Encodable activators of Src family kinases

Journal of the American Chemical Society

Volumn 128, Issue 51, 2006, Pages 16506-16507

  Zellefrow, Crystal D ^a   Griffiths, Jennifer S ^a   Saha, Sarmistha ^a   Hodges, Abby M ^a   Goodman, Jessica L ^a   Paulk, Joshiawa ^a   Kritzer, Joshua A ^a   Schepartz, Alanna ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HEMATOPOIETIC CELL KINASE; PROTEIN KINASE FYN; PROTEIN KINASE LCK; PROTEIN KINASE LYN; PROTEIN SH3; PROTEIN TYROSINE KINASE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; ENZYME ACTIVITY; FLUORESCENCE POLARIZATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN SECONDARY STRUCTURE; THERMOSTABILITY;

AMINO ACID SEQUENCE; ENZYME ACTIVATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEINS; SENSITIVITY AND SPECIFICITY; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845932345     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0672977     Document Type: Article

References (37)

1. Dalgarno, D. C.; Botfield, M. C.; Rickles, R. J. Peptide Sci. 1997, 43, 383-400.
2. (a) Boggon, T. J.; Eck, M. J. Oncogene 2004, 23, 7918-7927.
3. (b) Xu, W.; Harrison, S. C.; Eck, M. J. Nature 1997, 385, 595-602.
4. (c) Sicheri, F.; Moarefi, I.; Kuriyan, J. Nature 1997, 385, 602-609.
5. (d) Williams, J. C.; Weijland, A.; Gonfloni, S.; Thompson, A.; Courtneidge, S. A.; Superti-Furga, G.; Wierenga, R. K. J. Mol. Biol. 1997, 274, 757-775.
6. Moarefi, I.; LaFevre Bernt, M.; Sicheri, F.; Huse, M.; Lee, C. H.; Kuriyan, J.; Miller, W. T. Nature 1997, 385, 650-653.
7. (a) Lerner, E. C.; Smithgall, T. E. Nat. Struct. Biol. 2002, 9, 365-369.
8. (b) Lerner, E. C.; Trible, R. P.; Schiavone, A. P.; Hochrein, J. M.; Engen, J. R.; Smithgall, T. E. J. Biol. Chem. 2005, 280, 40832-40837.
9. (a) Guappone, A. C.; Flynn, D. C. Mol. Cell. Biochem. 1997, 175, 243-252.
10. (b) Thomas, J. W.; Ellis, B.; Boerner, R. J.; Knight, W. B.; White, G. C., II; Schaller, M. D. J. Biol. Chem. 1998, 273, 577-583.
11. (c) Maeno, K.; Sada, K.; Kyo, S.; Miah, S. M. S.; Kawauchi-Kamata, K.; Qu, X. J.; Shi, Y. H.; Yamamura, H. J. Biol. Chem. 2003, 278, 24912-24920.
12. Stauffer, T. P.; Martenson, C. H.; Rider, J. E.; Kay, B. K.; Meyer, T. Biochemistry 1997, 36, 9388-9394.
13. (a) Lawrence, D. S.; Niu, J. K. Pharmacol. Ther. 1998, 77, 81-114.
14. (b) Tsygankov, A. Y.; Shore, S. K. Curr. Pharm. Des. 2004, 10, 1745.
15. Feng, S.; Kasahara, C.; Rickles, R. J.; Schreiber, S. L. Proc. Natl. Acad. Sci. USA. 1995, 92, 12408-12415.
16. (a) Blundell, T.; Pitts, J.; Tickle, I.; Wood, S.; Wu, C. Proc. Natl. Acad. Sci. U.S.A. 1981, 78, 4175-4179.
17. (b) Lerch, M.; Mayrhofer, M.; Zerbe, O. J. Mol. Biol. 2004, 339, 1153-1168.
18. Bader, R.; Zerbe, O. ChemBioChem 2005, 6, 1520-1534.
19. See Supporting Information for details.
20. (a) Gemperli, A. C.; Rutledge, S. E.; Maranda, A.; Schepartz, A. J. Am. Chem. Soc. 2005, 127, 1596-1597.
21. (b) Kritzer, J. A.; Zutshi, R.; Cheah, M.; Ran, F. A.; Webman, R.; Wongjirad, T. M.; Schepartz, A. ChemBioChem 2006, 7, 29-31.
22. (c) Volkman, H. M.; Rutledge, S. E.; Schepartz, A. J. Am. Chem. Soc. 2005, 127, 4649-4658.
23. (d) Rutledge, S. E.; Volkman, H. M.; Schepartz, A. J. Am. Chem. Soc. 2003, 125, 14336-14347.
24. (e) Chin, J. W.; Schepartz, A. J. Am. Chem. Soc. 2001, 123, 2929-2930.
25. (f) Zondlo, N. J.; Schepartz, A. J. Am. Chem. Soc. 1999, 121, 6938-6939.
26. (a) Yang, L.; Schepartz, A. Biochemistry 2005, 44, 7469-7478.
27. (b) Golemi-Kotra, D.; Mahaffy, R.; Footer, M. J.; Holtzman, J. H.; Pollard, T. D.; Theriot, J. A.; Schepartz, A. J. Am. Chem. Soc. 2004, 126, 4-5.
28. (c) Chin, J. W.; Schepartz, A. Angew. Chem., Int. Ed. 2001, 40, 3806-3809.
29. Keire, D. A.; Bowers, C. W.; Solomon, T. E.; Reeve, J. R., Jr. Peptides 2002, 23, 305-321.
30. Rickles, R. J.; Botfield, M. C.; Zhou, X. M.; Henry, P. A.; Brugge, J. S.; Zoller, M. J. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 10909-10913.
31. Erpel, T.; Supetti-Furga, G.; Courtneidge, S. A. EMBO J. 1995, 14, 963-975.
32. Roskoski, R. Biochem. Biophys. Res. Commun. 2004, 324, 1155-1164.
33. (a) Kjellen, P.; Amdjadi, K.; Lund, T. C.; Medveczky, P. G.; Sefton, B. M. Virology 2002, 297, 281-288.
34. (b) Biesinger, B.; Tsygankov, A. Y.; Fickenscher, H.; Emmrich, F.; Fleckenstein, B.; Bolen, J. B.; Broker, B. M. J. Biol. Chem. 1995, 270, 4729-4734.
35. Barker, S. C.; Kassel, D. B.; Weigl, D.; Huang, X. Y.; Luther, M. A.; Knight, W. B. Biochemistry 1995, 34, 14843-14851.
36. Nguyen, J. T.; Porter, M.; Amoui, M.; Miller, W. T.; Zuckermann, R. N.; Lim, W. A. Chem. Biol. 2000, 7, 463-473.
37. Although phage display has been used previously to optimize the properties of miniature proteins based on aPP, in this case, it was not necessary to achieve the functions reported herein.