A TNF receptor antagonistic scFv, which is not secreted in mammalian cells, is expressed as a soluble mono- and bivalent scFv derivative in insect cells

Immunotechnology

Volumn 3, Issue 3, 1997, Pages 173-184

  Brocks, Bodo ^a   Rode, Hans Jürgen ^b   Klein, Michaela ^a   Gerlach, Elke ^a   Dübel, Stefan ^c   Little, Melvyn ^b   Pfizenmaier, Klaus ^a   Moosmayer, Dieter ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c Molecular Genetics   (Germany)

Author keywords

Eukaryotic cells; Insect cells; Single chain antibodies; Tumor necrosis factor

Indexed keywords

HYBRID PROTEIN; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; RECEPTOR ANTIBODY; RECEPTOR BLOCKING AGENT; SIGNAL PEPTIDE; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANTIBODY AFFINITY; ANTIBODY PRODUCTION; ARTICLE; BACULOVIRUS; CLONING VECTOR; CONTROLLED STUDY; GENE CASSETTE; GENE EXPRESSION; HALF LIFE TIME; HUMAN; HUMAN CELL; INSECT; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING;

ANIMALS; BACULOVIRIDAE; CELL LINE, TRANSFORMED; CLONING, MOLECULAR; COS CELLS; CRICETINAE; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; KIDNEY; MICE; RECEPTORS, TUMOR NECROSIS FACTOR; SOLUBILITY; SPODOPTERA;

EID: 0343035661     PISSN: 13802933     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1380-2933(97)00011-0     Document Type: Article

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