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Volumn 5, Issue 5, 2006, Pages 717-732

Cancer immunotherapy using virally transduced dendritic cells: Animal studies and human clinical trials

Author keywords

Adeno associated virus; Adenovirus; Canarypox virus; Cancer; Clinical trials; Dendritic cells; Fowlpox virus; Immunotherapy; Lentivirus; Onco retrovirus; Vaccinia virus

Indexed keywords

ALPHA FETOPROTEIN; ALPHA INTERFERON; BCR ABL PROTEIN; CARCINOEMBRYONIC ANTIGEN; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ETOPOSIDE; GLYCOPROTEIN GP 100; HEMAGGLUTININ; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 2; IRINOTECAN; MELAN A; MELANOMA ANTIGEN 3; MONOPHENOL MONOOXYGENASE; MUCIN 1; OVALBUMIN; PROSTATE SPECIFIC ANTIGEN; PROSTATE SPECIFIC MEMBRANE ANTIGEN; PROTEIN P53; PROTEIN TRP2; RECOMBINANT GAMMA INTERFERON; SMALL INTERFERING RNA; SUPPRESSOR OF CYTOKINE SIGNALING 1; SURVIVIN; TELOMERASE REVERSE TRANSCRIPTASE; TRASTUZUMAB; TUMOR ANTIGEN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33845871185     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.5.5.717     Document Type: Review
Times cited : (24)

References (88)
  • 1
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon-γ-dependent tumor surveillance system in immunocompetent mice
    • Kaplan DH, Shankaran V, Dighe AS et al. Demonstration of an interferon-γ-dependent tumor surveillance system in immunocompetent mice. Proc. Natl Acad. Sci. USA 95, 7556-7561 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1    Shankaran, V.2    Dighe, A.S.3
  • 2
    • 0035165729 scopus 로고    scopus 로고
    • Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis
    • Street SE, Cretney E, Smyth MJ. Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis. Blood 97, 192-197 (2001).
    • (2001) Blood , vol.97 , pp. 192-197
    • Street, S.E.1    Cretney, E.2    Smyth, M.J.3
  • 3
    • 0036645530 scopus 로고    scopus 로고
    • Suppression of lymphoma and epithelial malignancies effected by interferon-γ
    • Street SE, Trapani JA, MacGregor D, Smyth MJ. Suppression of lymphoma and epithelial malignancies effected by interferon-γ. J. Exp. Med. 196, 129-134 (2002).
    • (2002) J. Exp. Med , vol.196 , pp. 129-134
    • Street, S.E.1    Trapani, J.A.2    MacGregor, D.3    Smyth, M.J.4
  • 4
    • 0036852241 scopus 로고    scopus 로고
    • Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3, 991-998 (2002). • Provides an excellent overview of numerous types of interactions between tumor cells and the immune system.
    • Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3, 991-998 (2002). • Provides an excellent overview of numerous types of interactions between tumor cells and the immune system.
  • 5
    • 0037448353 scopus 로고    scopus 로고
    • Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    • Zhang L, Conejo-Garcia JR, Katsaros D et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. 348, 203-213 (2003).
    • (2003) N. Engl. J. Med , vol.348 , pp. 203-213
    • Zhang, L.1    Conejo-Garcia, J.R.2    Katsaros, D.3
  • 6
    • 23844510061 scopus 로고    scopus 로고
    • Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer
    • Yeon CH, Pegram MD. Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer. Invest. New Drugs 23(5), 391-409 (2005).
    • (2005) Invest. New Drugs , vol.23 , Issue.5 , pp. 391-409
    • Yeon, C.H.1    Pegram, M.D.2
  • 7
    • 0141645488 scopus 로고    scopus 로고
    • Mechanism of action of anti-HER2 monoclonal antibodies: Scientific update on trastuzumab and 2C4
    • Albanell J, Codony J, Rovira A, Mellado B, Gascon P. Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4. Ad. Exp. Med. Biol. 532, 253-268 (2003).
    • (2003) Ad. Exp. Med. Biol , vol.532 , pp. 253-268
    • Albanell, J.1    Codony, J.2    Rovira, A.3    Mellado, B.4    Gascon, P.5
  • 8
    • 0141742297 scopus 로고    scopus 로고
    • Steinman RM. Some interfaces of dendritic cell biology. APMIS 111(7-8), 675-697 (2003). • Offers a very detailed description of dendritic cell (DC) biology by one of the discoverers of DCs.
    • Steinman RM. Some interfaces of dendritic cell biology. APMIS 111(7-8), 675-697 (2003). • Offers a very detailed description of dendritic cell (DC) biology by one of the discoverers of DCs.
  • 9
    • 2642520623 scopus 로고    scopus 로고
    • Loading DCs with Ag
    • Vari F, Hart DN. Loading DCs with Ag. Cytotherapy 6(2), 111-121 (2004).
