Hematotoxicity response in rats by the novel copper-based anticancer agent: Casiopeina II

Toxicology

Volumn 194, Issue 1-2, 2003, Pages 103-113

  De Vizcaya Ruiz, A ^a,b   Rivero Muller A ^a,d   Ruiz Ramirez, L ^c   Howarth, J A ^a   Dobrota, M ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

Anticancer agents; Casiopeina; Copper; Hematotoxicity; Metal complexes toxicity; Rat; Spleen

Indexed keywords

ANTINEOPLASTIC AGENT; COPPER; COPPER(4,7 DIMETHYL 1,10 PHENANTHROLINE)GLYCINE NITRATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; BLOOD TOXICITY; CONTROLLED STUDY; ELECTRON MICROSCOPY; ERYTHROBLAST; ERYTHROCYTE COUNT; ERYTHROCYTE DISORDER; EXTRAMEDULLARY HEMATOPOIESIS; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HEMOLYTIC ANEMIA; HISTOPATHOLOGY; LEUKOCYTOSIS; MALE; MORPHOLOGY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULOCYTE; RETICULOENDOTHELIAL SYSTEM; SPLEEN WEIGHT;

EID: 0242494033     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2003.08.009     Document Type: Article

References (30)

1. Aruoma O.I., Halliwell B., Gajeweski E., Dizdaroglu M. Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem. J. 273:1991;601-604.
2. Barceloux D.G. Copper Clin. Tox. 37:1999;217-230.
3. Bremner I. Manifestations of copper excess. Am. J. Clin. Nut. 67:1998;1069S-1073S.
4. Byrnes R.W., Antholine W.E., Petering D.H. Oxidation-reduction reactions in erlich cells treated with copper-neucoprine. Free Rad. Biol. Med. 13:1992;469-478.
5. Cooper G.I., Bickford A.A., Charlton B.R., Galey F.D., Willoughby D.H., Grobner M.A. Copper poisoning in rabbits associated with acute intravascular hemolysis. J. Vet. Diagn. 8:1996;394-396.
6. De Vizcaya Ruiz A., Rivero-Muller A., Ruiz-Ramirez L., Kass G.E.N., Kelland L.R., Orr R.M., Dobrota M. Induction of apoptosis by a novel copper-based anticancer compound-Casiopeina II in L1210 murine leukaemia and CH1 human ovarian carcinoma. Tox. In Vitro. 14(1):2000;1-5.
7. Detmer C.A., Pamatong F.V., Bocarsly J.R. Nonrandom double strand cleavage of DNA by a monofunctional metal complex: mechanistic studies. Inorg. Chem. 35:1996;6292-6298.
8. Giuliodori M.J., Ramirez C.E., Ayala M. Acute copper intoxication after Cu-Ca EDTA injection in rats. Toxicology. 124:1997;173-177.
9. Gracia-Mora I., Ruiz-Ramirez L., Gomez-Ruiz C., Tinoco-Mendez M., Marquez-Quinones A., Lira L.-R.D., Marin-Hernandez A., Macias-Rosales L., Bravo-Gomez M.E. Knight's move in the periodic table, from copper to platinum, novel antitumor mixed chelate copper compounds, casiopeina, evaluated by an in vitro human and murine cancer cell line panel. Met. Based Drugs. 8:2001;19-28.
10. Greaves, P., 1990. Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, first ed. Elsevier, Amsterdam, pp. 114-115.
11. Hultberg B., Andersson A., Isaksson A. Alterations of thiol metabolism in human cell lines induced by low amounts of copper, mercury or cadmium ions. Toxicology. 126:1998;203-212.
12. Köpf-Maier P. Complexes of metals other than platinum as antitumour agents. Eur. J. Clin. Pharmacol. 47:1994;1-16.
13. Koropatnick, J., Leibbrandt, M.E.I., 1995. Effects of metals on gene expression. In: Goyer, R.A., Cherianz, M.G. (Eds.), Toxicology of Metals. Biochemical Aspects. Springer, Berlin, pp. 93-120.
