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Volumn 34, Issue 1, 2007, Pages 36-42

Polymorphisms in the IL4 and IL4RA genes in Colombian patients with rheumatoid arthritis

Author keywords

Genetic predisposition; Interleukin 4; Rheumatoid arthritis

Indexed keywords

GENOMIC DNA; IMMUNOGLOBULIN M; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; RECEPTOR SUBUNIT; RHEUMATOID FACTOR;

EID: 33846231479     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (31)

References (58)
  • 1
    • 84861808622 scopus 로고    scopus 로고
    • Epidemiology and genetics of rheumatoid arthritis
    • Silman AJ, Pearson J. Epidemiology and genetics of rheumatoid arthritis. Arthritis Res 2002;4 Suppl 3:S265-S272.
    • (2002) Arthritis Res , vol.4 , Issue.SUPPL. 3
    • Silman, A.J.1    Pearson, J.2
  • 2
    • 0035001640 scopus 로고    scopus 로고
    • The role of the DR4 shared epitope in selection and commitment of autoreactive T cells in rheumatoid arthritis
    • Nepom GT. The role of the DR4 shared epitope in selection and commitment of autoreactive T cells in rheumatoid arthritis. Rheum Dis Clin North Am 2001;27:305-15.
    • (2001) Rheum Dis Clin North Am , vol.27 , pp. 305-315
    • Nepom, G.T.1
  • 5
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 2001;344:907-16.
    • (2001) N Engl J Med , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 6
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumathoid arthritis
    • Firestein GS. Evolving concepts of rheumathoid arthritis. Nature 2003;423:356-61.
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 7
    • 0037129969 scopus 로고    scopus 로고
    • Rheumatoid arthritis. A molecular understanding
    • Smith JB, Haynes MK. Rheumatoid arthritis. A molecular understanding. Ann Intern Med 2002;36:908-22.
    • (2002) Ann Intern Med , vol.36 , pp. 908-922
    • Smith, J.B.1    Haynes, M.K.2
  • 8
  • 9
    • 0034467817 scopus 로고    scopus 로고
    • Differential in vitro effects of IL-4, IL-10, and IL-13 on proinflamatory cytokine production and fibroblast proliferation in rheumatoid synovium
    • Morita Y, Yamamura M, Kawashima M, et al. Differential in vitro effects of IL-4, IL-10, and IL-13 on proinflamatory cytokine production and fibroblast proliferation in rheumatoid synovium. Rheumatol Int 2001;20:49-54.
    • (2001) Rheumatol Int , vol.20 , pp. 49-54
    • Morita, Y.1    Yamamura, M.2    Kawashima, M.3
  • 10
    • 0025166982 scopus 로고
    • Low levels of interleukin-4 and high levels of trasforming growth factor β in rheumatoid synovitis
    • Miossec P, Navilliat M, Dupuy d'Angeac VJ, Sany J, Banchereau J. Low levels of interleukin-4 and high levels of trasforming growth factor β in rheumatoid synovitis. Arthritis Rheum 1990;33:1180-7.
    • (1990) Arthritis Rheum , vol.33 , pp. 1180-1187
    • Miossec, P.1    Navilliat, M.2    Dupuy d'Angeac, V.J.3    Sany, J.4    Banchereau, J.5
  • 11
    • 0032587779 scopus 로고    scopus 로고
    • Interleukin-1β, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 gene polymorphisms. Relationship to occurrence and severity of rheumatoid arthritis
    • Cantagrel A, Navaux F, Loubet-Lescoulié P, et al. Interleukin-1β, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 gene polymorphisms. Relationship to occurrence and severity of rheumatoid arthritis. Arthritis Rheum 1999;42:1093-100.
    • (1999) Arthritis Rheum , vol.42 , pp. 1093-1100
    • Cantagrel, A.1    Navaux, F.2    Loubet-Lescoulié, P.3
  • 13
    • 18844480971 scopus 로고    scopus 로고
    • DeSOVa1 variant of IL-4R upregulates IfE synthesis and associates with atopic asthma
    • Mitsuyasu H, Izuhara K, Mao X-Q, et al. DeSOVa1 variant of IL-4R upregulates IfE synthesis and associates with atopic asthma. Nature Genetics 1998;19:119-20.
    • (1998) Nature Genetics , vol.19 , pp. 119-120
    • Mitsuyasu, H.1    Izuhara, K.2    Mao, X.-Q.3
  • 14
    • 0033933776 scopus 로고    scopus 로고
    • IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion
    • Lubberts E, Joosten LAB, Chabaud M, et al. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. J Clin Invest 2000;105:1697-710.