    • (2004) Cytotherapy , vol.6 , Issue.2 , pp. 111-121
    • Vari, F.1    Hart, D.N.2
  • 10
    • 11144355864 scopus 로고    scopus 로고
    • Generation of carcinoembryonic antigen (CEA)-specific T-cell responses in HLA-A*0201 and HLA-A*2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded with CEA peptides
    • Liu KJ, Wang CC, Chen LT et al. Generation of carcinoembryonic antigen (CEA)-specific T-cell responses in HLA-A*0201 and HLA-A*2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded with CEA peptides. Clin. Cancer Res. 10(8), 2645-2651 (2004).
    • (2004) Clin. Cancer Res , vol.10 , Issue.8 , pp. 2645-2651
    • Liu, K.J.1    Wang, C.C.2    Chen, L.T.3
  • 11
    • 33646863192 scopus 로고    scopus 로고
    • Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: Antigen-specific T cell responses in DTH skin tests
    • Lesterhuis WJ, de Vries IJ, Schuurhuis DH et al. Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests. Ann. Oncol. 17(6), 974-980 (2006).
    • (2006) Ann. Oncol , vol.17 , Issue.6 , pp. 974-980
    • Lesterhuis, W.J.1    de Vries, I.J.2    Schuurhuis, D.H.3
  • 12
    • 24144459856 scopus 로고    scopus 로고
    • + progenitors and activated with type I interferon. J. Immunother. 28(5), 505-516 (2005).
    • + progenitors and activated with type I interferon. J. Immunother. 28(5), 505-516 (2005).
  • 13
    • 24144433435 scopus 로고    scopus 로고
    • Vaccination of adanced hepatocellular carcinoma patients with tumor lysatepulsed dendritic cells: A clinical trial
    • Lee WC, Wang HC, Hung CF et al. Vaccination of adanced hepatocellular carcinoma patients with tumor lysatepulsed dendritic cells: a clinical trial. J. Immunother. 28(5), 496-504 (2005).
    • (2005) J. Immunother , vol.28 , Issue.5 , pp. 496-504
    • Lee, W.C.1    Wang, H.C.2    Hung, C.F.3
  • 14
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • Therasse P, Arbuck SG, Eisenhauer EA et al. New guidelines to evaluate the response to treatment in solid tumors. J. Natl Cancer Inst. 92, 205-216 (2000).
    • (2000) J. Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 15
    • 33845882772 scopus 로고    scopus 로고
    • Comparison of strategies for tumor antigen loading of dendritic cells: Adenoviral vector and tumor lysate
    • Jeong JG, Lee HJ, Ahn HS. Comparison of strategies for tumor antigen loading of dendritic cells: adenoviral vector and tumor lysate. J. Immunother. 28(6), 614 (2005).
    • (2005) J. Immunother , vol.28 , Issue.6 , pp. 614
    • Jeong, J.G.1    Lee, H.J.2    Ahn, H.S.3
  • 17
    • 0030048724 scopus 로고    scopus 로고
    • Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity
    • Celluzzi CM, Mayordomo JI, Storkus WJ, Lotze MT, Falo LD Jr. Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity. J. Exp. Med. 183(1), 283-287 (1996).
    • (1996) J. Exp. Med , vol.183 , Issue.1 , pp. 283-287
    • Celluzzi, C.M.1    Mayordomo, J.I.2    Storkus, W.J.3    Lotze, M.T.4    Falo Jr., L.D.5
  • 18
    • 0035990375 scopus 로고    scopus 로고
    • Current methods for loading dendritic cells with tumor antigen for the induction of antitumor immunity
    • Zhou Y, Bosch ML, Salgaller ML. Current methods for loading dendritic cells with tumor antigen for the induction of antitumor immunity. J. Immunother. 25(4), 289-303 (2002).
    • (2002) J. Immunother , vol.25 , Issue.4 , pp. 289-303
    • Zhou, Y.1    Bosch, M.L.2    Salgaller, M.L.3
  • 19
    • 4744351649 scopus 로고    scopus 로고
    • Progress in the Development of immunotherapy of cancer using ex vivo-generated dendritic cells expressing multiple tumor antigen epitopes
    • Markiewicz MA, Kast WM. Progress in the Development of immunotherapy of cancer using ex vivo-generated dendritic cells expressing multiple tumor antigen epitopes. Cancer Invest. 22(3), 417-434 (2004).
    • (2004) Cancer Invest , vol.22 , Issue.3 , pp. 417-434
    • Markiewicz, M.A.1    Kast, W.M.2
  • 20
    • 0034517560 scopus 로고    scopus 로고
    • Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotoxic T lymphocytes
    • Strobel I, Berchtold S, Gotze A, Schulze U, Schuler G, Steinkasserer A. Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotoxic T lymphocytes. Gene Ther. 7, 2028-2035 (2000).
    • (2000) Gene Ther , vol.7 , pp. 2028-2035
    • Strobel, I.1    Berchtold, S.2    Gotze, A.3    Schulze, U.4    Schuler, G.5    Steinkasserer, A.6
  • 21
    • 10744219547 scopus 로고    scopus 로고
    • Human dendritic cells genetically engineered to express cytosolically retained fragment of prostate-specific membrane antigen prime cytotoxic T-cell responses to multiple epitopes
    • Milcho M, Serguei Z, Iskra A et al. Human dendritic cells genetically engineered to express cytosolically retained fragment of prostate-specific membrane antigen prime cytotoxic T-cell responses to multiple epitopes. Cancer Gene Ther. 10(12), 907-917 (2003).
