Local pulmonary immune stimulation by the Toll-like receptor 2 and 6 ligand MALP-2 in rats is age dependent

Immunology Letters

Volumn 108, Issue 2, 2007, Pages 167-173

  Lührmann, Anke ^a   Grote, Karsten ^a   Stephan, Michael ^a   Tschernig, Thomas ^a   Pabst, Reinhard ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Animal model; BAL; Lipopeptide; Lung

Indexed keywords

CYTOKINE; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COMPOSITION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNE RESPONSE; IMMUNOSTIMULATION; INFLAMMATION; LEUKOCYTE; LUNG; LUNG INTERSTITIUM; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION; B-LYMPHOCYTES; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; CHEMOKINE CCL2; DENDRITIC CELLS; GENE EXPRESSION; IMMUNIZATION; LUNG; LYMPHOCYTES; MACROPHAGES, ALVEOLAR; MALE; MONOCYTES; OLIGOPEPTIDES; RATS; RATS, INBRED LEW; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33846663469     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2006.12.008     Document Type: Article

References (38)

1. Meyer K.C. Aging Proc Am Thorac Soc 2 (2005) 433-439
2. Johnson C.C., Ownby D.R., Zoratti E.M., Alford S.H., Williams L.K., and Joseph C.L. Environmental epidemiology of pediatric asthma and allergy. Epidemiol Rev 24 (2002) 154-175
3. Woodland D.L., and Blackman M.A. Immunity and age: living in the past?. Trends Immunol 27 (2006) 303-307
4. Miller R.A. The aging immune system: primer and prospectus. Science 273 (1996) 70-74
5. Pawelec G., Solana R., Remarque E., and Mariani E. Impact of aging on innate immunity. J Leukoc Biol 64 (1998) 703-712
6. Palmans E., Vanacker N.J., Pauwels R.A., and Kips J.C. Effect of age on allergeninduced structural airway changes in brown Norway rats. Am J Respir Crit Care Med 165 (2002) 1280-1284
7. Plackett T.P., Boehmer E.D., Faunce D.E., and Kovacs E.J. Aging and innate immune cells. J Leukoc Biol 76 (2004) 291-299
8. Akira S., Takeda K., and Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2 (2001) 675-680
9. Hopkins P.A., and Sriskandan S. Mammalian Toll-like receptors: to immunity and beyond. Clin Exp Immunol 140 (2005) 395-407
10. Netea M.G., van der Graaf C., Van der Meer J.W., and Kullberg B.J. Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system. J Leukoc Biol 75 (2004) 749-755
11. Cario E., Brown D., McKee M., Lynch-Devaney K., Gerken G., and Podolsky D.K. Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am J Pathol 160 (2002) 165-173
12. Faure E., Thomas L., Xu H., Medvedev A., Equils O., and Arditi M. Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol 166 (2001) 2018-2024
13. Renshaw M., Rockwell J., Engleman C., Gewirtz A., Katz J., and Sambhara S. Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol 169 (2002) 4697-4701
14. Harju K., Glumoff V., and Hallman M. Ontogeny of Toll-like receptors Tlr2 and Tlr4 in mice. Pediatr Res 49 (2001) 81-83
15. Mühlradt P.F., Kiess M., Meyer H., Süssmuth R., and Jung G. Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J Exp Med 185 (1997) 1951-1958
16. Takeuchi O., Kaufmann A., Grote K., Kawai T., Hoshino K., Morr M., et al. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol 164 (2000) 554-557
17. Takeuchi O., Kawai T., Mühlradt P.F., Morr M., Radolf J.D., Zychlinsky A., et al. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 13 (2001) 933-940
18. Deiters U., and Mühlradt P.F. Mycoplasmal lipopeptide MALP-2 induces the chemoattractant proteins macrophage inflammatory protein 1alpha (MIP-1alpha), monocyte chemoattractant protein 1, and MIP-2 and promotes leukocyte infiltration in mice. Infect Immun 67 (1999) 3390-3398
