메뉴 건너뛰기




Volumn 9, Issue 1, 2007, Pages 63-70

The hepatitis C virus NS2/3 protease

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5A; PROTEINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 33846424965     PISSN: 14673037     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (39)

References (62)
  • 1
    • 1242319434 scopus 로고    scopus 로고
    • Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus
    • Agapov, E.V., Murray, C.L., Frolov, I., Qu, L., Myers, T.M., and Rice, C.M. (2004). Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus. J. Virol. 78, 2414-2425.
    • (2004) J. Virol. , vol.78 , pp. 2414-2425
    • Agapov, E.V.1    Murray, C.L.2    Frolov, I.3    Qu, L.4    Myers, T.M.5    Rice, C.M.6
  • 2
    • 0024293238 scopus 로고
    • Preparation by direct metal exchange and kinetic study of active site metal substituted class I and class II Clostridium histolyticum collagenases
    • Angleton, E.L., and Van Wart, H.E. (1988). Preparation by direct metal exchange and kinetic study of active site metal substituted class I and class II Clostridium histolyticum collagenases. Biochemistry 27, 7413-7418.
    • (1988) Biochemistry , vol.27 , pp. 7413-7418
    • Angleton, E.L.1    Van Wart, H.E.2
  • 3
    • 0029768642 scopus 로고    scopus 로고
    • Metal and pH dependence of heptapeptide catalysis by human matrilysin
    • Cha, J., Pedersen, M.V., and Auld, D.S. (1996). Metal and pH dependence of heptapeptide catalysis by human matrilysin. Biochemistry 35, 15831-15838.
    • (1996) Biochemistry , vol.35 , pp. 15831-15838
    • Cha, J.1    Pedersen, M.V.2    Auld, D.S.3
  • 4
    • 0026039916 scopus 로고
    • Processing of the yellow fever virus nonstructural polyprotein: A catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites
    • Chambers, T.J., Grakoui, A., and Rice, C.M. (1991). Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites. J. Virol. 65, 6042-6050.
    • (1991) J. Virol. , vol.65 , pp. 6042-6050
    • Chambers, T.J.1    Grakoui, A.2    Rice, C.M.3
  • 5
    • 0025201350 scopus 로고
    • Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein
    • Chambers, T.J., Weir, R.C., Grakoui, A., McCourt, D.W., Bazan, J.F., Fletterick, R.J., and Rice, C.M. (1990). Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proc. Natl. Acad. Sci. USA 87, 8898-8902.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8898-8902
    • Chambers, T.J.1    Weir, R.C.2    Grakoui, A.3    McCourt, D.W.4    Bazan, J.F.5    Fletterick, R.J.6    Rice, C.M.7
  • 6
    • 0034725610 scopus 로고    scopus 로고
    • Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis
    • Chen, Z., Guo, K., Toh, S.Y., Zhou, Z., and Li, P. (2000). Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis. J. Biol. Chem. 275, 22619-22622.
    • (2000) J. Biol. Chem. , vol.275 , pp. 22619-22622
    • Chen, Z.1    Guo, K.2    Toh, S.Y.3    Zhou, Z.4    Li, P.5
  • 7
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo, Q.L., Kuo, G., Weiner, A.J., Overby, L.R., Bradley, D.W., and Houghton, M. (1989). Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 8
    • 0033521138 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus NS2/3 processing by NS4A peptides. Implications for control of viral processing
    • Darke, P.L., Jacobs, A.R., Waxman, L., and Kuo, L.C. (1999). Inhibition of hepatitis C virus NS2/3 processing by NS4A peptides. Implications for control of viral processing. J. Biol. Chem. 274, 34511-34514.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34511-34514
    • Darke, P.L.1    Jacobs, A.R.2    Waxman, L.3    Kuo, L.C.4
  • 9
    • 0037404536 scopus 로고    scopus 로고
    • Protein-protein interactions between hepatitis C virus nonstructural proteins
    • Dimitrova, M., Imbert, I., Kieny, M.P., and Schuster, C. (2003). Protein-protein interactions between hepatitis C virus nonstructural proteins. J. Virol. 77, 5401-5414.
    • (2003) J. Virol. , vol.77 , pp. 5401-5414
    • Dimitrova, M.1    Imbert, I.2    Kieny, M.P.3    Schuster, C.4
  • 10
    • 0023258708 scopus 로고
    • Differences in virus-induced polypeptides in cells infected by cytopathic and noncytopathic biotypes of bovine virus diarrhea-mucosal disease virus
    • Donis, R.O., and Dubovi, E.J. (1987). Differences in virus-induced polypeptides in cells infected by cytopathic and noncytopathic biotypes of bovine virus diarrhea-mucosal disease virus. Virology 158, 168-173.