    • (2003) Cancer Gene Ther , vol.10 , Issue.12 , pp. 907-917
    • Milcho, M.1    Serguei, Z.2    Iskra, A.3
  • 22
    • 30644474832 scopus 로고    scopus 로고
    • Immunity to squamous carcinoma in mice immunized with dendritic cells transfected with genomic DNA from squamous carcinoma cells
    • O'Sullivan I, Ng LK, Martinez DM, Kim TS, Chopra A, Cohen EP. Immunity to squamous carcinoma in mice immunized with dendritic cells transfected with genomic DNA from squamous carcinoma cells. Cancer Gene Ther. 12, 825-834 (2005).
    • (2005) Cancer Gene Ther , vol.12 , pp. 825-834
    • O'Sullivan, I.1    Ng, L.K.2    Martinez, D.M.3    Kim, T.S.4    Chopra, A.5    Cohen, E.P.6
  • 23
    • 0036167308 scopus 로고    scopus 로고
    • Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors
    • Heiser A, Coleman D, Dannull J et al. Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J. Clin. Invest. 109, 409-417 (2002).
    • (2002) J. Clin. Invest , vol.109 , pp. 409-417
    • Heiser, A.1    Coleman, D.2    Dannull, J.3
  • 24
    • 2942559009 scopus 로고    scopus 로고
    • Cancer immunotherapy with mRNA-transfected dendritic cells
    • Gilboa E, Vieweg J. Cancer immunotherapy with mRNA-transfected dendritic cells. Immunol. Rev. 199, 251-263 (2004).
    • (2004) Immunol. Rev , vol.199 , pp. 251-263
    • Gilboa, E.1    Vieweg, J.2
  • 25
    • 4444370799 scopus 로고    scopus 로고
    • Gene therapy clinical trials worldwide 1989-2004 - an overview
    • Edelstein ML, Abedi RM, Wixon J, Edelstein RM. Gene therapy clinical trials worldwide 1989-2004 - an overview. J. Gene Med. 6, 597-602 (2004).
    • (2004) J. Gene Med , vol.6 , pp. 597-602
    • Edelstein, M.L.1    Abedi, R.M.2    Wixon, J.3    Edelstein, R.M.4
  • 26
    • 29144527555 scopus 로고    scopus 로고
    • Genetically modified dendritic cells for therapeutic immunity
    • Kikuchi T. Genetically modified dendritic cells for therapeutic immunity. Tohoku J. Exp. Med. 208(1), 1-8 (2006).
    • (2006) Tohoku J. Exp. Med , vol.208 , Issue.1 , pp. 1-8
    • Kikuchi, T.1
  • 27
    • 0141844624 scopus 로고    scopus 로고
    • The maturation of murine dendritic cells induced by human adenovirus is mediated by the fiber knob domain
    • Molinier-Frenkel V, Prevost-Blondel A, Hong SS et al. The maturation of murine dendritic cells induced by human adenovirus is mediated by the fiber knob domain. J. Biol. Chem. 278(39), 175-182 (2003).
    • (2003) J. Biol. Chem , vol.278 , Issue.39 , pp. 175-182
    • Molinier-Frenkel, V.1    Prevost-Blondel, A.2    Hong, S.S.3
  • 28
    • 0033152688 scopus 로고    scopus 로고
    • Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector
    • Tillman BW, de Gruijl TD, Luykx-de Bakker SA et al. Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector. J. Immunol. 162(11), 6378-6383 (1999).
    • (1999) J. Immunol , vol.162 , Issue.11 , pp. 6378-6383
    • Tillman, B.W.1    de Gruijl, T.D.2    Luykx-de Bakker, S.A.3
  • 29
    • 0037500890 scopus 로고    scopus 로고
    • Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy
    • Sili U, Huls MH, Davis AR et al. Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy. J. Immunother. 26(3), 241-256 (2003).
    • (2003) J. Immunother , vol.26 , Issue.3 , pp. 241-256
    • Sili, U.1    Huls, M.H.2    Davis, A.R.3
  • 30
    • 0033755728 scopus 로고    scopus 로고
    • Dependence of adenovirus infectivity on length of the fiber shaft domain
    • Shayakhmetov DM, Lieber A. Dependence of adenovirus infectivity on length of the fiber shaft domain. J. Virol. 74(22), 10274-10286 (2000).
    • (2000) J. Virol , vol.74 , Issue.22 , pp. 10274-10286
    • Shayakhmetov, D.M.1    Lieber, A.2
  • 32
    • 0034654576 scopus 로고    scopus 로고
    • Vaccinia virus-related events and phenotypic changes after infection of dendritic cells derived from human monocytes
    • Drillien R, Spehner D, Bohbot A, Hanau D. Vaccinia virus-related events and phenotypic changes after infection of dendritic cells derived from human monocytes. Virology 268, 471-481 (2000).
