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Volumn 136, Issue 47-48, 2006, Pages 745-756

Homocysteine as a risk factor for cardiovascular disease: Should we (still) worry about it?

Author keywords

Cardiovascular disease; Homocysteine; Risk factor; Screening; Treatment

Indexed keywords

CHOLESTEROL; FOLIC ACID; GLUCOSE; HOMOCYSTEINE;

EID: 33846356782     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (96)

References (124)
  • 1
    • 0035960630 scopus 로고    scopus 로고
    • Global burden of cardiovascular diseases: Part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization
    • Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001;104(22):2746-53.
    • (2001) Circulation , vol.104 , Issue.22 , pp. 2746-2753
    • Yusuf, S.1    Reddy, S.2    Ounpuu, S.3    Anand, S.4
  • 2
    • 0030248899 scopus 로고    scopus 로고
    • Rethinking disease: Where do we go from here?
    • Syme SL. Rethinking disease: where do we go from here? Ann Epidemiol. 1996;6(5):463-8.
    • (1996) Ann Epidemiol , vol.6 , Issue.5 , pp. 463-468
    • Syme, S.L.1
  • 3
    • 0035842405 scopus 로고    scopus 로고
    • The real contribution of the major risk factors to the coronary epidemics: Time to end the "only-50%" myth
    • Magnus P, Beaglehole R. The real contribution of the major risk factors to the coronary epidemics: time to end the "only-50%" myth. Arch Intern Med. 2001;161(22):2657-60.
    • (2001) Arch Intern Med , vol.161 , Issue.22 , pp. 2657-2660
    • Magnus, P.1    Beaglehole, R.2
  • 4
    • 0036990124 scopus 로고    scopus 로고
    • The search for new risk factors for coronary heart disease: Occupational therapy for epidemiologists? Int J Epidemiol
    • 1117-22; author reply 1134-1115W
    • Beaglehole R, Magnus P. The search for new risk factors for coronary heart disease: occupational therapy for epidemiologists? Int J Epidemiol. 2002;31(6):1117-22; author reply 1134-1115W.
    • (2002) , vol.31 , Issue.6
    • Beaglehole, R.1    Magnus, P.2
  • 5
    • 0023025526 scopus 로고
    • Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)
    • Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). Jama. 1986;256(20):2823-8.
    • (1986) Jama , vol.256 , Issue.20 , pp. 2823-2828
    • Stamler, J.1    Wentworth, D.2    Neaton, J.D.3
  • 8
    • 0037368292 scopus 로고    scopus 로고
    • Association between homocyst(e)ine levels and risk of vascular events
    • Kaplan ED. Association between homocyst(e)ine levels and risk of vascular events. Drugs Today. (Barc) 2003;39(3):175-92.
    • (2003) Drugs Today. (Barc) , vol.39 , Issue.3 , pp. 175-192
    • Kaplan, E.D.1
  • 9
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • The Homocysteine Studies Collaboration
    • The Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. Jama. 2002;288(16):2015-22.
    • (2002) Jama , vol.288 , Issue.16 , pp. 2015-2022
  • 10
    • 0036208436 scopus 로고    scopus 로고
    • Homocyst(e)ine and cardiovascular disease: A systematic review of the evidence with special emphasis on case-control studies and nested case-control studies
    • Ford ES, Smith SJ, Stroup DF, Steinberg KK, Mueller PW, Thacker SB. Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int J Epidemiol. 2002;31(1):59-70.
    • (2002) Int J Epidemiol , vol.31 , Issue.1 , pp. 59-70
    • Ford, E.S.1    Smith, S.J.2    Stroup, D.F.3    Steinberg, K.K.4    Mueller, P.W.5    Thacker, S.B.6
  • 11
    • 0036072883 scopus 로고    scopus 로고
    • Vitamins - dietary intake and intake from dietary supplements in Germany
    • Beitz R, Mensink GB, Fischer B, Thamm M. Vitamins - dietary intake and intake from dietary supplements in Germany. Eur J Clin Nutr. 2002;56(6):539-45.
    • (2002) Eur J Clin Nutr , vol.56 , Issue.6 , pp. 539-545
    • Beitz, R.1    Mensink, G.B.2    Fischer, B.3    Thamm, M.4
  • 12
    • 0033110923 scopus 로고    scopus 로고
    • (e)inemia - determining factors and treatment
    • Genest J Jr. Hyperhomocyst(e)inemia - determining factors and treatment. Can J Cardiol. 1999;15(Suppl B):35B-38B.
    • (1999) Can J Cardiol , vol.15 , Issue.SUPPL. B
    • Hyperhomocyst Jr., G.J.1
  • 13
    • 0033533454 scopus 로고    scopus 로고
    • Homocysteine in health and disease
    • Graham I. Homocysteine in health and disease. Ann Intern Med. 1999;131(5):387-88.
    • (1999) Ann Intern Med , vol.131 , Issue.5 , pp. 387-388
    • Graham, I.1
  • 14
    • 0030709337 scopus 로고    scopus 로고
    • Homocyst(e)ine and coronary artery disease. Clinical evidence and genetic and metabolic background
    • Moghadasian MH, McManus BM, Frohlich JJ. Homocyst(e)ine and coronary artery disease. Clinical evidence and genetic and metabolic background. Arch Intern Med. 1997;157(20):2299-308.
    • (1997) Arch Intern Med , vol.157 , Issue.20 , pp. 2299-2308
    • Moghadasian, M.H.1    McManus, B.M.2    Frohlich, J.J.3
  • 15
    • 18144436065 scopus 로고    scopus 로고
    • Eat right and take a multivitamin
    • Oakley GP Jr. Eat right and take a multivitamin. N Engl J Med. 1998;338(15):1060-1.
    • (1998) N Engl J Med , vol.338 , Issue.15 , pp. 1060-1061
    • Oakley Jr., G.P.1
  • 16
    • 0013327427 scopus 로고    scopus 로고
    • Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia
    • Peterson JC, Spence JD. Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia. Lancet. 1998;351 (9098):263.
