Immunohistologic evaluation of mechanisms mediating hyperacute lung rejection, and the effect of treatment with K76-COOH, FUT-175, and anti-Gal column immunoadsorption

Xenotransplantation

Volumn 6, Issue 4, 1999, Pages 249-261

  Zhang, Jian Ping ^a   Blum, Matthew G ^a   Chang, Andrew C ^a   Shyr, Yu ^a   Blair, Kelly S A ^a   Awwad, Michel ^b   Pierson III, Richard N ^a,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b BioTransplant Inc   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5; GALACTOSE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROPERDIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOTOXICITY; GRAFT REJECTION; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; LUNG PERFUSION; LUNG TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; XENOTRANSPLANTATION;

ACUTE DISEASE; ANIMALS; BLOOD TRANSFUSION; COMPLEMENT INACTIVATOR PROTEINS; GALACTOSIDES; GRAFT REJECTION; GUANIDINES; HUMANS; IMMUNOSORBENT TECHNIQUES; IMMUNOSUPPRESSION; LUNG; SESQUITERPENES; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033369751     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.1999.00029.x     Document Type: Article

References (30)

1. DALMASSO AP, VERCELLOTTI GM, FICHEL RJ, BOLMAN RM, BACH FH, PLATT JL. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am J Pathol 1992; 140: 1157-1166.
2. ALEXANDRE GPJ, GIANELLO P, LATINNE D. Plasmapheresis and splenectomy in experimental renal xenotransplantation. In: HARDY MA. ed. Xenograft 25. New York: Excerpta Medica, 1989: 259-266.
3. TUSO PJ, CRAMER DV, YASUNAGA C, COSENZA CA, WU GD, MAKOWKA L. Removal of natural human xenoantibodies to pig vascular endothelium by perfusion of blood through pig kidneys and livers. Transplantation 1993; 55: 1375-1378.
4. KROSHUS TJ, DALMASSO AP, LEVENTHAL JR, JOHN R, MATAS AJ, BOLMAN III RM. Antibody removal by column immunoabsorption prevents tissue injury in an ex vivo model of pig-to human xenograft hyperacute rejection. J Surg Res 1995; 59: 43-50.
5. SIMON PM, NEETHLING FA, TANIGUCHI S et al. Intravenous infusion of αGal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts. Transplantation 1998; 63: 346.
6. PRUITT SK, BALDWIN III WM, MARSH HC JR, LIN SS, YEH CG, BOLLINGER RR. The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. Transplantation 1991; 52 (5): 868-873.
7. MIYAGAWA S, SHIRAKURA R, MATSUMIYA G, FUKUSHIMA N, NAKATA S, MATSUDA H, MATSSUMOTO M, KITAMURA H, SEYE T. Prolonging discordant xenograft survival with anticomplement reagents K76COOH and FUT175. Transplantation 1993; 55: 709-713.
8. BLUM MG, COLLINS BJ, CHANG AC, ZHANG JP, KNAUS SA, PIERSON III RN. Complement inhibition by FUT-175 and K76-COOH in a pig-to-human xenotransplan-tation model. Xenotransplantation 1998; 5: 35-43.
9. KOBAYASHI T, NEETHLING FA, KROEN E, TANIGUCHI S, YE Y, NIEKRASZ M, HANCOCK WW, COOPER DKC. In vitro and in vivo investigation of anticomplement agents FUT-175 and K76COOH, in the prevention of hyper-acute rejection following discordant xenotransplantation in a non-human primate model. Transplant Proc 1996; 28: 604.
10. TANAKA M, MURASE N, YE Q, MIYAZAKI W, NOMOTO M, MIYAZAWA H, MANEZ R, TOYAMA Y, DEMETRIS AJ, TODO S, STARZL T. Effect of anticomplement agent K76 COOH on hamster-to rat and guinea pig-to-rat heart xenotransplantation. Transplantation 1996; 62: 681-688.
11. GRIDELLI B, GATTI S, ANDREANI P, DONATO MF, BERGAMASCHINI L, BERTI E, DI MAURO P, MAGGIONI L, ORSENIGO R, FASSATI LR, GALMARINI D. Xenogeneic orthotopic liver transplantation from sheep to pig: Delay of rejection by FUT 175 infusion. Transplant Proc 1996; 28: 784-787.
12. LEVENTHAL JR, DALMASSO AP, CROMWELL JW, PLATT JL, MANIVEL CJ, BOLMAN III RM, MATAS AJ. Prolongation of cardiac xenograft survival by depletion of complement. Transplantation 1993; 55 (4): 857-865.
