Expansion of TcRαβ+CD3+CD4-CD8- (CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome

Acta Haematologica

Volumn 111, Issue 3, 2004, Pages 163-167

  Carulli, Giovanni ^a,c   Lagomarsini, Ginetta ^b   Azzarà, Antonio ^a   Testi, Rossana ^a   Riccioni, Rossella ^a   Petrini, Mario ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Azienda Ospedaliera   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

CD4 CD8 double negative lymphocytes; Lymphocytes; Staphylococcal exotoxin TSST 1; Staphylococcus haemolyticus; Toxic shock syndrome

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; STAPHYLOCOCCUS TOXIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; DISEASE COURSE; FEMALE; HUMAN; LABORATORY TEST; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; STAPHYLOCOCCUS HAEMOLYTICUS; T LYMPHOCYTE; TOXIC SHOCK SYNDROME; TREATMENT OUTCOME; BLOOD CELL; BONE MARROW CELL; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTOSIS; MICROBIOLOGY; MIDDLE AGED; SEPTIC SHOCK; STAPHYLOCOCCUS;

ANTIGENS, CD3; BLOOD CELLS; BONE MARROW CELLS; FEMALE; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTOSIS; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SHOCK, SEPTIC; STAPHYLOCOCCUS; T-LYMPHOCYTES;

EID: 1842561638     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076526     Document Type: Article

References (25)

1. Lowy FD: Staphylococcus aureus infections. N Engl J Med 1998;339:520-532.
2. Dellaripa PF: Toxic shock syndrome. J Int Care Med 2000;15:314-320.
3. Krakauer T: Immune response to staphylococcal superantigens. Immunol Rev 1999;20:163-173.
4. Cameron SB, Nawijn MC, Kum WW, Savelkoul HF, Chow AW: Regulation of helper T cell responses to staphylococcal superantigens. Eur Cytokine Netw 2001;12:210-222.
5. Bone RC: Gram-positive organisms and sepsis. Arch Intern Med 1994;154:26-34.
6. The Working Group on Severe Streptococcal Infections: Defining the group A streptococcal toxic shock syndrome. Rationale and consensus definition. JAMA 1993;269:390-391.
7. Hoge CW, Schwartz B, Talkington DF, Breiman RF, MacNeill EM, Englender SJ: The changing epidemiology of invasive group A streptococcal infections and the emergence of streptococcal toxic shock-like syndrome. JAMA 1993;269:384-389.
8. Ben-Abraham R, Keller N, Vered R, Harel R, Barzilay Z, Paret G: Invasive group A streptococcal infections in a large tertiary center: Epidemiology, characteristics and outcome. Infection 2002;30:81-85.
9. Makida R, Hofer MF, Takase K, Cambier JC, Leung DY: Bacterial superantigens induce V beta-specific T cell receptor internalization. Mol Immunol 1996;33:891-900.
10. Arvand M, Schneider T, Jahn HU, Hahn H: Streptococcal toxic shock syndrome associated with marked gamma delta T cell expansion: A case report. Clin Infect Dis 1996;22:362-365.
11. Kazembe P, Simor AE, Swarney AE, Yap LG, Kreiswirth B, Ng J, Low DE: A study of the epidemiology of an endemic strain of Staphylococcus haemolyticus (TOR-35) in a neonatal intensive care unit. Scand J Infect Dis 1993;25:507-513.
12. Krcmery V Jr, Trupl J, Spanik S: Bacteremia due to teicoplanin-resistant and vancomycin-susceptible Staphylococcus haemolyticus in seven patients with acute leukaemia and neutropenia receiving prophylaxis with ofloxacin. Infection 1997;25:51-52.
13. Crispe IN: CD4/CD8-negative T cells with antigen receptors. Curr Opin Immunol 1994;6:438-441.
14. Schmidt-Wolf IGH, Dejbakhsh-Jones S, Ginzton P, Greemberg P, Strober S: T-cell subsets and suppressor cells in human bone marrow. Blood 1992;80:3242-3250.
15. Shivakumar S, Tsokos GC, Datta SK: T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenetic anti-DNA autoantibodies associated with lupus nephritis. J Immunol 1989;143:103-112.
16. Bleesing JJ, Brown MR, Dale JK, Straus SE, Lenardo MJ, Puck JM, Atkinson TP, Fleisher TA: TcR-alpha/beta(+) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clin Immunol 2001;100:314-324.
17. Bleesing JH, Brown MR, Straus SE, Dale JK, Siegel RM, Johnson M, Lenardo MJ, Puck JM, Fleisher TA: Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome. Blood 2001;98:2466-2473.
18. Suzushima H, Asou N, Nishimura S, Nishikawa K, Wang J-X, Okubo T, Naito M, Hattori T, Takatsuki K: Double-negative (CD4-CD8-) T cells from adult T-cell leukaemia patients also have poor expression of the T-cell receptor αβ/CD3 complex. Blood 1993;81:1032-1039.
19. Zhang ZX, Young K, Zhang L: CD3+CD4-CD8-alphabeta-TCR+ T cell as immune regulatory cell. J Mol Med 2001;79:419-427.
20. Young KJ, Yang L, Phillips MJ, Zhang L: Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative regulatory T cells. Blood 2002;100:3408-3414.
21. Hossain MS, Takimoto H, Ninomiya T, Yoshida H, Kishihara K, Matsuzaki G, Kimura G, Nomoto K: Characterization of CD4-CD8-CD3+ T-cell receptor- αβ+ T cells in murine cytomegalovirus infection. Immunology 2000;101:19-29.
22. Kadena T, Matsuzaki G, Fujise S, Kishihara K, Takimoto H, Sasaki M, Beppu M, Nakamura S, Nomoto K: TCR alpha beta+CD4-CD8-T cells differentiate extrathymically in an lck-independent manner and participate in early response against Listeria monocytogenes infection through interferon-gamma production. Immunology 1997;91:511-519.
23. Pied S, Roland J, Louise A, Voegtle D, Soulard V, Mazier D, Cazenave P-A: Liver CD4-CD8-NK1.1+ TCRαβ intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitro. J Immunol 2000;164:1463-1469.
24. Thomssen H, Ivanyi J, Espitia C, Arya A, Londei M: Human CD4-CD8-alpha beta+ T cell receptor T cells recognize different mycobacteria strains in the context of CD1b. Immunology 1995;85:33-40.
25. Marodon G, Warren D, Filomio MC, Posnett DN: Productive infection of double-negative T cells with HIV in vivo. Proc Natl Acad Sci USA 1999;96:11958-11963.