Novel anti-cholesterol monoclonal immunoglobulin G antibodies as probes and potential modulators of membrane raft-dependent immune functions

Journal of Lipid Research

Volumn 48, Issue 1, 2007, Pages 19-29

  Bíró, Adrienn ^a   Cervenak, László ^a   Balogh, Andrea ^b   Lorincz, András ^b   Uray, Katalin ^b   Horváth, Anna ^a   Romics, László ^a   Matkó, János ^b   Füst, George ^a   László, Glória ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Caveolae; Lipid rafts; Lipoproteins; Lymphocytes; Membrane cholesterol; Monocyte macrophage cells

Indexed keywords

HIGH DENSITY LIPOPROTEIN; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN; MONOCLONAL IMMUNOGLOBULIN G ANTIBODY; PAPAIN; PARAPROTEIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANTIBODY PRODUCTION; ARTICLE; BINDING AFFINITY; CAVEOLA; CELL SURFACE; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREACTIVITY; LIPID RAFT; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANTIBODIES, MONOCLONAL; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN G; JURKAT CELLS; KINETICS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; LIPOSOMES; MEMBRANE LIPIDS; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL;

EID: 33846000599     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600158-JLR200     Document Type: Article

References (38)

1. Swartz, G. M., M. K. Gentry, L. M. Amende, E. J. Blanchette-Mackie, and C. R. Alving. 1988. Antibodies to cholesterol. Proc. Natl. Acad. Sci. USA. 85: 1902-1906.
2. Alving, C. R., G. M. Swartz, and N. M. Wassef. 1989. Naturally occurring autoantibodies to cholesterol in humans. Biochem. Soc. Trans. 629: 637-639.
3. Alving, C. R., N. M. Wassef, and M. Potter. 1995. Antibodies to cholesterol: biological implications of antibodies to lipids. Curr. Top. Microbiol. Immunol. 210: 181-186.
4. Perl-Treves, D., N. Kessler, D. Izhaky, and L. Addadi. 1996. Monoclonal antibody recognition of cholesterol monohydrate crystal faces. Chem. Biol. 3: 567-577.
5. Kruth, H. S., I. Ifrim, J. Chang, L. Addadi, D. Perl-Treves, and W. Y. Yhang. 2001. Monoclonal antibody detection of plasma membrane cholesterol microdomains responsive to cholesterol trafficking. J. Lipid Res. 42: 1492-1500.
6. Matkó, J., and J. Szöllosi. 2004. Regulatory aspects of membrane microdomain (raft) dynamics in live cells: a biophysical approach. In Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine. M. Mattson, editor. Humana Press, Totowa, NJ. 15-46.
7. Alving, C. R., G. M. Swartz, N. M. Wassef, J. L. Ribas, E. E. Herderick, R. Virmani, F. D. Kolodgie, G. R. Matyas, and J. F. Cornhill. 1996. Immunisation with cholesterol-rich liposomes induces anti-cholesterol antibodies and reduces diet-induced hypercholesterolaemia and plaque formation. J. Lab. Clin. Med. 127: 40-49.
8. Horváth, A., G. Füst, I. Horváth, G. Vallus, J. Duba, P. Harcos, Z. Prohaszka, E. Rajnavolgyi, L. Janoskuti, M. Kovacs, et al. 2001. Anticholesterol antibody (ACHA) levels in patients with different atherosclerotic vascular diseases. Characterization of human ACHA. Atherosclerosis. 156: 185-192.
9. Veres, A., G. Füst, M. Smieja, M. McQueen, A. Horvath, Q. Yi, A. Biro, J. Pogue, L. Romics, I. Karadi, et al. 2002. Relationship of anti-60kDa heat shock protein and anti-cholesterol antibodies to cardiovascular events. Circulation. 106: 2775-2780.
10. Biro, A., A. Horvath, L. Varga, E. Nemesanszky, A. Csepregi, K. David, G. Tolvaj, E. Ibranyi, L. Telegdy, A. Par, et al. 2003. Serum anti-cholesterol antibodies in chronic hepatitis-C patients during IFN-α-2b treatment. Immunobiology. 207: 161-168.
11. Haks, M. C., S. M. Belkowski, M. Ciofani, M. Rhodes, J. M. Lefebvre, S. Trop, P. Hugo, J. C. Zuniga-Pflucker, and D. L. Wiest. 2003. Low activation threshold as a mechanism for ligand-independent signaling in pre-T-cells. J. Immunol. 170: 2853-2861.
12. Guo, B., R. M. Kato, M. Garcia-Lloret, M. I. Wahl, and D. J. Rawlings. 2000. Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex. Immunity. 13: 243-253.
13. Poloso, N. J., and P. A. Roche. 2004. Association of MHC class IIpeptide complexes with plasma membrane lipid microdomains. Curr. Opin. Immunol. 16: 103-107.
14. Friedl, P., and J. Storim. 2004. Diversity in immune-cell interactions: states and functions of the immunological synapse. Trends Cell Biol. 14: 557-567.
15. Holowka, D., and B. Baird. 2001. Fc(epsilon)RI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells. Semin. Immunol. 13: 99-105.
16. Rosenberger, C. M., J. H. Brumell, and B. B. Finlay. 2000. Microbial pathogenesis: lipid rafts as pathogen portals. Curr. Biol. 10: R823-R825.
