Behavioral effects of pubertal anabolic androgenic steroid exposure in male rats with low serotonin

Brain Research

Volumn 1132, Issue 1, 2007, Pages 129-138

  Keleta, Yonas B ^a   Lumia, Augustus R ^b   Anderson, George M ^c   McGinnis, Marilyn Y ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b TEXAS STATE UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aggression; Body weight; Irritability; Locomotion; Serotonin; Sexual behavior

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ANABOLIC AGENT; ANDROGEN; FENCLONINE; SEROTONIN; SODIUM CHLORIDE; TESTOSTERONE;

AGGRESSION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; COPULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IRRITABILITY; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION; PUBERTY; RAT; SEROTONIN BRAIN LEVEL; SEROTONIN RELEASE; SEXUAL BEHAVIOR;

AGGRESSION; ANDROGENS; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DOWN-REGULATION; FEMALE; FENCLONINE; HYDROXYINDOLEACETIC ACID; MALE; MOTOR ACTIVITY; PUBERTY; RATS; RATS, LONG-EVANS; SEROTONIN; SEROTONIN ANTAGONISTS; SOCIAL BEHAVIOR; TESTOSTERONE;

ANIMALIA; RATTUS;

EID: 33846187319     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.10.097     Document Type: Article

References (65)

1. Ahlenius S., Eriksson H., Larsson K., Modigh K., and Sodersten P. Mating behavior in the male rat treated with p-chlorophenylalanine methyl ester alone and in combination with pargyline. Psychopharmacology 20 (1971) 383-389
2. Altemus M., Glowa J., Galliven E., Leong Y.-M., and Murphy D. Effects of serotonergic agents on food-restriction-induced hyperactivity. Pharmacol. Biochem. Behav. 53 (1996) 123-131
3. Alves S.E., Hoskin E., Lee S.J., Brake W.G., Ferguson D., Luine V., Allen P.B., Greengard P., and McEwen B.S. Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus. Synapse 45 (2002) 143-151
4. Anderson S.J., Bolduc S.P., Coryllos E., Griesemer B., McLain L., Rowland T.W., and Tanner S.M. Adolescents and anabolic steroids: a subject review. Pediatrics 99 (1997) 904-908
5. Bahrke M.S., Yesalis C.E., and Brower K.J. Anabolic-androgenic steroid abuse and performance-enhancing drugs among adolescents. Child Adolesc. Psychiatr. Clin. N. Am. 7 (1998) 821-838
6. Berman M.E., Tracy J.I., and Coccaro E.F. The serotonin hypothesis of aggression revisited. Clin. Psychol. Rev. 17 (1997) 651-665
7. Bolles R.C. Species-specific defense reactions and avoidance learning. Psych. Rev. 77 (1970) 32-48
8. Bonson K.R., Johnson R.G., Fiorella D., Rabin R.A., and Winter J.C. Serotonergic control of androgen-induced dominance. Pharmacol. Biochem. Behav. 49 (1994) 313-322
9. Breuer M.E., McGinnis M.Y., Lumia A.R., and Possidente B.P. Aggression in male rats receiving anabolic androgenic steroids: effects of social and environmental provocation. Horm. Behav. 40 (2001) 409-418
10. Brown G.L., Goodwin F.K., Ballenger J.C., Goyer P.F., and Major I.F. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1 (1979) 131-139
11. Brown S., Botsis A., and van Praag H.M. Serotonin and aggression. In: Hildebrand M., and Pallone N.J. (Eds). The Psychobiology of Aggression (1994), The Haworth Press Inc., New York 27-39
12. Burnett K.F., and Kleiman M.E. Psychological characteristics of adolescent steroid users. Adolescence 29 (1994) 81-89
13. Caprara G.V., Cinnanni V., D'Imperio G., Passerini S., Renzi P., and Traiglia G. Indicators of impulsive aggression: present status of research on irritability and emotional susceptibility scales. Pers. Individ. Differ. 6 (1985) 665-674
14. Clark A.S., and Barber D.M. Anabolic-androgenic steroids and aggression in castrated male rats. Physiol. Behav. 56 (1994) 1107-1113
15. Coccaro E.F. Central serotonin and impulsive aggression. Br. J. Psychiatry 155 (1989) 52-62
16. Dahlof L., and Larsson K. PCPA potentiates the effects of specific copulatory experience on the sexual behavior of the pudendectomized male rat. Pharmacol. Biochem. Behav. 11 (1979) 701-704
17. Dalhouse A.D. Social cohesiveness, hypersexuality and irritability induced by p-CPA in the rat. Physiol. Behav. 17 (1975) 679-686
