Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells

International Archives of Allergy and Immunology

Volumn 132, Issue 4, 2003, Pages 336-345

  Genovese, Arturo ^a   Borgia, Guglielmo ^a   Bouvet, Jean Pierre ^b   Detoraki, Aikaterini ^a   De Paulis, Amato ^a   Piazza, Marcello ^a   Marone, Gianni ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b HÔPITAL BROUSSAIS   (France)

Author keywords

Cysteinyl leukotrienes; Histamine; IgE; Mast cells; Protein Fv; Superantigens

Indexed keywords

CYSTEINE; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEUKOTRIENE; PROSTAGLANDIN D2; SEPHAROSE; SIALOPROTEIN; SUPERANTIGEN; TRYPTASE; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DESENSITIZATION; HEPATITIS C VIRUS; HETEROLOGOUS EXPRESSION; HISTAMINE RELEASE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MAST CELL; MEDIATOR RELEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FV; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; VIRUS HEPATITIS;

ADULT; ANTIBODIES, ANTI-IDIOTYPIC; HEPATITIS C; HISTAMINE RELEASE; HUMANS; LEUKOTRIENE C4; LYMPHOKINES; MAST CELLS; MIDDLE AGED; MYOCARDIUM; MYOCYTES, CARDIAC; PROSTAGLANDIN D2; SERINE ENDOPEPTIDASES; SIALOGLYCOPROTEINS; SUPERANTIGENS; TRYPTASES;

EID: 0346058346     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074901     Document Type: Article

References (67)