    • (1998) Lancet , vol.351 , Issue.9098 , pp. 263
    • Peterson, J.C.1    Spence, J.D.2
  • 17
    • 0038165393 scopus 로고    scopus 로고
    • A strategy to reduce cardiovascular disease by more than 80%. BMJ
    • 7404:1419
    • Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80%. BMJ. 2003;326(7404):1419.
    • (2003) , pp. 326
    • Wald, N.J.1    Law, M.R.2
  • 18
    • 3042766490 scopus 로고    scopus 로고
    • Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases
    • Stanger O, Herrmann W, Pietrzik K, Fowler B, Geisel J, Dierkes J, et al. Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases. Z Kardiol. 2004;93(6):439-53.
    • (2004) Z Kardiol , vol.93 , Issue.6 , pp. 439-453
    • Stanger, O.1    Herrmann, W.2    Pietrzik, K.3    Fowler, B.4    Geisel, J.5    Dierkes, J.6
  • 19
    • 0033547616 scopus 로고    scopus 로고
    • When can a risk factor be used as a worthwhile screening test?
    • Wald NJ, Hackshaw AK, Frost CD. When can a risk factor be used as a worthwhile screening test? BMJ. 1999;319(7224):1562-5.
    • (1999) BMJ , vol.319 , Issue.7224 , pp. 1562-1565
    • Wald, N.J.1    Hackshaw, A.K.2    Frost, C.D.3
  • 20
    • 0030845376 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) mutation, homocyst(e)ine, and coronary artery disease
    • Wilcken DE, Wang XL, Wilcken B. Methylenetetrahydrofolate reductase (MTHFR) mutation, homocyst(e)ine, and coronary artery disease. Circulation. 1997;96(8):2738-40.
    • (1997) Circulation , vol.96 , Issue.8 , pp. 2738-2740
    • Wilcken, D.E.1    Wang, X.L.2    Wilcken, B.3
  • 21
    • 0032497941 scopus 로고    scopus 로고
    • Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinaemia but not to vascular disease: The result of a meta-analysis
    • Brattstrom L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinaemia but not to vascular disease: the result of a meta-analysis. Circulation. 1998;98(23):2520-6.
    • (1998) Circulation , vol.98 , Issue.23 , pp. 2520-2526
    • Brattstrom, L.1    Wilcken, D.E.2    Ohrvik, J.3    Brudin, L.4
  • 22
    • 24644458773 scopus 로고    scopus 로고
    • Are we losing homocysteine as a cardiovascular risk factor?
    • Bunout D, Hirsch S. Are we losing homocysteine as a cardiovascular risk factor? Nutrition. 2005;21(10):1068-9.
    • (2005) Nutrition , vol.21 , Issue.10 , pp. 1068-1069
    • Bunout, D.1    Hirsch, S.2
  • 23
    • 0041922337 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia: An independent risk factor or a simple marker of vascular disease? 2. Epidemiological data
    • Guilland JC, Favier A, Potier de Courcy G, Galan P, Hercberg S. Hyperhomocysteinaemia: an independent risk factor or a simple marker of vascular disease? 2. Epidemiological data. Pathol Biol. (Paris) 2003;51(2):111-21.
    • (2003) Pathol Biol. (Paris , vol.51 , Issue.2 , pp. 111-121
    • Guilland, J.C.1    Favier, A.2    Potier de Courcy, G.3    Galan, P.4    Hercberg, S.5
  • 24
    • 0037357647 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia: An independent risk factor or a simple marker of vascular disease?. 1. Basic data
    • Guilland JC, Favier A, Potier de Courcy G, Galan P, Hercberg S. Hyperhomocysteinaemia: an independent risk factor or a simple marker of vascular disease?. 1. Basic data. Pathol Biol. (Paris) 2003;51(2):101-10.
    • (2003) Pathol Biol. (Paris , vol.51 , Issue.2 , pp. 101-110
    • Guilland, J.C.1    Favier, A.2    Potier de Courcy, G.3    Galan, P.4    Hercberg, S.5
  • 25
    • 27744471516 scopus 로고    scopus 로고
    • Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate?
    • Lewis SJ, Ebrahim S, Davey Smith G. Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ. 2005;331(7524):1053.
    • (2005) BMJ , vol.331 , Issue.7524 , pp. 1053
    • Lewis, S.J.1    Ebrahim, S.2    Davey Smith, G.3
  • 26
    • 33646050916 scopus 로고    scopus 로고
    • Folic acid: A public-health challenge
    • Eichholzer M, Tönz O, Zimmermann R. Folic acid: a public-health challenge. Lancet. 2006;367:13 52-61.
    • (2006) Lancet , vol.367 , Issue.13 , pp. 52-61
    • Eichholzer, M.1    Tönz, O.2    Zimmermann, R.3
  • 27
    • 24344440989 scopus 로고    scopus 로고
    • Newborn Screening: Toward a Uniform Screening Panel and System
    • 1. American College ofMedical Genetics, Final Report, March 8, accessed: 2 May 2006
    • 1. American College ofMedical Genetics. Newborn Screening: Toward a Uniform Screening Panel and System. Final Report, March 8, 2005. http://mchb.hrsa.gov/screening/ (accessed: 2 May 2006).
    • (2005)
  • 29
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10(1):111-3.
    • (1995) Nat Genet , vol.10 , Issue.1 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 30
    • 0036019532 scopus 로고    scopus 로고
    • A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: Relationships with C677T polymorphism and homocysteine/folate metabolism
    • Friso S, Girelli D, Trabetti E, Stranieri C, Olivieri O, Tinazzi E, et al. A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism. Clin Exp Med. 2002;2(1):7-12.
