Brain nitric oxide synthase activity is decreased by intravenous anesthetics

Anesthesia and Analgesia

Volumn 83, Issue 3, 1996, Pages 591-594

  Galley, Helen F ^a   Webster, Nigel R ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ETOMIDATE; KETAMINE; MIDAZOLAM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYTOIN; THIOPENTAL;

ANESTHESIA MECHANISM; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; INTRAVENOUS ANESTHESIA; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029817757     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199609000-00027     Document Type: Article

References (28)

1. Moncada S, Higgs EA. Biological relevance of the L-arginine: nitric oxide pathway. In: Moncada S, Nistico G, Higgs EA, eds. Nitric oxide: brain and immune system. London: Portland Press Proceedings, 1993:1-12.
2. Garthwaite J, Charles SL, Chess-Williams R. Endothelium derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 1988;336:385-8.
3. Bredt DS. Neurobiological roles of nitric oxide synthase. In: Moncada S, Nistico G, Higgs EA, eds. Nitric oxide: brain and immune system. London: Portland Press Proceedings, 1993: 97-110.
4. Eskinder H, Hillard CJ, Flynn N, et al. Role of guanylate cyclase- cGMP systems in halothane induced vasodilation in canine cerebral arteries. Anesthesiology 1992;77:482-7.
5. Uggeri MJ, Proctor GJ, Johns RA. Halothane, enflurane and isoflurane attenuate both receptor- and non-receptor-mediated EDRF production in rat thoracic aorta. Anesthesiology 1992;76: 1012-7.
6. Stone DJ, Johns RA. Endothelium-dependent effects of halothane, enflurane and isoflurane on isolated rat aortic vascular rings. Anesthesiology 1989;71:126-32.
7. Blaise G, To Q, Parent M, et al. Does halothane interfere with the release, action or stability of endothelium-derived relaxing factor/nitric oxide? Anesthesiology 1994;80:417-26.
8. Terasako K, Nakamura K, Toda H, et al. Barbiturates inhibit endothelium dependent and independent relaxation mediated by cGMP. Anesth Analg 1994;78:823-30.
9. Galley HF, Nelson LR, Webster NR. Anaesthetic agents decrease the activity of nitric oxide synthase from human polymorphonuclear leucocytes. Br J Anaesth 1995;75:326-9.
10. Peterson GL. A simplification of the protein assay method of Lowry et al which is more generally applicable. Anal Biochem 1977;83:346-56.
11. Goode HF, Webster NR, Howdle PD, Walker BE. Nitric oxide production by human peripheral blood polymorphonuclear leucocytes. Clin Sci 1994;86:411-5.
12. Doyle MP, Hoekstra JW. Oxidation of nitrogen oxides by bound dioxygen in hemoproteins. J Inorg Chem 1981;14:351-8.
13. Knowles RG, Merrerr M, Salter M, Moncada S. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem J 1990;270:833-6.
14. Tobin JR, Martin LD, Breslow MJ, Traystman RJ. Selective anesthetic inhibition of brain nitric oxide synthase. Anesthesiology 1994;81:1264-9.
15. Rengasamy A, Ravichandran LV, Reikersdorfer CJ, Johns RA. Inhalational anesthetics do not alter nitric oxide synthase activity. J Pharmacol Exp Ther 1995;273:599-604.
16. Gryglewski RJ, Palmer RMJ, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived relaxing factor. Nature 1986;320:454-6.
17. Pou S, Pou WS, Bredt DS, et al. Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem 1992;267: 24173-6.
18. Luo D, Kanezevich S, Vincent SR. N-methyl D aspartate-induced nitric oxide release: an in vivo microdialysis study. Neuroscience 1993;57:897-900.
19. Illievisch UM, Zormow MH, Choi KT, et al. Effects of hypothermia or anesthetics on hypocampal glutamate and glycine concentrations after repeated transient global cerebral ischemia. Anesthesiology 1994;80:1771-86.
20. Reynolds JD, Brien JF. Affects of acute ethanol exposure on glutamate release in the hipocampus of the fetal and adult guinea pig. Alcohol 1994;11:259-67.
21. Mantz J, Cheramy A, Thierry AM, et al. Anesthetic properties of riluzole (54274 RPO) a new inhibitor of glutamate neurotransmission. Anesthesiology 1992;76:844-8.
22. Nicol B, Rowbotham DG, Lambert DJ. Glutamate uptake is not a major target site for anaesthetic agents. Br J Anaesth 1995;75: 61-5.
23. Yamamoto T, Shimoyama N, Mizuguchi T. Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw. Anesth Analg 1993;77:886-90.
24. Kuroda Y, Strebel S, Rafferty C, Bullock R. Neuroprotective doses of N-methyl-D-aspartate receptor antagonists profoundly reduce the minimum alveolar anesthetic concentration (MAC) for isoflurane in rats. Anesth Analg 1993;77:795-800.
25. Johns RA, Moscicki JC, DiFazio CA. Nitric oxide synthase inhibitor dose-dependently and reversibly reduces the threshold for halothane anaesthesia. Anesthesiology 1992;77:779-84.
26. Adachi T, Kurata J, Nakao S, et al. Nitric oxide synthase inhibition does not reduce minimum alveolar concentration of halothane in rats. Anesth Analg 1994;78:1154-7.
27. Marangoz C, Ayyildiz M, Agar E. Evidence that sodium nitroprusside possesses anticonvulsant effects mediated through nitric oxide. Neuroreport 1994;5:2454-6.
28. Wang Q, Theard MA, Pelligrino DA, et al. Nitric oxide is an endogenous anticonvulsant but not a mediator of the increase in cerebral blood flow accompanying biculline-induced seizures in rats. Brain Res 1994;658:192-8.