    • (2000) Virology , vol.268 , pp. 471-481
    • Drillien, R.1    Spehner, D.2    Bohbot, A.3    Hanau, D.4
  • 33
    • 1842684059 scopus 로고    scopus 로고
    • Poxvirus vaccines for cancer and HIV therapy
    • Essajee S, Kaufman HL. Poxvirus vaccines for cancer and HIV therapy. Exp. Opinion Biol. Ther. 4(4), 575-588 (2004).
    • (2004) Exp. Opinion Biol. Ther , vol.4 , Issue.4 , pp. 575-588
    • Essajee, S.1    Kaufman, H.L.2
  • 34
    • 5444250395 scopus 로고    scopus 로고
    • Retroviral vectors: New applications for an old tool
    • Barquinero J, Eixarch H, Perez-Melgosa M. Retroviral vectors: new applications for an old tool. Gene Ther. 11(Suppl. 1), S3-S9 (2004).
    • (2004) Gene Ther , vol.11 , Issue.SUPPL. 1
    • Barquinero, J.1    Eixarch, H.2    Perez-Melgosa, M.3
  • 35
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • Thomas CE, Ehrhardt A, Kay MA. Progress and problems with the use of viral vectors for gene therapy. Nat. Rev. Genet. 4(5), 346-358 (2003).
    • (2003) Nat. Rev. Genet , vol.4 , Issue.5 , pp. 346-358
    • Thomas, C.E.1    Ehrhardt, A.2    Kay, M.A.3
  • 36
    • 0037333336 scopus 로고    scopus 로고
    • Latest development in viral vectors for gene therapy
    • Lundstrom K. Latest development in viral vectors for gene therapy. Trends Biotechnol. 21(3), 117-122 (2003).
    • (2003) Trends Biotechnol , vol.21 , Issue.3 , pp. 117-122
    • Lundstrom, K.1
  • 37
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S, Von Kalle C, Schmidt M et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302(5644), 415-419 (2003).
    • (2003) Science , vol.302 , Issue.5644 , pp. 415-419
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 39
    • 32844455349 scopus 로고    scopus 로고
    • Comparison of recombinant adenovirus and synthetic peptide for DC-based melanoma vaccination
    • Steitz J, Tormo D, Schweichel D, Tuting T. Comparison of recombinant adenovirus and synthetic peptide for DC-based melanoma vaccination. Cancer Gene Ther. 13, 318-325 (2006).
    • (2006) Cancer Gene Ther , vol.13 , pp. 318-325
    • Steitz, J.1    Tormo, D.2    Schweichel, D.3    Tuting, T.4
  • 40
    • 0041562478 scopus 로고    scopus 로고
    • MART-1 adenovirus-transduced dendritic cell immunization in a murine model of metastatic central nervous system tumor
    • Broder H, Anderson A, Kremen TJ, Odesa SK, Liau LM. MART-1 adenovirus-transduced dendritic cell immunization in a murine model of metastatic central nervous system tumor. J. Neuro-Oncol. 64, 21-30 (2003).
    • (2003) J. Neuro-Oncol , vol.64 , pp. 21-30
    • Broder, H.1    Anderson, A.2    Kremen, T.J.3    Odesa, S.K.4    Liau, L.M.5
  • 41
    • 0141996929 scopus 로고    scopus 로고
    • Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice
    • Okada N, Masunaga Y, Okada Y et al. Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice. Gene Ther. 10, 1891-1902 (2003).
    • (2003) Gene Ther , vol.10 , pp. 1891-1902
    • Okada, N.1    Masunaga, Y.2    Okada, Y.3
  • 42
    • 7444247986 scopus 로고    scopus 로고
    • Vaccination by genetically modified dendritic cells expressing a truncated neu oncogene prevents development of breast cancer in transgenic mice
    • Sakai Y, Morrison BJ, Burke JD et al. Vaccination by genetically modified dendritic cells expressing a truncated neu oncogene prevents development of breast cancer in transgenic mice. Cancer Res. 64, 8022-8028 (2004).
    • (2004) Cancer Res , vol.64 , pp. 8022-8028
    • Sakai, Y.1    Morrison, B.J.2    Burke, J.D.3
  • 43
    • 2542547503 scopus 로고    scopus 로고
    • Antitumor effect of intratumoral administration of bone marrow-derived dendritic cells transduced with wild-type p53 gene
    • Murakami T, Tokunaga N, Waku T et al. Antitumor effect of intratumoral administration of bone marrow-derived dendritic cells transduced with wild-type p53 gene. Clin. Cancer Res. 3871(10), 3871-3880 (2004).
    • (2004) Clin. Cancer Res , vol.3871 , Issue.10 , pp. 3871-3880
    • Murakami, T.1    Tokunaga, N.2    Waku, T.3
  • 44
    • 0141919560 scopus 로고    scopus 로고
    • Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity
    • Tatsumi T, Huang J, Gooding WE et al. Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity. Cancer Res. 63(19), 6378-6386 (2003).
