C5-blocking antibody reduces fluid requirements and improves responsiveness to fluid infusion in hemorrhagic shock managed with hypotensive resuscitation

Journal of Applied Physiology

Volumn 102, Issue 2, 2007, Pages 673-680

  Peckham, Russell M ^a,b,d   Handrigan, Michael T ^a   Bentley, Timothy B ^a   Falabella, Michael J ^a   Chrovian, Andrew D ^a   Stahl, Gregory L ^c   Tsokos, George C ^a,b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Uniformed Services University of the Health Sciences   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NONE   (United States)

Author keywords

Complement; Hypotensive resuscitation; Resuscitation; Shock

Indexed keywords

BLOCKING ANTIBODY; C5 BLOCKING ANTIBODY; HETASTARCH; RINGER LACTATE SOLUTION; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTICLE; BLOOD SAMPLING; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; DRUG EFFECT; FLUID THERAPY; HEMODYNAMICS; HEMORRHAGIC SHOCK; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; RESUSCITATION;

ANIMALS; ANTIBODIES; BLOOD PRESSURE; COMPLEMENT C5; FLUID THERAPY; HYPOTENSION, CONTROLLED; INFUSIONS, INTRA-ARTERIAL; ISOTONIC SOLUTIONS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC;

EID: 33846882009     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00917.2006     Document Type: Article

References (38)