    • (2000) J Clin Invest , vol.105 , pp. 1697-1710
    • Lubberts, E.1    Joosten, L.A.B.2    Chabaud, M.3
  • 15
    • 0033374353 scopus 로고    scopus 로고
    • Intra-articular IL-4 gene therapy in arthritis: Anti-inflammatory effect and enhanced th2 activity
    • Boyle DL, Nguyen KHY, Zhuang S, et al. Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced th2 activity. Gene Ther 1999;6:1911-8.
    • (1999) Gene Ther , vol.6 , pp. 1911-1918
    • Boyle, D.L.1    Nguyen, K.H.Y.2    Zhuang, S.3
  • 16
    • 0031984663 scopus 로고
    • Effects of a monoclonal antibody against interleukin-4 on collagen-induced arthritis in mice
    • Yoshino S. Effects of a monoclonal antibody against interleukin-4 on collagen-induced arthritis in mice. Br J Pharmacol 1988;123:237-42.
    • (1988) Br J Pharmacol , vol.123 , pp. 237-242
    • Yoshino, S.1
  • 17
    • 0002130296 scopus 로고    scopus 로고
    • rHUIL-4 in subjects with active rheumatoid arthritis: A phase I dose escalating safety study [abstract]
    • S
    • Van der Hosch F, Russel A, Keystone EC, et al. rHUIL-4 in subjects with active rheumatoid arthritis: a phase I dose escalating safety study [abstract]. Arthritis Rheum 1998;41 Suppl:S56.
    • (1998) Arthritis Rheum , vol.41 , Issue.SUPPL. , pp. 56
    • Van der Hosch, F.1    Russel, A.2    Keystone, E.C.3
  • 18
    • 0036037377 scopus 로고    scopus 로고
    • In vivo activated T cells in rheumatoid synovitis. Analysis of Th1- and Th2-type cytokine production at clonal level in different stages of disease
    • Gerli R, Bistoni O, Russano A, et al. In vivo activated T cells in rheumatoid synovitis. Analysis of Th1- and Th2-type cytokine production at clonal level in different stages of disease. Clin Exp Immunol 2002;129:549-55.
    • (2002) Clin Exp Immunol , vol.129 , pp. 549-555
    • Gerli, R.1    Bistoni, O.2    Russano, A.3
  • 19
    • 21644479222 scopus 로고    scopus 로고
    • Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin
    • Raza K, Falciani F, Curnow SJ, et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther 2005;7:R784-R795.
    • (2005) Arthritis Res Ther , vol.7
    • Raza, K.1    Falciani, F.2    Curnow, S.J.3
  • 20
    • 0035883897 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet 2001;358:903-11.
    • (2001) Lancet , vol.358 , pp. 903-911
    • Lee, D.M.1    Weinblatt, M.E.2
  • 21
    • 0023945481 scopus 로고
    • American Rheumatism Association 1987 revised criteria for classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, et al. American Rheumatism Association 1987 revised criteria for classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3
  • 22
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 23
    • 0031925794 scopus 로고    scopus 로고
    • Association of asthma and the interleukin-4 promoter gene in Japanese
    • Noguchi E, Shibasaki M, Arinami T, et al. Association of asthma and the interleukin-4 promoter gene in Japanese. Clin Exp Allergy 1998;28:449-53.
    • (1998) Clin Exp Allergy , vol.28 , pp. 449-453
    • Noguchi, E.1    Shibasaki, M.2    Arinami, T.3
  • 24
    • 0032794926 scopus 로고    scopus 로고
    • No association between atopy/asthma and the ile50val polymorphism of IL-4 receptor
    • Noguchi E, Shibasaki M, Arinami T, et al. No association between atopy/asthma and the ile50val polymorphism of IL-4 receptor. Am J Respir Crit Care Med 1999;160:342-5.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 342-345
    • Noguchi, E.1    Shibasaki, M.2    Arinami, T.3
  • 25
    • 0036431721 scopus 로고    scopus 로고
    • Dichotomic nature of atopic dermatitis reflected by combined analysis of monocytes immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin 13 receptor gene: The dichotomy of extrinsin and intrinsic atopic dermatitis
    • Novak N, Kruse S, Kraft S, et al. Dichotomic nature of atopic dermatitis reflected by combined analysis of monocytes immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin 13 receptor gene: the dichotomy of extrinsin and intrinsic atopic dermatitis. J Invest Dermatol 2002;119:870-5.
