C5 complement inhibition attenuates shock and acute lung injury in an experimental model of ruptured abdominal aortic aneurysm

British Journal of Surgery

Volumn 92, Issue 10, 2005, Pages 1227-1234

  Harkin, D W ^a,b   Marron, C D ^b   Rother, R P ^c   Romaschin, A ^a   Rubin, B B ^a   Lindsay, T F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ROYAL VICTORIA HOSPITAL   (United Kingdom)

^c ALEXION PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5 INHIBITOR; INTERLEUKIN 6; MONOCLONAL ANTIBODY; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA; COMPLEMENT COMPONENT C5; PEROXIDASE; RNA;

ABDOMINAL AORTA ANEURYSM; ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA ISOLATION; SHOCK; UPREGULATION; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; AORTA RUPTURE; BLOOD PRESSURE; DRUG ANTAGONISM; ENZYMOLOGY; HEMORRHAGIC SHOCK; IMMUNOLOGY; METABOLISM; PERMEABILITY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; AORTIC ANEURYSM, ABDOMINAL; AORTIC RUPTURE; BLOOD PRESSURE; COMPLEMENT ACTIVATION; COMPLEMENT C5; INTERLEUKIN-6; MALE; PERMEABILITY; PEROXIDASE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY DISTRESS SYNDROME, ADULT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SHOCK, HEMORRHAGIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 26944493838     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1002/bjs.4938     Document Type: Article

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