    • (2002) Clin Exp Med , vol.2 , Issue.1 , pp. 7-12
    • Friso, S.1    Girelli, D.2    Trabetti, E.3    Stranieri, C.4    Olivieri, O.5    Tinazzi, E.6
  • 31
    • 0030975769 scopus 로고    scopus 로고
    • The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes
    • Malinow MR, Nieto FJ, Kruger WD, Duell PB, Hess DL, Gluckman RA, et al. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arterioscler Thromb Vasc Biol. 1997;17(6):1157-62.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , Issue.6 , pp. 1157-1162
    • Malinow, M.R.1    Nieto, F.J.2    Kruger, W.D.3    Duell, P.B.4    Hess, D.L.5    Gluckman, R.A.6
  • 33
    • 0034445732 scopus 로고    scopus 로고
    • Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification
    • Selhub J, Jacques PF, Bostom AG, Wilson PW, Rosenberg IH. Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification. Public Health Rev. 2000;28(1-4):117-45.
    • (2000) Public Health Rev , vol.28 , Issue.1-4 , pp. 117-145
    • Selhub, J.1    Jacques, P.F.2    Bostom, A.G.3    Wilson, P.W.4    Rosenberg, I.H.5
  • 34
    • 0033989359 scopus 로고    scopus 로고
    • Homocysteine, folate, vitamin Bi2, and cardiovascular risk in Indians, Malays, and Chinese in Singapore
    • Hughes K, Ong CN. Homocysteine, folate, vitamin Bi2, and cardiovascular risk in Indians, Malays, and Chinese in Singapore. J Epidemiol Community Health. 2000;54(1):31-4.
    • (2000) J Epidemiol Community Health , vol.54 , Issue.1 , pp. 31-34
    • Hughes, K.1    Ong, C.N.2
  • 35
    • 20244385461 scopus 로고    scopus 로고
    • Prevalences of hyperhomocysteinaemia, unfavorable cholesterol profile and hypertension in European populations
    • de Bree A, van der Put NM, Mennen LI, Verschuren WM, Blom HJ, Galan P, et al. Prevalences of hyperhomocysteinaemia, unfavorable cholesterol profile and hypertension in European populations. Eur J Clin Nutr. 2005;59(4):480-8.
    • (2005) Eur J Clin Nutr , vol.59 , Issue.4 , pp. 480-488
    • de Bree, A.1    van der Put, N.M.2    Mennen, L.I.3    Verschuren, W.M.4    Blom, H.J.5    Galan, P.6
  • 36
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinaemia: Implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocysteinaemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56(1):111-28.
    • (1969) Am J Pathol , vol.56 , Issue.1 , pp. 111-128
    • McCully, K.S.1
  • 37
    • 0017284939 scopus 로고
    • The pathogenesis of coronary artery disease. A possible role for methionine metabolism
    • Wilcken DE, Wilcken B. The pathogenesis of coronary artery disease. A possible role for methionine metabolism. J Clin Invest. 1976;57(4):1079-82.
    • (1976) J Clin Invest , vol.57 , Issue.4 , pp. 1079-1082
    • Wilcken, D.E.1    Wilcken, B.2
  • 38
    • 0032569645 scopus 로고    scopus 로고
    • Meta-analysis of hyperhomocysteinaemia as a risk factor for venous thromboembolic disease
    • Ray JG. Meta-analysis of hyperhomocysteinaemia as a risk factor for venous thromboembolic disease. Arch Intern Med. 1998;158(19):2101-6.
    • (1998) Arch Intern Med , vol.158 , Issue.19 , pp. 2101-2106
    • Ray, J.G.1
  • 41
    • 27244455440 scopus 로고    scopus 로고
    • Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A, 3rd. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005;82(3):627-35.
    • Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A, 3rd. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005;82(3):627-35.
  • 44
    • 25644439809 scopus 로고    scopus 로고
    • Homocysteine and folate metabolism in depression
    • Bottiglieri T. Homocysteine and folate metabolism in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(7):1103-12.
    • (2005) Prog Neuropsychopharmacol Biol Psychiatry , vol.29 , Issue.7 , pp. 1103-1112
    • Bottiglieri, T.1
  • 45
    • 5144231634 scopus 로고    scopus 로고
    • Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification
    • Ramos MI, Allen LH, Haan MN, Green R, Miller JW. Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. Am J Clin Nutr. 2004;80(4):1024-8.
    • (2004) Am J Clin Nutr , vol.80 , Issue.4 , pp. 1024-1028
    • Ramos, M.I.1    Allen, L.H.2    Haan, M.N.3    Green, R.4    Miller, J.W.5
  • 47
    • 0038387939 scopus 로고    scopus 로고
    • Homocysteine and Alzheimer's disease
    • Morris MS. Homocysteine and Alzheimer's disease. Lancet Neurol. 2003;2(7):425-8.
    • (2003) Lancet Neurol , vol.2 , Issue.7 , pp. 425-428
    • Morris, M.S.1
  • 48
    • 2942525889 scopus 로고    scopus 로고
    • Elevated plasma homocysteine level in patients with Parkinson disease: Motor, affective, and cognitive associations
    • O'Suilleabhain PE, Sung V, Hernandez C, Lacritz L, Dewey RB Jr, Bottiglieri T, et al. Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations. Arch Neurol. 2004;61(6):865-8.
    • (2004) Arch Neurol , vol.61 , Issue.6 , pp. 865-868
    • O'Suilleabhain, P.E.1    Sung, V.2    Hernandez, C.3    Lacritz, L.4    Dewey Jr, R.B.5    Bottiglieri, T.6
  • 49
    • 4544231573 scopus 로고    scopus 로고
    • Modification induced by homocysteine and low-density lipoprotein on human aortic endothelial cells: An in vitro study
    • Vignini A, Nanetti L, Bacchetti T, Ferretti G, Curatola G, Mazzanti L. Modification induced by homocysteine and low-density lipoprotein on human aortic endothelial cells: an in vitro study. J Clin Endocrinol Metab. 2004;89(9):4558-61.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.9 , pp. 4558-4561
    • Vignini, A.1    Nanetti, L.2    Bacchetti, T.3    Ferretti, G.4    Curatola, G.5    Mazzanti, L.6
  • 50
    • 24644490501 scopus 로고    scopus 로고
    • Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression
    • Su SJ, Huang LW, Pai LS, Liu HW, Chang KL. Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression. Nutrition. 2005;21(10):994-1002.