18. Datla K.P., and Curzon G. Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 35 (1996) 315-320
19. Dringenberg H., Hargreaves E., Baker G., Cooley R., and Vanderwolf C. p-Chlorophenylalanine-induced serotonin depletion: reduction in exploratory locomotion but no obvious sensory-motor deficits. Behav. Brain Res. 68 (1995) 229-237
20. Dunnett S.B., and Iversen B.D. Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum. Brain Res. 248 (1982) 121-127
21. Farrell S.F., and McGinnis M.Y. Effects of pubertal anabolic-androgenic steroid (AAS) administration on reproductive and aggressive behaviors in male rats. Behav. Neurosci. 117 (2003) 904-911
22. Farrell S.F., and McGinnis M.Y. Effects of pubertal anabolic-androgenic steroid exposure and withdrawal on reproductive endocrinology and physiology in male rats. Soc. Neurosci. 29 (2003) 353
23. Farrell S.F., and McGinnis M.Y. Long-term effects of pubertal anabolic-androgenic steroid exposure on reproductive and aggressive behaviors in male rats. Horm. Behav. 46 (2004) 193-203
24. Feinberg M.J., Lumia A.R., and McGinnis M.Y. The effects of anabolic-androgenic steroids on sexual behavior and reproductive tissues in male rats. Physiol. Behav. 62 (1997) 23-30
25. Gibbons J.L., Barr G.A., W.H. B., and Leibowitz S.F. Effects of par chlorophenylalanine and 5-hydroxytryptophan on mouse killing behavior in killer rats. Pharmacol. Biochem. Behav. 9 (1978) 91-98
26. Ginton A. Copulation in noncopulators: effect of PCPA in male rats. Pharmacol. Biochem. Behav. 4 (1976) 357-359
27. Grimes J.M., and Melloni Jr. R.H. Serotonin modulates offensive attack in adolescent anabolic steroid-treated hamsters. Pharmacol. Biochem. Behav. 73 (2002) 713-721
28. Janusonis S., Anderson G.M., Shifrovich I., and Rakic P. Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autism. J. Neurochem. 99 (2006) 1019-1031
29. Johnson M.D. Anabolic steroid use in adolescent athletes. Pediatr. Clin. North Am. 37 (1990) 1111-1123
30. Korenbrot C.C., Huhtaniemi I.T., and Weiner R.I. Preputial separation as an external sign of prepubertal development in the male rat. Biol. Reprod. 17 (1977) 298-303
31. Lindqvist A.S., Johansson-Steensland P., Nyberg F., and Fahlke C. Anabolic androgenic steroid affects competitive behaviour, behavioural response to ethanol and brain serotonin levels. Behav. Brain Res. 133 (2002) 21-29
32. Martinez-Conde E., Leret M., and Diaz S. The influence of testosterone in the brain of the male rat on levels of serotonin (5HT) and hydroxyindole-acetic acid (5-HIAA). Comp. Biochem. Physiol. 80 (1985) 411-414
33. Martinez-Sanchis S., Argon C.M., and Salvador A. Cocaine-induced locomotor activity is enhanced by exogenous testosterone. Physiol. Behav. 76 (2002) 605-609
34. Matte A.C., and Turnow H. Parachlorophenylalanine produces dissociated effects on aggression "emotionality" and motor activity. Neuropharmacology 17 (1978) 555-558
35. McGinnis M.Y. Anabolic androgenic steroids and aggression: studies using animal models. N. Y. Acad. Sci. 1036 (2004) 399-415
36. McGinnis M.Y., and Dreifuss R.M. Evidence for a role of testosterone-androgen receptor interactions in mediating masculine sexual behavior in male rats. Endocrinology 124 (1989) 618-626
37. McGinnis M.Y., Mirth M.C., Zebrowski A.F., and Dreifuss R.M. Critical exposure time for androgen activation of male sexual behavior in rats. Physiol. Behav. 46 (1989) 159-165
38. McGinnis M.Y., Williams G.W., and Lumia A.R. Inhibition of male sex behavior by androgen receptor blockade in preoptic area or hypothalamus, but not amygdala or septum. Physiol. Behav. 60 (1996) 783-789
39. McGinnis M.Y., Lumia A.R., Breuer M.E., and Possidente B.P. Physical provocation potentiates aggression in male rats receiving anabolic androgenic steroids. Horm. Behav. 41 (2002) 101-110
40. McIntosh T.K., and Barfield R.J. Brain monoaminergic control of male reproductive behavior. I. Serotonin and the post-ejaculatory refractory period. Behav. Brain Res. 12 (1984) 255-265
41. Miczek K., Fish E., De Bold J., and De Almeida R. Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. Psychopharmacology 163 (2002) 434-458