    • (1987) Virology , vol.158 , pp. 168-173
    • Donis, R.O.1    Dubovi, E.J.2
  • 12
    • 0025864149 scopus 로고
    • Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins
    • Falgout, B., Pethel, M., Zhang, Y.M., and Lai, C.J. (1991). Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins. J. Virol. 65, 2467-2475.
    • (1991) J. Virol. , vol.65 , pp. 2467-2475
    • Falgout, B.1    Pethel, M.2    Zhang, Y.M.3    Lai, C.J.4
  • 13
    • 13944275171 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted or degradation to the proteasome
    • Franck, N., Le Seyec, J., Guguen-Guillouzo, C., and Erdtmann, L. (2005). Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted or degradation to the proteasome. J. Virol. 79, 2700-2708.
    • (2005) J. Virol. , vol.79 , pp. 2700-2708
    • Franck, N.1    Le Seyec, J.2    Guguen-Guillouzo, C.3    Erdtmann, L.4
  • 14
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale, M.J., Jr., Korth, M.J., Tang, N.M., Tan, S.L., Hopkins, D.A., Dever, T.E., Polyak, S.J., Gretch, D.R., and Katze, M.G. (1997). Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230, 217-227.
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale Jr., M.J.1    Korth, M.J.2    Tang, N.M.3    Tan, S.L.4    Hopkins, D.A.5    Dever, T.E.6    Polyak, S.J.7    Gretch, D.R.8    Katze, M.G.9
  • 16
    • 0027163740 scopus 로고
    • Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
    • Hijikata, M., Mizushima, H., Akagi, T., Mori, S., Kakiuchi, N., Kato, N., Tanaka, T., Kimura, K., and Shimotohno, K. (1993a). Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J. Virol. 67, 4665-4675.
    • (1993) J. Virol. , vol.67 , pp. 4665-4675
    • Hijikata, M.1    Mizushima, H.2    Akagi, T.3    Mori, S.4    Kakiuchi, N.5    Kato, N.6    Tanaka, T.7    Kimura, K.8    Shimotohno, K.9
  • 19
    • 0028892387 scopus 로고
    • Structural analysis of zinc substitutions in the active site of thermolysin
    • Holland, D.R., Hausrath, A.C., Juers, D., and Matthews, B.W. (1995). Structural analysis of zinc substitutions in the active site of thermolysin. Protein Sci. 4, 1955-1965.
    • (1995) Protein Sci. , vol.4 , pp. 1955-1965
    • Holland, D.R.1    Hausrath, A.C.2    Juers, D.3    Matthews, B.W.4
  • 20
    • 0033845619 scopus 로고    scopus 로고
    • HCV-core protein accelerates recovery from the insensitivity of liver cells to Fas-mediated apoptosis induced by an injection of anti-Fas antibody in mice
    • Honda, A., Hatano, M., Kohara, M., Arai, Y., Hartatik, T., Moriyama, T., Imawari, M., Koike, K., Yokosuka, O., Shimotohno, K., and Tokuhisa, T. (2000). HCV-core protein accelerates recovery from the insensitivity of liver cells to Fas-mediated apoptosis induced by an injection of anti-Fas antibody in mice. J. Hepatol. 33, 440-447.
    • (2000) J. Hepatol. , vol.33 , pp. 440-447
    • Honda, A.1    Hatano, M.2    Kohara, M.3    Arai, Y.4    Hartatik, T.5    Moriyama, T.6    Imawari, M.7    Koike, K.8    Yokosuka, O.9    Shimotohno, K.10    Tokuhisa, T.11
  • 21
    • 0030928695 scopus 로고    scopus 로고
    • Hepatitis C: The clinical spectrum of disease
    • Hoofnagle, J. H. (1997). Hepatitis C: the clinical spectrum of disease. Hepatology 26, 15S-20S.
    • (1997) Hepatology , vol.26
    • Hoofnagle, J.H.1
  • 22
    • 0032080022 scopus 로고    scopus 로고
    • CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor
    • Inohara, N., Koseki, T., Chen, S., Wu, X., and Nunez, G. (1998). CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. Embo J. 17, 2526-2533.