    • (2003) Cancer Res , vol.63 , Issue.19 , pp. 6378-6386
    • Tatsumi, T.1    Huang, J.2    Gooding, W.E.3
  • 45
    • 0036566673 scopus 로고    scopus 로고
    • Type I interferons produced by dendritic cells promote their phenotypic and functional activation
    • Montoya M, Schiavoni G, Mattei F et al. Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood 99, 3263-3271 (2002).
    • (2002) Blood , vol.99 , pp. 3263-3271
    • Montoya, M.1    Schiavoni, G.2    Mattei, F.3
  • 46
    • 23444439371 scopus 로고    scopus 로고
    • Delivery of dendritic cells engineered to secrete IFN-α into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: Dependence on apoptotic pathways
    • Kuwashima N, Nishimura F, Eguchi J et al. Delivery of dendritic cells engineered to secrete IFN-α into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathways. J. Immunol. 175(4), 2730-2740 (2005).
    • (2005) J. Immunol , vol.175 , Issue.4 , pp. 2730-2740
    • Kuwashima, N.1    Nishimura, F.2    Eguchi, J.3
  • 47
    • 18844416079 scopus 로고    scopus 로고
    • Efficient transfer of PSA and PSMA cDNAs into DCs generates antibody and T cell antitumor responses in vivo
    • Medin JA, Liang SB, Whit-Shan Hou J, Kelley LS, Peace DJ, Fowler DH. Efficient transfer of PSA and PSMA cDNAs into DCs generates antibody and T cell antitumor responses in vivo. Cancer Gene Ther. 12, 540-551 (2005).
    • (2005) Cancer Gene Ther , vol.12 , pp. 540-551
    • Medin, J.A.1    Liang, S.B.2    Whit-Shan Hou, J.3    Kelley, L.S.4    Peace, D.J.5    Fowler, D.H.6
  • 48
    • 0034663035 scopus 로고    scopus 로고
    • Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro
    • Gruber A, Kan-Mitchell J, Kuhen KL, Mukai T, Wong-Staal F. Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro. Blood 96, 1327-1333 (2000).
    • (2000) Blood , vol.96 , pp. 1327-1333
    • Gruber, A.1    Kan-Mitchell, J.2    Kuhen, K.L.3    Mukai, T.4    Wong-Staal, F.5
  • 49
    • 20844459808 scopus 로고    scopus 로고
    • Modulation of human dendritic-cell function following transduction with viral vectors: Implications for gene therapy
    • Tan PH, Beutelspacher SC, Xue SA et al. Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy. Blood 105(10), 3824-3832 (2005).
    • (2005) Blood , vol.105 , Issue.10 , pp. 3824-3832
    • Tan, P.H.1    Beutelspacher, S.C.2    Xue, S.A.3
  • 50
    • 14844351569 scopus 로고    scopus 로고
    • Immunization with lentiviral vector-transduced dendritic cells induces strong and long-lasting T cell responses and therapeutic immunity
    • He Y, Zhang J, Mi Z, Robbins P, Falo LD Jr. Immunization with lentiviral vector-transduced dendritic cells induces strong and long-lasting T cell responses and therapeutic immunity. J. Immunol. 174, 3808-3817 (2005).
    • (2005) J. Immunol , vol.174 , pp. 3808-3817
    • He, Y.1    Zhang, J.2    Mi, Z.3    Robbins, P.4    Falo Jr., L.D.5
  • 51
    • 0035695838 scopus 로고    scopus 로고
    • Metharom P, Ellem K, Schmidt C, # Wei M. Lentiviral vector-mediated tyrosinase-related protein 2 gene transfer to dendritic cells for the therapy of melanoma. Hum. Gene Ther. 12, 2203-2213 (2001).
    • Metharom P, Ellem K, Schmidt C, # Wei M. Lentiviral vector-mediated tyrosinase-related protein 2 gene transfer to dendritic cells for the therapy of melanoma. Hum. Gene Ther. 12, 2203-2213 (2001).
  • 52
    • 0038379169 scopus 로고    scopus 로고
    • Immunotherapy of established tumors using bone marrow transplantation with antigen gene-modified hematopoietic stem cells
    • Cui Y, Kelleher E, Straley E et al. Immunotherapy of established tumors using bone marrow transplantation with antigen gene-modified hematopoietic stem cells. Nat. Med. 9(7), 952-958 (2003).
    • (2003) Nat. Med , vol.9 , Issue.7 , pp. 952-958
    • Cui, Y.1    Kelleher, E.2    Straley, E.3
  • 53
    • 11144254962 scopus 로고    scopus 로고
    • Shen L, Evel-Kabler K, Strube R, Chen SY. Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nat. Biotechnol. 22, 1546-1553 (2004). •• Demonstrates a novel method of enhancing antigen presentation for augmenting antitumor immune responses in a mouse model.
