Administration of GAS914 in an orthotopic pig-to-baboon heart transplantation model

Xenotransplantation

Volumn 12, Issue 2, 2005, Pages 134-141

  Brandl, Ulrike ^a,b   Michel, Sebastian ^a,b   Erhardt, Matthias ^a,b   Brenner, Paolo ^a   Bittmann, Iris ^a   Rössle, Matthias ^a   Baschnegger, Heiko ^a   Bauer, Andreas ^a   Hammer, Claus ^b   Schmoeckel, Michael ^a   Reichart, Bruno ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Acute vascular rejection; Anti Gal (1,3)Gal antibodies; Anti pig antibodies; GAS914; Hyperacute rejection; Induced antibodies; Orthotopic heart transplantation; Preformed antibodies

Indexed keywords

CYTOTOXIC ANTIBODY; GALACTOSYLGALACTOSE; GAS 914; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; BABOON; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GRAFT REJECTION; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HEART TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE; SURVIVAL TIME; SWINE; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; DISACCHARIDES; FEMALE; GALACTOSE; HEART TRANSPLANTATION; HEMOLYSIS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSION; MALE; MODELS, ANIMAL; MYOCARDIUM; PAPIO; SURVIVAL RATE; SWINE; TRANSPLANTATION, HETEROLOGOUS; TRISACCHARIDES;

EID: 20044391388     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2005.00208.x     Document Type: Article

References (51)

