SH3 domains and drug design: Ligands, structure, and biological function

Biopolymers

Volumn 43, Issue 5, 1997, Pages 383-400

  Dalgarno, D C ^a   Botfield, M C ^a   Rickles, R J ^a  

^a ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

Combinatorial chemistry; Costructure; Phage display; Pro rich peptide; SH3 (Src homology 3) domain; Structure based drug design

Indexed keywords

AMINO ACIDS; CHEMICAL BONDS; CONFORMATIONS; DRUG PRODUCTS; MOLECULAR ORIENTATION; MOLECULAR STRUCTURE;

LIGANDS; PEPTIDES;

PROTEINS;

PROTEIN TYROSINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

BINDING AFFINITY; DRUG DESIGN; LIGAND BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SRC HOMOLOGY DOMAINS;

EID: 0031418201     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1997)43:5<383::AID-BIP4>3.0.CO;2-R     Document Type: Article

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