Characterization of T cell-expressed chimeric receptors with antibody-type specificity for the CD4 binding site of HIV-1 gp120

European Journal of Immunology

Volumn 28, Issue 12, 1998, Pages 4177-4187

  Bitton, Natacha ^a   Verrier, Florence ^b   Debré, Patrice ^a   Gorochov, Guy ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

HIV; Recombinant TCR; Single chain fragment variable

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN GP 120; SPACER DNA; T LYMPHOCYTE RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOFLUOROMETRY; ENVELOPE GENE; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOGLOBULIN VARIABLE REGION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SEMLIKI FOREST ALPHAVIRUS; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0031739314     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199812)28:12<4177::AID-IMMU4177>3.0.CO;2-J     Document Type: Article

References (50)

1. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 1994. 68: 6103-6110.
2. Koup, R. A., Virus escape from CTL recognition [comment]. J. Exp. Med. 1994. 180: 779-782.
3. Klein, M. R., van Baalen, C. A., Holwerda, A. M., Kerkhof, G. S., Bende, R. J., Keet, I. P., Eeftinck, S. J., Osterhaus, A. D., Schuitemaker, H. and Miedema, F., Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J. Exp. Med. 1995. 181: 1365-1372.
4. Langlade-Demoyen, P., Ngo-Giang-Huong, N., Ferchal, F. and Oksenhendler, E., Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients [see comments]. J. Clin. Invest. 1994. 93: 1293-1297.
5. Harrer, T., Harrer, E., Kalams, S. A., Barbosa, P., Trocha, A., Johnson, R. P., Elbeik, T., Feinberg, M. B., Buchbinder, S. P. and Walker, B. D., Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J. Immunol. 1996. 156: 2616-2623.
6. Musey, L., Hughes, J., Schacker, T., Shea, T., Corey, L. and McElrath, M. J., Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection [see comments]. N. Engl. J. Med. 1997. 337: 1267-1274.
7. Pantaleo, G., Soudeyns, H., Demarest, J. F., Vaccarezza, M., Graziosi, C., Paolucci, S., Daucher, M. B., Cohen, O. J., Denis, F., Biddison, W. E., Sekaly, R. P. and Fauci, A. S., Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection. Eur. J. Immunol. 1997. 27: 3166-3173.
8. Daniel, M. D., Kirchhoff, F., Czajak, S. C., Sehgal, P. K. and Desrosiers, R. C., Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene [see comments]. Science 1992. 258: 1938-1941.
9. Hanson, D. L., Horsburgh, C. J., Fann, S. A., Havlik, J. A. and Thompson, S. D., Survival prognosis of HIVinfected patients. J. Acquir. Immune Defic. Syndr. 1993. 6: 624-629.
10. Burton, D. R., Pyati, J., Koduri, R. et al., Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science 1994. 266: 1024-1027.
11. Buchacher, A., Predl, R., Strutzenberger, K. et al., Generation of human monoclonal antibodies against HIV-1 proteins; electrofusion and Epstein-Barr virus transformation for peripheral blood lymphocyte immortalization. AIDS Res. Hum. Retroviruses 1994. 10: 359-369.
12. Conley, A. J., Gorny, M. K., Kessler, J. N., Boots, L. J., Ossorio, C. M., Koenig, S., Lineberger, D. W., Emini, E. A., Williams, C. and Zolla, P. S., Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D. J. Virol. 1994. 68: 6994-7000.
13. Roben, P., Moore, J. P., Thali, M., Sodroski, J., Barbas, C. R. and Burton, D. R., Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. J. Virol. 1994. 68: 4821-4828.
