Two Lactobacillus strains, isolated from breast milk, differently modulate the immune response

Journal of Applied Microbiology

Volumn 102, Issue 2, 2007, Pages 337-343

  Diaz Ropero M P ^a   Martin R ^b   Sierra, S ^a   Lara Villoslada, F ^a   Rodriguez J M ^b   Xaus, J ^a   Olivares, M ^a  

^a Puleva Biotech SA   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Breast milk; Immune response; Lactobacillus

Indexed keywords

IMMUNE SYSTEM; MACROPHAGES;

BONE MARROW; BREAST MILK; CYTOKINES; HUMAN BREAST MILKS; IMMUNE RESPONSE; LACTOBACILLUS; LACTOBACILLUS FERMENTUM; LACTOBACILLUS STRAINS; PROINFLAMMATORY CYTOKINES; SPLEEN CELLS;

STRAIN;

CYTOKINE; IMMUNOGLOBULIN A; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; PROBIOTIC AGENT;

ANTAGONISM; ANTIBODY; BACTERIUM; IMMUNE RESPONSE; IMMUNOASSAY; MILK; PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BONE MARROW CELL; BREAST MILK; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; LACTOBACILLUS; LACTOBACILLUS FERMENTUM; LACTOBACILLUS SALIVARIUS; MACROPHAGE; MOUSE; NONHUMAN; SPLEEN CELL;

LACTOBACILLUS; LACTOBACILLUS FERMENTUM; LACTOBACILLUS SALIVARIUS; MUS; RODENTIA;

EID: 33846318533     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2006.03102.x     Document Type: Article

References (39)

