4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway

Toxicology

Volumn 230, Issue 2-3, 2007, Pages 151-163

  Han, Hongbing ^a   Pan, Qiuzhen ^a   Zhang, Baolu ^a   Li, Jia ^a   Deng, Xuemei ^a,b   Lian, Zhengxing ^a,b   Li, Ning ^b  

^a AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

4 NQO; Apoptosis; KB cells; Mitochondrial signaling pathway

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; CASPASE 3; CASPASE 9; DNA; P21 ACTIVATED KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; UPREGULATION;

4-NITROQUINOLINE-1-OXIDE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOGENS; CASPASE 2; CASPASE 9; CELL LINE, TRANSFORMED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; G1 PHASE; HUMANS; KB CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33846322528     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.11.045     Document Type: Article

References (48)

1. Abraham R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases Genes. Development 15 (2001) 2177-2196
2. Adrain C., Creagh E.M., and Martin S.J. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J. 20 (2001) 6627-6636
3. Alexander E., Maccubbin J.P., Marianne S., Evans E.E., Budzinski H.B., Patrzyc M.K., and Harold C.B. DNA damage in UVB-irradiated keratinocytes. Carcinogenesis 16 (1995) 1659-1660
4. Anju T., Theresa G., and Eileen W. P53 mediates Bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene 46 (2000) 5259-5269
5. Aragane Y., Kulms D., Metze D., Wilkes G., Pöppelmann B., Luger T.A., and Schwarz T. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J. Cell Biol. 140 (1998) 171-182
6. Bailleul B., Daubersies P., Galiegue-Zouitina S., and Loucheux-Lefebvre M.H. Molecular basis of 4-nitroquinoline 1-oxide carcinogenesis. Jpn. J. Cancer Res. 80 (1989) 691-697
7. Burns T.F., and El-deriry W.S. The p53 pathway and apoptosis. J. Cell. Physiol. 181 (1999) 231-239
8. Caspari T. Checkpoints: how to activate p53. Curr. Biol. 10 (2000) R315-R317
9. Costantini P., Jacotot E., Decaudin D., and Kroemer G. Mitochondrion as a novel target of anticancer chemotherapy. J. Natl. Cancer Inst. 92 (2000) 1042-1053
10. 21Waf 1/Cip1 undergo normald evelopment, but are defective in Gl checkpoint control. Cell 82 (1995) 875-884
11. Denning M.F., Wang Y., Tibudan S., Alkan S., Nickoloff B.J., and Qin J.Z. Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell. Death Differ. 9 (2002) 40-52
12. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., and Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391 (1998) 43-50
13. Fronzal G., Campomenosi P., Lannonel R., and Abbondandolo A. The 4-nitroquinoline 1-oxide mutational spectrum in single stranded DNA is characterized by guanine to pyrimidine transversions. Nucl. Acids Res. 20 (1992) 1283-1287
14. Gottlieb T.M., and Oren M. p53 and apoptosis. Semin. Cancer Biol. 8 (1998) 359-368
15. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
16. Héron-Milhavet L., Karas M., Goldsmith C.M., Baum B.J., and LeRoith D. Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. J. Biol. Chem. 276 (2001) 18185-18192
17. Jiang H., Luo S., and Li H. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. J. Biol. Chem. 280 (2005) 20651-20659
18. Kashkar H., Wiegmann K., Yazdanpanah B., Haubert D., and Kronke M. Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane. J. Biol. Chem. 280 (2005) 20804-20813
19. Kiyohara C., Hirohata T., Kuratsune M., and Nagayama J. An improved method for the detection of differential survival between normal and xeroderma pigmentosum lymphoblastoid cell lines in culture with 4-nitroquinoline-1-oxide. Mutat. Res. 249 (1991) 111-117
20. Kluck R.M., Bossy-Wetzel E., Green D.R., and Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275 (1997) 1132-1136
21. Kuida K., Haydar T.F., Kuan C.Y., Gu Y., Taya C., Karasuyama H., Su M.S.-S., Rakic P., and Flavell R.A. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94 (1998) 325-337