    • (2002) J Invest Dermatol , vol.119 , pp. 870-875
    • Novak, N.1    Kruse, S.2    Kraft, S.3
  • 26
    • 0036401578 scopus 로고    scopus 로고
    • Association analysis of polymorphisms in the interleukin-4 receptor gene with atopic asthma in patients from western Mexico
    • Mujica-Lopez KI, Florez-Martínez SE, Ramos-Zepeda R, et al. Association analysis of polymorphisms in the interleukin-4 receptor gene with atopic asthma in patients from western Mexico. Eur J Immunogenet 2002;29:375-8.
    • (2002) Eur J Immunogenet , vol.29 , pp. 375-378
    • Mujica-Lopez, K.I.1    Florez-Martínez, S.E.2    Ramos-Zepeda, R.3
  • 28
    • 0003971442 scopus 로고
    • Methodology in medical genetics
    • London: Churchill Livingstone;
    • Emery AEH. Methodology in medical genetics. An introduction to statistical methods. London: Churchill Livingstone; 1976:3-10.
    • (1976) An introduction to statistical methods , pp. 3-10
    • Emery, A.E.H.1
  • 29
    • 33846263543 scopus 로고    scopus 로고
    • Base para el análisis de las ciencias de la salud
    • 4th ed
    • Daniel WW. Bioestadística. Base para el análisis de las ciencias de la salud. 4th ed. Mexico City: Limusa Wiley DF; 2002:571-657.
    • (2002) Mexico City: Limusa Wiley DF , pp. 571-657
    • Bioestadística, D.W.W.1
  • 30
    • 0041857847 scopus 로고    scopus 로고
    • Pedigree disequilibrium tests for multilocus haplotypes
    • Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003;25:115-21.
    • (2003) Genet Epidemiol , vol.25 , pp. 115-121
    • Dudbridge, F.1
  • 31
    • 33645511450 scopus 로고    scopus 로고
    • Pathomechanisms in rheumatoid arthritis - time for a string theory?
    • Weyand CM, Goronzy JJ. Pathomechanisms in rheumatoid arthritis - time for a string theory? J Clin Invest 2006;116:869-71.
    • (2006) J Clin Invest , vol.116 , pp. 869-871
    • Weyand, C.M.1    Goronzy, J.J.2
  • 32
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper lymphocytes
    • Abbas AK, Murphy KM, Sher A. Functional diversity of helper lymphocytes. Nature 1996;383:787.
    • (1996) Nature , vol.383 , pp. 787
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 33
    • 0033802387 scopus 로고    scopus 로고
    • Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells
    • Hochrein H, O'Keeffe M, Luft T, et al. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J Exp Med 2000;192:823-33.
    • (2000) J Exp Med , vol.192 , pp. 823-833
    • Hochrein, H.1    O'Keeffe, M.2    Luft, T.3
  • 34
    • 22344444092 scopus 로고    scopus 로고
    • Interleukin (IL)-4 inhibits IL-IO to promote IL-12 production by dendritic cells
    • Yao Y, Li W, Kaplan MH, Chang CH. Interleukin (IL)-4 inhibits IL-IO to promote IL-12 production by dendritic cells. J Exp Med 2005;201:1899-903.
    • (2005) J Exp Med , vol.201 , pp. 1899-1903
    • Yao, Y.1    Li, W.2    Kaplan, M.H.3    Chang, C.H.4
  • 35
    • 0035172957 scopus 로고    scopus 로고
    • IL-4 instructs TH1 responses and resistance to Leishmaniasis major in susceptible BALB/c mice
    • Biederman T, Himmelrich H, Gumy A, et al. IL-4 instructs TH1 responses and resistance to Leishmaniasis major in susceptible BALB/c mice. Nat Immunol 2001;2:1054-60.
    • (2001) Nat Immunol , vol.2 , pp. 1054-1060
    • Biederman, T.1    Himmelrich, H.2    Gumy, A.3
  • 36
    • 33646407864 scopus 로고    scopus 로고
    • Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE
    • Gregory GD, Raju SS, Winandy S, Brown MA. Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J Clin Invest 2006;116:1327-36.
    • (2006) J Clin Invest , vol.116 , pp. 1327-1336
    • Gregory, G.D.1    Raju, S.S.2    Winandy, S.3    Brown, M.A.4
  • 37
    • 33644819997 scopus 로고    scopus 로고
    • Early environmental factors and rheumatoid arthritis
    • Edwards CJ, Cooper C. Early environmental factors and rheumatoid arthritis. Clin Exp Immunol 2006;143:1-5.