    • Shen L, Evel-Kabler K, Strube R, Chen SY. Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nat. Biotechnol. 22, 1546-1553 (2004). •• Demonstrates a novel method of enhancing antigen presentation for augmenting antitumor immune responses in a mouse model.
  • 54
    • 18444408146 scopus 로고    scopus 로고
    • Lentiviral vector-transduced dendritic cells induce specific T cell response in a nonhuman primate model
    • Kung SP, Bonifacino A, Metzger ME, Ringpis GE, Donahue RE. Lentiviral vector-transduced dendritic cells induce specific T cell response in a nonhuman primate model. Hum. Gene Ther. 16, 527-532 (2005).
    • (2005) Hum. Gene Ther , vol.16 , pp. 527-532
    • Kung, S.P.1    Bonifacino, A.2    Metzger, M.E.3    Ringpis, G.E.4    Donahue, R.E.5
  • 55
    • 0036482930 scopus 로고    scopus 로고
    • Generation of dendritic cells from human bone marrow mononuclear cells: Advantages for clinical application in comparison to peripheral blood monocyte derived cells
    • Bai L, Feuerer P, Beckhove V, Umansky V, Schirrmacher V. Generation of dendritic cells from human bone marrow mononuclear cells: advantages for clinical application in comparison to peripheral blood monocyte derived cells. Int. J. Oncol. 20, 247-253 (2002).
    • (2002) Int. J. Oncol , vol.20 , pp. 247-253
    • Bai, L.1    Feuerer, P.2    Beckhove, V.3    Umansky, V.4    Schirrmacher, V.5
  • 56
    • 0037347485 scopus 로고    scopus 로고
    • Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T-cell response against different types of tumors
    • Frolkisa M, Fischera MB, Wang Z, Lebkowski JS, Chiu CP, Majumdar AS. Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T-cell response against different types of tumors. Cancer Gene Ther. 10, 239-249 (2003).
    • (2003) Cancer Gene Ther , vol.10 , pp. 239-249
    • Frolkisa, M.1    Fischera, M.B.2    Wang, Z.3    Lebkowski, J.S.4    Chiu, C.P.5    Majumdar, A.S.6
  • 57
    • 0031914321 scopus 로고    scopus 로고
    • Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2
    • Agrawal B, Krantz MJ, Reddish MA, Longenecker BM. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nat. Med. 4, 43-49 (1998).
    • (1998) Nat. Med , vol.4 , pp. 43-49
    • Agrawal, B.1    Krantz, M.J.2    Reddish, M.A.3    Longenecker, B.M.4
  • 58
    • 0034856787 scopus 로고    scopus 로고
    • Adenovirusmediated MUC1 gene transduction into human blood-derived dendritic cells
    • Maruyama K, Akiyama Y, Nara-Ashizawa N et al. Adenovirusmediated MUC1 gene transduction into human blood-derived dendritic cells. J. Immunother. 24(4), 345-353 (2001).
    • (2001) J. Immunother , vol.24 , Issue.4 , pp. 345-353
    • Maruyama, K.1    Akiyama, Y.2    Nara-Ashizawa, N.3
  • 59
    • 4344624918 scopus 로고    scopus 로고
    • Human dendritic cell maturation by adenovirus transduction enhances tumor antigen-specific T-cell responses
    • Schumacher L, Ribas A, Dissette VB et al. Human dendritic cell maturation by adenovirus transduction enhances tumor antigen-specific T-cell responses. J. Immunother. 27(3), 191-200 (2004).
    • (2004) J. Immunother , vol.27 , Issue.3 , pp. 191-200
    • Schumacher, L.1    Ribas, A.2    Dissette, V.B.3
  • 61
    • 0035136173 scopus 로고    scopus 로고
    • Dendritic cells transduced with fulllength wild-type p53 generate antitumor cytotoxic T lymphocytes from peripheral blood of cancer patients
    • Nikitina EY, Clark JI, Van Beynen J et al. Dendritic cells transduced with fulllength wild-type p53 generate antitumor cytotoxic T lymphocytes from peripheral blood of cancer patients. Clin. Cancer Res. 7(1), 127-135 (2001).
    • (2001) Clin. Cancer Res , vol.7 , Issue.1 , pp. 127-135
    • Nikitina, E.Y.1    Clark, J.I.2    Van Beynen, J.3
  • 62
    • 0035424915 scopus 로고    scopus 로고
    • The generation of both T killer and Th cell clones specific for the tumor-associated antigen HER2 using retrovirally transduced dendritic cells
    • Meyer zum Buschenfelde C, Metzger J, Hermann C, Nicklisch N, Peschel C, Bernhard H. The generation of both T killer and Th cell clones specific for the tumor-associated antigen HER2 using retrovirally transduced dendritic cells. J. Immunol. 167, 1712-1719 (2001).