22. Lakin N.D., and Jackson S.P. Regulation of p53 in response to DNA damage. Oncogene 18 (1999) 7644-7655
23. Lehman T.A., Modali R.P.B., Stanek J.W.P., Bennett J.A., Welsh R.A., Metcalf M.R., Stampfer N., Fusenig E.M., and Rogan C.C. P53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14 (1993) 833-839
24. Levine A.J. P53, the cellular gatekeeper for growth and division. Cell 88 (1997) 323-331
25. Martin S.J., Reutelingsperger C.P., McGahon A.J., Rader J.A., van Schie R.C., LaFace D.M., and Green D.R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182 (1995) 1545-1556
26. Miyashita T., and Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 (1995) 293-299
27. Morea V., Lesk A.M., and Tramontano A. Antibody modeling: implications for engineering and design. Methods 21 (2000) 179-272
28. Murphy G., Young A.R., Wulf H.C., Kulms D., and Schwarz T. The molecular determinants of sunburn cell formation. Exp. Dermatol. 10 (2001) 155-160
29. Narita M., Shimizu S., Ito T., Chittenden T., Lutz R.J., Matsuda H., and Tsujimoto Y. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 14681-14686
30. Nyberg K.A., Michelson R.J., Putnam C.W., and Weinert T.A. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36 (2002) 617-656
31. Pan G., Humke E.W., and Dixit V.M. Activation of caspases triggered by cytochrome c in vitro. FEBS Lett. 426 (1998) 151-154
32. Pietenpol J.A., and Stewart Z.A. Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. Toxicology 181/182 (2002) 475-481
33. Ramotar D., Belanger E., Brodeur I., Masson J.Y., and Drobetsky E.A. A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide. J. Biol. Chem. 273 (1998) 21489-21496
34. Reed J.C. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr. Opin. Oncol. 7 (1995) 541-546
35. Sheikh M.S., and Fornace Jr. A.J. Role of p53 family members in apoptosis. J. Cell. Physiol. 182 (2000) 171-181
36. Shimizu S., Narita M., and Tsujimoto Y. Bcl-1 family proteins regulate the release of apoptogenic cytodhrome c by the mitochondrial channel VDAC. Nature 399 (1999) 483-487
37. Sitailo L.A., Tibudan S.S., and Denning M.F. Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. J. Biol. Chem. 277 (2002) 19346-19352
38. Snyderwine E.G., and Bohr V.A. Gene- and strand-specific damage and repair in Chinese hamster ovary cells treated with 4-nitroquinoline 1-oxide. Cancer. Res. 52 (1992) 4183-4189
39. Spector D.L., Goldman R.D., and Leinwand L.A. Cell: A Laboratory Manual (1998), Cold Spring Harbor Press
40. Steller H. Mechaniems and genes of cellular suicide. Science 267 (1995) 1445-1449
41. Takimoto R., and El-Deiry W.S. DNA replication blockade impairs p53-transactivation. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 781-783
42. Vaux D.L., and Stanley J.K. Cell 96 (1999) 245-254
43. Cip1/Waf 1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis. J. Biol Chem. 280 (2005) 37725-37731
44. Yamamoto K., Inoue S., and Kawanishi S. Site-specific DNA damage and 8-hydroxydeoxyg-uanosine formation by hydroxylamine and 4-hydroxyaminoquinoline 1-oxide in the presence of Cu (II): role of active oxygen species. Carcinogenesis 14 (1993) 1397-1401
45. Yanaida Y., Kohno H., Yoshida K., Hirose Y., Yamada Y., Morr H., and Tanaka T. Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats. Carcinogenesis 23 (2002) 787-794
46. Yuan L.P., Mei W., Xu Y.M., and Qu C.K. SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively. J. Biol. Chem. 280 (2005) 42701-42706
47. Zamzami N., Brenner C., Marzo I., Susin S.A., and Kroemer G. Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Oncogene 16 (1998) 2265-2282
48. Ziegler A., Jonason A.S., Leffell D.J., Simon J.A., Sharma H.W., Kimmelman J., Remington L., Jacks T., and Brash D.E. Sunburn and p53 in the onset of cancer. Nature 372 (1994) 773-777