1. Bellamy RF. The causes of death in conventional land warfare: implications for combat casualty care research. Mil Med 149: 55-62, 1984.
2. Bickell WH, Bruttig SP, Millnamow GA, O'Benar J, Wade CE. The detrimental effects of intravenous crystalloid after aortotomy in swine. Surgery 110: 529-536, 1991.
3. Bickell WH, Wall MJ Jr, Pepe PE, Martin RR, Ginger VF, Allen MK, Mattox KL. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 331: 1105-1109, 1994.
4. Carrier M, Menasche P, Levy JH, Newman MF, Taylor KM, Haverich A, Chen JC, Shernan SK, van de Werf F, van der Laan M, Todaro TG, Adams PX, Verrier ED. Inhibition of complement activation by pexelizumab reduces death in patients undergoing combined aortic valve replacement and coronary artery bypass surgery. J Thorac Cardiovasc Surg 131: 352-356, 2006.
5. Cirino G, Cicala C, Bucci MR, Sorrentino L, Maraganore JM, Stone SR. Thrombin functions as an inflammatory mediator through activation of its receptor. J Exp Med 183: 821-827, 1996.
6. Dries DJ. Hypotensive resuscitation. Shock 6: 311-316, 1996.
7. Fruchterman TM, Spain DA, Wilson MA, Harris PD, Garrison RN. Complement inhibition prevents gut ischemia and endothelial cell dysfunction after hemorrhage/resuscitation. Surgery 124: 782-791, 1998.
8. Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 10: 1222-1226, 2004.
9. Guo RF, Ward PA. Role of C5a in inflammatory responses. Annu Rev Immunol 23: 821-852, 2005.
10. Handrigan MT, Bentley TB, Oliver JD, Tabaku LS, Burge JR, Atkins JL. Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake rats. Shock 23: 337-343, 2005.
11. Hardy JF, de Moerloose P, Samama CM. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth 53: S40-S58, 2006.
12. Harkin DW, Marron CD, Rother RP, Romaschin A, Rubin BB, Lindsay TF. C5 complement inhibition attenuates shock and acute lung injury in an experimental model of ruptured abdominal aortic aneurysm. Br J Surg 92: 1227-1234, 2005.
13. Harkin DW, Romaschin A, Taylor SM, Rubin BB, Lindsay TF. Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm. J Vasc Surg 39: 196-206, 2004.
14. Hecke F, Schmidt U, Kola A, Bautsch W, Klos A, Kohl J. Circulating complement proteins in multiple trauma patients: correlation with injury severity, development of sepsis, and outcome. Crit Care Med 25: 2015-2024, 1997.
15. Holers VM. Clinical Immunology Principles and Practice. London: Mosby, 2001.
16. Horstick G, Kempf T, Lauterbach M, Bhakdi S, Kopacz L, Heimann A, Malzahn M, Horstick M, Meyer J, Kempski O. C1-esterase-inhibitor treatment at early reperfusion of hemorrhagic shock reduces mesentry leukocyte adhesion and rolling. Microcirculation 8: 427-433, 2001.
17. Hoyt DB. A clinical review of bleeding dilemmas in trauma. Semin Hematol 41: 40-43, 2004.
18. Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA. Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med 12: 682-687, 2006.
19. Kirkpatrick AW, Balogh Z, Ball CG, Ahmed N, Chun R, McBeth P, Kirby A, Zygun DA. The secondary abdominal compartment syndrome: iatrogenic or unavoidable? J Am Coll Surg 202: 668-679, 2006.
20. Kochilas L, Campbell B, Scalia R, Lefer AM. Beneficial effects of C1 esterase inhibitor in murine traumatic shock. Shock 8: 165-169, 1997.
21. Levy JH. Massive transfusion coagulopathy. Semin Hematol 43: S59-S63, 2006.
22. Liu LM, Ward JA, Dubick MA. Effects of crystalloid and colloid resuscitation on hemorrhage-induced vascular hyporesponsiveness to norepinephrine in the rat. J Trauma 54: S159-S168, 2003.
23. Mapstone J, Roberts I, Evans P. Fluid resuscitation strategies: a systematic review of animal trials. J Trauma 55: 571-589, 2003.
24. Mayer MM. Complement and complement fixation. In: Experimental Immunochemistry, edited by Mayer MM and Kabat EA. Springfield, IL: Charles C. Thomas, 1965, p. 133-240.
25. National Association of Emergency Medical Technicians. PHTLS: Basic and Advanced Prehospital Trauma Life Support, Revised (5th ed.). St. Louis, MO: Mosby, 2006.
26. Owens TM, Watson WC, Prough DS, Uchida T, Kramer GC. Limiting initial resuscitation of uncontrolled hemorrhage reduces internal bleeding and subsequent volume requirements. J Trauma 39: 200-207, 1995.
27. Roche AM, James MF, Bennett-Guerrero E, Mythen MG. A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids. Anesth Analg 102: 1274-1279, 2006.
28. Spain DA, Fruchterman TM, Matheson PJ, Wilson MA, Martin AW, Garrison RN. Complement activation mediates intestinal injury after resuscitation from hemorrhagic shock. J Trauma 46: 224-233, 1999.
29. Stahl GL, Reenstra WR, Frendl G. Complement-mediated loss of endothelium-dependent relaxation of porcine coronary arteries. Role of the terminal membrane attack complex. Circ Res 76: 575-583, 1995.
30. Stern SA, Dronen SC, Birrer P, Wang X. Effect of blood pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury. Ann Emerg Med 22: 155-163, 1993.
31. Szebeni J, Baranyi L, Savay S, Gotze O, Alving CR, Bunger R, Mongan PD. Complement activation during hemorrhagic shock and resuscitation in swine. Shock 20: 347-355, 2003.
32. Thiemermann C, Szabo C, Mitchell JA, Vane JR. Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci USA 90: 267-271, 1993.
33. Vakeva AP, Agah A, Rollins SA, Matis LA, Li L, Stahl GL. Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy. Circulation 97: 2259-2267, 1998.
34. Verrier ED, Shernan SK, Taylor KM, Van de WF, Newman MF, Chen JC, Carrier M, Haverich A, Malloy KJ, Adams PX, Todaro TG, Mojcik CF, Rollins SA, Levy JH. Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial. JAMA 291: 2319-2327, 2004.
35. Wada K, Montalto MC, Stahl GL. Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat. Gastroenterology 120: 126-133, 2001.
36. Whiss PA. Pexelizumab Alexion. Curr Opin Invest Drugs 3: 870-877, 2002.
37. Younger JG, Sasaki N, Waite MD, Murray HN, Saleh EF, Ravage ZB, Hirschl RB, Ward PA, Till GO. Detrimental effects of complement activation in hemorrhagic shock. J Appl Physiol 90: 441-446, 2001.
38. Zhao KS, Huang X, Liu J, Huang Q, Jin C, Jiang Y, Jin J, Zhao G. New approach to treatment of shock: restitution of vasoreactivity. Shock 18: 189-192, 2002.