13. KOBAYASHI T, TANIGUCHI S, NEETHLING FA, ROSE G, YE Y, NIEKRASZ M, KOSANKE S, WRIGHT LJ, WHITE DJ, COOPER DK. Delayed xenograft rejection of pig-to-baboon cardiac transplantation after cobra venom factor therapy. Transplantation 1997: 64 (9): 1255-1261.
14. BYRNE GW, MCCURRY KR, MARTIN MJ, MCCLELLAN SM, PLATT JL, LOGAN JS. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 1997; 63 (1): 149-155.
15. KAPLON RJ, PLATT JL, KWIATKOWSKI PA, EDWARDS NM, XU H, SHAH AS, MASROOR S, MICHLER RE. Absence of hyperacute rejection in pig-to-primate orthotopic pulmonary xenografts. Transplantation 1995; 59 (3): 410-416.
16. YEATMAN M, DAGGETT CW, PARKER W, BYRNE GW, LOGAN JS, PLATT JL, DAVIS RD. Complement-mediated pulmonary xenograft injury: studies in swine-to-primate orthotopic single lung transplant models. Transplantation 1998, 65 (8): 1084-1093.
17. MACCHIARINI P, MAZMANIAN GM, ORIOL R, DE MONTPREVILLE V, DULMET E, FATTAL S, LIBERT JM, DOUBINE S, NOCHY D, RIEBEN R, DARTEVELLE P. Ex vivo lung model of pig-to-human hyperacute xenograft rejection. J Thorac Cardiovasc Surg 1997; 114 (3): 315-325.
18. KAMHOLZ SL, BREWER RJ, GRIJALVA G, BURACK J, DEL RIO MJ, VAYNBLATT M, LAWSON N, SQUINTO S, FODOR WL, NORIN AJ. Laboratory studies in cross-species lung transplantation. World J Surg 1997; 21 (9): 951-955.
19. PIERSON RN, 3rD KASPAR-KONIG W, TEW DN, YOUNG VK, DUNNING JJ, HORSLEY J, CAREY NRB, WALLWORK J, WHITE DJG. Hyperacute lung rejection in a pig-to-human transplant model: The role of anti-pig antibody and complement. Transplantation 1997; 63: 594-603.
20. PIERSON III RN, PINO-CHAVEZ G, YOUNG VK, KASPAR-KONIG W, WHITE DJ, WALLWORK J. Expression of human decay accelerating factor may protect pig lung from hyperacute rejection by human blood. J Heart Lung Transplant 1997; 16 (2): 231-239.
21. PIERSON III RN, PARKER RE. Thromboxane mediates pulmonary vasoconstriction and contributes to cytotoxicity in pig lungs perfused with human blood. Transplant Proc 1996; 28 (2): 625.
22. XU Y, LORF T, SABLINSKI T, GIANLLO P, BAILIN M, MONROY R, KOZLOWSKI T, AWWAD M, COOPER DK, SACHS DH. Removal of anti-porcine natural antibodies from human and primate plasma in vitro and in vivo by a Galα1-3Galβ1-4βGlc-X immunoaffinity column. Transplantation 1998; 65: 172-179.
23. KOZLOWSKI T, IERINO FL, LAMBRIGHTS D, FOLEY A, ANDREWS D, AWWAD M, MONROY R, COSIMI AB, COOPER DK, SACHS DH. Depletion of anti-Galα1, 3Gal antibody in baboons by specific α-Gal immunoaffinity columns. Xenotransplantation 1998; 5: 122-31.
24. LIANG KY, ZEGER SL. Longitudinal data analysis using generalized linear models. Biometrika 1986; 73: 13-22.
25. DIGGLE P, LIANG KY, ZEGER SL. Analysis of longitudinal data. Oxford. Clarendon Press, 1994.
26. LIN SS, KOOYMAN DL, DANIELS LJ, DAGGETT CW, PARKER W, LAWSON JH, HOOPES CW, GULLOTTO C, LI L, BIRCH P, DAVIS RD, DIAMOND LE, LOGAN JS, PLATT JL. The role of natural anti-Gal alpha 1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. Transpl Immunol, 1997; 5 (3): 212-218.
27. MACCHIARINI P, ORIOL R, AZIMZADEH A, DE MONTPREVILLE V, RIEBEN R, BOVIN N, MAZMANIAN M, DARTEVELLE P. Evidence of human non-alpha-galactosyl antibodies involved in the hyperacute rejection of pig lungs and their removal by pig organ perfusion. J Thorac Cardiovasc Surg 1998; 116 (5): 831-843.
28. SCHRAA EO, STOCKMANN HBAC, BROEKHUIZEN AJ et al. IgG, but not IgM, mediateshyperacute rejection in hepatic xenografting. Xenotransplantation 1999; 6 (2): 110.
29. KROSHUS TJ, BOLMAN III RM, DALMASSO AP. Selective IgM depletion prolongs organ survival in an ex vivo model of pig-to-human xenotransplantation. Transplantation 1996; 15: 62(1): 5-12.
30. ALWAYN IPJ, BASKER M, BUHLER L, COOPER DKC. The problem of anti-pig antibodies in pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of anti-pig antibodies. Xenotransplantation 1999; 6: 157-168.