    • (2006) Clin Exp Immunol , vol.143 , pp. 1-5
    • Edwards, C.J.1    Cooper, C.2
  • 38
    • 0036124607 scopus 로고    scopus 로고
    • Coincidence of immune-mediated diseases driven by Th1 and Th2 subsets suggests a common aetiology. A population-based study using computerized general practice data
    • Simpson CR, Anderson WJ, Helms PJ, et al. Coincidence of immune-mediated diseases driven by Th1 and Th2 subsets suggests a common aetiology. A population-based study using computerized general practice data. Clin Exp Allergy 2002;32:37-42.
    • (2002) Clin Exp Allergy , vol.32 , pp. 37-42
    • Simpson, C.R.1    Anderson, W.J.2    Helms, P.J.3
  • 39
    • 0036843171 scopus 로고    scopus 로고
    • HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis
    • Maksymowych WP, Suarez-Almazor M, Buenviaje H, et al. HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. J Rheumatol 2002;29:2319-26.
    • (2002) J Rheumatol , vol.29 , pp. 2319-2326
    • Maksymowych, W.P.1    Suarez-Almazor, M.2    Buenviaje, H.3
  • 41
    • 11744253408 scopus 로고    scopus 로고
    • Rosenwasser LJ. Structure/function variants as candidates genes in asthma: linkage vs association for relevance. Clin Exp Allergy 1998;28Suppl 1:90-2.
    • Rosenwasser LJ. Structure/function variants as candidates genes in asthma: linkage vs association for relevance. Clin Exp Allergy 1998;28Suppl 1:90-2.
  • 42
    • 0031777128 scopus 로고    scopus 로고
    • Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families
    • Kawashima T, Noguchi E, Arinami T, et al. Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families. J Med Genet 1998;35:502-4.
    • (1998) J Med Genet , vol.35 , pp. 502-504
    • Kawashima, T.1    Noguchi, E.2    Arinami, T.3
  • 43
    • 0036093695 scopus 로고    scopus 로고
    • Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis
    • Inoue T, Kira R, Nakao F, et al. Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis. Arch Neurol 2002;59:822-7.
    • (2002) Arch Neurol , vol.59 , pp. 822-827
    • Inoue, T.1    Kira, R.2    Nakao, F.3
  • 44
    • 0035865347 scopus 로고    scopus 로고
    • IL-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis
    • Relic B, Guicheux J, Mezin F, et al. IL-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis. J Immunol 2001;166:2775-82.
    • (2001) J Immunol , vol.166 , pp. 2775-2782
    • Relic, B.1    Guicheux, J.2    Mezin, F.3
  • 45
    • 0030767061 scopus 로고    scopus 로고
    • Inhibition of T cell apoptosis: A mechanism for persistence in chronic inflammation
    • Salmon M, Pilling D, Borthwick NJ, Akbar AN. Inhibition of T cell apoptosis: a mechanism for persistence in chronic inflammation. The Immunologist 1997;5:87-92.
    • (1997) The Immunologist , vol.5 , pp. 87-92
    • Salmon, M.1    Pilling, D.2    Borthwick, N.J.3    Akbar, A.N.4
  • 46
    • 0029961746 scopus 로고    scopus 로고
    • CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells
    • Zhou LJ, Tedder TF. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci USA 1996;93:2588-92.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2588-2592
    • Zhou, L.J.1    Tedder, T.F.2
  • 47
    • 0142029009 scopus 로고    scopus 로고
    • Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns
    • Parsonage G, Falciani F, Burman A, et al. Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns. Thromb Haemost 2003;90:688-97.
    • (2003) Thromb Haemost , vol.90 , pp. 688-697
    • Parsonage, G.1    Falciani, F.2    Burman, A.3
  • 48
    • 0035869303 scopus 로고    scopus 로고
    • Redirection of T cell IL-2Rβ/IL-4Ra chimeric cytokine receptor transgene
    • Chen Y, Rosloniec E, Goral MJ, Boothby M, Chen J. Redirection of T cell IL-2Rβ/IL-4Ra chimeric cytokine receptor transgene. J Immunol 2001;166:4163-9.
    • (2001) J Immunol , vol.166 , pp. 4163-4169
    • Chen, Y.1    Rosloniec, E.2    Goral, M.J.3    Boothby, M.4    Chen, J.5
  • 49
    • 0029980268 scopus 로고    scopus 로고
    • Relationship between Thl/Th2 cytokine patterns and the arthritogenic response in collagen induced arthritis
    • Mauri C, Williams RO, Walmsley M, Feldmann M. Relationship between Thl/Th2 cytokine patterns and the arthritogenic response in collagen induced arthritis. Eur J Immunol 1996;26:1511-8.