    • (2001) J. Immunol , vol.167 , pp. 1712-1719
    • Meyer zum Buschenfelde, C.1    Metzger, J.2    Hermann, C.3    Nicklisch, N.4    Peschel, C.5    Bernhard, H.6
  • 63
    • 0036371235 scopus 로고    scopus 로고
    • Use of a lentiviral flap vector for induction of CTL immunity against melanoma. Perspectives for immunotherapy
    • Firat H, Zennou V, Garcia-Pons F et al. Use of a lentiviral flap vector for induction of CTL immunity against melanoma. Perspectives for immunotherapy. J. Gene Med. 4, 38-45 (2002).
    • (2002) J. Gene Med , vol.4 , pp. 38-45
    • Firat, H.1    Zennou, V.2    Garcia-Pons, F.3
  • 64
    • 0842312143 scopus 로고    scopus 로고
    • Lentivirally transduced dendritic cells as a tool for cancer immunotherapy
    • Breckpot K, Dullaers M, Bonehill A et al. Lentivirally transduced dendritic cells as a tool for cancer immunotherapy. J. Gene Med. 5, 654-667 (2003).
    • (2003) J. Gene Med , vol.5 , pp. 654-667
    • Breckpot, K.1    Dullaers, M.2    Bonehill, A.3
  • 65
    • 20044366384 scopus 로고    scopus 로고
    • Use and specificity of breast cancer antigen/milk protein BA46 for generating anti-self-cytotoxic T lymphocytes by recombinant adeno-associated virus-based gene loading of dendritic cells
    • Liu Y, Chiriva-Internati M, You C et al. Use and specificity of breast cancer antigen/milk protein BA46 for generating anti-self-cytotoxic T lymphocytes by recombinant adeno-associated virus-based gene loading of dendritic cells. Cancer Gene Ther. 12, 304-312 (2005).
    • (2005) Cancer Gene Ther , vol.12 , pp. 304-312
    • Liu, Y.1    Chiriva-Internati, M.2    You, C.3
  • 66
    • 0036605994 scopus 로고    scopus 로고
    • Immunogenicity of a p210BCR-ABL fusion domain candidate DNA vaccine targeted to dendritic cells by a recombinant adeno-associated virus vector in vitro
    • Sun J-Y, Krouse RS, Forman SJ et al. Immunogenicity of a p210BCR-ABL fusion domain candidate DNA vaccine targeted to dendritic cells by a recombinant adeno-associated virus vector in vitro. Cancer Res. 62, 3175-3183 (2002).
    • (2002) Cancer Res , vol.62 , pp. 3175-3183
    • Sun, J.-Y.1    Krouse, R.S.2    Forman, S.J.3
  • 67
    • 0036147989 scopus 로고    scopus 로고
    • Efficient generation of cytotoxic T lymphocytes against cervical cancer cells by adeno-associated virus/human papillomavirus type 16 E7 antigen gene transduction into dendritic cells
    • Chiriva-Internati M, Liu Y, Salati E et al. Efficient generation of cytotoxic T lymphocytes against cervical cancer cells by adeno-associated virus/human papillomavirus type 16 E7 antigen gene transduction into dendritic cells. Eur. J. Immunol. 32, 30-38 (2002).
    • (2002) Eur. J. Immunol , vol.32 , pp. 30-38
    • Chiriva-Internati, M.1    Liu, Y.2    Salati, E.3
  • 68
    • 0142245614 scopus 로고    scopus 로고
    • Testing recombinant adeno-associated virus-gene loading of dendritic cells for generating potent cytotoxic T lymphocytes against a prototype self-antigen, multiple myeloma HM1.24
    • Chiriva-Internati M, Liu Y, Weidanz JA et al. Testing recombinant adeno-associated virus-gene loading of dendritic cells for generating potent cytotoxic T lymphocytes against a prototype self-antigen, multiple myeloma HM1.24. Blood 102, 3100-3107 (2003).
    • (2003) Blood , vol.102 , pp. 3100-3107
    • Chiriva-Internati, M.1    Liu, Y.2    Weidanz, J.A.3
  • 69
    • 0035425003 scopus 로고    scopus 로고
    • Cross-presentation by dendritic cells of tumor antigen expressed in apoptotic recombinant Canarypox virus-infected dendritic cells
    • Motta I, Andre F, Lim A et al. Cross-presentation by dendritic cells of tumor antigen expressed in apoptotic recombinant Canarypox virus-infected dendritic cells. J. Immunol. 167, 1795-1802 (2001).
    • (2001) J. Immunol , vol.167 , pp. 1795-1802
    • Motta, I.1    Andre, F.2    Lim, A.3
  • 70
    • 0034766337 scopus 로고    scopus 로고
    • Transduction of human dendritic cells with a recombinant modified vaccinia Ankara virus encoding MUC1 and IL-2
    • Trevor KT, Hersh EM, Brailey J, Balloul JM, Acres B. Transduction of human dendritic cells with a recombinant modified vaccinia Ankara virus encoding MUC1 and IL-2. Cancer Immunol. Immunother. 50(8), 397-407 (2001).