1. Arunachalam, K., Gill, H.S. and Chandra, R.K. (2000) Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr 54, 1-5.
2. Borruel, N., Casellas, F., Antolin, M., Llopis, M., Carol, M., Espiin, E., Naval, J., Guarner, F. et al. (2003) Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa. Am J Gastroenterol 98, 865-870.
3. Christensen, H.R., Frokiaer, H. and Pestka, J.J. (2002) Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 168, 171-178.
4. Cross, M.L. (2002a) Immunoregulation by probiotic lactobacilli: pro-Th1 signals and their relevance to human health. Clin Appl Immunol Rev 3, 115-125.
5. Cross, M.L. (2002b) Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens. FEMS Immunol Med Microbiol 34, 245-253.
6. D'Andrea, A., Aste-Amezaga, M., Valiante, N.M., Ma, X., Kubin, M. and Trinchieri, G. (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 178, 1041-1048.
7. Donnet-Hughes, A., Rochat, F., Serrant, P., Aeschlimann, J.M. and Schiffrin, E.J. (1999) Modulation of nonspecific mechanisms of defense by lactic acid bacteria: effective dose. J Dairy Sci 82, 863-869.
8. Fanaro, S., Chierici, R., Guerrini, P. and Vigi, V. (2003) Intestinal microflora in early infancy: composition and development. Acta Paediatr 441, 48-55.
9. Gill, H.S. (1998) Stimulation of the immune system by lactic cultures. Int Dairy J 8, 535-544.
10. Gill, H.S. and Rutherfurd, K.J. (2001) Viability and dose-response studies on the effects of the immunoenhancing lactic acid bacterium Lactobacillus rhamnosus in mice. Br J Nutr 86, 285-289.
11. Gill, H.S., Rutherfurd, K.J., Prasad, J. and Gopal, P.K. (2000) Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr 83, 167-176.
12. Gill, H.S., Rutherfurd, K.J. and Cross, M.L. (2001) Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J Clin Immunol 21, 264-271.
13. Grönlund, M.M., Arvilommi, H., Kero, P., Lehtonen, O.P. and Isolauri, E. (2000) Importance of intestinal colonization in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months. Arch Dis Child Fetal Neonatal Ed 83, F186-F192.
14. Groux, H., Bigler, M., de Vries, J.E. and Roncarolo, M.G. (1996) Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med 184, 19-29.
15. Ibnou-Zekri, N., Blum, S., Schiffrin, E.J. and von der Weid, T. (2003) Divergent patterns of colonization and immune response elicited from two intestinal Lactobacillus strains that display similar properties in vitro. Infect Immun 71, 428-436.
16. Institute of Laboratory Animal Resource Commission of Life Sciences (1996) Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press.
17. Isolauri, E., Sütas, Y., Kankaanpää, P., Arvilommi, H. and Salminen, S. (2001) Probiotics: effects on immunity. Am J Clin Nutr 73, 444S-450S.
18. Kaila, M., Isolauri, E., Soppi, E., Virtanen, E., Laine, S. and Arvilommi, H. (1992) Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res 32, 141-144.
19. Kaila, M., Isolauri, E., Saxelin, M., Arvilommi, H. and Vesikari, T. (1995) Viable versus inactivated lactobacillus strain GG in acute rotavirus diarrhoea. Arch Dis Child 72, 51-53.
20. Karlsson, H., Hessle, C. and Rudin, A. (2002) Innate immune responses of human neonatal cells to bacteria from the normal gastrointestinal flora. Infect Immun 70, 6688-6696.
21. Karlsson, H., Larsson, P., Wold, A.E. and Rudin, A. (2004) Pattern of cytokine responses to gram-positive and gram-negative commensal bacteria is profoundly changed when monocytes differentiate into dendritic cells. Infect Immun 72, 2671-2678.
22. Lara-Villoslada, F., Olivares, M. and Xaus, J. (2005) The balance between caseins and whey proteins in cow's milk determines its allergenicity. J Dairy Sci 88, 1654-1660.
23. Link-Amster, H., Rochat, F., Saudan, K.Y., Mignot, O. and Aeschlimann, J.M. (1994) Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunol Med Microbiol 10, 55-64.
24. Majamaa, H., Isolauri, E., Saxelin, M. and Vesikari, T. (1995) Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr 20, 333-338.
25. Martín, R., Langa, S., Reviriego, C., Jiménez, E., Marín, M.L., Xaus, J., Fernandez, L. and Rodríguez, J.M. (2003) Human milk is a source of lactic acid bacteria for the infant gut. J Pediatr 143, 754-758.
26. Martín, R., Langa, S., Reviriego, C., Jiménez, E., Marín, M.L., Olivares, M., Boza, J., Jiménez, J. et al. (2004) The commensal microflora of human milk: new perspectives for food bacteriotherapy and probiotics. Trends Food Sci Technol 15, 121-127.
27. Martín, R., Olivares, M., Marín, M.L., Fernández, L., Xaus, J. and Rodríguez, J.M. (2005) Probiotic potential of 3 lactobacilli strains isolated from breast milk. J Hum Lact 21, 8-17.
28. Martín, R., Jiménez, E., Olivares, M., Marín, M.L., Fernández, L., Xaus, J. and Rodríguez, J.M. (2006) Lactobacillus salivarius CECT 5713, a potential probiotic strain isolated from infant feces and breast milk of a mother-child pair. Int J Food Microbiol 101, 72-79
29. Medzhitov, R. and Janeway, C.A. Jr (1997) Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 9, 4-9.
30. Olivares, M., Díaz-Ropero, M.P., Martín, R., Rodríguez, J.M. and Xaus, J. (2006) Antimicrobial potential of four Lactobacillus strains isolated from breast milk. J Appl Microbiol 101, 72-79.
31. Pelto, L., Isolauri, E., Lilius, E.M., Nuutila, J. and Salminen, S. (1998) Probiotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in healthy subjects. Clin Exp Allergy 28, 1474-1479.
32. Peran, L., Camuesco, D., Comalada, M., Nieto, A., Concha, A., Diaz-Ropero, M.P., Olivares, M., Xaus, J. et al. (2005) Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis. World J Gastroenterol 11, 5185-5192.
33. Peran, L., Camuesco, D., Comalada, M., Nieto, A., Concha, A., Adrio, J.L., Olivares, M., Xaus, J. et al. (2006) Lactobacillus fermentum, a probiotic capable to release glutathione, prevents colonic inflammation in the TNBS model of rat colitis. Int J Colorectal Dis (in press, abstract available on line).
34. Salminen, S., Ouwehand, A., Benno, Y. and Lee, Y.K. (2000) Probiotics: how should they be defined? Trends Food Sci Technol 10, 107-110.
35. Schiffrin, E.J., Rochat, F., Link-Amster, H., Aeschlimann, J.M. and Donnet-Hughes, A. (1995) Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J Dairy Sci 78, 491-497.
36. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K. and Akira, S. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451.
37. Trinchieri, G. (1993) Interleukin-12 and its role in the generation of TH1 cells. Immunol Today 14, 335-338.
38. de Vrese, M., Rautengerg, P., Laue, C., Koopmans, M., Herremans, T. and Schrezenmeir, J. (2005) Probiotic bacteria stimulate virus-specific neutralizing antibodies following a booster polio vaccination. Eur J Nutr 44, 406-413.
39. Xaus, J., Cardó, M., Vellador, A.F., Soler, C., Lloveras, J. and Celada, A. (1999) Interferon gamma induces the expression of p21waf and arrest macrophage cell cycle preventing induction of apoptosis. Immunity 2, 103-113.