE, Warburton DE, Lewanczuk RZ, et al. Arterial compliance in young children: the role of aerobic fitness. Eur J Cardiovasc Prev Rehabil. 2005;12:492-497.
47. Jakubowski H. Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J Nutr. 2000;130:377S-381S.
48. Kado DM, Bucur A, Selhub J, Rowe JW, Seeman T. Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. Am J Med. 2002;113:537-542.
49. Husemoen LL, Thomsen TF, Fenger M, Jorgensen T. Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study. Eur J Clin Nutr. 2006;60:614-622.
50. Duncan GE, Perri MG, Anton SD, et al. Effects of exercise on emerging and traditional cardiovascular risk factors. Prev Med. 2004;39:894-902.
51. Randeva HS, Lewandowski KC, Drzewoski J, et al. Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002;87:4496-4501.
52. Gallistl S, Sudi KM, Erwa W, Aigner R, Borkenstein M. Determinants of homocysteine during weight reduction in obese children and adolescents. Metabolism. 2001;50:1220-1223.