Feeding strategies for E. coli fermentations demanding an enriched environment

Bioprocess and Biosystems Engineering

Volumn 30, Issue 1, 2007, Pages 13-25

  De Mare L ^a   Cimander, C ^b   Elfwing, A ^b   Hagander, P ^a  

^a LUND UNIVERSITY   (Sweden)

^b Novozymes Biopharma DK A S   (United Kingdom)

Author keywords

Amino acid; Complex medium; Escherichia coli; Fed batch cultivation; Feeding strategy; Fermentation process

Indexed keywords

AMINO ACIDS; BIOTECHNOLOGY; CARBON; COMPUTER SIMULATION; ESCHERICHIA COLI;

COMPLEX MEDIUM; FED BATCH CULTIVATION; FEED CONTROLLERS; FEEDING STRATEGY;

FERMENTATION;

AMINO ACID; CARBON;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; ENVIRONMENT; ESCHERICHIA COLI; FEEDING BEHAVIOR; FERMENTATION TECHNIQUE; NONHUMAN; PRIORITY JOURNAL; SIMULATION; SPECIES CULTIVATION;

COMPUTER SIMULATION; CULTURE MEDIA; ESCHERICHIA COLI; FERMENTATION; GLUCOSE; KINETICS; OXYGEN CONSUMPTION;

ESCHERICHIA COLI;

EID: 33845898187     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-006-0090-z     Document Type: Article

References (18)

1. Riesenberg D, Guthke R (1999) High cell-density cultivation of microorgansims. Appl Microbiol 51:422-430
2. Lee SY (1996) High cell-density culture of Escherichia coli. Trends Biotechnol 14:98-105
3. Luli GW, Strohl WR (1990) Comparison of growth, acetate production and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations. Appl Environ Microbiol 56:1004-1011
4. Panda AK, Khan RH, Mishra S, Rao KBCA, Totey AM (2000) Influences of yeast extract on specific cellular yield of Ovine growth hormone during fed-batch fermentations of E. coli. Bioprocess Eng 22:379-383
5. Zawada J, Swartz J (2005) Maintaining rapid growth in moderate density Escherichia coli fermentations. Biotechnol Bioeng 89:407-415
6. Yoon SK, Kang WK, Park TH (1994) Fed-batch operation of recombinant E. coli containing trpa promoter with controlled specific growth rate. Biotechnol Bioeng 43:996-999
7. Han K, Lim HC, Hong J (1992) Acetic acid formation in E. coli fermentation. Biotechnol Bioeng 39:663-671
8. Koh BT, Nakashimada U, Pfeiffer M, Yap MGS (1992) Comparison of acetate inhibition on growth of host and recombinant E. coli K12 strains. Biotechnol Lett 14:1115-1118
9. Yamane T, Shimizu S (1984) Fed-batch techniques in microbial processes. Adv Biochem Eng Biotechnol 30:147-194
10. Iding K, Buntemeyer H, Gudermann F, Deutschmann SM, Kionka C, Lehmann J (2001) An automatic system for the assessment of complex medium additives under cultivation conditions. Biotechnol Bioeng 73:442-448
11. Johnston WA, Stewart M, Ledd P, Cooney M (2003) Tracking the acetate threshold using DO-transient control during medium and high cell density cultivation of recombinant Escherichia coli in complex media. Biotechnol Bioeng 84:314-323
12. Whiffin VS, Cooney MJ, Cord-Ruwisch R (2004) Online detection of feed demand in high cell density cultures of E. coli by measurement of changes in dissolved oxygen transients in complex media. Biotechnol Bioeng 85:422-433
13. Akesson M, Hagander P, Axelsson JP (2001) Avoiding acetate accumulation in Escherichia coli cultures using feedback control of glucose feeding. Biotechnol Bioeng 73:223-230
14. Åkesson M, Hagander P, Axelsson JP (2001) Probing control of fed-batch cultures: analysis and tuning. Control Eng Practice 9:709-723
15. Gschaedler A, Boudrant J (1994) Amino acid utilization during batch and continuous cultures of Escherichia coli on a semi-synthetic medium. J Biotechnol 37:235-251
16. Ingraham JL, Maaloe O, Neidhardt FC (1983) Growth of the bacterial cell. Sunderland Mass, Sinauer Associates
17. Meyer H-P, Leist C, Fiechter A (1984) Acetate formation in continuous culture of Escherichia coli K12 D1 on defined and complex media. J Biotechnol 1:355-358
18. de Maré L, Velut S, Ledung E, Cimander C, Norrman B, Nordberg Karlsson E, Holst O, Hagander P (2005) A cultivation technique for E. coli fed-batch cultivations operating close to the maximum oxygen transfer capacity of the reactor. Biotechnol Lett 27:983-990