    • (2005) Nutrition , vol.21 , Issue.10 , pp. 994-1002
    • Su, S.J.1    Huang, L.W.2    Pai, L.S.3    Liu, H.W.4    Chang, K.L.5
  • 51
    • 0033565899 scopus 로고    scopus 로고
    • Homocysteine decreases endothelin-1 production by cultured human endothelial cells
    • Demuth K, Atger V, Borderie D, Benoit MO, Sauvaget D, Lotersztajn S, et al. Homocysteine decreases endothelin-1 production by cultured human endothelial cells. Eur J Biochem. 1999;263(2):367-76.
    • (1999) Eur J Biochem , vol.263 , Issue.2 , pp. 367-376
    • Demuth, K.1    Atger, V.2    Borderie, D.3    Benoit, M.O.4    Sauvaget, D.5    Lotersztajn, S.6
  • 53
  • 54
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer RH, Wilson BD, Gubler DB, Fitzgerald LA, Rodgers GM. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb. 1993;13(9):1327-33.
    • (1993) Arterioscler Thromb , vol.13 , Issue.9 , pp. 1327-1333
    • Fryer, R.H.1    Wilson, B.D.2    Gubler, D.B.3    Fitzgerald, L.A.4    Rodgers, G.M.5
  • 55
    • 1842411860 scopus 로고    scopus 로고
    • Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
    • Upchurch GR Jr, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr, et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 1997;272(27):17012-7.
    • (1997) J Biol Chem , vol.272 , Issue.27 , pp. 17012-17017
    • Upchurch Jr, G.R.1    Welch, G.N.2    Fabian, A.J.3    Freedman, J.E.4    Johnson, J.L.5    Keaney Jr, J.F.6
  • 56
    • 0027531427 scopus 로고
    • Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen
    • Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993;91(1):308-18.
    • (1993) J Clin Invest , vol.91 , Issue.1 , pp. 308-318
    • Stamler, J.S.1    Osborne, J.A.2    Jaraki, O.3    Rabbani, L.E.4    Mullins, M.5    Singel, D.6
  • 57
    • 0347252674 scopus 로고    scopus 로고
    • Endothelial cell oxidative stress and signal transduction
    • Foncea R, Carvajal C, Almarza C, Leighton F. Endothelial cell oxidative stress and signal transduction. Biol Res. 2000;33(2):89-96.
    • (2000) Biol Res , vol.33 , Issue.2 , pp. 89-96
    • Foncea, R.1    Carvajal, C.2    Almarza, C.3    Leighton, F.4
  • 58
    • 0035107609 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia enhances vascular inflammation and accelerates atherosclerosis in a murine model
    • Hofmann MA, Lalla E, Lu Y, Gleason MR, Wolf BM, Tanji N, et al. Hyperhomocysteinaemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest. 2001;107(6):675-83.
    • (2001) J Clin Invest , vol.107 , Issue.6 , pp. 675-683
    • Hofmann, M.A.1    Lalla, E.2    Lu, Y.3    Gleason, M.R.4    Wolf, B.M.5    Tanji, N.6
  • 59
    • 0030917545 scopus 로고    scopus 로고
    • Putative mechanisms for vascular damage by homocysteine
    • Bellamy MF, McDowell IF. Putative mechanisms for vascular damage by homocysteine. J Inherit Metab Dis. 1997;20(2):307-15.
    • (1997) J Inherit Metab Dis , vol.20 , Issue.2 , pp. 307-315
    • Bellamy, M.F.1    McDowell, I.F.2
  • 60
    • 0033826673 scopus 로고    scopus 로고
    • Folate dependence of hyperhomocysteinaemia and vascular dysfunction in cystathionine beta-synthase-deficient mice
    • Lentz SR, Erger RA, Dayal S, Maeda N, Malinow MR, Heistad DD, et al. Folate dependence of hyperhomocysteinaemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Am J Physiol Heart Circ Physiol. 2000;279(3):H970-5.
    • (2000) Am J Physiol Heart Circ Physiol , vol.279 , Issue.3
    • Lentz, S.R.1    Erger, R.A.2    Dayal, S.3    Maeda, N.4    Malinow, M.R.5    Heistad, D.D.6
  • 61
    • 11144230938 scopus 로고    scopus 로고
    • Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinaemia
    • Namekata K, Enokido Y, Ishii I, Nagai Y, Harada T, Kimura H. Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinaemia. J Biol Chem. 2004;279(51):52961-9.
    • (2004) J Biol Chem , vol.279 , Issue.51 , pp. 52961-52969
    • Namekata, K.1    Enokido, Y.2    Ishii, I.3    Nagai, Y.4    Harada, T.5    Kimura, H.6
  • 62
    • 0035282903 scopus 로고    scopus 로고
    • Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinaemia and decreased methylation capacity, with neuropathology and aortic lipid deposition
    • Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, et al. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinaemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet. 2001;10(5):433-43.
    • (2001) Hum Mol Genet , vol.10 , Issue.5 , pp. 433-443
    • Chen, Z.1    Karaplis, A.C.2    Ackerman, S.L.3    Pogribny, I.P.4    Melnyk, S.5    Lussier-Cacan, S.6
  • 63
    • 0030119805 scopus 로고    scopus 로고
    • Homocysteine and hemostasis: Pathogenic mechanisms predisposing to thrombosis
    • Harpel PC, Zhang X, Borth W. Homocysteine and hemostasis: pathogenic mechanisms predisposing to thrombosis. J Nutr. 1996;126(4 Suppl):1285S-9S.
    • (1996) J Nutr , vol.126 , Issue.4 SUPPL.
