IL-12 Facilitates Both the Recovery of Endogenous Hematopoiesis and the Engraftment of Stem Cells after Ionizing Radiation

Experimental Hematology

Volumn 35, Issue 2, 2007, Pages 203-213

  Chen, Tingchao ^a   Burke, Kathleen A ^a   Zhan, Yuxia ^a   Wang, Xingchao ^b   Shibata, Darryl ^a   Zhao, Yi ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; INTERLEUKIN 12 RECEPTOR; RECOMBINANT INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL COUNT; BONE MARROW CELL; BONE MARROW SUPPRESSION; BONE MARROW TRANSPLANTATION; CELL PROTECTION; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; IONIZING RADIATION; LEUKOCYTE; LIFESPAN; LOW DRUG DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; STEM CELL; STEM CELL TRANSPLANTATION; SURVIVAL TIME;

ANIMALS; BLOOD CELLS; BONE MARROW; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; GASTROINTESTINAL TRACT; GRAFT SURVIVAL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; RADIATION-PROTECTIVE AGENTS; RECOVERY OF FUNCTION; STEM CELLS; SURVIVAL RATE; TIME FACTORS; WHOLE-BODY IRRADIATION;

ANIMALIA;

EID: 33846349940     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.10.002     Document Type: Article

References (49)

