CD34+ hematopoietic stem cells exert accessory function in lipopolysaccharide-induced T cell stimulation and CD80 expression on monocytes

Journal of Experimental Medicine

Volumn 189, Issue 4, 1999, Pages 693-699

  Mattern, Taila ^a   Girroleit, Gundolf ^a   Flad, Hans Dieter ^a   Rietschel, Ernst T ^a   Ulmer, Artur J ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Antigen presentation; Immunity, cellular; Immunocompetence; Immunoreactivity; Lymphocyte cooperation

Indexed keywords

B7 ANTIGEN; CD34 ANTIGEN; GAMMA INTERFERON; LIPOPOLYSACCHARIDE;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IMMUNOFLUORESCENCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD34; ANTIGENS, CD80; BLOOD CELLS; CELL LINE; CELLS, CULTURED; DENDRITIC CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOMAGNETIC SEPARATION; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MONOCYTES; T-LYMPHOCYTE SUBSETS; TUBERCULIN;

EID: 0033557256     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.4.693     Document Type: Article

References (27)

1. Cavaillon, J.M., and N. Haeffner-Cavaillon. 1990. Signals involved in interleukin 1 synthesis and release by lipopolysaccharide-stimulated monocytes/macrophages. Cytokine. 2:313-329.
2. Cavaillon, J.M., C. Fitting, N. Haeffner-Cavaillon, S.J. Kirsch, and H.S. Warren. 1990. Cytokine response by monocytes and macrophages to free and lipoprotein-bound lipopolysaccharide. Infect. Immun. 58:2375-2382.
3. Loppnow, H., and P. Libby. 1989. Adult human vascular endothelial cells express the IL-6 gene differently in response to LPS and IL-1. Cell. Immunol. 122:493-503.
4. Schade, F.U., I. Burmeister, and R. Engel. 1987. Increased 13-hydroxyoctadecadienoic acid content in lipopolysaccharide-stimulated macrophages. Biochem. Biophys. Res. Commun. 147:695-700.
5. Gery, I., J. Krüger, and S.Z. Spiesel. 1972. Stimulation of B-lymphocytes by endotoxin. J. Immunol. 108:1088-1091.
6. Greaves, M., G. Janossy, and M. Doenhoff. 1974. Selective triggering of human T and B lymphocytes in vitro by polyclonal mitogens. J. Exp. Med. 140:1-18.
7. Baker, P.J., C.E. Taylor, and F.S. Ekwunife. 1992. Bacterial polysaccharides, endotoxins, and immunomodulation. Adv. Exp. Med. Biol. 319:31-38.
8. Milner, E.C.B., J.A. Rudbach, and K.B. VonEschen. 1983. Cellular responses to bacterial lipopolysaccharide: T cells recognize LPS determinants. Scand. J. Immunol. 18:21-28.
9. Vogel, S.N., M.L. Hilfiker, and M.J. Caulfield. 1983. Endotoxin-induced T lymphocyte proliferation. J. Immunol. 130: 1774-1779.
10. Le, J., J.-X. Lin, D. Hennksen-Destefano, and J. Vilcek. 1986. Bacterial lipopolysaccharide-induced interferon-γ production: roles of interleukin 1 and interleukin 2. J. Immunol. 136:4525-4530.
11. Blanchard, D.K., J.Y. Djeu, T.W. Klein, H. Friedman, and W.E. Steward. 1986. Interferon-γ induction by lipopolysaccharide: dependence on interleukin 2 and macrophages. J. Immunol. 136:963-970.
12. Nitta, T., H. Imai, Y. Ogasawara, and M. Nakano. 1994. Mitogenicity of bacterial lipopolysaccharide on the T lymphocyte population bearing γδ T cell receptor. J. Endotoxin Res. 1:101-107.
13. Mattern, T., A. Thanhäuser, N. Reiling, K.-M. Toellner, M. Duchrow, S. Kusumoto, E.T. Rietschel, M. Ernst, H. Brade, H.-D. Flad, and A.J. Ulmer. 1994. Endotoxin and lipid A stimulate proliferation of human T cells in the presence of autologous monocytes. J. Immunol. 153:2996-3004.
14. Mattern, T., H.-D. Flad, L. Brade, E.T. Rietschel, and A.J. Ulmer. 1998. Stimulation of human T lymphocytes by LPS is MHC unrestricted, but strongly dependent on B7 interactions. J. Immunol. 160:3412-3418.
15. Böyum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Lab. Clin. Invest. 21:77-89.
16. + cells in peripheral and cord blood by flow cytometry. Exp. Hematol. 22:1003-1010.
17. + progenitors in human bone marrow. J. Immunol. 149:2681-2688.
18. Caux, C., C. Dezutter-Dambuyant, D. Schmitt, and J. Banchereau. 1992. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature. 360:258-261.
19. Santiago-Schwarz, F., E. Belilos, B. Diamond, and S.E. Carson. 1992. TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages. J. Leukocyte Biol. 52:274-281.
20. Caux, C., C. Massacrier, C. Dezutter-Dambuyant, B. Vanbervliet, C. Jacquet, D. Schmitt, and J. Banchereau. 1995. Human dendritic Langerhans cells generated in vitro from CD34+ progenitors can prime naive CD4+ T cells and process soluble antigen. J. Immunol. 155:5427-5435.
21. Bernhard, H., M.L. Disis, S. Heimfeld, S. Hand, J.R. Gralow, and M.A. Cheever. 1995. Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood. Cancer Res. 55:1099-1104.
22. Hay, R., M. Macy, T.R. Chen, P. McClintock, and Y. Reid. 1988. American Type Culture Collection. Rockville, MD.
23. + T-lymphocytes, and NK cells. J. Immunol. 149:3495-3502.
24. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211-222.
25. Murphy, E.E., G. Terres, S.E. Macatonia, C.-S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and Interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223-231.
26. Li, C.K., P.M. Yuen, K.W. Chik, M.M. Shing, K.S. Tsang, A. Wong, T.F. Leung, and C. Lai. 1998. Allogenic peripheral blood stem cell transplantation in children. Med. Pediatr. Oncol 30:147-151.
27. Link, H., and L. Arseniev. 1997. CD34 positive blood stem cells for allogeneic progenitor and stem cell transplantation. Leuk. Lymphoma. 26:451-465.