    • Harpel, P.C.1    Zhang, X.2    Borth, W.3
  • 64
    • 28344446460 scopus 로고    scopus 로고
    • Mechanisms of homocysteine-induced atherothrombosis
    • Lentz SR. Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost. 2005;3(8):1646-54.
    • (2005) J Thromb Haemost , vol.3 , Issue.8 , pp. 1646-1654
    • Lentz, S.R.1
  • 65
    • 0035848341 scopus 로고    scopus 로고
    • Randomized trial of folic acid supplementation and serum homocysteine levels
    • Wald DS, Bishop L, Wald NJ, Law M, Hennessy E, Weir D, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med. 2001;161(5):695-700.
    • (2001) Arch Intern Med , vol.161 , Issue.5 , pp. 695-700
    • Wald, D.S.1    Bishop, L.2    Wald, N.J.3    Law, M.4    Hennessy, E.5    Weir, D.6
  • 66
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Jama. 1995;274(13):1049-57.
    • (1995) Jama , vol.274 , Issue.13 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 67
    • 0029955917 scopus 로고    scopus 로고
    • Folic acid fortification of the food supply. Potential benefits and risks for the elderly population
    • Tucker KL, Mahnken B, Wilson PW, Jacques P, Selhub J. Folic acid fortification of the food supply. Potential benefits and risks for the elderly population. Jama. 1996;276(23):1879-85.
    • (1996) Jama , vol.276 , Issue.23 , pp. 1879-1885
    • Tucker, K.L.1    Mahnken, B.2    Wilson, P.W.3    Jacques, P.4    Selhub, J.5
  • 68
    • 17644400183 scopus 로고    scopus 로고
    • Impact of voluntary folate fortification on plasma homocysteine and serum folate in Australia from 1995 to 2001: A population based cohort study
    • Hickling S, Hung J, Knuiman M, Jamrozik K, McQuillan B, Beilby J, et al. Impact of voluntary folate fortification on plasma homocysteine and serum folate in Australia from 1995 to 2001: a population based cohort study. J Epidemiol Community Health. 2005;59(5):371-6.
    • (2005) J Epidemiol Community Health , vol.59 , Issue.5 , pp. 371-376
    • Hickling, S.1    Hung, J.2    Knuiman, M.3    Jamrozik, K.4    McQuillan, B.5    Beilby, J.6
  • 69
    • 0035570015 scopus 로고    scopus 로고
    • Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: A multicenter observational study
    • Yap S, Boers GH, Wilcken B, Wilcken DE, Brenton DP, Lee PJ, et al. Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: a multicenter observational study. Arterioscler Thromb Vasc Biol. 2001;21(12):2080-5.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , Issue.12 , pp. 2080-2085
    • Yap, S.1    Boers, G.H.2    Wilcken, B.3    Wilcken, D.E.4    Brenton, D.P.5    Lee, P.J.6
  • 70
    • 12244308479 scopus 로고    scopus 로고
    • Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage
    • Moat SJ, Hill MH, McDowell IF, Pullin CH, Ashfield-Watt PA, Clark ZE, et al. Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage. Eur J Clin Nutr. 2003;57(3):483-9.
    • (2003) Eur J Clin Nutr , vol.57 , Issue.3 , pp. 483-489
    • Moat, S.J.1    Hill, M.H.2    McDowell, I.F.3    Pullin, C.H.4    Ashfield-Watt, P.A.5    Clark, Z.E.6
  • 71
    • 2242477014 scopus 로고    scopus 로고
    • Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ. 1998;316(7135):894-8.
    • Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ. 1998;316(7135):894-8.
  • 72
    • 0033547813 scopus 로고    scopus 로고
    • Homocyst(e)ine, diet, and cardiovascular diseases: A statement for healthcare professionals from the Nutrition Committee, American Heart Association
    • Malinow MR, Bostom AG, Krauss RM. Homocyst(e)ine, diet, and cardiovascular diseases: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation. 1999;99(1):178-82.
    • (1999) Circulation , vol.99 , Issue.1 , pp. 178-182
    • Malinow, M.R.1    Bostom, A.G.2    Krauss, R.M.3
  • 73
    • 33846357925 scopus 로고    scopus 로고
    • National Nutrient Database for Standard Reference of the US Department of Agriculture (USDA, release 18). http://www.nal.usda.gov/fnic/foodcomp/srch/ search.htm (accessed: 20 March 2006).
    • National Nutrient Database for Standard Reference of the US Department of Agriculture (USDA, release 18). http://www.nal.usda.gov/fnic/foodcomp/srch/ search.htm (accessed: 20 March 2006).
  • 74
    • 0030695338 scopus 로고    scopus 로고
    • de Bree A, van Dusseldorp M, Brouwer IA, van het Hof KH, Steegers-Theunissen RP. Folate intake in Europe: recommended, actual and desired intake. Eur J Clin Nutr. 1997;51(10):643-60.
    • de Bree A, van Dusseldorp M, Brouwer IA, van het Hof KH, Steegers-Theunissen RP. Folate intake in Europe: recommended, actual and desired intake. Eur J Clin Nutr. 1997;51(10):643-60.
  • 75
    • 4444240064 scopus 로고    scopus 로고
    • No effect of folic acid on markers of endothelial dysfunction or inflammation in patients with type 2 diabetes mellitus and mild hyperhomocysteinaemia
    • Spoelstra-de MA, Brouwer CB, Terheggen F, Bollen JM, Stehouwer CD, Smulders YM. No effect of folic acid on markers of endothelial dysfunction or inflammation in patients with type 2 diabetes mellitus and mild hyperhomocysteinaemia. Neth J Med. 2004;62(7):246-53.
    • (2004) Neth J Med , vol.62 , Issue.7 , pp. 246-253
    • Spoelstra-de, M.A.1    Brouwer, C.B.2    Terheggen, F.3    Bollen, J.M.4    Stehouwer, C.D.5    Smulders, Y.M.6
  • 79
    • 12344309062 scopus 로고    scopus 로고
    • Homocysteine and stroke: Evidence on a causal link from mendelian randomisation
    • Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet. 2005;365(9455):224-32.
