메뉴 건너뛰기




Volumn 10, Issue 2, 2007, Pages 161-168

VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; KINESIN; RECEPTOR;

EID: 33846639295     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1835     Document Type: Article
Times cited : (70)

References (45)
  • 1
    • 33644871213 scopus 로고    scopus 로고
    • Navigating the anterior-posterior axis with Wnts
    • Zou, Y. Navigating the anterior-posterior axis with Wnts. Neuron 49, 787-789 (2006).
    • (2006) Neuron , vol.49 , pp. 787-789
    • Zou, Y.1
  • 2
    • 0037032812 scopus 로고    scopus 로고
    • Molecular mechanisms of axon guidance
    • Dickson, B.J. Molecular mechanisms of axon guidance. Science 298, 1959-1964 (2002).
    • (2002) Science , vol.298 , pp. 1959-1964
    • Dickson, B.J.1
  • 3
    • 0025332245 scopus 로고    scopus 로고
    • Hedgecock, E.M., Culotti, J.G. & Hall, D.H. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61-85 (1990).
    • Hedgecock, E.M., Culotti, J.G. & Hall, D.H. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61-85 (1990).
  • 4
    • 0026481173 scopus 로고
    • UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans
    • Ishii, N., Wadsworth, W.G., Stern, B.D., Culotti, J.G. & Hedgecock, E.M. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9, 873-881 (1992).
    • (1992) Neuron , vol.9 , pp. 873-881
    • Ishii, N.1    Wadsworth, W.G.2    Stern, B.D.3    Culotti, J.G.4    Hedgecock, E.M.5
  • 5
    • 0033582914 scopus 로고    scopus 로고
    • Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
    • Brose, K. et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96, 795-806 (1999).
    • (1999) Cell , vol.96 , pp. 795-806
    • Brose, K.1
  • 6
    • 0032559170 scopus 로고    scopus 로고
    • The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans
    • Zallen, J.A., Yi, B.A. & Bargmann, C.I. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans. Cell 92, 217-227 (1998).
    • (1998) Cell , vol.92 , pp. 217-227
    • Zallen, J.A.1    Yi, B.A.2    Bargmann, C.I.3
  • 7
    • 0033965112 scopus 로고    scopus 로고
    • Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans
    • Su, M. et al. Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans. Development 127, 585-594 (2000).
    • (2000) Development , vol.127 , pp. 585-594
    • Su, M.1
  • 8
    • 0027163671 scopus 로고
    • Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally
    • Hamelin, M., Zhou, Y., Su, M.W., Scott, I.M. & Culotti, J.G. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 364, 327-330 (1993).
    • (1993) Nature , vol.364 , pp. 327-330
    • Hamelin, M.1    Zhou, Y.2    Su, M.W.3    Scott, I.M.4    Culotti, J.G.5
  • 9
    • 0032006352 scopus 로고    scopus 로고
    • Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans
    • Colavita, A. & Culotti, J.G. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev. Biol. 194, 72-85 (1998).
    • (1998) Dev. Biol , vol.194 , pp. 72-85
    • Colavita, A.1    Culotti, J.G.2
  • 10
    • 0032055881 scopus 로고    scopus 로고
    • vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity
    • Wolf, F.W., Hung, M.S., Wightman, B., Way, J. & Garriga, G. vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity. Neuron 20, 655-666 (1998).
    • (1998) Neuron , vol.20 , pp. 655-666
    • Wolf, F.W.1    Hung, M.S.2    Wightman, B.3    Way, J.4    Garriga, G.5
  • 11
    • 0030064181 scopus 로고    scopus 로고
    • The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration
    • Wightman, B. et al.The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration. Development 122, 671-682 (1996).
