MALDI-TOF MS for quantification of substrates and products in cultivations of Corynebacterium glutamicum

Biotechnology and Bioengineering

Volumn 72, Issue 6, 2001, Pages 642-647

  Wittmann, Christoph ^a   Heinzle, Elmar ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Corynebacterium; Lysine; MALDI TOF MS; Mass spectrometry; Metabolites; Quantification

Indexed keywords

ALANINE; GLUCOSE; LYSINE; STABLE ISOTOPE; SUCROSE;

ARTICLE; BACTERIUM CULTURE; CORYNEBACTERIUM GLUTAMICUM; MASS SPECTROMETRY; MEASUREMENT; METABOLITE; NONHUMAN; STANDARD;

CELL CULTURE TECHNIQUES; CORYNEBACTERIUM; FERMENTATION; LYSINE; REFERENCE STANDARDS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

CORYNEBACTERIUM; CORYNEBACTERIUM GLUTAMICUM;

EID: 0035916866     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0290(20010320)72:6<642::AID-BIT1030>3.0.CO;2-7     Document Type: Article

References (9)

1. Quantitative analysis of low molecular weight compounds of biological interest by matrix-assisted laser desorption ionization
2. Mass spectrometry of low molecular mass solids by matrix-assisted laser desorption ionization
3. Measurement of enantiomeric excess by kinetic resolution and mass spectrometry
4. Recent advances in the physiology and genetics of amino-acid producing Corynebacteria
5. Laser desorption and ionization of proteins with molecular masses exceeding 10000 daltons
6. Ultraviolet-laser desorption/ionization mass spectrometry of femtomolar amounts of large proteins
7. LC/MS applications in drug development
8. Protein and polymer analyses up to 100000 m/z by laser ionization time-of-flight mass spectrometry
9. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction