Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorder

European Psychiatry

Volumn 22, Issue 1, 2007, Pages 32-38

  Delorme, Richard ^a,b   Goussé, Véronique ^a   Roy, Isabelle ^a,c   Trandafir, Anca ^c   Mathieu, Flavie ^a   Mouren Siméoni, Marie Christine ^b   Betancur, Catalina ^a   Leboyer, Marion ^a,c  

^a UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c HENRI MONDOR HOSPITAL   (France)

Author keywords

Endophenotype; Planning; Tower of London; Working memory

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ASSOCIATION; AUTISM; BRAIN DYSFUNCTION; BRAIN FUNCTION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; EDUCATIONAL STATUS; FAMILY STUDY; FEMALE; FUNCTIONAL ASSESSMENT; HERITABILITY; HUMAN; LEARNING; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; NEUROPSYCHOLOGICAL TEST; OBSESSIVE COMPULSIVE DISORDER; PARENT; PHENOTYPE; PLANNING; PRIORITY JOURNAL; RELATIVE; RESPONSE TIME; SCHOOL CHILD; SIBLING; TASK PERFORMANCE; VERBAL BEHAVIOR; WORKING MEMORY;

ADOLESCENT; ADULT; AUTISTIC DISORDER; CHILD; COGNITION DISORDERS; EDUCATIONAL STATUS; FAMILY; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; OBSESSIVE-COMPULSIVE DISORDER; PARENTS; PSYCHIATRIC STATUS RATING SCALES; REFERENCE VALUES; SIBLINGS;

EID: 33846519358     PISSN: 09249338     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2006.05.002     Document Type: Article

References (57)

1. Ardila A., Galeano L.M., and Rosselli M. Toward a model of neuropsychological activity. Neuropsychol Rev 8 (1998) 171-190
2. Ardila A., Pineda D., and Rosselli M. Correlation between intelligence test scores and executive function measures. Arch Clin Neuropsychol 15 (2000) 31-36
3. Benton A.L. Differential behavioral effects in frontal lobe disease. Neuropsychologia 6 (1968) 53-60
4. Bolton P., Macdonald H., Pickles A., Rios P., Goode S., Crowson M., et al. A case-control family history study of autism. J Child Psychol Psychiatry 35 (1994) 877-900
5. Bolton P.F., Pickles A., Murphy M., and Rutter M. Autism, affective and other psychiatric disorders: patterns of familial aggregation. Psychol Med 28 (1998) 385-395
6. Buxbaum J.D., Silverman J., Keddache M., Smith C.J., Hollander E., Ramoz N., et al. Linkage analysis for autism in a subset families with obsessive-compulsive behaviors: evidence for an autism susceptibility gene on chromosome 1 and further support for susceptibility genes on chromosome 6 and 19. Mol Psychiatry 9 (2004) 144-150
7. Cornblatt B.A., and Malhotra A.K. Impaired attention as an endophenotype for molecular genetic studies of schizophrenia. Am J Med Genet 105 (2001) 11-15
8. Dawson G., Munson J., Estes A., Osterling J., McPartland J., Toth K., et al. Neurocognitive function and joint attention ability in young children with autism spectrum disorder versus developmental delay. Child Dev 73 (2002) 345-358
9. Dawson G., Webb S., Schellenberg G.D., Dager S., Friedman S., Aylward E., et al. Defining the broader phenotype of autism: genetic, brain, and behavioral perspectives. Dev Psychopathol 14 (2002) 581-611
10. Demakis G.J., and Harrison D.W. Relationships between verbal and non-verbal fluency measures: implications for assessment of executive functioning. Psychol Rep 81 (1997) 43-48
11. Folstein S.E., Santangelo S.L., Gilman S.E., Piven J., Landa R., Lainhart J., et al. Predictors of cognitive test patterns in autism families. J Child Psychol Psychiatry 40 (1999) 1117-1128
12. Galderisi S., Mucci A., Catapano F., D'Amato A.C., and Maj M. Neuropsychological slowness in obsessive-compulsive patients. Is it confined to tests involving the fronto-subcortical systems?. Br J Psychiatry 167 (1995) 394-398
13. Goldberg T.E., and Weinberger D.R. Genes and the parsing of cognitive processes. Trends Cogn Sci 8 (2004) 325-335
14. Gottesman II, and Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160 (2003) 636-645
15. Goussé V., Delorme R., Chabane N., Perez-Diaz F., Mathieu F., Mouren-Siméoni M.C., et al. Is age at onset associated with executive dysfunction in obsessive-compulsive disorder?. Encéphale 31 (2005) 666-671
16. Griffith E.M., Pennington B.F., Wehner E.A., and Rogers S.J. Executive functions in young children with autism. Child Dev 70 (1999) 817-832
17. Hasler G., Drevets W.C., Manji H.K., and Charney D.S. Discovering endophenotypes for major depression. Neuropsychopharmacology 29 (2004) 1765-1781
18. Hill E.L. Executive dysfunction in autism. Trends Cogn Sci 8 (2004) 26-32
19. Hollander E., Anagnostou E., Chaplin W., Esposito K., Haznedar M.M., Licalzi E., et al. Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. Biol Psychiatry 58 (2005) 226-232
20. Hollander E., King A., Delaney K., Smith C.J., and Silverman J.M. Obsessive-compulsive behaviors in parents of multiplex autism families. Psychiatry Res 117 (2003) 11-16
21. Hughes C., Leboyer M., and Bouvard M. Executive function in parents of children with autism. Psychol Med 27 (1997) 209-220
22. Hughes C., Plumet M.H., and Leboyer M. Towards a cognitive phenotype for autism: increased prevalence of executive dysfunction and superior spatial span amongst siblings of children with autism. J Child Psychol Psychiatry 40 (1999) 705-718
23. Jones-Gotman M., and Milner B. Design fluency: the invention of nonsense drawings after focal cortical lesions. Neuropsychologia 15 (1977) 653-674
24. Kathmann N., Hochrein A., Uwer R., and Bondy B. Deficits in gain of smooth pursuit eye movements in schizophrenia and affective disorder patients and their unaffected relatives. Am J Psychiatry 160 (2003) 696-702
25. Keith Berg W., and Byrd D. The Tower of London spatial problem-solving task: enhancing clinical and research implementation. J Clin Exp Neuropsychol 24 (2002) 586-604
26. Kuelz A.K., Hohagen F., and Voderholzer U. Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol 65 (2004) 185-236
27. Leboyer M. Searching for alternative phenotypes in psychiatric genetics. Methods Mol Med 77 (2003) 145-161
28. Lezack M.D. Lezack, Neuropsychological Assessment. 3rd ed. (1995), Oxford University Press, New York
29. Lord C., Rutter M., and Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24 (1994) 659-685
