5-Fluorouracil mediates apoptosis and G1/S arrest in laryngeal squamous cell carcinoma via a p53-independent pathway

Cancer Journal

Volumn 12, Issue 6, 2006, Pages 482-493

  Han, Ching Liu ^a   Chen, George G ^a   Vlantis, Alexander C ^a   Leung, Billy C S ^a   Tong, Michael C F ^a   Van Hasselt, C Andrew ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

5 fluorouracil; Cell death; Laryngeal cancer; p53

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; DEATH ASSOCIATED PROTEIN KINASE; FLUOROURACIL; LIPOCORTIN 5; PROTEIN P53; RETINOBLASTOMA PROTEIN;

AGED; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DOSE INCREASE; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; LARYNX CARCINOMA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DNA REPLICATION; FLUOROURACIL; G1 PHASE; HUMANS; LARYNGEAL NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33845876338     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/00130404-200611000-00008     Document Type: Article

References (38)

1. Sankaranarayanan R, Masuyer E, Swaminathan R et al. Head and neck cancer: a global perspective on epidemiology and prognosis. Anticancer Res 1998;18:4779-4786.
2. Hong Kong Cancer Registry, Hospital Authority of Hong Kong 2000: Highlights on Cancer Statistics 2000. Hong Kong Cancer Registry, Hospital Authority of Hong Kong.
3. Forastiere AA, Goefert H, Maor M et al. Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer. N Engl J Med 2003;349:2091-2098.
4. The Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991;324:1685-1690.
5. Hong WK, Lippman SM, Wolf GT. Recent advances in head and neck cancer - larynx preservation and cancer chemoprevention: the Seventeenth Annual Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res 1993;53:5113-5120.
6. Parker WB and Cheng YC. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther 1990;48:381-395.
7. Lee BJ, Chon KM, Kim YS et al. Effects of cisplatin, 5-fluorouracil, and radiation on cell cycle regulation and apoptosis in the hypopharyngeal carcinoma cell line. Chemotherapy 2005;51:103-110.
8. Didelot C, Mirjolet JF, Barberi-Heyob M et al. Oncoprotein expression of E6 and E7 does not prevent 5-fluorouracil (5-FU) mediated G1/S arrest and apoptosis in 5-FU resistant carcinoma cell lines. Int J Oncol 2003;23:81-87.
9. Didelot C, Mirjolet JF, Barberi-Heyob M et al. Radiation could induce p53-independent and cell cycle-unrelated apoptosis in 5-fluorouracil radiosensitized head and neck carcinoma cells. Can J Physiol Pharmacol 2002;80:638-643.
10. Gasco M, Crook T. The p53 network in head and neck cancer. Oral Oncology 2003;39:222-231.
11. Oren M. Decision making by p53: Life, death and cancer. Cell Death Differ 2003;10:431-442.
12. Liu G, Lozano G. p21 stability: Linking chaperones to a cell cycle checkpoint. Cancer Cell 2005;7:113-114.
13. Gartel AL, Radhakrishnan SK. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 2005;65:3980-3985.
14. Sherr CJ, McCormick F. The Rb and p53 pathways in cancer. Cancer Cell 2002;2:103-112.
15. Krause CJ, Carey TE, Ott RW et al. Human squamous-cell carcinoma. Establishment and characterization of new permanent cell lines. Arch Otolaryngol 1981;107:703-710.
16. Hauser U, Balz V, Carey TE, et al. Reliable detection of p53 aberrations in squamous cell carcinomas of the head and neck requires transcript analysis of the entire coding region. Head Neck 2002;24:868-873.
17. Bradford CR, Zhu S, Ogawa H et al. P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines. Head Neck 2003;25:654-661.
18. Kastan MB, Onyekwere O, Sidransky D et al. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991;51:6304-6311.
19. Kuerbitz SJ, Plunkett BS, Walsh WV et al. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 1992;89:7491-7495.
20. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-331.
21. 1 arrest and apoptosis. Proc Natl Acad Sci USA 1995;92:9019-9023.
22. Lee BJ, Chon KM, Kim YS et al. Effects of Cisplatin, 5-Fluorouracil, and radiation on cell cycle regulation and apoptosis in the hypopharyngeal carcinoma cell line. Chemotherapy 2005;52:103-110.
23. Tong D, Poot M, Hu D et al. 5-Fluorouracil-induced apoptosis in cultured oral cancer cells. Oral Oncology 2000;36:236-241.
24. Inada T, Ichikawa A, Kubota T et al. 5-FU induced apoptosis correlates with efficacy against human gastric and colon cancer xenografts in nude mice. Anticancer Res 1997;17:1965-1971.
25. Inada T, Ichikawa A, Igarashi S et al. Effect of preoperative 5-fluorouracil on apoptosis of advanced gastric cancer. J Surg Oncol 1997;65:106-110.
26. Yang B, Eshleman JR, Berger NA et al. Wild-type p53 protein potentiates cytotoxicity of therapeutic agents in human colon cancer cells. Clin Cancer Res 1996;2:1649-1657.
27. WAF1/CIP1 on apoptosis and sensitivity to cancer chemotherapy. Drug Resist Updates 2003;6:183-195.
28. Tso YP, Huang SJ, Chang JL et al. Adenovirus-mediated p21(Waf1/SdII/Cip1) gene transfer induces apoptosis of human cervical cancer cell lines. J Virol 1999;73:4983-4990.
29. Wu Q, Kirschmeier P, Hockenberry T et al. Transcriptional regulation during p21/WAF1/Cip1-induced apoptosis in human ovarian cancer cells. J Biol Chem 2002;277:36329-36337.
30. Schepper SD, Bruwiere H, Werhulst T et al. Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin. J Pharmacol Exp Ther 2003;304:881-888.
31. Zhang Y, Fujita N, Tsuruo T. Caspase-mediated cleavage of p21/Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene 1999;18:1131-1138.
32. Ramondetta L, Mills GB, Burke TW et al. Adenovirus-mediated expression of p53 and p21 in papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: Potential application of gene therapy to endometrial cancer. Clin Cancer Res 2000;6:278-284.
33. 2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 1998;18:629-643.
34. Wagner S, Roemer K. Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. Biochem Pharmacol 2005;69:1059-1067.
35. Decesse JT, Medjkane S, Batto MB et al. RB regulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2001;20:962-971.
36. Harbour JW, Dean DC. Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2000;2:E65-67.
37. Strait KA, Dabbas B, Hammond EH et al. Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb and Id proteins. Mol Cancer Ther 2002;1:1181-1190.
38. Swanton C. Cell-cycle targeted therapies. Lancet Oncol 2004;5:27-36.