Effects of ertiprotafib on hepatic cytochrome P450 and peroxisomal enzymes in rats and dogs, and in rat and human primary hepatocytes

Xenobiotica

Volumn 37, Issue 1, 2007, Pages 1-18

  Tong, Z ^a   Chandrasekaran, A ^a   Jordan, R ^a   Markiewicz, V ^a   Li, H ^a   Xiang, Q ^a   Shen, L ^a   Scatina, J ^a  

^a PFIZER INC   (United States)

Author keywords

Enzyme induction; Ertiprotafib; Peroxisome profilerator; Peroxisome proliferator activated receptors (PPARs); PTP1B inhibitor

Indexed keywords

CARNITINE ACETYLTRANSFERASE; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 3A; CYTOCHROME P450 4A; CYTOCHROME P450 4A1; ERTIPROTAFIB; LIVER ENZYME; MESSENGER RNA; PALMITOYL COENZYME A; PALMITOYL COENZYME A OXIDASE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOG; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; HYPOTHESIS; LIVER CELL; LIVER WEIGHT; MALE; NONHUMAN; PEROXISOME; PROTEIN INDUCTION; RAT;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; ENZYME INDUCTION; FEMALE; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; HYDROXYUREA; HYPOGLYCEMIC AGENTS; LIVER; MALE; MICROSOMES, LIVER; ORGAN SIZE; PEROXISOMES; PHENYLPROPIONATES; RATS; RNA, MESSENGER; THIAZOLIDINEDIONES; THIOPHENES; THYROID GLAND;

CANIS FAMILIARIS; RODENTIA;

EID: 33845913538     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600965115     Document Type: Article

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