Online Detection of Feed Demand in High Cell Density Cultures of Escherichia coli by Measurement of Changes in Dissolved Oxygen Transients in Complex Media

Biotechnology and Bioengineering

Volumn 85, Issue 4, 2004, Pages 422-433

  Whiffin, Victoria S ^a   Cooney, Michael J ^b   Cord Ruwisch, Ralf ^a  

^a MURDOCH UNIVERSITY   (Australia)

^b UNIVERSITY OF HAWAII   (United States)

Author keywords

Acetate; Dissolved oxygen transients; Escherichia coli; Fed batch; Feeding strategy; High cell density culture

Indexed keywords

ALGORITHMS; BIOCHEMICAL OXYGEN DEMAND; CELL CULTURE; GLUCOSE; ONLINE SYSTEMS;

CELL DENSITY; FEED DEMANDS;

ESCHERICHIA COLI;

ACETIC ACID; DISSOLVED OXYGEN; GLUCOSE;

ALGORITHM; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BIOMASS; BIOREACTOR; CELL DENSITY; ESCHERICHIA COLI; FED BATCH CULTURE; NONHUMAN;

ALGORITHMS; BIOREACTORS; CELL COUNT; CELL CULTURE TECHNIQUES; CELL DIVISION; CULTURE MEDIA; ESCHERICHIA COLI; FEEDBACK; GLUCOSE; MODELS, BIOLOGICAL; ONLINE SYSTEMS; OXYGEN; OXYGEN CONSUMPTION;

ESCHERICHIA COLI;

EID: 0442294019     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10802     Document Type: Article

References (28)

1. Akesson M. 1999. Probing control of glucose feeding in Escherichia coli cultivations. PhD Thesis. Department of Automatic Control. Lund, Sweden: Lund Institute of Technology.
2. Akesson M, Karlsson E, Hagander P, Axelsson J, Tocaj A. 1999. On-line detection of acetate formation in Escherichia coli cultures using dissolved oxygen responses to feed transients. Biotechnol Bioeng 64:590-598.
3. Akesson M, Hagander P, Axelsson JP. 2001. Avoiding acetate accumulation in Escherichia coli cultures using feedback control of glucose feeding. Biotechnol Bioeng 73:223-230.
4. Bauer S, Shiloach J. 1974. Maximal exponential growth rate and yield of E. coli obtainable in a bench scale fermenter. Biotechnol Bioeng 16:933-941.
5. Bech Jensen E, Carlsen S. 1990. Production of recombinant human growth hormone in Escherichia coli: expression of different precursors and physiological effects of glucose, acetate and salts. Biotechnol Bioeng 36:1-11.
6. Bermejo L, Welker N, Papoutsakis E. 1998. Expression of Clostridium acetobutylicum ATCC 824 genes in Esherichia coli for acetone production and acetate detoxification. Appl Environ Microbiol 64:1079-1085.
7. Cutayar J, Poillon D. 1989. High cell density culture of E. coli in a fed-batch system with dissolved oxygen as substrate feed indicator. Biotechnol Lett 11:155-160.
8. Hangos KM, Cameron IT. 2001. Process modelling and model analysis, vol. 4. London: Academic Press.
9. Holms H. 1996. Flux analysis and control of the central metabolic pathways in Escherichia coli. FEMS Microbiol Rev 19:85-116
10. Johnston W. 2003. Development of acetate threshold tracking control algorithms for fed-batch control of recombinant E. coli. PhD Thesis. School of Engineering. Perth, Australia: Murdoch University.
11. Johnston W, Cord-Ruwisch R, Cooney MJ. 2002. Industrial control of recombinant E. coli fed-batch culture: new perspectives on traditional controlled variables. Bioproc Biosystems Eng 25:111-120.
12. Kleman G, Chalmers J, Luli G, Strohl W. 1991. A predictive and feedback control algorithm maintains a constant glucose concentration in fed-batch fermentations. Appl Environ Microbiol 57:910-917.
13. Konstantinov K, Yoshida T. 1990. On-line monitoring of representative structural variables in fed-batch cultivation of recombinant Escherichia coli for phenylalanine production. J Ferm Bioeng 70:420-426.
14. Konstantinov K, Kishimoto M, Seki T, Yoshida T. 1990. A balanced DO-stat and its application to the control of acetic acid excretion by recombinant E. coli. Biotechnol Bioeng 36:750-758.
15. Landwall P, Holme T. 1977. Removal of inhibitors of bacterial growth by dialysis culture. J Gen Microbiol 103:345-352.
16. Lee S. 1996. High cell density culture of Escherichia coli. Trends Biotechnol 14:98-105.
17. Lee S, Chang H. 1993. High cell density cultivation of Escherichia coli W using sucrose as a carbon source. Biotechnol Lett 15:971-974.
18. Luli G, Strohl W. 1990. Comparison of growth, acetate production, and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations. Appl Environ Microbiol 56:1004-1011.
19. Majewski RA, Domach MM. 1990. Simple constrained-optimization view of acetate overflow in E. coli. Biotechnol Bioeng 35:732-738.
20. Ramchuran SO, Nordberg E, Velut S, de Mare L, Hagander P, Holst O. 2002. Production of heterologous thermostable glycoside hydrolase and the presence of host-cell proteases in substrate limited fed-batch cultures of Escherichia coli BL21 (DE3). Appl Microbiol Biotechnol 60:408-416.
21. Riesenberg D, Guthke R. 1999. High cell density cultivation of microogranisms. Appl Microbiol Biotechnol 51:422-430.
22. Robbins J, Taylor K. 1989. Optimisation of Escherichia coli growth by controlled addition of glucose. Biotechnol Bioeng 34:1289-1294.
23. Saucedo V, Karim M. 1996. A decreasing feeding profile for the optimisation of ethanol production in a recombinant Escherichia coli fed-batch fermentation. Biotechnol Lett 18:1055-1060.
24. Schügerl K, Hitzmann B, Jurgens H, Kullick T, Ulber R, Weigal B. 1996. Challenges in integrating biosensors and FIA for on-line monitoring and control. Trends Biotechnol 14:21-31.
25. Shiloach J, Kaufman J, Guillard A, Fass R. 1996. Effect of glucose supply strategy on acetate accumulation, growth and recombinant protein production by Escherichia coli BL21 (lambda DE3) and Escherichia coli JM109. Biotechnol Bioeng 49:421-428.
26. Suzuki T, Yamane T, Shimizu S. 1990. Phenomenological background and some preliminary trials of automated substrate supply in pH-stat modal fed-batch culture using a setpoint of high limit. J Ferment Bioeng 69:292-297.
27. Turner C, Gregory M, Thornhill N. 1994. Closed-loop control of fed-batch cultures of recombinant E. coli using online HPLC. Biotechnol Bioeng 44:819-829.
28. van de Walle M, Shiloach J. 1998. Proposed mechanism of acetate accumulation in two recombinant Escherichia coli strains during high density fermentation. Biotechnol Bioeng 57:71-78.