Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes

Journal of Biological Chemistry

Volumn 281, Issue 42, 2006, Pages 31369-31379

  He, Hua Jun ^a   Zhu, Tie Nian ^a   Xie, Yi ^a   Fan, Jinshui ^a,b   Kole, Sutapa ^a   Saxena, Satya ^a   Bernier, Michel ^a,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTES; INSULIN RESISTANCE; PLASMA PROTEINS; TRANSCRIPTIONAL COACTIVATORS;

ACTIVATION ANALYSIS; BIOCHEMISTRY; CELLS; ENZYME KINETICS; INSULIN;

PROTEINS;

BINDING PROTEIN; CAAT ENHANCER BINDING PROTEIN BETA; ESTROGEN RECEPTOR; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; INTERLEUKIN 6; PYRROLIDINE DITHIOCARBAMATE; STAT3 PROTEIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INFLAMMATION; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TRANSCRIPTION INITIATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTIOXIDANTS; CELL NUCLEUS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DOWN-REGULATION; HEPATOCYTES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-6; PYRROLIDINES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TAMOXIFEN; THIOCARBAMATES; TRANS-ACTIVATION (GENETICS);

EID: 33845973376     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M603762200     Document Type: Article

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