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•• Lotsch J, Geisslinger G: Current evidence for a genetic modulation of the response to analgesics. Pain 2006, 121:1-5. This review presented current evidence for contributions of specific genes to individual differences in responses to analgesics. The authors propose that pharmacogenetic-based dose adaptation of medications may be possible with further study.
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•• Diatchenko L, Slade GD, Nackley AG, et al.: Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 2005, 14:135-143. This prospective cohort study examined the associations of COMT haplotypes with experimental pain sensitivity and the development of persistent orofacial pain. Certain COMT haplotypes were associated with both a "low pain sensitivity" profile and a reduced probability of developing temporomandibular joint pain.
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