    • (2005) Lancet , vol.365 , Issue.9455 , pp. 224-232
    • Casas, J.P.1    Bautista, L.E.2    Smeeth, L.3    Sharma, P.4    Hingorani, A.D.5
  • 80
    • 33645084282 scopus 로고    scopus 로고
    • Limits to causal inference based on Mendelian randomization: A comparison with randomized controlled trials
    • Nitsch D, Molokhia M, Smeeth L, DeStavola BL, Whittaker JC, Leon DA. Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials. Am J Epidemiol. 2006;163(5):397-403.
    • (2006) Am J Epidemiol , vol.163 , Issue.5 , pp. 397-403
    • Nitsch, D.1    Molokhia, M.2    Smeeth, L.3    DeStavola, B.L.4    Whittaker, J.C.5    Leon, D.A.6
  • 81
    • 0032984676 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia in chronic renal disease
    • Bostom AG, Culleton BF. Hyperhomocysteinaemia in chronic renal disease. J Am Soc Nephrol. 1999;10(4):891-900.
    • (1999) J Am Soc Nephrol , vol.10 , Issue.4 , pp. 891-900
    • Bostom, A.G.1    Culleton, B.F.2
  • 82
    • 0028788020 scopus 로고    scopus 로고
    • Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. Jama. 1995;274{19:1526-33.
    • Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. Jama. 1995;274{19):1526-33.
  • 83
    • 0033960134 scopus 로고    scopus 로고
    • Homocysteine: "expensive creatinine" or important modifiable risk factor for arteriosclerotic outcomes in renal transplant recipients?
    • Bostom AG. Homocysteine: "expensive creatinine" or important modifiable risk factor for arteriosclerotic outcomes in renal transplant recipients? J Am Soc Nephrol. 2000;11(1):149-51.
    • (2000) J Am Soc Nephrol , vol.11 , Issue.1 , pp. 149-151
    • Bostom, A.G.1
  • 84
    • 0033980289 scopus 로고    scopus 로고
    • Serum total homocysteine and cardiovascular disease occurrence in chronic, stable renal transplant recipients: A prospective study
    • Ducloux D, Motte G, Challier B, Gibey R, Chalopin JM. Serum total homocysteine and cardiovascular disease occurrence in chronic, stable renal transplant recipients: a prospective study. J Am Soc Nephrol. 2000;11(1):134-7.
    • (2000) J Am Soc Nephrol , vol.11 , Issue.1 , pp. 134-137
    • Ducloux, D.1    Motte, G.2    Challier, B.3    Gibey, R.4    Chalopin, J.M.5
  • 85
    • 0029871268 scopus 로고    scopus 로고
    • Serial measures of plasma homocyst(e)ine after acute myocardial infarction
    • Egerton W, Silberberg J, Crooks R, Ray C, Xie L, Dudman N. Serial measures of plasma homocyst(e)ine after acute myocardial infarction. Am J Cardiol. 1996;77(9):759-61.
    • (1996) Am J Cardiol , vol.77 , Issue.9 , pp. 759-761
    • Egerton, W.1    Silberberg, J.2    Crooks, R.3    Ray, C.4    Xie, L.5    Dudman, N.6
  • 86
    • 0029924647 scopus 로고    scopus 로고
    • Homocysteine metabolism and risk of myocardial infarction: Relation with vitamins B6, B12, and folate
    • Verhoef P, Stampfer MJ, Buring JE, Gaziano JM, Allen RH, Stabler SP, et al. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am J Epidemiol. 1996;143(9):845-59.
    • (1996) Am J Epidemiol , vol.143 , Issue.9 , pp. 845-859
    • Verhoef, P.1    Stampfer, M.J.2    Buring, J.E.3    Gaziano, J.M.4    Allen, R.H.5    Stabler, S.P.6
  • 87
    • 0028950274 scopus 로고
    • Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid
    • Landgren F, Israelsson B, Lindgren A, Hultberg B, Andersson A, Brattstrom L. Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. J Intern Med. 1995;237(4):381-8.
    • (1995) J Intern Med , vol.237 , Issue.4 , pp. 381-388
    • Landgren, F.1    Israelsson, B.2    Lindgren, A.3    Hultberg, B.4    Andersson, A.5    Brattstrom, L.6
  • 88
    • 0031050366 scopus 로고    scopus 로고
    • Marginal folate deficiency as a possible cause of hyperhomocystinaemia in stroke patients
    • Hultberg B, Andersson A, Lindgren A. Marginal folate deficiency as a possible cause of hyperhomocystinaemia in stroke patients. Eur J Clin Chem Clin Biochem. 1997;35(1):25-8.
    • (1997) Eur J Clin Chem Clin Biochem , vol.35 , Issue.1 , pp. 25-28
    • Hultberg, B.1    Andersson, A.2    Lindgren, A.3
  • 89
    • 0029896088 scopus 로고    scopus 로고
    • Low whole-blood S-adenosylmethionine and correlation between 5- methyltetrahydrofolate and homocysteine in coronary artery disease
    • Loehrer FM, Angst CP, Haefeli WE, Jordan PP, Ritz R, Fowler B. Low whole-blood S-adenosylmethionine and correlation between 5- methyltetrahydrofolate and homocysteine in coronary artery disease. Arterioscler Thromb Vasc Biol. 1996;16(6):727-33.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , Issue.6 , pp. 727-733
    • Loehrer, F.M.1    Angst, C.P.2    Haefeli, W.E.3    Jordan, P.P.4    Ritz, R.5    Fowler, B.6
  • 91
    • 3042742587 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia in healthy young men and elderly men with normal serum folate concentration is not associated with poor vascular reactivity or oxidative stress
    • Hirsch S, Ronco AM, Vasquez M, de la Maza MP, Garrido A, Barrera G, et al. Hyperhomocysteinaemia in healthy young men and elderly men with normal serum folate concentration is not associated with poor vascular reactivity or oxidative stress. J Nutr. 2004;134(7):1832-5.
