메뉴 건너뛰기




Volumn 173, Issue 7, 2004, Pages 4523-4528

An IL-4Rα allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR ALPHA; ISOLEUCINE; STAT6 PROTEIN; UNCLASSIFIED DRUG; VALINE;

EID: 4644312320     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.7.4523     Document Type: Article
Times cited : (17)

References (38)
  • 1
    • 0034121188 scopus 로고    scopus 로고
    • Molecular genetics of allergic diseases
    • Ono, S. J. 2000. Molecular genetics of allergic diseases. Annu. Rev. Immunol. 18:347.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 347
    • Ono, S.J.1
  • 2
    • 0030903861 scopus 로고    scopus 로고
    • A genome-wide search for asthma susceptibility loci in ethnically diverse populations
    • Collaborative Study on the Genetics of Asthma (CSGA). 1997. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat. Genet. 15:389.
    • (1997) Nat. Genet. , vol.15 , pp. 389
  • 6
    • 0031908032 scopus 로고    scopus 로고
    • The TH1/TH2 paradigm in allergy
    • Maggi, E. 1998. The TH1/TH2 paradigm in allergy. Immunotechnology 3:233.
    • (1998) Immunotechnology , vol.3 , pp. 233
    • Maggi, E.1
  • 7
    • 0030638775 scopus 로고    scopus 로고
    • Interleukin-4 and its receptor: Essential mediators of the allergic response
    • Ryan, J. I. 1997. Interleukin-4 and its receptor: essential mediators of the allergic response. J. Allergy Clin. Immunol. 99:1.
    • (1997) J. Allergy Clin. Immunol. , vol.99 , pp. 1
    • Ryan, J.I.1
  • 11
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
    • (1996) Immunity , vol.4 , pp. 313
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 14
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    • Kuperman, D., B. Schofield, M. Wills-Karp, and M. J. Grusby. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187:939.
    • (1998) J. Exp. Med. , vol.187 , pp. 939
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 18
    • 0001325237 scopus 로고    scopus 로고
    • The association of atopy with a gain of function mutation in the a subunit of the interluekin-4 receptor
    • Hershey, G. K., F. F. Michal, L. A. Esswein, M. L. Thomas, and T. A. Chatila. 1997. The association of atopy with a gain of function mutation in the a subunit of the interluekin-4 receptor. N. Engl. J. Med. 337:1720.
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1720
    • Hershey, G.K.1    Michal, F.F.2    Esswein, L.A.3    Thomas, M.L.4    Chatila, T.A.5
  • 20
    • 0025046552 scopus 로고
    • Interleukin 4 receptors on normal human B lymphocytes: Characterization and regulation
    • Galizzi, J. P., N. Harada, I. Durand, J. Banchereau, and C. E. Zuber. 1990. Interleukin 4 receptors on normal human B lymphocytes: characterization and regulation. Cell Immunol 129:329.
    • (1990) Cell Immunol. , vol.129 , pp. 329
    • Galizzi, J.P.1    Harada, N.2    Durand, I.3    Banchereau, J.4    Zuber, C.E.5
  • 21
    • 0027236954 scopus 로고
    • Production of high-titer helper-free retroviruses by transient transfection
    • Pear, W. S., G. P. Nolan, M. L. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8392
    • Pear, W.S.1    Nolan, G.P.2    Scott, M.L.3    Baltimore, D.4
  • 25
    • 0032752703 scopus 로고    scopus 로고
    • Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation
    • Goenka, S., J. Youn, L. M. Dzurek, U. Schindler, L.-y. Yu-Lee, and M. Boothby. 1999. Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation. J. Immunol. 163: 4663.
    • (1999) J. Immunol. , vol.163 , pp. 4663
    • Goenka, S.1    Youn, J.2    Dzurek, L.M.3    Schindler, U.4    Yu-Lee, L.-Y.5    Boothby, M.6
  • 26
    • 0036133110 scopus 로고    scopus 로고
    • Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis
    • Wurster, A. L., D. J. Withers, T. Uchida, M. F. White, and M. J. Grusby. 2002. Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol. Cell. Biol. 22:117.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 117
    • Wurster, A.L.1    Withers, D.J.2    Uchida, T.3    White, M.F.4    Grusby, M.J.5
  • 28
    • 0035898446 scopus 로고    scopus 로고
    • + T cells during T helper (Th)1/Th2 differentiation: Critical downregulatory role of IL-4
    • + T cells during T helper (Th)1/Th2 differentiation: critical downregulatory role of IL-4. J. Exp. Med. 194: 143.
    • (2001) J. Exp. Med. , vol.194 , pp. 143
    • Smeltz, R.B.1    Chen, J.2    Hu-Li, J.3    Shevach, E.M.4
  • 29
    • 0037097540 scopus 로고    scopus 로고
    • Role of IFN-γ in Th1 differentiation: IFN-γ regulates IL-18Rα expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor β2 expression
    • Smeltz, R. B., J. Chen, R. Ehrhardt, and E. M. Shevach. 2002. Role of IFN-γ in Th1 differentiation: IFN-γ regulates IL-18Rα expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor β2 expression. J. Immunol. 168:6165.
    • (2002) J. Immunol. , vol.168 , pp. 6165
    • Smeltz, R.B.1    Chen, J.2    Ehrhardt, R.3    Shevach, E.M.4
  • 31
    • 0035864834 scopus 로고    scopus 로고
    • IL-4 promotes airway eosinophilia by suppressing IFN-γ production: Defining a novel role for IFN-γ in the regulation of allergic airway inflammation
    • Conn, L., C. Herrick, N. Niu, R. J. Homer, and K. Bottomly. 2001. IL-4 promotes airway eosinophilia by suppressing IFN-γ production: defining a novel role for IFN-γ in the regulation of allergic airway inflammation. J. Immunol. 166:2760.
    • (2001) J. Immunol. , vol.166 , pp. 2760
    • Conn, L.1    Herrick, C.2    Niu, N.3    Homer, R.J.4    Bottomly, K.5
  • 32
    • 0033230302 scopus 로고    scopus 로고
    • T helper 1 cells and IFN-γ regulate allergic airway inflammation and mucus production
    • Cohn, L., R. J. Homer, N. Niu, and K. Bottomly. 1999. T helper 1 cells and IFN-γ regulate allergic airway inflammation and mucus production. J. Exp. Med. 190:1309.
    • (1999) J. Exp. Med. , vol.190 , pp. 1309
    • Cohn, L.1    Homer, R.J.2    Niu, N.3    Bottomly, K.4
  • 35
    • 0036888556 scopus 로고    scopus 로고
    • Present status on the genetic studies of asthma
    • Hoffjan, S., and C. Ober. 2002. Present status on the genetic studies of asthma. Curr. Opin. Immunol. 14:709.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 709
    • Hoffjan, S.1    Ober, C.2
  • 36
    • 0034581314 scopus 로고    scopus 로고
    • Interleukin-4 receptor α gene variants and allergic disease
    • Hall, I. P. 2000. Interleukin-4 receptor α gene variants and allergic disease. Respir. Res. 1:6.
    • (2000) Respir. Res. , vol.1 , pp. 6
    • Hall, I.P.1
  • 38
    • 0347379898 scopus 로고    scopus 로고
    • Differential roles of C-terminal activation motifs in the establishment of State transcriptional specificity
    • Goenka, S., C. Marlar, U. Schindler, and M. Boothby. 2003. Differential roles of C-terminal activation motifs in the establishment of State transcriptional specificity. J. Biol. Chem. 278:50362.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50362
    • Goenka, S.1    Marlar, C.2    Schindler, U.3    Boothby, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.