Effect of leptin administration on ovulation in food-restricted rhesus monkeys

Neuroendocrinology

Volumn 84, Issue 2, 2007, Pages 103-114

  Lujan, Marla E ^a,b   Krzemien, Alicja A ^a   Reid, Robert L ^a   Van Vugt, Dean A ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Anovulation; Diet restriction, rhesus monkey; Leptin; Progesterone

Indexed keywords

FOLLITROPIN; HYDROCORTISONE; LIOTHYRONINE; RECOMBINANT LEPTIN;

AMENORRHEA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOVULATION; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; FEMALE; HORMONE RELEASE; HYDROCORTISONE RELEASE; IMMUNE RESPONSE; NEUROENDOCRINE SYSTEM; NONHUMAN; OVULATION; PRIORITY JOURNAL; RHESUS MONKEY; WEIGHT GAIN;

ADAPTATION, PHYSIOLOGICAL; AMENORRHEA; ANALYSIS OF VARIANCE; ANIMALS; ANOVULATION; CALORIC RESTRICTION; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; HYDROCORTISONE; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MACACA MULATTA; NUTRITIONAL STATUS; OVULATION; RECOMBINANT PROTEINS; TRIIODOTHYRONINE;

EID: 33846450683     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000097071     Document Type: Article

References (46)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
2. Barash IA, Cheung CC, Weigle DS, Ren H, Kabigting EB, Kuijper JL, Clifton DK, Steiner RA: Leptin is a metabolic signal to the reproductive system. Endocrinology 1996;137:3144-3147.
3. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG: Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996;98:1101-1106.
4. Bodkin NL, Nicolson M, Ortmeyer HK, Hansen BC: Hyperleptinemia: relationship to adiposity and insulin resistance in the spontaneously obese rhesus monkey. Horm Metab Res 1996;28:674-678.
5. Baskin DG, Figlewicz Lattemann D, Seeley RJ, Woods SC, Porte D Jr, Schwartz MW: Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res 1999;848:114-123.
6. Cunningham MJ, Clifton DK, Steiner RA: Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 1999;60:216-222.
7. Chehab FF, Lim ME, Lu R: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996;12:318-320.
8. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA, O'Rahilly S: Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-884.
9. Oral EA, Ruiz E, Andewelt A, Sebring N, Wagner AJ, Depaoli AM, Gorden P: Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy. J Clin Endocrinol Metab 2002;87:3110-3117.
10. Laughlin GA, Yen SS: Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea. J Clin Endocrinol Metab 1997;82:318-321.
11. Miller KK, Parulekar MS, Schoenfeld E, Anderson E, Hubbard J, Klibanski A, Grinspoon SK: Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake. J Clin Endocrinol Metab 1998;83:2309-2312.
12. Warren MP, Voussoughian F, Geer EB, Hyle EP, Adberg CL, Ramos RH: Functional hypothalamic amenorrhea: hypoleptinemia and disordered eating. J Clin Endocrinol Metab 1999;84:873-877.
13. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, Depaoli AM, Karalis A, Mantzoros CS: Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 2004;351:987-997.
14. Lujan ME, Krzemien AA, Reid RL, Van Vugt DA: Developing a model of nutritional amenorrhea in rhesus monkeys. Endocrinology 2006;147:483-492.
15. Jen KL, Hansen BC, Metzger BL: Adiposity, anthropometric measures, and plasma insulin levels of rhesus monkeys. Int J Obes 1985;9:213-224.
16. Van Vugt DA, Diefenbach WD, Alston E, Ferin M: Gonadotropin-releasing hormone pulses in third ventricular cerebrospinal fluid of ovariectomized rhesus monkeys: correlation with luteinizing hormone pulses. Endocrinology 1985;117:1550-1558.
17. Barker-Gibb ML, Sahu A, Pohl CR, Plant TM: Elevating circulating leptin in prepubertal male rhesus monkeys (Macaca mulatta) does not elicit precocious gonadotropinreleasing hormone release, assessed indirectly. J Clin Endocrinol Metab 2002;87:4976-4983.
18. Hunter R: Standardization of the chloramine-T method of protein iodination. Proc Soc Exp Biol Med 1970;133:989-992.
19. Oral EA, Ruiz E, Andewelt A, Sebring N, Wagner AJ, Depaoli AM, Gorden P: Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy. J Clin Endocrinol Metab 2002;87:3110-3117.
20. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA, O'Rahilly S: Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-884.
21. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S: Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110:1093-1103.
22. Miller KK, Grinspoon S, Gleysteen S, Grieco KA, Ciampa J, Breu J, Herzog DB, Klibanski A: Preservation of neuroendocrine control of reproductive function despite severe undernutrition. J Clin Endocrinol Metab 2004;89:4434-4438.