    • (2004) J Nutr , vol.134 , Issue.7 , pp. 1832-1835
    • Hirsch, S.1    Ronco, A.M.2    Vasquez, M.3    de la Maza, M.P.4    Garrido, A.5    Barrera, G.6
  • 93
    • 19944429119 scopus 로고    scopus 로고
    • Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: A randomized substudy of the VITATOPS trial
    • Dusitanond P, Eikelboom JW, Hankey GJ, Thom J, Gilmore G, Loh K, et al. Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy of the VITATOPS trial. Stroke. 2005;36(1):144-6.
    • (2005) Stroke , vol.36 , Issue.1 , pp. 144-146
    • Dusitanond, P.1    Eikelboom, J.W.2    Hankey, G.J.3    Thom, J.4    Gilmore, G.5    Loh, K.6
  • 94
    • 0041695231 scopus 로고    scopus 로고
    • Emerging risk factors for atherosclerotic vascular disease: A critical review of the evidence
    • Hackam DG, Anand SS. Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. Jama. 2003;290(7):932-40.
    • (2003) Jama , vol.290 , Issue.7 , pp. 932-940
    • Hackam, D.G.1    Anand, S.S.2
  • 95
    • 1342309318 scopus 로고    scopus 로고
    • Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. Jama. 2004;291(5):565-75.
    • Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. Jama. 2004;291(5):565-75.
  • 96
    • 33645753544 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B vitamins in vascular disease
    • Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354(15):1567-77.
    • (2006) N Engl J Med , vol.354 , Issue.15 , pp. 1567-1577
    • Lonn, E.1    Yusuf, S.2    Arnold, M.J.3    Sheridan, P.4    Pogue, J.5    Micks, M.6
  • 97
    • 33645796222 scopus 로고    scopus 로고
    • Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006;354(15):1578-88.
    • (2006) N Engl J Med , vol.354 , Issue.15 , pp. 1578-1588
    • Bonaa, K.H.1    Njolstad, I.2    Ueland, P.M.3    Schirmer, H.4    Tverdal, A.5    Steigen, T.6
  • 98
    • 33646050916 scopus 로고    scopus 로고
    • Folic acid: A public-health challenge
    • Eichholzer M, Tonz O, Zimmermann R. Folic acid: a public-health challenge. Lancet. 2006;367(9519):1352-61.
    • (2006) Lancet , vol.367 , Issue.9519 , pp. 1352-1361
    • Eichholzer, M.1    Tonz, O.2    Zimmermann, R.3
  • 99
    • 24044507638 scopus 로고    scopus 로고
    • Biochemical indicators of B vitamin status in the US population after folic acid fortification: Results from the National Health and Nutrition Examination Survey 1999-2000
    • Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr. 2005;82(2):442-50.
    • (2005) Am J Clin Nutr , vol.82 , Issue.2 , pp. 442-450
    • Pfeiffer, C.M.1    Caudill, S.P.2    Gunter, E.W.3    Osterloh, J.4    Sampson, E.J.5
  • 100
    • 33846351361 scopus 로고    scopus 로고
    • Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: The Inter99 study
    • Husemoen LL, Thomsen TF, Fenger M, Jorgensen T. Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study. Eur J Clin Nutr 2005.
    • (2005) Eur J Clin Nutr
    • Husemoen, L.L.1    Thomsen, T.F.2    Fenger, M.3    Jorgensen, T.4
  • 102
    • 12844260983 scopus 로고    scopus 로고
    • Secondary prevention of recurrent stroke
    • Hankey GJ. Secondary prevention of recurrent stroke. Stroke. 2005;36(2):218-21.
    • (2005) Stroke , vol.36 , Issue.2 , pp. 218-221
    • Hankey, G.J.1
  • 103
    • 27844435736 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy and early progression of transplant vasculopathy: A prospective, randomized, IVUS-based study
    • Potena L, Grigioni F, Magnani G, Ortolani P, Coccolo F, Sassi S, et al. Homocysteine-lowering therapy and early progression of transplant vasculopathy: a prospective, randomized, IVUS-based study. Am J Transplant. 2005;5(9):2258-64.
    • (2005) Am J Transplant , vol.5 , Issue.9 , pp. 2258-2264
    • Potena, L.1    Grigioni, F.2    Magnani, G.3    Ortolani, P.4    Coccolo, F.5    Sassi, S.6
  • 104
    • 33745607390 scopus 로고    scopus 로고
    • Diet and lifestyle recommendations revision 2006: A scientific statement from the American Heart Association Nutrition Committee
    • Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation. 2006;114(1):82-96.
    • (2006) Circulation , vol.114 , Issue.1 , pp. 82-96
    • Lichtenstein, A.H.1    Appel, L.J.2    Brands, M.3    Carnethon, M.4    Daniels, S.5    Franch, H.A.6
  • 107
    • 0033778284 scopus 로고    scopus 로고
    • 12, serum folate, and red cell folate levels in relation to plasma homocysteine: Is a preventable public health issue on the rise?
    • 12, serum folate, and red cell folate levels in relation to plasma homocysteine: is a preventable public health issue on the rise? Clin Biochem. 2000;33(5):337-43.
    • (2000) Clin Biochem , vol.33 , Issue.5 , pp. 337-343
    • Ray, J.G.1    Cole, D.E.2    Boss, S.C.3
  • 112
    • 0036798802 scopus 로고    scopus 로고
    • Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease
    • Neal B, MacMahon S, Ohkubo T, Tonkin A, Wilcken D. Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease. Eur Heart J. 2002;23(19):1509-15.
    • (2002) Eur Heart J , vol.23 , Issue.19 , pp. 1509-1515
    • Neal, B.1    MacMahon, S.2    Ohkubo, T.3    Tonkin, A.4    Wilcken, D.5
  • 113
    • 0036187533 scopus 로고    scopus 로고
    • The VTTATOPS (Vitamins to Prevent Stroke) Trial: rationale and design of an international, large, simple, randomised trial of homocysteine-lowering multivitamin therapy in patients with recent transient ischaemic attack or stroke. Cerebrovasc Dis. 2002;13(2):120-6.
