Investigation of the mechanism of nicotine demethylation in Nicotiana through 2H and 15N heavy isotope effects: Implication of cytochrome P450 oxidase and hydroxyl ion transfer

Archives of Biochemistry and Biophysics

Volumn 458, Issue 2, 2007, Pages 175-183

  Molinié, Roland ^a   Kwiecień, Renata A ^b   Paneth, Piotr ^b   Hatton, Wilfried ^c   Lebreton, Jacques ^c   Robins, Richard J ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^c Centre National de la Recherche Scientifique   (France)

Author keywords

Cytochrome P450; Demethylation; Hydroxyl ion transfer; Nicotine; SAM1

Indexed keywords

CYTOCHROME P450 REDUCTASE; HYDROXYL GROUP; ISOTOPE; N METHYL 2 PHENYLPYRROLIDINE; NICOTINE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; DEMETHYLATION; DRUG MECHANISM; DRUG STRUCTURE; IN VIVO STUDY; ION TRANSPORT; PLANT CELL CULTURE; PRIORITY JOURNAL; REACTION ANALYSIS; TOBACCO;

DEUTERIUM; HYDROXIDES; METHYLATION; MODELS, CHEMICAL; NADPH-FERRIHEMOPROTEIN REDUCTASE; NICOTINE; NITROGEN ISOTOPES; PYRROLIDINES; TOBACCO;

NICOTIANA;

EID: 33846841954     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.12.013     Document Type: Article

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