14. Kessler, J. N., McKenna, P. M., Emini, E. A., Chan, C. P., Patel, M. D., Gupta, S. K., Mark, G. R., Barbas, C. R., Burton, D. R. and Conley, A. J., Recombinant human monoclonal antibody IgG1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates. AIDS Res. Hum. Retroviruses 1997. 13: 575-582.
15. Parren, P. W., Ditzel, H. J., Gulizia, R. J., Binley, J. M., Barbas, C. R., Burton, D. R. and Mosier, D. E., Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site. AIDS 1995. 9: F1-6.
16. Parren, P. W., Gauduin, M. C., Koup, R. A., Poignard, P., Fisicaro, P., Burton, D. R. and Sattentau, Q. J., Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design [corrected and republished in Immunol. Lett. 1997. 58: 125-132]. Immunol. Lett. 1997. 57: 105-112.
17. Gauduin, M. C., Parren, P. W., Weir, R., Barbas, C. F., Burton, D. R. and Koup, R. A., Passive immunization with a human monoclonal antibody protects hu-PBLSCID mice against challenge by primary isolates of HIV-1. Nature Med. 1997. 3: 1389-1393.
18. Hwu, P., Yang, J. C., Cowherd, R., Treisman, J., Shafer, G. E., Eshhar, Z. and Rosenberg, S. A., In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes. Cancer Res. 1995. 55: 3369-3373.
19. Moritz, D. and Groner, B., A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity. Gene Ther. 1995. 2: 539-546.
20. Stancovsky, I., Schindler, D. G., Waks, T., Yarden, Y., Sela, M. and Eshhar, Z., Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors. J. Immunol. 1993. 151: 6577-6582.
21. Weijtens, M. E., Willemsen, R. A., Valerio, D., Stam, K. and Bolhuis, R. L., Single chain Ig/gamma generedirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity. J. Immunol. 1996. 157: 836-843.
22. Tran, A. C., Zhang, D., Byrn, R. and Roberts, M. R., Chimeric zeta-receptors direct human natural killer (NK) effector function to permit killing of NK-resistant tumor cells and HIV-infected T lymphocytes. J. Immunol. 1995. 155: 1000-1009.
23. + T lymphocytes armed with universal T-cell receptors. Blood 1994. 84: 2878-2889.
24. Gross, G. and Eshhar, Z., Endowing T cells with antibody specificity using chimeric T cell receptors. FASEB J. 1992. 6: 3370-3378.
25. Eshhar, Z., Waks, T., Gross, G. and Schindler, D. G., Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc. Natl. Acad. Sci. USA 1993. 90: 720-724.
26. Burton, D. R., Barbas, C. D., Persson, M. A., Koenig, S., Chanock, R. M. and Lerner, R. A., A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc. Natl. Acad. Sci. USA 1991. 88: 10134-10137.
27. Bird, R. E., Hardman, K. D., Jacobson, J. W., Johnson, S., Kaufman, B. M., Lee, S. M., Lee, T., Pope, S. H., Riordan, G. S. and Whitlow, M., Single-chain antigenbinding proteins [published erratum appears in Science 1989. 244: 409]. Science 1988. 242: 423-426.
28. Barbas, C. R., Hu, D., Dunlop, N., Sawyer, L., Cababa, D., Hendry, R. M., Nara, P. L. and Burton, D. R., In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity. Proc. Natl. Acad. Sci. USA 1994. 91: 3809-3813.
29. Gross, G., Waks, T. and Eshhar, Z., Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc. Natl. Acad. Sci. USA 1989. 86: 10024-10028.
30. Yang, O. O., Tran, A. C., Kalams, S. A., Johnson, R. P., Roberts, M. R. and Walker, B. D., Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells. Proc. Natl. Acad. Sci. USA 1997. 94: 11478-11483.
31. VanCott, T. C., Bethke, F. R., Polonis, V. R., Gorny, M. K., Zolla, P. S., Redfield, R. R. and Birx, D. L., Dissociation rate of antibody-gp120 binding interactions is predictive of V3-mediated neutralization of HIV-1. J. Immunol. 1994. 153: 449-459.
