Ferritin synthesis by Caco-2 cells as an indicator of iron bioavailability: Application to milk-based infant formulas

Food Chemistry

Volumn 102, Issue 3, 2007, Pages 925-931

  Viadel, Blanca ^a   Perales, Sara ^a   Barberá, Reyes ^a   Lagarda, María Jesús ^a   Farré, Rosaura ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Caco 2 cells; Ferritin; In vitro digestion; Infant formulas; Iron bioavailability

Indexed keywords

ASCORBIC ACID; FERRITIN; IRON;

ARTICLE; ARTIFICIAL MILK; BIFIDOBACTERIUM; BIOAVAILABILITY; BIOSYNTHESIS; CELL ACTIVITY; CELL CULTURE; CELL STRAIN CACO 2; CHEMICAL COMPOSITION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIALYSIS; ENZYME IMMUNOASSAY; ENZYME METABOLISM; FOLLOW UP; IN VITRO STUDY; IRON TRANSPORT; MILK PRODUCTION; NONHUMAN; PHYSICAL PHASE; PROTEIN ANALYSIS; PROTEIN SYNTHESIS; STATISTICAL SIGNIFICANCE; TODDLER;

BIFIDOBACTERIUM;

EID: 33846234255     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2006.06.053     Document Type: Article

References (21)

1. Álvarez-Hernández X., Nichols G.M., and Glass J. Caco-2 cell line: a system for studying intestinal transport across cell monolayers. Biochimica et Biophysica Acta 1070 (1991) 205-208
2. Alvarez-Hernandez X., and Smith M. Regulation of iron uptake and transport by transferrin in Caco-2 cells, an intestinal cell line. Biochimica et Biophysica Acta 1192 (1994) 215-222
3. Domínguez R., et al. Study of the effect of different iron salts used to fortified infant formulas on the bioavailability of trace elements using IPC-OES. International Dairy Journal 14 (2004) 1081-1087
4. Etcheverry P., Wissler W., Wortley G., and Glahn R. Caco-2 cell iron uptake from human milk and infant formula. Nutrition Research 24 (2004) 573-579
5. Gangloff M.B., Lai C., Van Campen D.R., Miller D.D., Norvell W.A., and Glahn R.P. Ferrous iron uptake but not transfer is down regulated in Caco-2 cells grown in high iron serum-free medium. Journal of Nutrition 126 (1996) 3118-3127
6. Gárate M.A., and Núñez M.T. Overexpression of the ferritin iron-responsive element decreases the labile iron pool and abolishes the regulation of iron absorption by intestinal epithelial (Caco-2) cells. Journal of Biological Chemistry 275 (2000) 1651-1655
7. García R., Alegría A., Barberá R., Farré R., and Lagarda M.J. Dialyzability of iron, zinc and copper of different types of infant formulas marketed in Spain. Biological Trace Element Research 65 (1998) 1-11
8. Garcia-Casal M.N., Leets I., and Layrisse M. Ethylendiaminetetracetic acid (EDTA) does not increase iron uptake or ferritin synthesis by Caco-2 cells. Journal of Nutritional Biochemistry 15 (2004) 261-266
9. Glahn R.P., Olivia A.L., Yeung A., Goldman M.I., and Miller D.D. Caco-2 cell ferritin formation predicts nonradiolabeled food iron availability in an in vitro digestion/Caco-2 cell culture model. Journal of Nutrition 128 (1998) 1555-1561
10. Han O., Failla M.K., Hill A.D., Morris E.R., and Smith J.C. Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells. Journal of Nutrition 125 (1995) 1291-1299
11. Hidalgo I.J., Raub T.J., and Borchardt R.T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96 (1989) 736-749
12. Jovaní M., Barberá R., Farré R., and Martin de Aguilera E. Calcium, iron, and zinc uptake from digests of infant formulas by Caco-2 cells. Journal of Agricultural and Food Chemistry 49 (2001) 3480-3485
13. Jovaní M., Viadel B., Laparra M., Barberá R., and Farré R. Improvement of analytical conditions of mineral Caco-2 cell uptake assays. Food Science and Technology International 10 (2004) 137-201
14. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193 (1951) 265-275
15. Núñez T.M., Tapia V., Toyokuni S., and Okada S. Iron-induced oxidative damage in colon carcinoma (Caco-2) cells. Free Radical Research 34 (2001) 57-68
16. Pinto M., Robine-Leon S., Appay M.D., Kedinger M., Triadou N., Dussaulx E., et al. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biology of the Cell 47 (1983) 323-330
17. Sarriá B., and Vaquero M.P. Zinc and iron bioavailability in a powder or in-bottle-sterilized infant formula estimated by in vitro and in suckling rats. Journal of Nutritional Biochemistry 12 (2001) 266-273
18. Sarriá B., and Vaquero M.P. Iron bioavailability from powdered and in-bottle-sterilized infant formulas in suckling and weanling rats. Nutrition 20 (2004) 788-793
19. Tapia V., Arredondo M., and Núñez M.T. Regulation of Fe absorption by cultured intestinal epithelia (Caco-2) cell monolayers with varied Fe status. American Journal of Physiology 271 (1996) G443-G447
20. Wienk K.J.H., Marx J.J.M., and Beynen A.C. The concept of iron bioavailability and its assessment. European Journal of Clinical Nutrition 38 (1999) 51-75
21. Yun-Ji K. Iron bioavailability in iron-fortified market milk. Han'guk Skip'um Yongyang Kwahak Hoechi 28 (1999) 705-709