1. GALILI U, RACHMILEWITZ EA, PELEG A, FLECHNER I. A unique natural human IgG antibody with anti-alpha-galactosyl specificity. J Exp Med 1984; 160: 1519.
2. GALILI U, CLARK MR, SHOHET SB, BUEHLER J, MACHER BA. Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1-3Gal epitope in primates. Proc Natl Acad Sci U S A 1987; 84: 1369.
3. GALILI U. The α-Gal epitope (Galα1-3Gal1-4GlcNAc-R) in xenotransplantation. Biochimie 2001; 83: 557.
4. MCMORROW IM, COMRACK CA, SACHS DH, DERSIMONIAN H. Heterogeneity of human natural antibodies cross-reactive with the Gal([alpha]1,3)galactose epitope. Transplantation 1997; 64: 505.
5. GALILI U, CHEN Z, MASAHIRO T et al. Understanding the induced antibody response. Graft 2001; 4: 32.
6. LIN SS, WEIDNER BC, BYRNE GW et al. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J Clin Invest 1998; 101: 1745.
7. WHITE DJG, LANGFORD GA, COZZI E, YOUNG VK. Protective effect of human DAF in transgenic pigs. Xeno 1995; 3: 48.
8. SCHMOECKEL M, BHATTI F, ZAIDI A et al. Orthotopic heart transplantation in a transgenic pig-to-primate model. Transplantation 1998; 65: 1570.
9. PLATT JL. Understanding the mechanism of hyperacute rejection. Graft 2001; 4: 8.
10. GALILI U. The nature of elicited xenoantibodies. Transplant Proc 2001; 33: 688.
11. GIANELLO P. Preventing hyperacute rejection. Graft 2001; 4: 18.
12. ALWAYN IPJ, BASKER M, BÜHLER L, COOPER DKC. The problem of anti-pig antibodies in the pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of anti-pig antibodies. Xenotransplantation 1999; 6: 157.
13. BRENNER P, SCHMOECKEL M, REICHENSPURNER H et al. Technique of immunoapheresis in heterotopic and orthotopic xenotransplantation of pig hearts into cynomolgus and rhesus monkeys. Transplant Proc 2000; 32: 187.
14. NEETHLING FA, KOREN E, ORIOL R et al. Immunoadsorption of natural antibodies from human serum by affinity chromatography utilizing specific carbohydrates protects pig cells from cytotoxic destruction. Tranplant Proc 1994; 26: 1378.
15. TANIGUCHI S, NEETHLING FA, KORCHAGINA EY et al. In vivo immunoadsorbtion of antipig antibodies in baboons using a specific Gal[alpha]1-3Gal column. Transplantation 1996; 62: 1379.
16. ALWAYN IPJ, MURALI B, TERANISHI K et al. Suppressing natural antibody production. Graft 2001; 4: 23.
17. YE Y, NEETHLING FA, NIEKRASZ M et al. Evidence that intravenously administered [alpha]-galactosyl carbohydratesreduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts. Transplantation 1994; 58: 330.
18. NEETHLING FA, KOREN E, YE Y et al. Protection of pig kidney (PK15) cells from the cytotoxic effect of anti-pig antibodies by [alpha]-galactosyl oligosaccharides. Transplanation 1994; 57: 959.
19. SIMON PM, NEETHLING FA, TANIGUCHI S et al. Intravenous infusion of Galalpha1,3Gal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts. Transplantation 1998; 65: 346.
20. TERANISHI K, ALWAYN IPJ, BÜHLER L et al. Depletion of anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model. Transplant Proc 2002; 34: 2757.
21. KATAPODIS AG, WARNER RG, DUTHALER RO et al. Removal of anti-Galα(1,3)Gal xenoantibodies with an injectable polymer. J Clin Invest 2002; 110: 1869.
22. RIEBEN R, BOVIN NV, KORCHAGINA EY et al. Xenotransplantation: in vitro analysis of synthetic alpha-galactosyl inhibitors of human anti-Galalpha 1,3Gal IgM and IgG antibodies. Glycobiology 2000; 10: 141.
23. BRANDL U, ERHARDT M, MICHEL S et al. GAS914 Tested on hDAF Pig Hearts Perfused with Human Blood in a Working Heart Model (abstract). Glasgow: IXA, 2003.
24. COZZI E, WHITE DJG. The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995; 1: 964.
25. HOLMES BJ, RICHARDS AC, AWWAD M et al. Anti-pig antibody levels in naïve baboons and cynomolgus monkeys. Xenotransplantation 2002; 9: 135.
26. ROSE AG, COOPER DKC. A histopathologic grading system of hyperacute (humoral, antibody-mediated) cardiac xenograft and allograft rejection. J Heart Lung Transplant 1996; 15: 804.
27. ROSE AG. Determining the histopathology of hyperacute rejection. Graft 2001; 4: 14.
28. MANEZ R, CRESPO F, GONZALEZ E et al. Neutralization of anti-αGalactosyl antibodies without immunosuppression prevents hyperacute rejection but not acute vascular rejection of pig organs transplanted into baboons. Transplant Proc 2000; 32: 888.