32. Garcia, K. C., Tallquist, M. D., Pease, L. R., Brunmark, A., Scott, C. A., Degano, M., Stura, E. A., Peterson, P. A., Wilson, I. A. and Teyton, L., Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. Proc. Natl. Acad. Sci. USA 1997. 94: 13838-13843.
33. Fitzer, A. C., Schindler, D. G., Waks, T. and Eshhar, Z., Direct T cell activation by chimeric single chain Fv-Syk promotes Syk-Cbl association and CbI phosphorylation. J. Biol. Chem. 1997. 272: 8551-8557.
34. Lanzavecchia, A., Understanding the mechanisms of sustained signaling and T cell activation [comment], J. Exp. Med. 1997. 185: 1717-1719.
35. Moore, J. P. and Jarrett, R. F., Sensitive ELISA for the gp120 and gp160 surface glycoproteins of HIV-1. AIDS Res. Hum. Retroviruses 1988. 4: 369-379.
36. Oh, S. K., Cruikshank, W. W., Raina, J., Blanchard, G. C., Adler, W. H., Walker, J. and Kornfeld, H., Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patients. J. Acquir. Immune Defic. Syndr. 1992. 5: 251-256.
37. Palella, F. J., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J. and Holmberg, S. D., Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection. N. Engl. J. Med. 1998. 338: 853-860.
38. Chun, T. W., Stuyver, L, Mizell, S. B., Ehler, L. A., Mican, J. A., Baseler, M., Lloyd, A. L., Nowak, M. A. and Fauci, A. S., Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. USA 1997. 94: 13193-13197.
39. Ogg, G. S., Jin, X., Bonhoeffer, S., Dunbar, P. R., Nowak, M. A., Monard, S., Segal, J. P., Cao, Y., Rowland, J. S., Cerundolo, V., Hurley, A., Markowitz, M., Ho, D. D., Nixon, D. F. and McMichael, A. J., Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 1998. 279: 2103-2106.
40. Chun, T. W., Stuyver, L., Mizell, S. B., Ehler, L. A., Mican, J. A., Baseler, M., Lloyd, A. L., Nowak, M. A. and Fauci, A. S., Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. USA 1997. 94: 13193-13197.
41. Cohen, J., Exploring how to get at- and eradicatehidden HIV [news]. Science 1998. 279: 1854-1855.
42. Hoogenboom, H. R., Marks, J. D., Griffiths, A. D. and Winter, G., Building antibodies from their genes, Immunol. Rev. 1992. 130: 41-68.
43. McCafferty, J., Griffiths, A. D., Winter, G. and Chiswell, D. J., Phage antibodies: filamentous phage displaying antibody variable domains. Nature 1990. 348: 552-554.
44. Southern, P. J. and Berg, P., Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1982. 1: 327-341.
45. Rammensee, H. G., Julius, M. H., Nemazee, D., Langhorne, J., Lamers, R. and Köhler, G., Targeting cytotoxic T cells to antigen-specific B lymphocytes. Eur. J. Immunol. 1987. 17: 433-436.
46. Potter, H., Weir, L. and Leder, P., Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc. Natl. Acad. Sci. USA 1984. 81: 7161-7165.
47. Kaufmann, Y., Berke, G. and Eshhar, Z., Cytotoxic T lymphocyte hybridomas that mediate specific tumor-cell lysis in vitro. Proc. Natl. Acad. Sci. USA 1981. 78: 2502-2506.
48. + lymphocytes after contact with membrane-bound HIV-1 envelope glycoprotein. Virology 1994. 198: 360-365.
49. Marasco, W. A., Bagley, J., Zani, C., Posner, M., Cavacini, L., Haseltine, W. A. and Sodroski, J., Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody. J. Clin. Invest. 1992. 90: 1467-1478.
50. Verrier, F. C., Chameau, P., Altmeyer, R., Laurent, S., Borman, A. M. and Girard, M., Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophagetropic HIV-1 isolate. Proc. Natl. Acad. Sci. USA 1997. 94: 9326-9331.