30. Maxwell M.E. Family Interview for Genetic Studies. Clinical Neurogenetic Branch, Intramural Research Program, NIMH (1992)
31. Micali N., Chakrabarti S., and Fombonne E. The broad autism phenotype: findings from an epidemiological survey. Autism 8 (2004) 21-37
32. Miguel E.C., Leckman J.F., Rauch S., do Rosario-Campos M.C., Hounie A.G., Mercadante M.T., et al. Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol Psychiatry 10 (2005) 258-275
33. Muhle R., Trentacoste S.V., and Rapin I. The genetics of autism. Pediatrics 113 (2004) 472-486
34. Nestadt G., Addington A., Samuels J., Liang K.Y., Bienvenu O.J., Riddle M., et al. The identification of OCD-related subgroups based on comorbidity. Biol Psychiatry 53 (2003) 914-920
35. Nurnberger Jr. J.I., Blehar M.C., Kaufmann C.A., York-Cooler C., Simpson S.G., Harkavy-Friedman J., et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51 (1994) 849-859
36. Orvaschel H., Puig-Antich J., Chambers W., Tabrizi M.A., and Johnson R. Retrospective assessment of prepubertal major depression with the Kiddie-SADS-e. J Am Acad Child Psychiatry 21 (1982) 392-397
37. Ozonoff S., Cook I., Coon H., Dawson G., Joseph R.M., Klin A., et al. Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network. J Autism Dev Disord 34 (2004) 139-150
38. Ozonoff S., and Jensen J. Brief report: specific executive function profiles in three neurodevelopmental disorders. J Autism Dev Disord 29 (1999) 171-177
39. Ozonoff S., Rogers S.J., Farnham J.M., and Pennington B.F. Can standard measures identify subclinical markers of autism?. J Autism Dev Disord 23 (1993) 429-441
40. Penades R., Catalan R., Andres S., Salamero M., and Gasto C. Executive function and non-verbal memory in obsessive-compulsive disorder. Psychiatry Res 133 (2005) 81-90
41. Pennington B.F., and Ozonoff S. Executive functions and developmental psychopathology. J Child Psychol Psychiatry 37 (1996) 51-87
42. Purcell R., Maruff P., Kyrios M., and Pantelis C. Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function. Biol Psychiatry 43 (1998) 348-357
43. Purcell R., Maruff P., Kyrios M., and Pantelis C. Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiatry 55 (1998) 415-423
44. Reitan M., and Wolfson D. The Halstead-Reitan Neuropsychological Test Battery (1985), Neuropsychology Press, Tucson
45. Russell A.J., Mataix-Cols D., Anson M., and Murphy D.G. Obsessions and compulsions in Asperger syndrome and high-functioning autism. Br J Psychiatry 186 (2005) 525-528
46. Savage C.R., Baer L., Keuthen N.J., Brown H.D., Rauch S.L., and Jenike M.A. Organizational strategies mediate non-verbal memory impairment in obsessive-compulsive disorder. Biol Psychiatry 45 (1999) 905-916
47. Scarone S., Colombo C., Livian S., Abbruzzese M., Ronchi P., Locatelli M., et al. Increased right caudate nucleus size in obsessive-compulsive disorder: detection with magnetic resonance imaging. Psychiatry Res 45 (1992) 115-121
48. Shallice T. Specific impairments of planning. Philos Trans R Soc Lond B Biol Sci 298 (1982) 199-209
49. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59 (1998) 22-33
50. Silverman J.M., Smith C.J., Schmeidler J., Hollander E., Lawlor B.A., Fitzgerald M., et al. Symptom domains in autism and related conditions: evidence for familiarity. Am J Med Genet 114 (2002) 64-73
51. Spiker D., Lotspeich L., Kraemer H.C., Hallmayer J., McMahon W., Petersen P.B., et al. Genetics of autism: characteristics of affected and unaffected children from 37 multiplex families. Am J Med Genet 54 (1994) 27-35
52. Szatmari P., Jones M.B., Tuff L., Bartolucci G., Fisman S., and Mahoney W. Lack of cognitive impairment in first-degree relatives of children with pervasive developmental disorders. J Am Acad Child Adolesc Psychiatry 32 (1993) 1264-1273
53. Troyer A.K., Moscovitch M., Winocur G., Alexander M.P., and Stuss D. Clustering and switching on verbal fluency: the effects of focal frontal- and temporal-lobe lesions. Neuropsychologia 36 (1998) 499-504
54. Van den Heuvel O.A., Veltman D.J., Groenewegen H.J., Cath D.C., van Balkom A.J., van Hartskamp J., et al. Frontal-striatal dysfunction during planning in obsessive-compulsive disorder. Arch Gen Psychiatry 62 (2005) 301-309
55. Veale D.M., Sahakian B.J., Owen A.M., and Marks I.M. Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder. Psychol Med 26 (1996) 1261-1269
56. Welsh M.C., Labbe E.E., and Delayney D. Cognitive strategies and personality variables in adherence to exercise. Psychol Rep 68 (1991) 1327-1335
57. Wilcox J.A., Tsuang M.T., Schnurr T., and Baida-Fragoso N. Case-control family study of lesser variant traits in autism. Neuropsychobiology 47 (2003) 171-177