1. Lemischka I.R. Microenvironmental regulation of hematopoietic stem cells. Stem Cells 15 Suppl 1 (1997) 63-68
2. Zhu J., and Emerson S.G. A new bone to pick: osteoblasts and the haematopoietic stem-cell niche. Bioessays 26 (2004) 595-599
3. Moore K.A. Recent advances in defining the hematopoietic stem cell niche. Curr Opin Hematol 11 (2004) 107-111
4. Taichman R.S. Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood 105 (2005) 2631-2639
5. Arai F., Hirao A., Ohmura M., et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118 (2004) 149-161
6. Calvi L.M., Adams G.B., Weibrecht K.W., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425 (2003) 841-846
7. Zhang J., Niu C., Ye L., et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425 (2003) 836-841
8. Kiel M.J., Yilmaz O.H., Iwashita T., Yilmaz O.H., Terhorst C., and Morrison S.J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121 (2005) 1109-1121
9. Kopp H.-G., Avecilla S.T., Hooper A.T., et al. Tie2 activation contributes to hemangiogenic regeneration after myelosuppression. Blood 106 (2005) 505-513
10. Zsebo K.M., Smith K.A., Hartley C.A., et al. Radioprotection of mice by recombinant rat stem cell factor. Proc Natl Acad Sci U S A 89 (1992) 9464-9468
11. Maddens S., Charruyer A., Plo I., et al. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLCγ 1: implication in stem cell factor radioprotective effect. Blood 100 (2002) 1294-1301
12. Dalmau S.R., Freitas C.S., and Tabak D.G. Interleukin-1 and tumor necrosis factor-α as radio- and chemoprotectors of bone marrow. Bone Marrow Transplant 12 (1993) 551-563
13. Gratwohl A., John L., Baldomero H., et al. FLT-3 ligand provides hematopoietic protection from total body irradiation in rabbits. Blood 92 (1998) 765-769
14. Neta R., Stiefel S.M., Finkelman F., Herrmann S., and Ali N. IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation. J Immunol 153 (1994) 4230-4237
15. Drouet M., Mourcin F., Grenier N., et al. Single administration of stem cell factor, FLT-3 ligand, megakaryocyte growth and development factor, and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression: long-term follow-up of hematopoiesis. Blood 103 (2004) 878-885
16. Herodin F., Bourin P., Mayol J.F., Lataillade J.J., and Drouet M. Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma-irradiation promotes survival. Blood 101 (2003) 2609-2616
17. Neelis K.J., Visser T.P., Dimjati W., et al. A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells. Blood 92 (1998) 1586-1597
18. Paris F., Fuks Z., Kang A., et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. [see comment]. Science 293 (2001) 293-297
19. Kobayashi M., Fitz L., Ryan M., et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170 (1989) 827-845
20. Manetti R., Parronchi P., Giudizi M., et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 177 (1993) 1199-1204
21. Zeh III H.J., Hurd S., Storkus W.J., and Lotze M.T. Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: implications for the immunotherapy of cancer. J Immunother 14 (1993) 155-161
22. Ploemacher R.E., van Soest P.L., Voorwinden H., and Boudewijn A. Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture. Leukemia 7 (1993) 1381-1388
23. Hirayama F., Katayama N., Neben S., et al. Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture. Blood 83 (1994) 92-98
24. Kang H., Mansel R.E., and Jiang W.G. Genetic manipulation of stromal cell-derived factor-1 attests the pivotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells. Int J Oncol 26 (2005) 1429-1434
25. Landuzzi L., De Giovanni C., Nicoletti G., et al. The metastatic ability of Ewing's sarcoma cells is modulated by stem cell factor and by its receptor c-kit. Am J Pathol 157 (2000) 2123-2131
26. Maulik G., Bharti A., Khan E., Broderick R.J., Kijima T., and Salgia R. Modulation of c-Kit/SCF pathway leads to alterations in topoisomerase-I activity in small cell lung cancer. J Environ Pathol Toxicol Oncol 23 (2004) 237-251
27. Porcile C., Bajetto A., Barbieri F., et al. Stromal cell-derived factor-1α (SDF-1α/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation. Exp Cell Res 308 (2005) 241-253
28. Colombo M.P., and Trinchieri G. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev 13 (2002) 155-168
29. Voest E.E., Kenyon B.M., O'Reilly M.S., Truitt G., D'Amato R.J., and Folkman J. Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst 87 (1995) 581-586
30. Yao L., Pike S.E., Setsuda J., et al. Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12. Blood 96 (2000) 1900-1905
31. Zhao Y., Lin Y., Zhan Y., et al. Murine hematopoietic stem cell characterization and its regulation in BM transplantation. Blood 96 (2000) 3016-3022
32. Till J.E., and McCulloch E.A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14 (1961) 213-222
33. Dempke W., Von Poblozki A., Grothey A., and Schmoll H.J. Human hematopoietic growth factors: old lessons and new perspectives. Anticancer Res 20 (2000) 5155-5164
34. Weissman I.L., Anderson D.J., and Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 17 (2001) 387-403
35. Osawa M., Hanada K., Hamada H., and Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273 (1996) 242-245
36. Verheij M., and Bartelink H. Radiation-induced apoptosis. Cell Tissue Res 301 (2000) 133-142
37. Held K.D. Radiation-induced apoptosis and its relationship to loss of clonogenic survival. Apoptosis 2 (1997) 265-282
38. Baddoo M., Hill K., Wilkinson R., et al. Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection. J Cell Biochem 89 (2003) 1235-1249
39. Kotton D.N., Summer R.S., Sun X., Ma B.Y., and Fine A. Stem cell antigen-1 expression in the pulmonary vascular endothelium. Am J Physiol Lung Cell Mol Physiol 284 (2003) L990-L996
40. Luna G., Paez J., and Cardier J.E. Expression of the hematopoietic stem cell antigen Sca-1 (LY-6A/E) in liver sinusoidal endothelial cells: possible function of Sca-1 in endothelial cells. Stem Cells Dev 13 (2004) 528-535
41. Shaw J.P., Basch R., and Shamamian P. Hematopoietic stem cells and endothelial cell precursors express Tie-2, CD31 and CD45. Blood Cells Mol Dis 32 (2004) 168-175
42. Balduino A., Hurtado S.P., Frazao P., et al. Bone marrow subendosteal microenvironment harbours functionally distinct haemosupportive stromal cell populations. Cell Tissue Res 319 (2005) 255-266
43. Stier S., Ko Y., Forkert R., et al. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med 201 (2005) 1781-1791
44. Jiang Y., Jahagirdar B.N., Reinhardt R.L., et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418 (2002) 41-49
45. Zhao Y., Zhan Y., Burke K.A., and Anderson W.F. Soluble factor(s) from bone marrow cells can rescue lethally irradiated mice by protecting endogenous hematopoietic stem cells. Exp Hematol 33 (2005) 428-434
46. Neta R. Role of cytokines in radioprotection. Pharmacol Ther 39 (1988) 261-266
47. Neta R. Modulation with cytokines of radiation injury: suggested mechanisms of action. Environ Health Perspect 105 Suppl 6 (1997) 1463-1465
48. Randall T.D., and Weissman I.L. Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment. Blood 89 (1997) 3596-3606
49. Ortiz M., Wine J.W., Lohrey N., Ruscetti F.W., Spence S.E., and Keller J.R. Functional characterization of a novel hematopoietic stem cell and its place in the c-kit maturation pathway in bone marrow cell development. Immunity 10 (1999) 173-182