    • The VTTATOPS (Vitamins to Prevent Stroke) Trial: rationale and design of an international, large, simple, randomised trial of homocysteine-lowering multivitamin therapy in patients with recent transient ischaemic attack or stroke. Cerebrovasc Dis. 2002;13(2):120-6.
  • 114
    • 14044251441 scopus 로고    scopus 로고
    • Sustained homocysteine-lowering effect over time of folic acid-based multivitamin therapy in stroke patients despite increasing folate status in the population
    • Hankey GJ, Eikelboom JW, Loh K, Tang M, Pizzi J, Thom J, et al. Sustained homocysteine-lowering effect over time of folic acid-based multivitamin therapy in stroke patients despite increasing folate status in the population. Cerebrovasc Dis. 2005;19(2):110-6.
    • (2005) Cerebrovasc Dis , vol.19 , Issue.2 , pp. 110-116
    • Hankey, G.J.1    Eikelboom, J.W.2    Loh, K.3    Tang, M.4    Pizzi, J.5    Thom, J.6
  • 116
    • 33747204679 scopus 로고    scopus 로고
    • Rationale and design of the Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT) trial
    • Bostom AG, Carpenter MA, Kusek JW, Hunsicker LG, Pfeffer MA, Levey AS, et al. Rationale and design of the Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT) trial. Am Heart J. 2006;152(3):448-53.
    • (2006) Am Heart J , vol.152 , Issue.3 , pp. 448-453
    • Bostom, A.G.1    Carpenter, M.A.2    Kusek, J.W.3    Hunsicker, L.G.4    Pfeffer, M.A.5    Levey, A.S.6
  • 117
    • 4544292844 scopus 로고    scopus 로고
    • Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention
    • Bleie O, Refsum H, Ueland PM, Vollset SE, Guttormsen AB, Nexo E, et al. Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention. Am J Clin Nutr. 2004;80(3):641-8.
    • (2004) Am J Clin Nutr , vol.80 , Issue.3 , pp. 641-648
    • Bleie, O.1    Refsum, H.2    Ueland, P.M.3    Vollset, S.E.4    Guttormsen, A.B.5    Nexo, E.6
  • 118
    • 0141495170 scopus 로고    scopus 로고
    • 12 and/or omega-3 fatty acids on the prevention of recurrent ischemic events in subjects with atherosclerosis in the coronary or cerebral arteries
    • 12 and/or omega-3 fatty acids on the prevention of recurrent ischemic events in subjects with atherosclerosis in the coronary or cerebral arteries. J Nutr Health Aging. 2003;7(6):428-35.
    • (2003) J Nutr Health Aging , vol.7 , Issue.6 , pp. 428-435
    • Galan, P.1    de Bree, A.2    Mennen, L.3    Potier de Courcy, G.4    Preziozi, P.5    Bertrais, S.6
  • 119
    • 33646190409 scopus 로고    scopus 로고
    • Design and statistical issues in the homocysteinemia in kidney and end stage renal disease (HOST) study
    • Jamison RL, Hartigan P, GazianoJM, Fortmann SP, Goldfarb DS, Haroldson JA, et al. Design and statistical issues in the homocysteinemia in kidney and end stage renal disease (HOST) study. Clin Trials. 2004;1(5):451-60.
    • (2004) Clin Trials , vol.1 , Issue.5 , pp. 451-460
    • Jamison, R.L.1    Hartigan, P.2    Gaziano, J.M.3    Fortmann, S.P.4    Goldfarb, D.S.5    Haroldson, J.A.6
  • 120
    • 1242278327 scopus 로고    scopus 로고
    • Blinded comparison of folic acid and placebo in patients with ischemic heart disease: An outcome
    • trial, 3642 abstract
    • Baker F, Picton D, Blackwood S, HuntJ, Erskine M, Dyas M. Blinded comparison of folic acid and placebo in patients with ischemic heart disease: an outcome trial. Circulation. 2002;106(3642 (abstract)).
    • (2002) Circulation , pp. 106
    • Baker, F.1    Picton, D.2    Blackwood, S.3    Hunt, J.4    Erskine, M.5    Dyas, M.6
  • 121
    • 0347363547 scopus 로고    scopus 로고
    • Routine vitamin supplementation to prevent cancer and cardiovascular disease: Recommendations and rationale
    • U.S. Preventive Services Task Force
    • U.S. Preventive Services Task Force. Routine vitamin supplementation to prevent cancer and cardiovascular disease: recommendations and rationale. Am Fam Physician. 2003;68 (12):2422-4.
    • (2003) Am Fam Physician , vol.68 , Issue.12 , pp. 2422-2424
  • 122
    • 33846397224 scopus 로고    scopus 로고
    • International Task Force for Prevention of Coronary Heart Disease, accessed: 3 May 2006
    • International Task Force for Prevention of Coronary Heart Disease. http://www.chd-taskforce.de/guidelines/kap23.htm (accessed: 3 May 2006).
  • 123
    • 33846396522 scopus 로고    scopus 로고
    • AHA (American Heart Association) & CDC Centers of Disease Control and Prevention, accessed: 3 May 2006
    • AHA (American Heart Association) & CDC (Centers of Disease Control and Prevention). http://www.americanheart. org/presenter.jhtml?identifier=4677 (accessed: 3 May 2006).
  • 124
    • 33846401883 scopus 로고    scopus 로고
    • National Guideline Clearinghouse. Preventive health care: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. http://guideline.gov/summary/pdf.aspx?doc_id=2702&stat= 1&string= (accessed: 3 May 2006). 2000.
    • National Guideline Clearinghouse. Preventive health care: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. http://guideline.gov/summary/pdf.aspx?doc_id=2702&stat= 1&string= (accessed: 3 May 2006). 2000.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.