17. Gombos, I., E. Kiss, C. Detre, G. László, and J. Matkó. 2006. Cholesterol and sphingolipids as lipid organizers of the immune cells' plasma membrane: their impact on the function of MHC molecules, effector T-lymphocytes and cell death. Immunol. Lett. 104: 59-69.
18. Rajnavölgyi, É ., A. Horváth, P. Gogolák, G. K. Tóth, G. Fazakas, M. Fridkin, and I. Pecht. 1997. Characterizing immunodominant and protective influenza hemagglutinin epitopes by functional activity and relative binding to major histocompatibility complex class II sites. Eur. J. Immunol. 27: 3105-3114.
19. Dijkstra, J., G. M. Swartz, J. J. Raney, J. Aniagolu, L. Toro, C. A. Nacy, and S. J. Green. 1996. Interactions of anti-cholesterol antibodies with human lipoproteins. J. Immunol. 157: 2006-2013.
20. Szöllosi, J., J. Matkó, and G. Vereb. 2004. Cytometry of fluorescence resonance energy transfer (FRET). Methods Cell Biol. 75: 105-152.
21. Gombos, I., C. Detre, G. Vamosi, and J. Matko. 2004. Rafting MHC-II domains in the APC (presynaptic) plasma membrane and the thresholds for T-cell activation and immunological synapse formation. Immunol. Lett. 92: 117-124.
22. Rouquette-Jazdanian, A. K., C. Pelassy, J. P. Breittmayer, and C. Aussel. 2006. Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling. Cell. Signal. 18: 105-122.
23. Vereb, G., J. Matko, G. Vamosi, S. M. Ibrahim, E. Magyar, S. Varga, J. Szollosi, A. Jenei, R. Gaspar, Jr., T. A. Waldmann, et al. 2000. Cholesterol dependent clustering of IL-2Ra and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts. Proc. Natl. Acad. Sci. USA. 97: 6013-6018.
24. Gombos, I., Z. Bacso, C. Detre, H. Nagy, K. Goda, M. Andrasfalvy, G. Szabo, and J. Matko. 2004. Cholesterol sensitivity of detergent resistance: a rapid flow cytometric test for detecting constitutive or induced raft association of membrane proteins. Cytometry. 61: 117-126.
25. Lupu, C., C. A. Goodwin, A. D. Westmuckett, J. J. Emeis, M. F. Scully, V. V. Kakkar, and F. Lupu. 1997. Tissue factor pathway inhibitor in endothelial cells colocalizes with glycolipid microdomains/ caveolae. Regulatory mechanism(s) of the anticoagulant properties of the endothelium. Arterioscler. Thromb. Vasc. Biol. 17: 2964-2974.
26. Bacia, K., D. Scherfeld, N. Kahya, and P. Schwille. 2004. Fluorescence correlation spectroscopy relates rafts in model and native membranes. Biophys. J. 87: 1034-1043.
27. Hiltbold, E. M., N. J. Poloso, and P. A. Roche. 2003. MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse. J. Immunol. 170: 1329-1338.
28. Steinberg, D. 1978. The rediscovery of high density lipoprotein: a negative risk factor in atherosclerosis. Eur. J. Clin. Invest. 8: 107-109.
29. Rossner, S., K. G. Kjellin, K. L. Mettinger, A. Siden, and C. E. Soderstrom. 1978. Normal serum-cholesterol but low H.D.L.-cholesterol concentration in young patients with ischaemic cerebrovascular disease. Lancet. 18: 577-579.
30. Newman, W. P., D. S. Freedman, A. W. Voors, P. D. Gard, S. R. Srinivasan, J. L. Cresanta, G. D. Williamson, L. S. Webber, and G. S. Berenson. 1986. Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. N. Engl. J. Med. 16: 138-144.
31. Rossner, S., K. G. Kjellin, K. L. Mettinger, A. Siden, and C. E. Soderstrom. 1978. Dyslipoproteinemia in patients with ischemic cerebrovascular disease: a study of stroke before the age of 55. Atherosclerosis. 30: 199-209.
32. Kruth, H. S. 2001. Lipoprotein cholesterol and atherosclerosis. Curr. Mol. Med. 1: 633-653.
33. Alving, C. R., and N. M. Wassef. 1999. Naturally occurring antibodies to cholesterol: a new theory of LDL cholesterol metabolism. Immunol. Today. 20: 362-366.
34. Bíró, A., E. Dósa, A. Horváth, Z. Prohászka, S. Rugonfalvi-Kiss, A. Szabó, I. Karadi, G. Acsady, L. Selmeczi, L. Entz, et al. 2005. Dramatic changes in the serum levels of anti-cholesterol antibodies after endarterectomy in patients with severe carotid atherosclerosis. Immunol. Lett. 99: 51-56.
35. Tuosto, L., I. Parolini, S. Schroder, M. Sargiacomo, A. Lanzavecchia, and A. Viola. 2001. Organization of plasma membrane functional rafts upon T-cell activation. Eur. J. Immunol. 31: 345-349.
36. Alonso, M. A., and J. Millan. 2001. The role of lipid rafts in signalling and membrane trafficking in T-lymphocytes. J. Cell Sci. 114: 3957-3965.
37. Shin, J. S., Z. Gao, and S. N. Abraham. 1999. Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. Biosci. Rep. 19: 421-432.
38. th European Congress of Immunology. Paris, France, September 6-9, 2006).