Gelsolin segment 5 inhibits HIV-induced T-cell apoptosis via Vpr-binding to VDAC

FEBS Letters

Volumn 581, Issue 3, 2007, Pages 535-540

  Qiao, Hongjiang ^a,b   McMillan, James R ^a,b  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

AIDS; Cell death; Cytoskeletal protein; Mitochondria

Indexed keywords

CYTOCHROME C; GELSOLIN; VOLTAGE DEPENDENT ANION CHANNEL; VOLTAGE GATED CALCIUM CHANNEL; VPR PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HEK293; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKEMIA CELL LINE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION;

APOPTOSIS; BASE SEQUENCE; CELL LINE; DNA, COMPLEMENTARY; GELSOLIN; GENE PRODUCTS, VPR; HIV-1; HUMANS; JURKAT CELLS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TRANSFECTION; VOLTAGE-DEPENDENT ANION CHANNEL 1;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33846436457     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.12.057     Document Type: Article

References (25)

1. Roshal M., Zhu Y., and Planelles V. Apoptosis in AIDS. Apoptosis 6 (2001) 103-116
2. Bukrinsky M., and Adzhubei A. Viral protein R of HIV-1. Reviews in Medical Virology 9 (1999) 39-49
3. Ayyavoo V., Mahalingam S., Rafaeli Y., Kudchodkar S., Chang D., Nagashunmugam T., Williams W.V., and Weiner D.B. HIV-1 viral protein R (Vpr) regulates viral replication and cellular proliferation in T cells and monocytoid cells in vitro. Journal of Leukocyte Biology 62 (1997) 93-99
4. Emerman M. HIV-1, Vpr and the cell cycle. Current Biology 6 (1996) 1096-1103
5. Nishizawa M., Kamata M., Mojin T., Nakai Y., and Aida Y. Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G(2) arrest of the cell cycle. Virology 276 (2000) 16-26
6. Jacotot E., Ravagnan L., Loeffler M., Ferri K.F., Vieira H.L., Zamzami N., Costantini P., Druillennec S., Hoebeke J., Briand J.P., Irinopoulou T., Daugas E., Susin S.A., Cointe D., Xie Z.H., Reed J.C., Roques B.P., and Kroemer G. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J. Exp. Med. 191 (2000) 33-46
7. Basanez G., and Zimmerberg J. HIV and apoptosis death and the mitochondrion. J. Exp. Med. 193 (2001) F11-F14
8. Kwiatkowski D.J., Stossel T.P., Orkin S.H., Mole J.E., Colten H.R., and Yin H.L. Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature 323 (1986) 455-458
9. Sun H.Q., Yamamoto M., Mejillano M., and Yin H.L. Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. 274 (1999) 33179-33182
10. Kothakota S., Azuma T., Reinhard C., Klippel A., Tang J., Chu K., McGarry T.J., Kirschner M.W., Koths K., Kwiatkowski D.J., and Williams L.T. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278 (1997) 294-298
11. Burtnick L.D., Urosev D., Irobi E., Narayan K., and Robinson R.C. Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF. EMBO J. 23 (2004) 2713-2722
12. Ohtsu M., Sakai N., Fujita H., Kashiwagi M., Gasa S., Shimizu S., Eguchi Y., Tsujimoto Y., Sakiyama Y., Kobayashi K., and Kuzumaki N. Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J. 16 (1997) 4650-4656
13. Koya R.C., Fujita H., Shimizu S., Ohtsu M., Takimoto T., Tsujimoto Y., and Kuzumaki N. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J. Biol. Chem. 275 (2000) 15343-15349
14. Klampfer L., Huang J., Sasazuki T., Shirasawa S., and Augenlicht L. Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression. J. Biol. Chem. 279 (2004) 36680-36688 (Journal Article)
15. Furukawa K., Fu W., Li Y., Witke W., Kwiatkowski D.J., and Mattson M.P. The Actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons. J. Neurosci. 17 (1997) 8178-8186
16. Harms C., Bosel J., Lautenschlager M., Harms U., Braun J.S., Hortnagl H., Dirnagl U., Kwiatkowski D.J., Fink K., and Endres M. Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization. Mol. Cell. Neurosci. 25 (2004) 69-82
17. Qiao H., Koya R.C., Nakagawa K., Tanaka H., Fujita H., Takimoto M., and Kuzumaki N. Inhibition of Alzheimer's amyloid-β peptide-induced reduction of mitochondrial membrane potential and neurotoxicity by gelsolin. Neurobiology of Aging 26 (2005) 849-855
18. Orth P., Schnappinger D., Hillen W., Saenger W., and Hinrichs W. Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nat. Struct. Biol. 7 (2000) 215-219
19. Jacotot E., Ferri K.F., El Hamel C., Brenner C., Druillennec S., Hoebeke J., Rustin P., Metivier D., Lenoir C., Geuskens M., Vieira H.L., Loeffler M., Belzacq A.S., Briand J.P., Zamzami N., Edelman L., Xie Z.H., Reed J.C., Roques B.P., and Kroemer G. Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein R and Bcl-2. J. Exp. Med. 193 (2001) 509-519
20. Kusano H., Shimizu S., Koya R.C., Fujita H., Kamada S., Kuzumaki N., and Tsujimoto Y. Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene 19 (2000) 4807-4814
21. Andrea C., Cristina M., Nicola M., Vanni B., Anna S., Bruno D.R., and Claudio F. Mitochondria alterations and dramatic tendency to undergo apoptosis in peripheral blood lymphocytes during acute HIV syndrome. AIDS 11 (1997) 19-26
22. Ensoli F., Fiorelli V., De Cristofaro M., Collacchi B., Santini Muratori D., Alario C., Sacco G., Iebba F., and Aiuti F. Endogenous cytokine production protects T cells from spontaneous apoptosis during highly active antiretroviral therapy. HIV Medicine 3 (2002) 105-117
23. Nakagawa K., and Kuzumaki N. Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification. Genes to Cells 10 (2005) 835-850
24. Mao M., Fu G., Wu J.S., Zhang Q.H., Zhou J., Kan L.X., Huang Q.H., He K.L., Gu B.W., Han Z.G., Shen Y., Gu J., Yu Y.P., Xu S.H., Wang Y., Chen S.J., and Chen Z. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc. Natl. Acad. Sci. USA 95 (1998) 8175-8180
25. Longthorne V.L., and Williams G.T. Caspase activity is required for commitment to Fas-mediated apoptosis. EMBO J. 16 (1997) 3805-3812