ORC function in late G1: Maintaining the license for DNA replication

Cell Cycle

Volumn 6, Issue 2, 2007, Pages 128-130

  Da Silva, Lance F ^a   Duncker, Bernard P ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

DNA replication; Minichromosome maintenance protein; Origin recognition complex; Pre replicative complex

Indexed keywords

DNA; MINICHROMOSOME MAINTENANCE PROTEIN; ORIGIN RECOGNITION COMPLEX;

CELL CYCLE G1 PHASE; DNA REPLICATION; ENZYME ACTIVATION; NONHUMAN; PROTEIN DEPLETION; REVIEW;

SACCHAROMYCETALES;

EID: 33846896981     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.2.3743     Document Type: Review

References (24)

1. Bell SP. The origin recognition complex: From simple origins to complex functions. Genes Dev 2002; 16:659-72.
2. DePamphilis ML. Cell cycle dependent regulation of the origin recognition complex. Cell Cycle 2005; 4:70-9.
3. Chong JP, Mahbubani HM, Khoo CY, Blow JJ. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 1995; 375:418-21.
4. Rowley A, Cocker JH, Harwood J, Diffley JFX. Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. EMBO J 1995; 14:2631-41.
5. Liang C, Weinreich M, Stillman B. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 1995; 81:667-76.
6. Chuang RY, Chretien L, Dai J, Kelly TJ. Purification and characterization of the Schizosaccharomyces pombe origin recognition complex. J Biol Chem 2002; 277:16920-27.
7. Romanowski P, Madine MA, Rowles A, Blow JJ, Laskey RA. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr Biol 1996; 6:1416-25.
8. Rowles A, Chong JPJ, Brown L, Howell M, Evan GI, Blow JJ. Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 1996; 87:287-96.
9. Mendez J, Stillman B. Chromatin association of human origin recognition complex, Cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis. Mol Cell Biol 2000; 20:8602-12.
10. Baltin J, Leist S, Odronitz F, Wollscheid HP, Baack M, Kapitza T, Schaarschmidt D, Knippers R. DNA replication in protein extracts from human cells requires ORC and Mcm proteins. J Biol Chem 2006; 281:12428-35.
11. Kawasaki Y, Hiraga SI, Sugino A. Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae. Genes Cells 2000; 5:975-89.
12. Homesley L, Lei M, Kawasaki Y, Sawyer S, Christensen T, Tye BK Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev 2000; 14:913-26.
13. Donovan S, Harwood J, Drury LS, Diffley JF. Cdc6p-dependent loading of Mcm proteins onto prereplicative chromatin in budding yeast. Proc Natl Acad Sci USA 1997; 94:5611-16.
14. Bowers JL, Randell JCW, Chen S, Bell SP. ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication. Mol Cell 2004; 16:967-78.
15. Mahbubani HM, Chong JPJ, Chevalier S, Thommes P, Blow JJ. Cell cycle regulation of the replication licensing system: Involvement of a Cdk-dependent inhibitor. J Cell Biol 1997; 136:125-35.
16. Edwards MC, Tutter AV, Cvetic C, Gilbert CH, Prokhorova TA, Walter JC. MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J Biol Chem 2002; 277:33049-57.
17. Lei M, Kawasaki Y, Tye BK. Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae. Mol Cell Biol 1996; 16:5081-90.
18. Rowles A, Tada S, Blow JJ. Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins. J Cell Sci 1999; 112:2011-18.
19. Semple JW, Da-Silva LF, Jervis EJ, Ah-Kee J, Al-Attar H, Kummer L, Heikkila JJ, Pasero P, Duncker BP. An essential role for Orc6 in DNA replication through maintenance of prereplicative complexes. EMBO J 2006; 25:5150-58.
20. Lee DG, Bell SP. Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 1997; 7159-68.
21. Zhang Y, Yu Z, Fu X, Liang C. Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell 2002; 109:849-60.
22. Shimada K, Pasero P, Gasser SM. ORC and the intra-S-pkase checkpoint: A threshold regulates Rad53p activation in S phase. Genes Dev 2002; 16:3236-52.
23. Weinberger M, Ramachandran L, Feng L, Sharma K, Sun X, Marchetti M, Huberman JA, Burhans WC. Apoptosis in budding yeast caused by defects in initiation of DNA replication. J Cell Sci 2005; 118:3543-53.
24. Gibson DG, Bell SP, Aparicio OM. Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Genes Cells 2006; 11:557-73.