Synergy between LPS and immobilized anti-human CD3ε mAb for activation of cord blood CD3+ T cells

International Immunology

Volumn 19, Issue 1, 2007, Pages 99-103

  Goldberg, Michael R ^a   Luknar Gabor, Noemi ^a   Zadik Mnuhin, Galia ^a   Koch, Penina ^a   Tovbin, Joseph ^a   Katz, Yitzhak ^a  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; IMMOBILIZED ANTIBODY; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY CD3; T LYMPHOCYTE RECEPTOR;

ACCESSORY CELL; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFANT; INNATE IMMUNITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; CELL PROLIFERATION; DRUG SYNERGISM; FEMALE; FETAL BLOOD; HUMANS; IMMUNITY, NATURAL; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MATERNAL-FETAL EXCHANGE; PREGNANCY; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL;

EID: 33845890771     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl126     Document Type: Article

References (29)

1. Adkins, B., Leclerc, C. and Marshall-Clarke, S. 2004. Neonatal adaptive immunity comes of age. Nat. Rev. Immunol. 4:553.
2. Upham, J. W., Rate, A., Rowe, J., Kusel, M., Sly, P. D. and Holt, P. G. 2006. Dendritic cell immaturity during infancy restricts the capacity to express vaccine-specific T-cell memory. Infect. Immun. 74:1106.
3. Prescott, S. L., Macaubas, C., Holt, B. J. et al. 1998. Transplacental priming of the human immune system to environmental allergens: Universal skewing of initial T cell responses toward the Th2 cytokine profile. J. Immunol. 160:4730.
4. Adderson, E. E. 2001. Antibody repertoires in infants and adults: effects of T-independent and T-dependent immunizations. Springer Semin. Immunopathol. 23:387.
5. Bessler, H., Komlos, L., Punsky, I. et al. 2001. CD14 receptor expression and lipopolysaccharide-induced cytokine production in preterm and term neonates. Biol. Neonate. 80:186.
6. Trivedi, H. N., HayGlass, K. T., Gangur, V., Allardice, J. G., Embree, J. E. and Plummer, F. A. 1997. Analysis of neonatal T cell and antigen presenting cell functions. Hum. Immunol. 57:69.
7. Bertotto, A., Gerli, R., Lanfrancone, L. et al. 1990. Activation of cord T lymphocytes. II. Cellular and molecular analysis of the defective response induced by anti-CD3 monoclonal antibody. Cell. Immunol. 127:247.
8. Vekemans, J., Amedei, A., Ota, M. O. et al. 2001. Neonatal bacillus Calmette-Guerin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes. Eur. J. Immunol. 31:1531.
9. Bashir, M., Louie, E. S., Shi, H. N. and Nagler-Anderson, C. 2004. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J. Immunol. 172:6978.
10. Braun-Fahrlander, C., Riedler, J., Herz, U. et al. 2002. Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Engl. J. Med. 347:869.
11. Miscia, S., DiBaldassarre, A., Sabatino, G. et al. 1999. Inefficient phospholipase C activation and reduced Lck expression characterize the signaling defect of umbilical cord T lymphocytes. J. Immunol. 163:2416.
12. Matsumoto, M., Yamada, T., Yoshinaga, S. K. et al. 2002. Essential role of NF-kappa B-inducing kinase in T cell activation through the TCR/CD3 pathway. J. Immunol. 169:1151.
13. Akira, S. and Takeda, K. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499.
14. Adkins, B. and Hamilton, K. 1992. Freshly isolated, murine neonatal T cells produce IL-4 in response to anti-CD3 stimulation. J. Immunol. 149:3448.
15. Gerli, R., Bertotto, A., Crupi, S. et al. 1989. Activation of cord T lymphocytes. I. Evidence for a defective T cell mitogenesis induced through the CD2 molecule. J. Immunol. 142:2583.
16. Goodier, M. R. and Londei, M. 2001. Low concentrations of lipopolysaccharide synergize with peptides to augment human T-cell proliferation and can prevent the induction of non-responsiveness by CTLA4-Ig. Immunology 102:15.
17. Yaqub, S., Solhaug, V., Vang, T. et al. 2003. A human whole blood model of LPS-mediated suppression of T cell activation. Med. Sci. Monit. 3:BR120.
18. Caron, G., Duluc, D., Fremaux, I. et al. 2005. Direct stimulation of human T cells via TLR5 and TLR7/8: Flagellin and R-848 upregulate proliferation and IFN-gamma production by memory CD4+ T cells. J. Immunol. 175:1551.
19. Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M. and Demengeot, J. 2003. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197:403.
20. Takahata, Y., Nomura, A., Takada, H. et al. 2004. CD25+CD4+ T cells in human cord blood: An immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene. Exp. Hematol. 32:622.
21. Mattern, T., Flad, H. D., Brade, L., Rietschel, E. T. and Ulmer, A. J. 1998. Stimulation of human T lymphocytes by LPS is MHC unrestricted, but strongly dependent on B7 interactions. J. Immunol. 160:3412.
22. Ulmer, A. J., Flad, H., Rietschel, T. and Mattern, T. 2000. Induction of proliferation and cytokine production in human T lymphocytes by lipopolysaccharide (LPS). Toxicology 152:37.
23. Banchereau, J. and Steinman, R. M. 1998. Dendritic cells and the control of immunity. Nature 392:245.
24. Mattern, T., Girroleit, G., Flad, H. D., Rietschel, E. T. and Ulmer, A. J. 1999. CD34+ hematopoietic stem cells exert accessory function in lipopolysaccharide-induced T cells stimulation and CD80 expression on monocytes. J. Exp. Med. 189:693.
25. Mattern, T., Thanhauser, A., Reiling, N. et al. 1994. Endotoxin and lipid A stimulate proliferation of human T cells in the presence of autologous monocytes. J. Immunol. 153:2996.
26. Tulic, M. K., Fiset, P. O., Manoukian, J. J. et al. 2004. Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults. Lancet 363:1689.
27. Eisenthal, A., Hassner, A., Shenav, M., Baron, S. and Lifschitz-Mercer, B. 2003. Phenotype and function of lymphocytes from the neonatal umbilical cord compared to paired maternal peripheral blood cells isolated during delivery. Exp. Mol. Pathol. 75:45.
28. Upham, J. W., Holt, B. J., Baron-Hay, M. J. et al. 1995. Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: Covert responses are unmasked by serum-free medium. Clin. Exp. Allergy 25:634.
29. Kopp, M. V., Pichler, J., Halmerbauer, G. et al. 2000. Culture conditions for the detection of allergen-specific T-cell reactivity in cord blood: Influence of cell number. Pediatr. Allergy Immunol. 11:4.