1. Bouvet J-P, Pirès R, Lunel-Fabiani F, Crescenzo-Chaigne B, Maillard P, Valla D, Opolon P, Pillot J: Protein F: A novel F(ab)-binding factor, present in normal liver, and largely released in the digestive tract during hepatitis. J Immunol 1990;145:1176-1180.
2. Bouvet J-P, Pirès R, Charlemagne J, Pillot J, Iscaki S: Non-immune binding of human protein Fv to immunoglobulins from various mammalian and nonmammalian species. Scand J Immunol 1991;34:491-496.
3. Bouvet J-P, Pirès R, Quan C, Iscaki S, Pillot J: Non-immune VH-binding specificity of human protein Fv. Scand J Immunol 1991;33:381-386.
4. Lee WM: Hepatitis B virus infection. N Engl J Med 1997;337:1733-1745.
5. Willson RA: Extrahepatic manifestations of chronic viral hepatitis. Am J Gastroenterol 1997;92:4-17.
6. Lauer GM, Walker BD: Hepatitis C virus infection. N Engl J Med 2001;345:41-52.
7. Bell H: Cardiac manifestations of viral hepatitis. JAMA 1971;218:387-391.
8. Kanda T, Kobayashi I, Suzuki T, Murata K, Radio SJ, McManus BM: Elevation of ALT to AST ratio in patients with enteroviral myocarditis. J Med 1995;26:153-162.
9. Nagaratnam N, DeSilva D, Gunawardene K: Myocardial involvement in infectious hepatitis. Postgrad Med J 1971;47:785-788.
10. Ursell PC, Habib A, Sharma P, Mesa-Tejada R, Lefkowitch JH, Fenoglio JJ Jr: Hepatitis B virus and myocarditis. Hum Pathol 1984;15: 481-484.
11. Agnello V, Chung RT, Kaplan LM: A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 1992;327:1490-1495.
12. Dammacco F, Sansonno D: Antibodies to hepatitis C virus in essential mixed cryoglobulinaemia. Clin Exp Immunol 1992;87:352-356.
13. Gorevic PD, Kassab HJ, Levo Y, Kohn R, Meltzer M, Prose P, Franklin EC: Mixed cryoglobulinemia: Clinical aspects and long-term follow-up of 40 patients. Am J Med 1980;69:287-308.
14. Marone G, Lichtenstein LM, Galli SJ: Mast Cells and Basophils. San Diego, Academic Press, 2000.
15. Ochensberger B, Tassera L, Bifrare D, Rihs S, Dahinden CA: Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. Eur J Immunol 1999;29:11-22.
16. Lantz CS, Boesiger J, Song CH, Mach N, Kobayashi T, Mulligan RC, Nawa Y, Dranoff G, Galli SJ: Role for interleukin-3 in mast cell and basophil development and in immunity to parasites. Nature 1998;392:90-93.
17. Bradding P, Feather IH, Howarth PH, Mueller R, Roberts JA, Britten K, Bews JPA, Hunt TC, Okayama Y, Heusser CH, Bullock GR, Church MK, Holgate ST: Interleukin 4 is localized to and released by human mast cells. J Exp Med 1992;176:1381-1386.
18. Ochensberger B, Daepp G-C, Rihs S, Dahinden CA: Human blood basophils produce in-terleukin-13 in response to IgE-receptor-dependent and -independent activation. Blood 1996; 88:3028-3037.
19. Patella V, Marinò I, Arbustini E, Lamparter-Schummert B, Verga L, Adt M, Marone G: Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. Circulation 1998;97:971-978.
20. Romagnani P, de Paulis A, Beltrame C, An-nunziato F, Dente V, Maggi E, Romagnani S, Marone G: Tryptasechymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines. Am J Pathol 1999;155:1195-1204.
21. Bankl HC, Radaszkiewicz T, Klappacher GW, Glogar D, Sperr WR, Grossschmidt K, Bankl H, Lechner K, Valent P: Increase and redistribution of cardiac mast cells in auricular thrombosis. Possible role of kit ligand. Circulation 1995;91:275-283.
22. Patella V, Marinò I, Lampärter B, Arbustini E, Adt M, Marone G: Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. J Immunol 1995;154:2855-2865.
23. Kalsner S, Richards R: Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: A mechanism for coronary spasm. Science 1984;223:1435-1437.
24. Kaartinen M, Penttilä A, Kovanen PT: Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture. Circulation 1994;90:1669-1678.
25. Estensen RD: Eosinophilic myocarditis: A role for mast cells? Arch Pathol Lab Med 1984;108:358-359.
26. Patella V, de Crescenzo G, Marinö I, Genovese A, Adt M, Gleich GJ, Marone G: Eosinophil granule proteins activate human heart mast cells. J Immunol 1996;157:1219-1225.
27. Silverman GJ, Pirès R, Bouvet J-P: An endogenous sialoprotein and a bacterial B cell super-antigen compete in their VH family-specific binding interactions with human Igs. J Immunol 1996;157:4496-4502.
28. Genovese A, Bouvet J-P, Florio G, Lamparter-Schummert B, Björck L, Marone G: Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. Infect Immun 2000;68:5517-5524.
29. Marone G, Tamburini M, Giudizi MG, Biagiotti R, Almerigogna F, Romagnani S: Mechanism of activation of human basophils by Staphylococcus aureus Cowan 1. Infect Immun 1987;55:803-809.
30. Siraganian RP: An automated continuous-flow system for the extraction and fluorometric analysis of histamine. Anal Biochem 1974;57:383-394.
31. Snedecor GW, Cochran WG: Statistical Methods. Ames, Iowa State University Press, 1980.
32. Schefler WC: Statistics for Health Professional. Reading, Addison-Wesley, 1984.
33. 2, that inhibits platelet aggregation and constricts blood vessels. J Biol Chem 1985;280:14621-14625.
34. 4 in man. Int J Clin Lab Res 1997;27:178-184.