14. Kovachev T.B., Stamberov P.N., Ivanov D.S., Mitcheva M.K., Marinova S.P., Astroug H.A., Stoychkov J.N. Synthesis, toxicity and immunomodulating activity of Co(II), Ni(II) Cu(II) and Zn(II) complexes of L(-)-2,3,5,6-tetrahydro-6- phenylimidazo[2,1-b]thiazole (levamisole). Pharmazie. 49:1994;25-27.
15. Kratz F., Schutte M.T. Anticancer metal complexes and tumour targeting strategies. Cancer J. 11:1998;60-67.
16. Linder M.C., Hazegh-Azam M. Copper biochemistry and molecular biology. Am. J. Clin. Nut. 63:1996;797S-811S.
17. Mazumder A., Gupta M., Perrin M., Sigman D.S., Rabinovitz M., Pmmier Y. Inhibition of human immunodeficiency virus type 1 integrase hydrophobic cation: the phenanthroline-cuprous complex. AIDS Res. Hum. Retrovir. 11:1995;115-125.
18. Mendoza-Diaz G., Garcia-Nieto R.M., Gracia-Mora I., Arias-Negrete S., Ruiz-Ramirez L., Cosenza I.L., Ireta J., Moreno-Esparza R., Panell K.H., Cervantes-Lee F. Synthesis, characterization and biological activity of some mixed complexes of Cu(II) and Zn(II) with antibiotics of the nalidixic acid family and N-N ligands. J. Inorg. Biochem. 43:1991;640.
19. Nocentini G., Berzi A. The 2,2′-bipyrydyl-6-carbothiolamide copper (II) complex differs from the iron (II) complex in its biochemical effects in tumour cells, suggesting possible differences in the mechanism leading to cytotoxicity. Biochem. Pharmacol. 52:1996;65-71.
20. Okada S. Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals. Pathol. Int. 46:1996;311-332.
21. ® Trade Mark Reg. 407543 SECOFI, MEXICO 1992.
22. Rolfe D.S., Twedt D.C. Copper-associated hepatopathies in dogs. Vet. Clin. North Am.: Sm. Anim. Pract. 25:1995;399-417.
23. Rosse W.F. The spleen as a filter. New Engl. J. Med. 317:1987;704-706.
24. Ruiz-Azuara, L., 1996. Process to obtain new mixed copper aminoacidate from methyl phenanthroline complexes to be used as anticancer agents. US Patent application serial no. 07/628,628 (1992); Patent no. 5,576,326 (November 1996).
25. Ruiz-Azuara, L., 1997. Process to obtain new mixed copper aminoacidate from phenylatephenthroline complexes to be used as anticancer agents. US Patent application serial no. 07/628,843 (21 April 1992); no. 5,107,005; US Patent Re 35,458,18 (Febraury 1997).
26. Sansinanea A.S., Cerone S.I., Elperding A., Auza N. Glucose-6-phosphate dehydrogenase activity in erythrocytes from chronically copper-poisoned sheep. Comp. Biochem. Physiol. 114C:1996;197-200.
27. Sarkar S., Yadav P., Trivedi R., Bansal A.K., Bhatnagar D. Cadmium-induced lipid peroxidation and the status of the antioxidant system in rat tissues. J. Tr. El. Biol. Med. 9:1995;144-149.
28. Sigman D.S., Kuwabara M.D. Footprinting DNA-protein complexes in situ following gel retardation assays using 1,10 phenanthroline-copper ion: Escherichia coli RNA polymerase-lac promoter complexes. Biochemistry. 26:1987;7234-7238.
29. Van Birgelen A.P.J.M., Hebert C.D., Wenk M.L., Grimes L.K., Chapin R.E., Mahler J., Travlos G.S., Bucher J.R. Toxicity of 3,3′,4,4′- tetrachloroazobenzene in rats and mice. Toxicol. Appl. Pharmacol. 156:1999;147-159.
30. White A.R., Multhap G., Maher F., Bellingham S., Camarakis J., Zheng H., Bush A.I., Beyreuther K., Masters C.L., Cappai R. The Alzhemier's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures. J. Neurosci. 19:1999;9170-9179.