19. Lührmann A., Deiters U., Skokowa J., Hanke M., Gessner J.E., Muhlradt P., et al. In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application. Infect Immun 70 (2002) 3785-3792
20. Borsutzky S., Ebensen T., Link C., Becker P.D., Fiorelli V., Cafaro A., et al. Efficient systemic and mucosal responses against the HIV-1 Tat protein by prime/boost vaccination using the lipopeptide MALP-2 as adjuvant. Vaccine 24 (2006) 2049-2056
21. Rharbaoui F., Drabner B., Borsutzky S., Winckler U., Morr M., Ensoli B., et al. The Mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant. Eur J Immunol 32 (2002) 2857-2865
22. Lührmann A., Tschernig T., Pabst R., and Niewiesk S. Improved intranasal immunization with live-attenuated measles virus after co-inoculation of the lipopeptide MALP-2. Vaccine 23 (2005) 4721-4726
23. Jacobs E. Mycoplasma infections of the human respiratory tract. Wien Klin Wochenschr 109 (1997) 574-577
24. Glaab T., Hoymann H.G., Hohlfeld J.M., Korolewitz R., Hecht M., Alarie Y., et al. Noninvasive measurement of midexpiratory flow indicates bronchoconstriction in allergic rats. J Appl Physiol 93 (2002) 1208-1214
25. von Mutius E. Paediatric origins of adult lung disease. Thorax 56 (2001) 153-157
26. Shinagawa K., and Kojima M. Mouse model of airway remodeling: strain differences. Am J Respir Crit Care Med 168 (2003) 959-967
27. Ramos-Barbon D., Ludwig M.S., and Martin J.G. Airway remodeling: lessons from animal models. Clin Rev Allergy Immunol 27 (2004) 3-21
28. Antonini J.M., Roberts J.R., Clarke R.W., Yang H.M., Barger M.W., Ma J.Y., et al. Effect of age on respiratory defense mechanisms: pulmonary bacterial clearance in Fischer 344 rats after intratracheal instillation of Listeria monocytogenes. Chest 120 (2001) 240-249
29. Weiss R.A., Chanana A.D., and Joel D.D. Postnatal maturation of pulmonary antimicrobial defense mechanisms in conventional and germ-free lambs. Pediatr Res 20 (1986) 496-504
30. Zeligs B.J., Nerurkar L.S., Bellanti J.A., and Zeligs J.D. Maturation of the rabbit alveolar macrophage during animal development. Perinatal influx into alveoli and ultrastructural differentiation. Pediatr Res 11 (1977) 197-208
31. Kaliste E., Linnainmaa M., Meklin T., Torvinen E., and Nevalainen A. The bedding of laboratory animals as a source of airborne contaminants. Lab Anim 38 (2004) 25-37
32. Pabst R., and Tschernig T. Control of lymphocyte trafficking through the lung. In: Lambrecht B.N., Hoogsteden H.C., and Diamant Z. (Eds). The immunological basis of asthma (2003), M. Dekker, New York 293-309
33. Nelson D.J., McMenamin C., McWilliam A.S., Brenan M., and Holt P.G. Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract. J Exp Med 179 (1994) 203-212
34. Vermaelen K., and Pauwels R. Pulmonary dendritic cells. Am J Respir Crit Care Med 172 (2005) 530-551
35. Grigg J., and Riedler J. Developmental airway cell biology. The "normal" young child. Am J Respir Crit Care Med 162 (2000) S52-S55
36. Flo J., and Massouh E. Age-related changes of naive and memory CD4 rat lymphocyte subsets in mucosal and systemic lymphoid organs. Dev Comp Immunol 21 (1997) 443-453
37. Singh P., Daniels M., Winsett D.W., Richards J., Doerfler D., Hatch G., et al. Phenotypic comparison of allergic airway responses to house dust mite in three rat strains. Am J Physiol Lung Cell Mol Physiol 284 (2003) L588-L598
38. Ewaldsson B., Fogelmark B., Feinstein R., Ewaldsson L., and Rylander R. Microbial cell wall product contamination of bedding may induce pulmonary inflammation in rats. Lab Anim 36 (2002) 282-290