The microglial gene regulatory network activated by interferon-gamma

Journal of Neuroimmunology

Volumn 183, Issue 1-2, 2007, Pages 1-6

  Moran, Linda B ^a   Duke, Dawn C ^a   Graeber, Manuel B ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Antigen presentation; Expression profiling; Microarrays; Microglial function; Pathway signature

Indexed keywords

COMPLEMENT COMPONENT C1S INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 1BETA CONVERTING ENZYME; NEUROPROTECTIVE AGENT;

ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL DEATH; COMPUTER MODEL; CONTROLLED STUDY; EUKARYOTIC CELL; EXTRACELLULAR MATRIX; FALSE POSITIVE RESULT; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MAPPING; MICROARRAY ANALYSIS; MICROGLIA; MOLECULAR INTERACTION; NERVE STIMULATION; NEUROPROTECTION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; INTERFERON-GAMMA; MICROGLIA; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED LEW;

EID: 33846810062     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.10.023     Document Type: Article

References (27)

1. Armbrust T., Schwogler S., Zohrens G., and Ramadori G. C1 esterase inhibitor gene expression in rat Kupffer cells, peritoneal macrophages and blood monocytes: modulation by interferon gamma. J. Exp. Med. 178 (1993) 373-380
2. Badie B., Schartner J., Vorpahl J., and Preston K. Interferon-γ induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro. Exp. Neurol. 162 (2000) 290-296
3. Banati R. Visualising microglial activation in vivo. Glia 40 (2002) 206-217
4. Banati R.B., Newcombe J., Gunn R.N., Cagnin R.N., Turkheimer F., Heppner F., Price G., Wegner F., Giovannoni G., Miller D.H., Perkin G.D., Smith T., Hewson A.K., Bydder G., Kreutzberg G.W., Jones T., Cuzner M.L., and Myers R. The peripheral benzodiazepine binding site in the brain in multiple sclerosis Quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123 (2000) 2321-2337
5. Blalock E.M., Chen K.C., Stromberg A.J., Norris C.M., Kadish I., Kraner S.D., Porter N.M., and Landfield P.W. Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation. Ageing. Res. Rev. 4 (2005) 481-512
6. Boehm U., Klamp T., Groot M., and Howard J.C. Cellular responses to interferon-gamma. Annu. Rev. Immunol. 15 (1997) 749-795
7. Conti B., Park L.C., Calingasan N.Y., Kim Y., Kim H., Bae Y., Gibson G.E., and Joh T.H. Cultures of astrocytes and microglia express interleukin 18. Brain. Res. Mol. Brain. Res. 67 (1999) 46-52
8. Croisier E., Moran L.B., Dexter D.T., Pearce R.K.B., and Graeber M.B. Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. J. Neuroinflam. 2094 (2005) 2-14
9. Duke D.C., Moran L.B., Turkheimer F.E., Banati R., and Graeber M.B. Microglia in culture: what genes do they express?. Dev. Neurosci. 26 (2004) 30-37
10. Eugenin E.A., D'Aversa T.G., Lopez L., Calderon T.M., and Berman J.W. MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J. Neurochem. 85 (2003) 1299-1311
11. Frei K., Siepl C., Groscurth P., Bodmer S., Schwerdel C., and Fontana A. Antigen presentation and tumor cytotoxicity by interferon-gamma treated microglial cells. Eur. J. Immunol. 17 (1987) 1271-1278
12. Fu Y., Hashimoto M., Ino H., Murakami M., Yamazaki M., and Moriya H. Spinal root avulsion-induced upregulation of osteopontin expression in the adult rat spinal cord. Acta Neuropathol. (Berl) 107 (2004) 8-16
13. Graeber M.B., Banati R.B., Streit W.J., and Kreutzberg G.W. Immunophenotypic characterization of rat brain macrophages in culture. Neurosci. Lett. 103 (1989) 241-246
14. Giulian D., and Baker T.J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6 (1986) 2163-2178
15. Iczkiewicz J., Jackson M.J., Smith L.A., Rose S., and Jenner P. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain Res. 1118 1 (2006) 239-250 (2006 Sep 6; Epub ahead of print)
16. Lee P., Lee J., Kim S., Lee M.S., Yagita H., Kim S.Y., Kim H., and Suk K. NO as an autocrine mediator in the apoptosis of activated microglial cells: correlation between activation and apoptosis of microglial cells. Brain Res. 892 (2001) 380-385
17. Meller R., Stevens S.L., Minami M., Cameron J.A., King S., Rosenzweig H., Doyle K., Lessov N.S., Simon R.P., and Stenzel-Poore M.P. Neuroprotection by osteopontin in stroke. J. Cereb. Blood Flow Metab. 25 (2005) 217-225
18. Moran L.B., Duke D.C., Turkheimer F.E., Banati R.B., and Graeber M.B. Towards a transcriptome definition of microglial cells. Neurogenetics 5 (2004) 95-108
19. Nikitin A., Egorov S., Daraselia N., and Mazo I. Pathway studio - the analysis and navigation of molecular networks. Bioinformatocs 19 (2003) 2155-2157
20. Patston P.A., Gettins P., Beechem J., and Schapira M. Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate. Biochemistry 30 (1991) 8876-8882
21. Schroder K., Hertzog P.J., Ravasi T., and Hume D.A. Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75 (2004) 163-189
22. Seder R.A., and Paul W.E. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12 (1994) 635-673
23. Takeuchi H., Wang J., Kawanokuchi J., Mitsuma N., Mizuno T., and Suzumura A. Interferon-gamma induces microglial-activation-induced cell death: a hypothetical mechanism of relapse and remission in multiple sclerosis. Neurobiol. Dis. 22 (2006) 33-39
24. Viedt C., Dechend R., Fei J., Hansch G.M., Kreuzer J., and Orth S.R. MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1. J. Am. Soc. Nephrol. 13 (2002) 1534-1547
25. Vogt M.H., Lopatinskaya L., Smits M., Polman C.H., and Nagelkerken L. Elevated osteopontin levels in active relapsing-remitting multiple sclerosis. Ann. Neurol. 53 (2003) 819-822
26. Walker D.G., Yasuhara O., Patston P.A., McGeer E.G., and McGeer P.L. Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease. Brain Res. 675 (1995) 75-82
27. Wu Z., and Irizarry R.A. Preprocessing of oligonucleotide array data. Nat. Biotechnol. 22 (2004) 656-658