    • (1996) Development , vol.122 , pp. 671-682
    • Wightman, B.1
  • 12
    • 33846625269 scopus 로고    scopus 로고
    • Watari-Goshima, N., Ogura, K.-i., Wolf, F.W., Goshima, Y. & Garriga, G. C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations. Nat. Neurosci. advance online publication, 21 January 2007 (doi:10.1038/nn1834).
    • Watari-Goshima, N., Ogura, K.-i., Wolf, F.W., Goshima, Y. & Garriga, G. C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations. Nat. Neurosci. advance online publication, 21 January 2007 (doi:10.1038/nn1834).
  • 13
    • 0030592485 scopus 로고    scopus 로고
    • UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
    • Chan, S.S. et al.UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87, 187-195 (1996).
    • (1996) Cell , vol.87 , pp. 187-195
    • Chan, S.S.1
  • 14
    • 0030062518 scopus 로고    scopus 로고
    • Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
    • Wadsworth, W.G., Bhatt, H. & Hedgecock, E.M. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron 16, 35-46 (1996).
    • (1996) Neuron , vol.16 , pp. 35-46
    • Wadsworth, W.G.1    Bhatt, H.2    Hedgecock, E.M.3
  • 15
    • 0025332945 scopus 로고
    • Mutations affecting embryonic cell migrations in Caenorhabditis elegans
    • Manser, J. & Wood, W.B. Mutations affecting embryonic cell migrations in Caenorhabditis elegans. Dev. Genet. 11, 49-64 (1990).
    • (1990) Dev. Genet , vol.11 , pp. 49-64
    • Manser, J.1    Wood, W.B.2
  • 16
    • 17944370144 scopus 로고    scopus 로고
    • Hao, J.C. et al. C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor. Neuron 32, 25-38 (2001).
    • Hao, J.C. et al. C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor. Neuron 32, 25-38 (2001).
  • 17
    • 11844304062 scopus 로고    scopus 로고
    • The role of the Rho GTPases in neuronal development
    • Govek, E.E., Newey, S.E. & Van Aelst, L. The role of the Rho GTPases in neuronal development. Genes Dev. 19, 1-49 (2005).
    • (2005) Genes Dev , vol.19 , pp. 1-49
    • Govek, E.E.1    Newey, S.E.2    Van Aelst, L.3
  • 18
    • 2542633389 scopus 로고    scopus 로고
    • Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans
    • Dalpe, G., Zhang, L.W., Zheng, H. & Culotti, J.G. Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans. Development 131, 2073-2088 (2004).
    • (2004) Development , vol.131 , pp. 2073-2088
    • Dalpe, G.1    Zhang, L.W.2    Zheng, H.3    Culotti, J.G.4
  • 19
    • 0037081172 scopus 로고    scopus 로고
    • ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegans
    • Kishore, R.S. & Sundaram, M.V. ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegans. Dev. Biol. 241, 339-348 (2002).
    • (2002) Dev. Biol , vol.241 , pp. 339-348
    • Kishore, R.S.1    Sundaram, M.V.2
  • 20
    • 0035195553 scopus 로고    scopus 로고
    • Lundquist, E.A., Reddien, P.W., Hartwieg, E., Horvitz, H.R. & Bargmann, C.I. Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128, 4475-4488 (2001).
    • Lundquist, E.A., Reddien, P.W., Hartwieg, E., Horvitz, H.R. & Bargmann, C.I. Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128, 4475-4488 (2001).
  • 21
    • 0032549710 scopus 로고    scopus 로고
    • UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans
    • Steven, R. et al. UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92, 785-795 (1998).
    • (1998) Cell , vol.92 , pp. 785-795
    • Steven, R.1
  • 22
    • 0036392188 scopus 로고    scopus 로고
    • Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth
    • Wu, Y.C., Cheng, T.W., Lee, M.C. & Weng, N.Y. Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth. Dev. Biol. 250, 145-155 (2002).