    • (1998) Embo J. , vol.17 , pp. 2526-2533
    • Inohara, N.1    Koseki, T.2    Chen, S.3    Wu, X.4    Nunez, G.5
  • 23
    • 0030879817 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator
    • Kato, N., Lan, K.H., Ono-Nita, S.K., Shiratori, Y., and Omata, M. (1997). Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator. J. Virol. 71, 8856-8859.
    • (1997) J. Virol. , vol.71 , pp. 8856-8859
    • Kato, N.1    Lan, K.H.2    Ono-Nita, S.K.3    Shiratori, Y.4    Omata, M.5
  • 25
    • 33748741785 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    • Kaukinen, P., Sillanpaa, M., Kotenko, S., Lin, R., Hiscott, J., Melen, K., and Julkunen, I. (2006). Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression. Virol. J. 3, 66.
    • (2006) Virol. J. , vol.3 , pp. 66
    • Kaukinen, P.1    Sillanpaa, M.2    Kotenko, S.3    Lin, R.4    Hiscott, J.5    Melen, K.6    Julkunen, I.7
  • 26
    • 33646018620 scopus 로고    scopus 로고
    • Complex formation between hepatitis C virus NS2 and NS3 proteins
    • Kiiver, K., Merits, A., Ustav, M., and Zusinaite, E. (2006). Complex formation between hepatitis C virus NS2 and NS3 proteins. Virus Res. 117, 264.
    • (2006) Virus Res. , vol.117 , pp. 264
    • Kiiver, K.1    Merits, A.2    Ustav, M.3    Zusinaite, E.4
  • 28
    • 0032837572 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B
    • Koch, J.O., and Bartenschlager, R. (1999). Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B. J. Virol. 73, 7138-7146.
    • (1999) J. Virol. , vol.73 , pp. 7138-7146
    • Koch, J.O.1    Bartenschlager, R.2
  • 29
    • 0033920304 scopus 로고    scopus 로고
    • Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo
    • Kolykhalov, A.A., Mihalik, K., Feinstone, S.M., and Rice, C.M. (2000). Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo. J. Virol. 74, 2046-2051.
    • (2000) J. Virol. , vol.74 , pp. 2046-2051
    • Kolykhalov, A.A.1    Mihalik, K.2    Feinstone, S.M.3    Rice, C.M.4
  • 30
    • 2642708375 scopus 로고    scopus 로고
    • Bovine viral diarrhea virus strain Oregon: A novel mechanism for processing of NS2-3 based on point mutations
    • Kummerer, B.M., Stoll, D., and Meyers, G. (1998). Bovine viral diarrhea virus strain Oregon: a novel mechanism for processing of NS2-3 based on point mutations. J. Virol. 72, 4127-4138.
    • (1998) J. Virol. , vol.72 , pp. 4127-4138
    • Kummerer, B.M.1    Stoll, D.2    Meyers, G.3
  • 32
    • 4544222881 scopus 로고    scopus 로고
    • Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus
    • Lackner, T., Muller, A., Pankraz, A., Becher, P., Thiel, H.J., Gorbalenya, A.E., and Tautz, N. (2004). Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus. J. Virol. 78, 10765-10775.
    • (2004) J. Virol. , vol.78 , pp. 10765-10775
    • Lackner, T.1    Muller, A.2    Pankraz, A.3    Becher, P.4    Thiel, H.J.5    Gorbalenya, A.E.6    Tautz, N.7
  • 33
    • 0028290389 scopus 로고
    • Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
    • Lin, C., Lindenbach, B.D., Pragai, B.M., McCourt, D.W., and Rice, C.M. (1994). Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. J. Virol. 68, 5063-5073.
    • (1994) J. Virol. , vol.68 , pp. 5063-5073
    • Lin, C.1    Lindenbach, B.D.2    Pragai, B.M.3    McCourt, D.W.4    Rice, C.M.5
  • 35
    • 0033608212 scopus 로고    scopus 로고
    • The hepatitis C virus NS2 protein generated by NS2-3 autocleavage is required for NS5A phosphorylation
    • Liu, Q., Bhat, R.A., Prince, A.M., and Zhang, P. (1999). The hepatitis C virus NS2 protein generated by NS2-3 autocleavage is required for NS5A phosphorylation. Biochem. Biophys. Res. Commun. 254, 572-577.
    • (1999) Biochem. Biophys. Res. Commun. , vol.254 , pp. 572-577
    • Liu, Q.1    Bhat, R.A.2    Prince, A.M.3    Zhang, P.4
  • 36
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • Lohmann, V., Korner, F., Koch, J., Herian, U., Theilmann, L., and Bartenschlager, R. (1999). Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285, 110-113.