42. Midgley S.J., Heather N., and Davies J.B. Levels of aggression among a group of anabolic-androgenic steroid users. Med. Sci. Law 41 (2001) 309-314
43. Mitler M., Morder B., Levine A., and Dement W. The effects of parachlorophenylalanine on the mating behavior of male rats. Physiol. Behav. 8 (1972) 1147-1150
44. Oades R., and Isaacson R. p-Chlorophenylalanine-produced effects on behavior in intact and brain-damaged rats. Behav. Biol. 20 (1977) 500-506
45. Paxinos G., Atrens D.M., and Jackson D.M. 5-hydroxytryptamine depletion with para chlorophenylalanine: effects on eating, drinking, muricide, and copulation. Pharmacol. Biochem. Behav. 6 (1977) 439-447
46. Qureshi G.A., Forsberg G., Bednar I., and Sodersten P. Tryptophan, 5-HTP, 5 HT and 5-HIAA in the cerebrospinal fluid and sexual behavior in male rats. Neurosci. Lett. 97 (1989) 227-231
47. Romeo R.D., Richardson H.N., and Sisk C.L. Puberty and the maturation of the male brain and sexual behavior: recasting a behavioral potential. Neurosci. Biobehav. Rev. 26 (2002) 381-391
48. Salvador A., Moya-Albiol L., Martinez-Sanchis S., and Simon V.M. Lack of effects of anabolic-androgenic steroids on locomotor activity in intact male mice. Percept. Mot. Skills 88 (1999) 319-328
49. Sewell R., Gallus J., Gault F., and Cleary J. p-Chlorophenylalanine effects on shock induced attack and bar pressing responses in rats. Pharmacol. Biochem. Behav. 17 (1982) 945-950
50. Shishkina G.T., and Dygalo N.N. Role of the serotoninergic system in the acceleration of sexual maturation in wild Norway rats selected for reduced aggressiveness toward humans. Comp. Biochem. Physiol. 125 (2000) 45-51
51. Sisk C.L., Schulz K.M., and Zehr J.L. Puberty: a finishing school for male social behavior. N. Y. Acad. Sci. 1007 (2003) 189-198
52. Smith W.J., Stewart J., and Pfaus J.G. Tail pinch induces Fos immunoreactivity within several regions of the male rat brain: effects of age. Physiol. Behav. 61 (1997) 717-723
53. Soulairac M.-L., and Soulairac A. Monoaminergic and Cholinergic Control of Sexual Behavior in the Male Rat (1975), Raven Press, New York
54. Spear L.P. The adolescent brain and age-related behavioral manifestations. Neurosci. Biobehav. Rev. 24 (2000) 417-463
55. Spoont M.R. Modulatory role of serotonin in neural information processing: implications for human psychopathology. Psychol. Bull. 112 (1992) 330-350
56. Stadler C., Schmeck K., Nowraty I., Muller W.E., and Poustka F. Platelet 5-HT uptake in boys with conduct disorder. Neuropsychobiology 50 (2004) 244-251
57. Su T.-P., Pagliaro M., Schmidt P.J., Pickar D., Wolkowitz O., and Rubinow D.R. Neuropsychiatric effects of anabolic steroids in male normal volunteers. J. Am. Med. Assoc. 269 (1993) 2760-2764
58. Svare B.B. Anabolic steroids and behavior: a preclinical research perspective. NIDA Res. Monogr. 102 (1990) 224-241
59. Tartar R.E., Blackson T., Brigham J., Moss H., and Caprara G.V. The association between childhood irritability and liability to substance use in early adolescent: a 2-year follow-up study of boys at risk for substance abuse. Drug Alcohol Depend. 39 (1995) 253-261
60. Vagell M.E., and McGinnis M.Y. The role of gonadal steroid receptor activation in the restoration of sociosexual behavior in adult male rats. Horm. Behav. 33 (1998) 163-179
61. Vergnes M., Depaulis A., and Boehrer A. Parachlorophenylalanine-induced serotonin depletion increases offensive but not defensive aggression in male rats. Physiol. Behav. 36 (1986) 653-658
62. Wesson D.W., and McGinnis M.Y. Stacking anabolic androgenic steroids (AAS) during puberty in rats: a neuroendocrine and behavioral assessment. Pharmacol. Biochem. Behav. 83 (2006) 410-419
63. Yesalis C.E., and Bahrke M.S. Anabolic-androgenic steroids. Sports Med. 19 (1995) 326-340
64. Yesalis C.E., and Bahrke M.S. Doping among adolescent athletes. Bailliere's Best Pract. Res., Clin. Endocrinol. Metab. 14 (2000) 25-35
65. Young S.N., and Leyton M. The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels. Pharmacol. Biochem. Behav. 71 (2002) 857-865