Detrimental effects of complement activation in hemorrhagic shock

Journal of Applied Physiology

Volumn 90, Issue 2, 2001, Pages 441-446

  Younger, John G ^a,e   Sasaki, Nobuyoshi ^b   Waite, Michael D ^c   Murray, Holt N ^c   Saleh, Edward F ^a   Ravage, Zachary A ^a   Hirschl, Ronald B ^d   Ward, Peter A ^a   Till, Gerd O ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Anaphylatoxin; C5a; Carboxypeptidase N; Cobra venom factor; Ischemia reperfusion; Traumatic shock

Indexed keywords

ANAPHYLATOXIN; ARGININE CARBOXYPEPTIDASE; BICARBONATE; COBROTOXIN; COMPLEMENT COMPONENT C5A; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PH; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CONTROLLED STUDY; DEATH; HEMODYNAMICS; HEMOLYSIS; HEMORRHAGIC SHOCK; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; METABOLIC ACIDOSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RESUSCITATION;

EID: 0035142425     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2001.90.2.441     Document Type: Article

References (21)

1. Two anticomplementary factors in cobra venom: Hemolysis of guinea pig erythrocytes by one of them
2. Protective effects of C 5a blockade in sepsis
3. Complement activation following multiple injuries
4. Complement inhibition prevents gut ischemia and endothelial cell dysfunction after hemorrhage/resuscitation
5. Circulating complement proteins in multiple trauma patients: Correlation with injury severity, development of sepsis, and outcome
6. Complement activation and hematologic, hemodynamic, and respiratory reactions early after soft-tissue injury
7. Terminal complement complexes and anaphylatoxins in septic and ischemic patients
8. Effect of nonviable tissue and abscesses on complement depletion and the development of bacteremia
9. Soluble complement receptor type-1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat
10. Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase (SCPN). I. Lethality and pathologic effects on pulmonary tissue
11. Complement plays an essential role in shock following intestinal ischemia in rats
12. Accentuated formation of the terminal C5b-9 complement complex in patient plasma precedes development of the adult respiratory distress syndrome
13. A potent mercapto bi-product analogue inhibitor for human carboxypeptidase-N
14. Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium
15. Complement studies of sera and other biological fluids
16. Intravascular activation of complement and acute lung injury
17. Complement and the severity of pulmonary failure
18. Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement
19. The pattern of early lung parenchymal and airspace injury following acute blood loss
20. Partial liquid ventilation protects lung during resuscitation from hemorrhagic shock
21. Complement activation and the prognostic value of C 3a in patients at risk of adult respiratory distress syndrome