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1    Korner, F.2    Koch, J.3    Herian, U.4    Theilmann, L.5    Bartenschlager, R.6
  • 37
    • 33747452685 scopus 로고    scopus 로고
    • Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
    • Lorenz, I.C., Marcotrigiano, J., Dentzer, T.G., and Rice, C.M. (2006). Structure of the catalytic domain of the hepatitis C virus NS2-3 protease. Nature 442, 831-835.
    • (2006) Nature , vol.442 , pp. 831-835
    • Lorenz, I.C.1    Marcotrigiano, J.2    Dentzer, T.G.3    Rice, C.M.4
  • 38
    • 0030592514 scopus 로고    scopus 로고
    • The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
    • Love, R.A., Parge, H.E., Wickersham, J.A., Hostomsky, Z., Habuka, N., Moomaw, E.W., Adachi, T., and Hostomska, Z. (1996). The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 87, 331-342.
    • (1996) Cell , vol.87 , pp. 331-342
    • Love, R.A.1    Parge, H.E.2    Wickersham, J.A.3    Hostomsky, Z.4    Habuka, N.5    Moomaw, E.W.6    Adachi, T.7    Hostomska, Z.8
  • 41
    • 0028265186 scopus 로고
    • Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2
    • Mizushima, H., Hijikata, M., Tanji, Y., Kimura, K., and Shimotohno, K. (1994). Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2. J. Virol. 68, 2731-2734.
    • (1994) J. Virol. , vol.68 , pp. 2731-2734
    • Mizushima, H.1    Hijikata, M.2    Tanji, Y.3    Kimura, K.4    Shimotohno, K.5
  • 42
    • 0033856798 scopus 로고    scopus 로고
    • Activation of the interferon-inducible 2′-5′-oligoadenylate synthetase gene by hepatitis C virus core protein
    • Naganuma, A., Nozaki, A., Tanaka, T., Sugiyama, K., Takagi, H., Mori, M., Shimotohno, K., and Kato, N. (2000). Activation of the interferon-inducible 2′-5′-oligoadenylate synthetase gene by hepatitis C virus core protein. J. Virol. 74, 8744-8750.
    • (2000) J. Virol. , vol.74 , pp. 8744-8750
    • Naganuma, A.1    Nozaki, A.2    Tanaka, T.3    Sugiyama, K.4    Takagi, H.5    Mori, M.6    Shimotohno, K.7    Kato, N.8
  • 43
    • 0032710924 scopus 로고    scopus 로고
    • Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein
    • Neddermann, P., Clementi, A., and De Francesco, R. (1999). Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein. J. Virol. 73, 9984-9991.
    • (1999) J. Virol. , vol.73 , pp. 9984-9991
    • Neddermann, P.1    Clementi, A.2    De Francesco, R.3
  • 47
    • 0023114840 scopus 로고
    • Variation in the intracellular polypeptide profiles from different isolates of bovine virus diarrhoea virus
    • Pocock, D.H., Howard, C.J., Clarke, M.C., and Brownlie, J. (1987). Variation in the intracellular polypeptide profiles from different isolates of bovine virus diarrhoea virus. Arch. Virol. 94, 43-53.
    • (1987) Arch. Virol. , vol.94 , pp. 43-53
    • Pocock, D.H.1    Howard, C.J.2    Clarke, M.C.3    Brownlie, J.4
  • 48
    • 0029114785 scopus 로고
    • Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein
    • Ray, R.B., Lagging, L.M., Meyer, K., Steele, R., and Ray, R. (1995). Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res. 37, 209-220.
    • (1995) Virus Res. , vol.37 , pp. 209-220
    • Ray, R.B.1    Lagging, L.M.2    Meyer, K.3    Steele, R.4    Ray, R.5
  • 49
    • 0029059334 scopus 로고
    • Hepatitis C virus-encoded NS2-3 protease: Cleavage-site mutagenesis and requirements for bimolecular cleavage
    • Reed, K.E., Grakoui, A., and Rice, C.M. (1995). Hepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavage. J. Virol. 69, 4127-4136.
    • (1995) J. Virol. , vol.69 , pp. 4127-4136
    • Reed, K.E.1    Grakoui, A.2    Rice, C.M.3
  • 50
    • 0033992516 scopus 로고    scopus 로고
    • Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties
    • Reed, K.E., and Rice, C.M. (2000). Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. Curr. Topics Microbiol. Immunol. 242, 55-84.
