Do lipases also catalyse the ring cleavage of inactivated cyclic trans-β-lactams?

Tetrahedron Asymmetry

Volumn 17, Issue 23, 2006, Pages 3193-3196

  Forró, Eniko ^a   Fülöp, Ferenc ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BETA AMINO ACID; BETA LACTAM DERIVATIVE; BICYCLO COMPOUND; HETEROCYCLIC COMPOUND;

ARTICLE; CIS TRANS ISOMERISM; COLUMN CHROMATOGRAPHY; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME MECHANISM; PRIORITY JOURNAL; RING OPENING; SEPARATION TECHNIQUE; STEREOCHEMISTRY;

EID: 33846240843     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2006.11.030     Document Type: Article

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33. 9a
34. 23NO: C, 74.59; H, 11.07; N, 6.69. Found: C, 74.50; H, 10.99; N, 6.52.
35. 23NO: C, 74.59; H, 11.07; N, 6.69. Found: C, 70.50; H, 11.18; N, 6.62.
36. 2). Anal. found: C, 59.14; H, 10.02; N, 5.31.
37. 2O): δ (ppm) data for (1R,2S)-1a·HCl and (1S,2S)-2a·HCl are similar to those for (1S,2R)-1c·HCl and (1R,2R)-2a·HCl. Anal. found for (1R,2S)-1a·HCl: C, 59.05; H, 9.90; N, 5.30. Anal. found for (1S,2S)-2a·HCl: C, 59.11; H, 9.78; N, 5.22.
38. 25 = - 36.1 (c 0.4, MeOH); ee >98%].