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Volumn 128, Issue 6, 2006, Pages 1868-1872

Effect of pressure on a heavy-atom isotope effect of yeast alcohol dehydrogenase

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOCHEMISTRY; HYDROGEN BONDS; HYDROSTATIC PRESSURE; ISOTOPES; MASS SPECTROMETRY; OXIDATION; YEAST;

EID: 33244478782     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja056525e     Document Type: Article
Times cited : (21)

References (38)
  • 2
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    • Buncel, E., Lee, C. C., Eds.; Elsevier: London, UK
    • Isaacs, N. S. In Isotope Effects in Organic Chemistry, Volume 6; Buncel, E., Lee, C. C., Eds.; Elsevier: London, UK, 1984; pp 67-105.
    • (1984) Isotope Effects in Organic Chemistry , vol.6 , pp. 67-105
    • Isaacs, N.S.1
  • 8
    • 33244495644 scopus 로고    scopus 로고
    • note
    • Previous papers from this laboratory incorrectly listed a value of 82.0578 in the text for the gas constant. This value applies to pressures measured in atmospheres, not bars. However, all computer regression analyses in these papers used the correct value of 83.133739.
  • 15
    • 0002590285 scopus 로고
    • Cleland, W. W., O'Leary, M. H., Northrop, D. B., Eds.; University Park Press: Baltimore
    • Northrop, D. B. In Isotope Effects on Enzyme-Catalyzed Reactions; Cleland, W. W., O'Leary, M. H., Northrop, D. B., Eds.; University Park Press: Baltimore, 1977; pp 122-152.
    • (1977) Isotope Effects on Enzyme-Catalyzed Reactions , pp. 122-152
    • Northrop, D.B.1
  • 20
    • 0008517981 scopus 로고
    • McElroy, W., Glass, G., Eds.; Johns Hopkins University Press: Baltimore, MD
    • (a) Eyring, H.; Lumry, R.; Spikes, J. In Mechanism of Enzyme Action; McElroy, W., Glass, G., Eds.; Johns Hopkins University Press: Baltimore, MD, 1954; pp 123-135.
    • (1954) Mechanism of Enzyme Action , pp. 123-135
    • Eyring, H.1    Lumry, R.2    Spikes, J.3
  • 23
    • 0002358185 scopus 로고
    • Kuby, S. A., Ed.; CRC Press: Boca Raton, FL
    • (d) Lumry, R. In Mechanism of Enzyme Action, Vol. 2; Kuby, S. A., Ed.; CRC Press: Boca Raton, FL, 1991; pp 3-81.
    • (1991) Mechanism of Enzyme Action , vol.2 , pp. 3-81
    • Lumry, R.1
  • 24
    • 0002889522 scopus 로고
    • Gregory, R. B., Ed.; Marcel Dekker: New York
    • (e) Lumry, R. In Protein-Solvent Interactions; Gregory, R. B., Ed.; Marcel Dekker: New York, 1995; pp 1-141.
    • (1995) Protein-Solvent Interactions , pp. 1-141
    • Lumry, R.1
  • 25
    • 0029077135 scopus 로고
    • Johnson, M. L., Ackers, G. K., Eds.; Methods in Enzymology 259; Academic Press: New York
    • (f) Lumry, R. In Energetics of Biological Macromolecules; Johnson, M. L., Ackers, G. K., Eds.; Methods in Enzymology 259; Academic Press: New York, 1995; pp 628-720.
    • (1995) Energetics of Biological Macromolecules , pp. 628-720
    • Lumry, R.1
  • 26
    • 33244483220 scopus 로고    scopus 로고
    • 916-Pos Part 2
    • (g) Lumry, R. Biophys. J. 2000, 78, 156A (916-Pos Part 2).
    • (2000) Biophys. J. , vol.78
    • Lumry, R.1
  • 30
    • 0032769661 scopus 로고    scopus 로고
    • (a) Hayward, S. Proteins 1999, 36, 425-435.
    • (1999) Proteins , vol.36 , pp. 425-435
    • Hayward, S.1
  • 36
    • 33244474793 scopus 로고    scopus 로고
    • note
    • 18f refers to this phenomenon as an "overshoot". The same reviewer suggested that, because pressure drives water into the interior of proteins, pressure may cause the dynamics in proteins to be more pronounced. For example, some of the inserted water will solvate buried ions, so some salt bridges could be weakened or broken under pressure, making the protein more flexible.
  • 38
    • 0001438084 scopus 로고
    • Bernasconi, C. F., Ed.; John Wiley & Sons: New York
    • Equation 8 was derived for trace labeled substrates. When dealing with comparable levels of labeled and unlabeled substrates, a more complex form of eq 4 applies (see eq 55 of Cleland, W. W. In Investigations of Rates and Mechanisms of Reactions, Vol. 6; Bernasconi, C. F., Ed.; John Wiley & Sons: New York, 1986; pp 791-870). However, the differences are insignificant with small isotope effects of 5% or less (W. W. Cleland, personal communication).
    • (1986) Investigations of Rates and Mechanisms of Reactions , vol.6 , pp. 791-870
    • Cleland, W.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.