    • (2000) Curr. Topics Microbiol. Immunol. , vol.242 , pp. 55-84
    • Reed, K.E.1    Rice, C.M.2
  • 51
    • 0034856181 scopus 로고    scopus 로고
    • A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus
    • Rinck, G., Birghan, C., Harada, T., Meyers, G., Thiel, H.J., and Tautz, N. (2001). A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus. J. Virol. 75, 9470-9482.
    • (2001) J. Virol. , vol.75 , pp. 9470-9482
    • Rinck, G.1    Birghan, C.2    Harada, T.3    Meyers, G.4    Thiel, H.J.5    Tautz, N.6
  • 52
    • 0031550806 scopus 로고    scopus 로고
    • Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein
    • Ruggieri, A., Harada, T., Matsuura, Y., and Miyamura, T. (1997). Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Virology 229, 68-76.
    • (1997) Virology , vol.229 , pp. 68-76
    • Ruggieri, A.1    Harada, T.2    Matsuura, Y.3    Miyamura, T.4
  • 53
    • 0028832632 scopus 로고
    • The NS2 protein of hepatitis C virus is a transmembrane polypeptide
    • Santolini, E., Pacini, L., Fipaldini, C., Migliaccio, G., and Monica, N. (1995). The NS2 protein of hepatitis C virus is a transmembrane polypeptide. J. Virol. 69, 7461-7471.
    • (1995) J. Virol. , vol.69 , pp. 7461-7471
    • Santolini, E.1    Pacini, L.2    Fipaldini, C.3    Migliaccio, G.4    Monica, N.5
  • 54
    • 0029798235 scopus 로고    scopus 로고
    • Cytopathogenicity of a pestivirus correlates with a 27-nucleotide insertion
    • Tautz, N., Meyers, G., Stark, R., Dubovi, E.J., and Thiel, H.J. (1996). Cytopathogenicity of a pestivirus correlates with a 27-nucleotide insertion. J. Virol. 70, 7851-7858.
    • (1996) J. Virol. , vol.70 , pp. 7851-7858
    • Tautz, N.1    Meyers, G.2    Stark, R.3    Dubovi, E.J.4    Thiel, H.J.5
  • 55
    • 0028334978 scopus 로고
    • Pathogenesis of mucosal disease: A cytopathogenic pestivirus generated by an internal deletion
    • Tautz, N., Thiel, H.J., Dubovi, E.J., and Meyers, G. (1994). Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by an internal deletion. J. Virol. 68, 3289-3297.
    • (1994) J. Virol. , vol.68 , pp. 3289-3297
    • Tautz, N.1    Thiel, H.J.2    Dubovi, E.J.3    Meyers, G.4
  • 56
    • 0035824669 scopus 로고    scopus 로고
    • In vitro characterization of a purified NS2/3 protease variant of hepatitis C virus
    • Thibeault, D., Maurice, R., Pilote, L., Lamarre, D., and Pause, A. (2001). In vitro characterization of a purified NS2/3 protease variant of hepatitis C virus. J. Biol. Chem. 276, 46678-46684.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46678-46684
    • Thibeault, D.1    Maurice, R.2    Pilote, L.3    Lamarre, D.4    Pause, A.5
  • 60
    • 0037031947 scopus 로고    scopus 로고
    • Membrane topology of the hepatitis C virus NS2 protein
    • Yamaga, A.K., and Ou, J.H. (2002). Membrane topology of the hepatitis C virus NS2 protein. J. Biol. Chem. 277, 33228-33234.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33228-33234
    • Yamaga, A.K.1    Ou, J.H.2
  • 61
    • 33748944822 scopus 로고    scopus 로고
    • HCV NS2 protein inhibits cell proliferation and induces cell cycle arrest in the S-phase in mammalian cells through down-regulation of cyclin A expression
    • Yang, X.-J., Liu, J., Ye, L., Liao, Q.-J., Wu, J.-G., Gao, J.-R., She, Y.-L., Wu, Z.-H., and Ye, L.-B. (2006). HCV NS2 protein inhibits cell proliferation and induces cell cycle arrest in the S-phase in mammalian cells through down-regulation of cyclin A expression. Virus Res. 121, 134.
    • (2006) Virus Res. , vol.121 , pp. 134
    • Yang, X.-J.1    Liu, J.2    Ye, L.3    Liao, Q.-J.4    Wu, J.-G.5    Gao, J.-R.6    She, Y.-L.7    Wu, Z.-H.8    Ye, L.-B.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.