Probing control of fed-batch cultivations: Analysis and tuning

Control Engineering Practice

Volumn 9, Issue 7, 2001, Pages 709-723

  Akesson M ^a   Hagander, P ^a   Axelsson, J P ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Biotechnology; Control system analysis; Fermentation processes; Probing; Process control

Indexed keywords

ESCHERICHIA COLI; GENETICALLY MODIFIED ORGANISM; GLUCOSE; NUTRIENT UPTAKE; PROCESS CONTROL; PROTEIN PRODUCTION; PROTEIN STABILITY;

FEEDING; GLUCOSE; MUTAGENESIS; PROTEINS; STABILITY; TUNING;

PROBING CONTROLS;

CULTIVATION;

BATCH PROCESS; BIOTECHNOLOGY; CONTROL SYSTEM; MICROORGANISM;

EID: 0035392147     PISSN: 09670661     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0967-0661(01)00020-X     Document Type: Article

References (18)

1. A gain-scheduling approach for control of dissolved oxygen in stirred bioreactors
2. A probing feeding strategy for Escherichia coli cultures
3. On-line detection of acetate formation in Escherichia coli cultures using dissolved oxygen responses to feed transients
4. Are growth rates of Escherichia coli in batch cultures limited by respiration?
5. Improved expression of human interleukin-2 in high-cell-density fermentor cultures of Escherichia coli K-12 by a phosphotransacetylase mutant
6. Production of recombinant human growth hormone in Escherichia coli: Expression of different precursors and physiological effects of glucose, acetate and salts
7. Oxygen transfer coefficients by dynamic model moment analysis
8. High cell-density culture of Escherichia coli
9. Comparison of growth, acetate production, and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations
10. Simple constrained-optimization view of acetate overflow in E. coli
11. The growth rate control in Escherichia coli at near to maximum growth rates: The A-stat approach
12. Expression of active human tissue-type plasminogen activator in Escherichia coli
13. Mass culture of Escherichia coli: Medium development for low and high density cultivation of Escherichia coli B/r in minimal and complex media
14. High-cell-density cultivation of microorganisms
15. Fed-batch cultures of recombinant Escherichia coli with inhibitory substance monitoring
16. A study of the effect of specific growth rate and acetate on recombinant protein production of E. coli JM 107
17. Modeling of overflow metabolism in batch and fed-batch cultures of Escherichia coli