23. Eckert ED, Pomeroy C, Raymond N, Kohler PF, Thuras P, Bowers CY: Leptin in anorexia nervosa. J Clin Endocrinol Metab 1998;83:791-795.
24. Tang-Christensen M, Havel PJ, Jacobs RR, Larsen PJ, Cameron JL: Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab 1999;84:711-717.
25. Ramsey JJ, Kemnitz JW, Colman RJ, Cunningham D, Swick AG: Different central and peripheral responses to leptin in rhesus monkeys: brain transport may be limited. J Clin Endocrinol Metab 1998;83:3230-3235.
26. Xiao E, Xia-Zhang L, Vulliemoz NR, Ferin M, Wardlaw SL: Leptin modulates inflammatory cytokine and neuroendocrine responses to endotoxin in the primate. Endocrinology 2003;144:4350-4353.
27. Wilson ME, Fisher J, Brown J: Chronic subcutaneous leptin infusion diminishes the responsiveness of the hypothalamic-pituitaryadrenal (HPA) axis in female rhesus monkeys. Physiol Behav 2005;84:449-458.
28. Licinio J, Mantzoros C, Negrao AB, Cizza G, Wong ML, Bongiorno PB, Chrousos GP, Karp B, Allen C, Flier JS, Gold PW: Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 1997;3:575-579.
29. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS: Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology 1997;138:3859-3863.
30. Chan JL, Heist K, Depaoli AM, Veldhuis JD, Mantzoros CS: The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 2003;111:1409-1421.
31. Schurgin S, Canavan B, Koutkia P, DePaoli AM, Grinspoon S: Endocrine and metabolic effects of physiologic r-metHuLeptin administration during acute caloric deprivation in normal-weight women. J Clin Endocrinol Metab 2004;89:5402-5409.
32. Berga SL, Mortola JF, Girton L, Suh B, Laughlin G, Pham P, Yen SS: Neuroendocrine aberrations in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab 1989;68:301-308.
33. Suh BY, Liu JH, Berga SL, Quigley ME, Laughlin GA, Yen SS: Hypercortisolism in patients with functional hypothalamic amenorrhea. J Clin Endocrinol Metab 1988;66:733-739.
34. Biller B, Federoff HJ, Koenig JI, Klibanski A: Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea. J Clin Endocrinol Metab 1990;70:311-317.
35. Herpertz S, Wagner R, Albers N, Blum WF, Pelz B, Langkafel M, Kopp W, Henning A, Oberste-Berghaus C, Mann K, Senf W, Hebebrand J: Circadian plasma leptin levels in patients with anorexia nervosa: relation to insulin and cortisol. Horm Res 1998;50:197-204.
36. Yen SSC: Chronic anovulation due to CNS-hypothalamic-pituitary dysfunction; in Yen SSC (ed): Reproductive Endocrinology. Philadelphia, Saunders, 1991, pp 631-688.
37. Huang Q, Rivest R, Richard D: Effects of leptin on corticotropin- releasing factor (crf) synthesis and crf neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice. Endocrinology 1998;139:1524-1532.
38. Helmreich DL, Mattern LG, Cameron JL: Lack of a role of the hypothalamic-pituitary-adrenal axis in the fasting-induced suppression of luteinizing hormone secretion in adult male rhesus monkeys (Macaca mulatta). Endocrinology 1993;132:2427-2437.
39. Baker DG, Ekhator NN, Kasckow JW, Dashevsky B, Horn PS, Bednarik L, Geracioti TD Jr: Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorder. Am J Psychiatry 2005;162:992-994.
40. Brundu B, Loucks TL, Adler LJ, Cameron JL, Berga SL: Increased cortisol in the cerebrospinal fluid of women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab 2006;91:1561-1565.
41. Berga SL, Loucks-Daniels TL, Adler LJ, Chrousos GP, Cameron JL, Matthews KA, Marcus MD: Cerebrospinal fluid levels of corticotropin-releasing hormone in women with functional hypothalamic amenorrhea. Am J Obstet Gynecol 2000;182:776-781.
42. Kurrimbux D, Gaffen Z, Farrell CL, Martin D, Thomas SA: The involvement of the blood-brain and the blood-cerebrospinal fluid barriers in the distribution of leptin into and out of the rat brain. Neuroscience 2004;123:527-536.
43. Williams NI, Helmreich DL, Parfitt DB, Caston-Balderrama A, Cameron JL: Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training. J Clin Endocrinol Metab 2001;86:5184-5193.
44. Holtkamp K, Mika C, Grzella I, Heer M, Pak H, Hebebrand J, Herpertz-Dahlmann B: Reproductive function during weight gain in anorexia nervosa: leptin represents a metabolic gate to gonadotropin secretion. J Neural Transm 2003;110:427-435.
45. Audi L, Mantzoros CS, Vidal-Puig A, Vargas D, Gussinye M, Carrascosa A: Leptin in relation to resumption of menses in women with anorexia nervosa. Mol Psychiatry 1998;3:544-547.
46. Golden NH, Jacobson MS, Schebendach J, Solanto MV, Hertz SM, Shenker IR: Resumption of menses in anorexia nervosa. Arch Pediatr Adolesc Med 1997;151:16-21.