Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells

Molecular Cancer Therapeutics

Volumn 6, Issue 1, 2007, Pages 82-92

  Park, Moon Taek ^a   Kang, Young Hee ^a   Park, In Chul ^b   Kim, Chun Ho ^b   Lee, Yun Sil ^b   Chung, Hee Yong ^c   Lee, Su Jae ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ARSENIC TRIOXIDE; CYTOCHROME C; ISOQUINOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHYTOSPHINGOSINE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME RELEASE; GENETIC TRANSFECTION; HUMAN; LEUKEMIA CELL; MITOCHONDRION; MOLECULAR MECHANICS; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; ARSENICALS; BCL-2-ASSOCIATED X PROTEIN; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; NEOPLASMS; OXIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; SPHINGOSINE;

EID: 33846837271     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0349     Document Type: Article

References (47)

1. Soignet SL. Clinical experience of arsenic trioxide in relapsed acute promyelocytic leukemia. Oncologist 2001;6:11-6.
2. Shen Y, Shen ZX, Yen H, et al. Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage. Leukemia 2001;15:735-41.
3. Uslu R, Sanli UA, Sezgin C, et al. Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines. Clin Cancer Res 2000; 6:4957-64.
4. Shen ZY, Shen J, Cai WJ, et al. The alteration of mitochondria is an early event of arsenic trioxide induced apoptosis in esophageal carcinoma cells. Int J Mol Med 2000;5:155-8.
5. 3) in the orthotopic metastasis model of androgen-independent prostate cancer. Cancer Res 2001; 61:5432-40.
6. Jing Y, Dai J, Chalmers-Redman RM, et al. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis. Blood 1999;94: 2102-11.
7. Jabs T. Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem Pharmacol 1999;57:231-45.
8. Chou WC, Jie C, Kenedy AA, et al. Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A 2004; 101:4578-83.
9. Bernstam L, Nriagu J. Molecular aspects of arsenic stress. J Toxicol Environ Health B Crit Rev 2000;3:293-322.
10. Chen YC, Lin-Shiau SY, Lin JK. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J Cell Physiol 1998;177:324-33.
11. Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, Waxman S. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis. Blood 1999;94:2102-11.
12. Dai J, Weinberg RS, Waxman S, et al. Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide trough modulation of the glutathione redox system. Blood 1999;93: 268-77.
13. Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A 1997;94: 3668-72.
14. Wolter KG, Hsu YT, Smith CL, et al. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 1997;139:1281-92.
15. Nechushtan A, Smith CL, Hsu YT, et al. Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J 1999;18: 2330-41.
16. Xiang J, Chao DT, Korsmeyer SJ. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci U S A 1996;93:14559-63.
17. 2+ ions. J Cell Biol 1998; 143:217-24.
18. Jurgensmeier JM, Xie Z, Deveraux Q, et al. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 1998;95:4997-5002.
19. Desagher S, Osen-Sand A, Nichols A, et al. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol 1999;144:891-901.
20. Finucane DM, Bossy-Wetzel E, Waterhouse NJ, et al. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 1999;274:2225-33.
21. Ghatan S, Larner S, Kinoshita Y, et al. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol 2000; 150:335-47.
22. Park MT, Choi JA, Kim MJ, et al. Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. J Biol Chem 2003;278:50624-34.
23. Choi JA, Park MT, Kang CM, et al. Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of P13K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways. Oncogene 2004;23:9-20.
24. Cheng A, Chan SL, Milhavet O, et al. p38 MAP kinase mediates nitric oxide-induced apoptosis of neural progenitor cells. J Biol Chem 2001;276: 43320-7.
25. Galan A, Garcia-Bermejo ML, Troyano A, et al. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells. J Biol Chem 2000;275:11418-24.
26. de Murcia G, Schreiber V, Molinete M, et al. Structure and function of poly (ADP-ribose) polymerase. Mol Cell Biochem 1994;138:15-24.
27. Lautier D, Lagueux J, Thibodeau J, et al. Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem 1993; 122:171-93.
28. Szabo C, Zingarelli B, O'Connor M, et al. DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci U S A 1996;93:1753-8.
29. Ha HC, Snyder SH. Poly(ADP-ribose) polymerase-1 in the nervous system. Neurobiol Dis 2000;7:225-39.
30. Park MT, Kim MJ, Kang YH, et al. Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. Blood 2005; 105:1724-33.
31. Yu SW, Wang H, Poitras MF, et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002;297:259-63.
32. Ha HC, Snyder SH. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci U S A 1999;96: 13978-82.
33. Szabo C, Dawson VL. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 1998; 19:287-98.
34. + depletion and mitochondrial permeability transition. J Biol Chem 2004; 279:18895-902.
35. Kang YH, Yi MJ, Kim MJ, et al. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. Cancer Res 2004;64:8960-7.
36. Maceyka M, Payne SG, Milstien S, et al. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta 2002; 1585:193-201.
37. Cuvillier O. Sphingosine in apoptosis signaling. Biochim Biophys Acta 2002;1585:153-62.
38. Kolesnick RN, Kronke M. Regulation of ceramide production and apoptosis. Annu Rev Physiol 1998;60:643-65.
39. Bose R, Verheij M, Haimovitz-Friedman A, et al. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 1995;82:405-14.
40. Kimura K, Bowen C, Spiegel S, et al. Tumor necrosis factor sensitizes prostate cancer cells to -irradiation-induced apoptosis. Cancer Res 1999; 59:1606-14.
41. Pastorino JG, Chen ST, Tafani M, et al. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 1998;273:7770-5.
42. Mandic A, Viktorsson K, Molin M, et al. Cisplatin induces the proapoptotic conformation of Bak in a MEKK1-dependent manner. Mol Cell Biol 2001;21:3684-91.
43. Alessenko AV. The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death. Membr Cell Biol 2000; 13:303-20.
44. Zhuang S, Demirs JT, Kochevar IE. p38 Mitogen-activated protein kinase mediates Bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide. J Biol Chem 2000;275:25939-48.
45. Martin IDS, Lonergan PE, Boland B, et al. Apoptotic changes in the aged brain are triggered by interleukin-1-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. J Biol Chem 2002;277: 34239-46.
46. Kim SJ, Hwang SG, Shin DY, et al. p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFB-dependent transcription and stabilization by serine 15 phosphorylation. J Biol Chem 2002;277:33501-8.
47. Tsuruta F, Masuyama N, Gotoh Y. The phosphatidylinositol 3-kinase (Pl3K)-Akt pathway suppresses Bax translocation to mitochondria. J Biol Chem 2002;277:14040-7.