    • (2002) Dev. Biol , vol.250 , pp. 145-155
    • Wu, Y.C.1    Cheng, T.W.2    Lee, M.C.3    Weng, N.Y.4
  • 23
    • 0141781088 scopus 로고    scopus 로고
    • Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo
    • Kubiseski, T.J., Culotti, J. & Pawson, T. Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo. Mol. Cell. Biol. 23, 6823-6835 (2003).
    • (2003) Mol. Cell. Biol , vol.23 , pp. 6823-6835
    • Kubiseski, T.J.1    Culotti, J.2    Pawson, T.3
  • 24
    • 0030866898 scopus 로고    scopus 로고
    • Role of a new Rho family member in cell migration and axon guidance in C. elegans
    • Zipkin, I.D., Kindt, R.M. & Kenyon, C.J. Role of a new Rho family member in cell migration and axon guidance in C. elegans. Cell 90, 883-894 (1997).
    • (1997) Cell , vol.90 , pp. 883-894
    • Zipkin, I.D.1    Kindt, R.M.2    Kenyon, C.J.3
  • 25
    • 0036850623 scopus 로고    scopus 로고
    • Growth cone turning induced by direct local modification of microtubule dynamics
    • Buck, K.B. & Zheng, J.Q. Growth cone turning induced by direct local modification of microtubule dynamics. J. Neurosci. 22, 9358-9367 (2002).
    • (2002) J. Neurosci , vol.22 , pp. 9358-9367
    • Buck, K.B.1    Zheng, J.Q.2
  • 26
    • 0037020231 scopus 로고    scopus 로고
    • The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism
    • Li, X. et al.The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. J. Biol. Chem. 277, 37788-37797 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 37788-37797
    • Li, X.1
  • 27
    • 0037177822 scopus 로고    scopus 로고
    • Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells
    • Li, X., Saint-Cyr-Proulx, E., Aktories, K. & Lamarche-Vane, N. Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. J. Biol. Chem. 277, 15207-15214 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 15207-15214
    • Li, X.1    Saint-Cyr-Proulx, E.2    Aktories, K.3    Lamarche-Vane, N.4
  • 28
    • 0036152522 scopus 로고    scopus 로고
    • The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1
    • Shekarabi, M. & Kennedy, T.E. The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. Mol. Cell. Neurosci. 19, 1-17 (2002).
    • (2002) Mol. Cell. Neurosci , vol.19 , pp. 1-17
    • Shekarabi, M.1    Kennedy, T.E.2
  • 29
    • 16244390509 scopus 로고    scopus 로고
    • Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion
    • Shekarabi, M. et al. Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. J. Neurosci. 25, 3132-3141 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 3132-3141
    • Shekarabi, M.1
  • 30
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • Sulston, J.E., Schierenberg, E., White, J.G. & Thomson, J.N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64-119 (1983).
    • (1983) Dev. Biol , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 31
    • 0023229321 scopus 로고
    • Genetics of cell and axon migrations in Caenorhabditis elegans
    • Hedgecock, E.M., Culotti, J.G., Hall, D.H. & Stern, B.D. Genetics of cell and axon migrations in Caenorhabditis elegans. Development 100, 365-382 (1987).
    • (1987) Development , vol.100 , pp. 365-382
    • Hedgecock, E.M.1    Culotti, J.G.2    Hall, D.H.3    Stern, B.D.4
  • 32
    • 0033694801 scopus 로고    scopus 로고
    • Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans
    • Honigberg, L. & Kenyon, C. Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans. Development 127, 4655-4668 (2000).
    • (2000) Development , vol.127 , pp. 4655-4668
    • Honigberg, L.1    Kenyon, C.2
  • 33
    • 33644499841 scopus 로고    scopus 로고
    • Wnt signals and Frizzled activity orient anterior-posterior axon outgrowth in C. elegans
    • Hilliard, M.A. & Bargmann, C.I. Wnt signals and Frizzled activity orient anterior-posterior axon outgrowth in C. elegans. Dev. Cell 10, 379-390 (2006).