29. BÜHLER L, AWWARD M, SACHS DH, COOPER DKC. Preventing the induced anti-pig antibody response. Graft 2001; 4: 36.
30. DEHOUX JP, DE LA PARRA B, LATINNE D, BAZIN H, GIANELLO P. Characterization of baboon anti-porcine IgG antibodies during acute vascular rejection of porcine kidney xenograft. Xenotransplantation 2002; 9: 338.
31. DOMENECH N, DIAZ T, MOSCOSO I et al. Elicited non-anti-αGal antibodies may cause acute humoral rejection of hDAF pig hearts transplanted in baboons. Transplant Proc 2003; 35: 2049.
32. SANDRIN MS, VAUGHAN AV, DABKOWSKI PL, MCKENZIE IFC. Anti-pig IgM antibodies in human serum react predominantly with Gal(α1,3)Gal epitopes. Proc Natl Acad Sci U S A 1993; 90: 11291.
33. DEHOUX JP, HORI S, TALPE S et al. Specific depletion of preformed IgM natural antibodies by administration of anti-mu monoclonal antibody suppresses hyperacute rejection of pig to baboon renal xenografts. Transplantation 2000; 70: 935.
34. THERANISHI K, MANEZ R, AWWAD M, COOPER DKC. Anti-Galα(1,3)Gal IgM and IgG antibody levels in sera of humans and old world nonhuman primates. Xenotransplantation 2002; 9: 148.
35. ROOS A, ESSERS M, VAN GIJLSWIJK-JANSSEN D, BOVIN NV, DAHA MR. Both IgG and IgM anti-pig antibodies induce complement activation and cytotoxicity. Xenotransplantation 2001; 8: 3.
36. WATIER H, CUILLAUMIN JM, PILLER F et al. Removal of terminal αgalactosyl residues from xenogeneic porcine endothelial cells. Decrease in complement-mediated cytotoxicity. Transplantation 1996; 62: 105.
37. MCKANE W, LEE J, PRESTON R et al. Polymorphism in the human anti-pig natural antibody repertoire: implications for antigen-specific immunoadsorption. Transplantation 1998; 66: 616.
38. COOPER DKC et al. Extracorporal immunoadsorption of (alpha)Gal antibodies. Xeno 1996; 4: 26.
39. ROOS A, DAHA MR. Antibody-mediated activation of the classical complement pathway in xenograft rejection. Transpl Immunol 2002; 9: 257.
40. COOKE SP, PEARSON JD, SAVAGE CO. Human IgG xenoreactive antibodies mediate damage of porcine endothelial cells in vitro by both humoral and cellular mechanisms. Transpl Immunol 1997; 5: 39.
41. GOLDBERG LC, LEE J, CAIRNS T et al. Polymorphism within the human anti-pig repertoir. Transplant Proc 1996; 28: 549.
42. MARINO IR, CELLI S, FERLA G et al. Antibody binding to endothelial and epithelial antigens triggers pig-to-rabbit xenograft rejection and its absence results in atypical complement deposition. Transpl Int 1992; 5 Suppl 1: 320.
43. XU Y, LORF T, SABLINSKI T et al. Removal of anti-porcine natural antibodies from human and nonhuman plasma in vitro and in vivo by Gal(alpha)1-3Gal(beta)1-4(beta)Glc-X immunoaffinity column. Transplantation 1998; 65: 172.
44. XU H, YIN D, NAZIRUDDIN B et al. The in vitro and in vivo effects of anti-galactose antibodies on endothelial cell activation and xenograft rejection. J Immunol 2003; 170: 1531.
45. YIN D, ZENG H, MA L et al. Cutting edge: NK cells mediate IgG1-dependent hyperacute rejection of xenografts. J Immunol 2004; 172: 7235.
46. MACCHIARINI P, ORIOL R, AZIMZADEH A et al. Evidence of human non-agalactosyl antibodies involved in the hyperacute rejection of pig lungs and their removal by pig organ perfusion. J Thorac Cardiovasc 1998; 116: 831.
47. GHANEKAR A, LAJOIE G, LUO Y et al. Treatment with rabbit antithymocyte serum permits a cyclophosphamide-free approach to prevention of hdaf transgenic porcine kidney xenograft rejection in baboons. Transplant Proc 2001; 33: 3849.
48. GHANEKAR A, LAJOIE G, LUO Y et al. Improvement in rejection of human decay accelerating factor transgenic pig-to-primate renal xenografts with administration of rabbit antithymocyte serum. Transplantation 2002; 74: 28.
49. BÜHLER L, XU Y, LI W, ZHU A, COOPER DKC. An investigation of the specificity of induced anti-pig antibodies in baboons. Xenotransplantation 2003; 10: 88.
50. ZHONG R, LUO Y, YANG H et al. Improvement in human decay accelerating factor transgenic porcine kidney xenograft rejection with intravenous administration of gas914, a polymeric form of [alpha]gal. Transplantation 2003; 75: 10.
51. LAM TT, HAUSEN B, BOEKE-PURKIS K et al. Hyperacute rejection of hDAF-transgenic pig organ xenografts in cynomolgus monkeys: influence of pre-existing anti-pig antibodies and prevention and prevention by the αGal glycoconjugate GAS914. Xenotransplantation 2004; 11: 517.