    • (1996) Eur J Immunol , vol.26 , pp. 1511-1518
    • Mauri, C.1    Williams, R.O.2    Walmsley, M.3    Feldmann, M.4
  • 50
    • 0031938883 scopus 로고    scopus 로고
    • Streptococcal cell wall-induced arthritis: Requirements for IL-4, IL-10, IFN-γ, and monocyte chemoattractant protein 1
    • Schimmer RC, Schrier DJ, Flory CM, et al. Streptococcal cell wall-induced arthritis: requirements for IL-4, IL-10, IFN-γ, and monocyte chemoattractant protein 1. J Immunol 1998;160:1466-71.
    • (1998) J Immunol , vol.160 , pp. 1466-1471
    • Schimmer, R.C.1    Schrier, D.J.2    Flory, C.M.3
  • 51
    • 0036228632 scopus 로고    scopus 로고
    • Revival of, the autoantibody model in rheumatoid arthritis
    • Hirano T. Revival of, the autoantibody model in rheumatoid arthritis. Nature Immunol 2002;3:342-4.
    • (2002) Nature Immunol , vol.3 , pp. 342-344
    • Hirano, T.1
  • 53
    • 0034113234 scopus 로고    scopus 로고
    • Changes in the Th1 or Th2 cytokine dominance in the synovium of rheumatoid arthritis (RA): A kinetic study of the Th subsets in one unusual RA patient
    • Aarvak T, Chabaud M, Thoen J, Miossec P, Natvig JB. Changes in the Th1 or Th2 cytokine dominance in the synovium of rheumatoid arthritis (RA): a kinetic study of the Th subsets in one unusual RA patient. Rheumatology Oxford 2000;39:513-22.
    • (2000) Rheumatology Oxford , vol.39 , pp. 513-522
    • Aarvak, T.1    Chabaud, M.2    Thoen, J.3    Miossec, P.4    Natvig, J.B.5
  • 54
    • 33846199092 scopus 로고    scopus 로고
    • Factor reumatoideo ý otros auotanticuerpos en artritis reumatoide
    • Ramírez LA, Anaya J-M, editors, 2 ed. Bogotá: Editorial Edimeco SA;
    • Saaibi DL. Factor reumatoideo ý otros auotanticuerpos en artritis reumatoide. In: Ramírez LA, Anaya J-M, editors. Artritis reumatoide. 2 ed. Bogotá: Editorial Edimeco SA; 2004:117-25.
    • (2004) Artritis reumatoide , pp. 117-125
    • Saaibi, D.L.1
  • 55
    • 0036229687 scopus 로고    scopus 로고
    • Rheumatoid factor is the major predictor of increasing severity of radiographic erosions in rheumatoid arthritis
    • Bukhari M, Lunt M, Harrison BJ, Scott DGI, Symmons DPM, Silman AJ. Rheumatoid factor is the major predictor of increasing severity of radiographic erosions in rheumatoid arthritis. Arthritis Rheum 2002;46:906-12.
    • (2002) Arthritis Rheum , vol.46 , pp. 906-912
    • Bukhari, M.1    Lunt, M.2    Harrison, B.J.3    Scott, D.G.I.4    Symmons, D.P.M.5    Silman, A.J.6
  • 56
    • 1042290337 scopus 로고    scopus 로고
    • Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors
    • Markus M, Nielen J, van Schaardenburg D, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors. Arthritis Rheumatism 2004;50:380-6.
    • (2004) Arthritis Rheumatism , vol.50 , pp. 380-386
    • Markus, M.1    Nielen, J.2    van Schaardenburg, D.3
  • 57
    • 4644312320 scopus 로고    scopus 로고
    • An IL-4Ra allelic variant, 150, acts as a gain-of-function variant relative to V50 for STAT6, but not Th2 differentiation
    • Stephenson L, Johns MH, Woodward E, Mora AL, Boothby M. An IL-4Ra allelic variant, 150, acts as a gain-of-function variant relative to V50 for STAT6, but not Th2 differentiation. J Immunol 2004;173:4523-8.
    • (2004) J Immunol , vol.173 , pp. 4523-4528
    • Stephenson, L.1    Johns, M.H.2    Woodward, E.3    Mora, A.L.4    Boothby, M.5
  • 58
    • 0001325237 scopus 로고    scopus 로고
    • The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor
    • Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. New Engl J Med 1997;337:1720-5.
    • (1997) New Engl J Med , vol.337 , pp. 1720-1725
    • Hershey, G.K.1    Friedrich, M.F.2    Esswein, L.A.3    Thomas, M.L.4    Chatila, T.A.5


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