35. Samuelsson B: The discovery of the leukotrienes. Am J Respir Crit Care Med 2000;161:S2-S6.
36. 2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 2001;193:255-261.
37. MacGlashan DW Jr, Peters SP, Warner J, Lichtenstein LM: Characteristics of human ba-sophil sulfidopeptide leukotriene release: Releasability defined as the ability of the basophil to respond to dimeric cross-links. J Immunol 1986;136:2231-2239.
38. Riske F, Hakimi J, Mallamaci M, Griffin M, Pilson B, Tobkes N, Lin P, Danho W, Kochan J, Chizzonite R: High affinity human IgE receptor (FcεRI). Analysis of functional domains of the α-subunit with monoclonal antibodies. J Biol Chem 1991;266:11245-11251.
39. Silverman GJ, Roben P, Bouvet J-P, Sasano M: Superantigen properties of a human sialoprotein involved in gut-associated immunity. J Clin Invest 1995;96:417-426.
40. Sala P, Tonutti E, Ruscio M, Colle R, Antonutto G, Falconieri G: IgE myeloma. Report of a new case and review of the literature. Haematologica 1981;66:788-795.
41. Bouvet J-P, Pirès R, Iscaki S, Pillot J: Nonimmune macromolecular complexes of Ig in human gut lumen. Probable enhancement of antibody functions. J Immunol 1993;151:2562-2572.
42. Sharma MD, Maillard P, Vrati S, Mukherjee R, Rajagopalan MS, Poynard T, Talwar GP, Pillot J: Serial passage of west-European sporadic non-A non-B hepatitis in rhesus monkeys by inoculation with fecal extracts. J Med Virol 1990;30:36-41.
43. Genovese A, Bouvet J-P, Florio G, Lamparter-Schummert B, Björck L, Marone G: Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. Infect Immun 2000;68:5517-5524.
44. + cells through interaction with the κ light chains of IgE. J Immunol 2003;170:1854-1861.
45. H3 region of IgE. J Immunol 2000;164:589-595.
46. Guihard AI, Pirès R, Bouvet J-P: An endogenous superantigen in the rat gut lumen as a model to study the role of human protein-Fv. Scand J Immunol 1997;45:36-42.
47. 2-binding molecule (protein Fv) in mucosal immunity; in Tsuchiya M, Yodoi J, Hibi T, Miura S (eds): Current Topics in Mucosal Immunology. Amsterdam, Elsevier, 1994, pp 169-174.
48. Andrieux C, Pirès R, Moreau MC, Bouvet J-P: Release of the soluble co-receptor (protein Fv) of secretory immunoglobulins after colonization of axenic rats by the human gut microflora. Scand J Immunol 1998;48:192-195.
49. 1 receptor on coronary hemodynamics in man. Circulation 1986;73:1175-1182.
50. Schwartz LB, Kawahara MS, Hugli TE, Vik D, Fearon DT, Austen KF: Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase. J Immunol 1983;130:1891-1895.
51. Segool RA, Lejtenyi C, Taussig LM: Articular and cutaneous prodromal manifestations of viral hepatitis. J Pediatr 1975;87:709-712.
52. Weiss TD, Tsai CC, Baldassare AR, Zuckner J: Skin lesions in viral hepatitis. Am J Med 1977;64:269-273.
53. Popp JW Jr, Harrist TJ, Dienstag JL, Bhan AK, Wands JR, LaMont JT, Mihm MC: Cutaneous vasculitis associated with acute and chronic hepatitis. Arch Intern Med 1981;141:623-629.
54. Vaida GA, Goldman MA, Bloch KJ: Testing for hepatitis B virus in patients with chronic urticaria and angioedema. J Allergy Clin Immunol 1983;72:193-198.
55. Miadonna A, Tedeschi A, Leggieri E, Invernizzi F, Zanussi C: Basophil activation in idiopathic mixed cryoglobulinemia. J Clin Immunol 1982;2:309-313.
56. Heiner DC, Rose B: Elevated levels of γ-E (IgE) in conditions other than classical allergy. J Allergy 1970;45:30-42.
57. Joske RA, Turner KJ, Murphy BP: Serum IgE levels in patients with liver disease. Med J Aust 1976;2:555-557.
58. Vanepps E, Husby R, Williams RC Jr, Stricklnd RG: Liver disease - A prominent cause of serum IgE elevation. Clin Exp Immunol 1976;23:444-450.
59. Patella V, Bouvet J-P, Marone G: Protein Fv produced during viral hepatitis is a novel activator of human basophils and mast cells. J Immunol 1993;151:5685- 5698.
60. Matsumori A, Matoba Y, Nishio R, Shioi T, Ono K, Sasayama S: Detection of hepatitis virus RNA from the heart of patients with hypertrophic cardiomyopathy. Biochem Biophys Res Comm 1996;222:678-682.
61. Matsumori A, Yutani C, Ikeda Y, Kawai S, Sasayama S: Hepatitis C virus from the hearts of patients with myocarditis and cardiomyopathy. Lab Invest 2000;80:1137-1142.
62. Hawkins RA, Claman HN, Clark RAF, Steigerwald JC: Increased dermal mast cell population in progressive systemic sclerosis: a link in chronic fibrosis? Ann Intern Med 1985;102:182-186.
63. Broide DH, Smith CM, Wassermann SI: Mast cells and pulmonary fibrosis. Identification of a histamine releasing factor in bronchoalveolar lavage fluid. J Immunol 1990;145:1838-1844.
64. de Paulis A, Valentini G, Spadaro G, Lupoli S, Tirri G, Marone G: Human basophil releasability in patients with scleroderma. Arthritis Rheum 1991;34:1289-1296.
65. Hatamochi A, Fujiwara K, Ueki H: Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin. Arch Dermatol Res 1985;277:60-64.
66. Ruoss SJ, Hartmann T, Caughey GH: Mast cells tryptase is a mitogen from cultured fibroblasts. J Clin Invest 1991;88:493-499.
67. 1. J Clin Invest 1992;90:35-41.