    • (2006) Dev. Cell , vol.10 , pp. 379-390
    • Hilliard, M.A.1    Bargmann, C.I.2
  • 34
    • 0034854201 scopus 로고    scopus 로고
    • Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly
    • O'Brien, L.E. et al. Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nat. Cell Biol. 3, 831-838 (2001).
    • (2001) Nat. Cell Biol , vol.3 , pp. 831-838
    • O'Brien, L.E.1
  • 35
    • 19944376460 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIOMIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO
    • deBakker, C.D. et al. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIOMIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr. Biol. 14, 2208-2216 (2004).
    • (2004) Curr. Biol , vol.14 , pp. 2208-2216
    • deBakker, C.D.1
  • 36
    • 0035168371 scopus 로고    scopus 로고
    • Kinectin is a key effector of RhoG microtubule-dependent cellular activity
    • Vignal, E., Blangy, A., Martin, M., Gauthier-Rouviere, C. & Fort, P. Kinectin is a key effector of RhoG microtubule-dependent cellular activity. Mol. Cell. Biol. 21, 8022-8034 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 8022-8034
    • Vignal, E.1    Blangy, A.2    Martin, M.3    Gauthier-Rouviere, C.4    Fort, P.5
  • 37
    • 19644377414 scopus 로고    scopus 로고
    • Mechanics of the kinesin step
    • Carter, N.J. & Cross, R.A. Mechanics of the kinesin step. Nature 435, 308-312 (2005).
    • (2005) Nature , vol.435 , pp. 308-312
    • Carter, N.J.1    Cross, R.A.2
  • 38
    • 1642423898 scopus 로고    scopus 로고
    • Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension
    • Bouchard, J.F. et al. Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: a novel mechanism regulating commissural axon extension. J. Neurosci. 24, 3040-3050 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 3040-3050
    • Bouchard, J.F.1
  • 39
    • 1842557804 scopus 로고    scopus 로고
    • Lipid rafts mediate chemotropic guidance of nerve growth cones
    • Guirland, C., Suzuki, S., Kojima, M., Lu, B. & Zheng, J.Q. Lipid rafts mediate chemotropic guidance of nerve growth cones. Neuron 42, 51-62 (2004).
    • (2004) Neuron , vol.42 , pp. 51-62
    • Guirland, C.1    Suzuki, S.2    Kojima, M.3    Lu, B.4    Zheng, J.Q.5
  • 40
    • 18844448477 scopus 로고    scopus 로고
    • DCC association with lipid rafts is required for netrin-1-mediated axon guidance
    • Herincs, Z. et al. DCC association with lipid rafts is required for netrin-1-mediated axon guidance. J. Cell Sci. 118, 1687-1692 (2005).
    • (2005) J. Cell Sci , vol.118 , pp. 1687-1692
    • Herincs, Z.1
  • 41
    • 22944455544 scopus 로고    scopus 로고
    • Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration
    • Jekely, G., Sung, H.H., Luque, C.M. & Rorth, P. Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev. Cell 9, 197-207 (2005).
    • (2005) Dev. Cell , vol.9 , pp. 197-207
    • Jekely, G.1    Sung, H.H.2    Luque, C.M.3    Rorth, P.4
  • 42
    • 23644449576 scopus 로고    scopus 로고
    • Centrosome localization determines neuronal polarity
    • de Anda, F.C. et al. Centrosome localization determines neuronal polarity. Nature 436, 704-708 (2005).
    • (2005) Nature , vol.436 , pp. 704-708
    • de Anda, F.C.1
  • 44
    • 0028990430 scopus 로고
    • Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans
    • Gettner, S.N., Kenyon, C. & Reichardt, L.F. Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans. J. Cell Biol. 129, 1127-1141 (1995).
    • (1995) J. Cell Biol , vol.129 , pp. 1127-1141
    • Gettner, S.N.1    Kenyon, C.2    Reichardt, L.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.