    • (2001) Cancer Immunol. Immunother , vol.50 , Issue.8 , pp. 397-407
    • Trevor, K.T.1    Hersh, E.M.2    Brailey, J.3    Balloul, J.M.4    Acres, B.5
  • 71
    • 32944468708 scopus 로고    scopus 로고
    • Antonia SJ, Mirza N, Fricke I et al. Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin. Cancer Res. 12(3 Pt 1), 878-887 (2006). •• Illustrates the benefit of merging DC-mediated immunotherapy with a conventional treatment modality in a clinical setting.
    • Antonia SJ, Mirza N, Fricke I et al. Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin. Cancer Res. 12(3 Pt 1), 878-887 (2006). •• Illustrates the benefit of merging DC-mediated immunotherapy with a conventional treatment modality in a clinical setting.
  • 72
    • 4143110212 scopus 로고    scopus 로고
    • +-derived dendritic cell vaccination: A Phase I trial in metastatic melanoma
    • +-derived dendritic cell vaccination: a Phase I trial in metastatic melanoma. Clin. Cancer Res. 10(16), 5381-5390 (2004).
    • (2004) Clin. Cancer Res , vol.10 , Issue.16 , pp. 5381-5390
    • Di Nicola, M.1    Carlo-Stella, C.2    Mortarini, R.3
  • 73
    • 20244383301 scopus 로고    scopus 로고
    • Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules
    • Morse MA, Clay TM, Hobeika AC et al. Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules. Clin. Cancer Res. 11(8), 3017-3024 (2005).
    • (2005) Clin. Cancer Res , vol.11 , Issue.8 , pp. 3017-3024
    • Morse, M.A.1    Clay, T.M.2    Hobeika, A.C.3
  • 74
    • 0037989796 scopus 로고    scopus 로고
    • T-cell immune responses in the brain and their relevance for cerebral malignancies
    • Walker PR, Calzascia T, de Tribolet N, Dietrich PY. T-cell immune responses in the brain and their relevance for cerebral malignancies. Brain Res. Rev. 42(2), 97-122 (2003).
    • (2003) Brain Res. Rev , vol.42 , Issue.2 , pp. 97-122
    • Walker, P.R.1    Calzascia, T.2    de Tribolet, N.3    Dietrich, P.Y.4
  • 75
    • 33744968445 scopus 로고    scopus 로고
    • Breaking ignorance: The case of the brain
    • Wekerle H. Breaking ignorance: the case of the brain. Curr. Top. Microbiol. Immunol. 305, 25-50 (2006).
    • (2006) Curr. Top. Microbiol. Immunol , vol.305 , pp. 25-50
    • Wekerle, H.1
  • 76
    • 2642577695 scopus 로고    scopus 로고
    • Current issues in delivering DCs for immunotherapy
    • Barratt-Boyes SM, Figdor CG. Current issues in delivering DCs for immunotherapy. Cytotherapy 6(2), 105-110 (2004).
    • (2004) Cytotherapy , vol.6 , Issue.2 , pp. 105-110
    • Barratt-Boyes, S.M.1    Figdor, C.G.2
  • 77
    • 0034662858 scopus 로고    scopus 로고
    • Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice
    • Pirtskhalaishvili G, Shurin GV, Gambotto A et al. Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice. J. Immunol. 165(4), 1956-1964 (2000).
    • (2000) J. Immunol , vol.165 , Issue.4 , pp. 1956-1964
    • Pirtskhalaishvili, G.1    Shurin, G.V.2    Gambotto, A.3
  • 78
    • 33744775341 scopus 로고    scopus 로고
    • The boosting effect of co-transduction with cytokine genes on cancer vaccine therapy using genetically modified dendritic cells expressing tumor-associated antigen
    • Ojima T, Iwahashi M, Nakamura M et al. The boosting effect of co-transduction with cytokine genes on cancer vaccine therapy using genetically modified dendritic cells expressing tumor-associated antigen. Int. J. Oncol. 28(4), 947-953 (2006).
    • (2006) Int. J. Oncol , vol.28 , Issue.4 , pp. 947-953
    • Ojima, T.1    Iwahashi, M.2    Nakamura, M.3
  • 79
    • 0345734266 scopus 로고    scopus 로고
    • Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration
    • Teitz-Tennenbaum S, Li Q, Rynkiewicz S et al. Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res. 63(23), 8466-8475 (2003).
    • (2003) Cancer Res , vol.63 , Issue.23 , pp. 8466-8475
    • Teitz-Tennenbaum, S.1    Li, Q.2    Rynkiewicz, S.3
  • 80
    • 14744275172 scopus 로고    scopus 로고
    • Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma
    • Chi KH, Liu SJ, Li CP et al. Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J. Immunother. 28(2), 129-135 (2005).
    • (2005) J. Immunother , vol.28 , Issue.2 , pp. 129-135
    • Chi, K.H.1    Liu, S.J.2    Li, C.P.3
  • 81
    • 33644660741 scopus 로고    scopus 로고
    • Immune regulation in tumor-bearing hosts
    • Baecher-Allan C, Anderson DE. Immune regulation in tumor-bearing hosts. Curr. Opin. Immunol. 18(2), 214-219 (2006).
    • (2006) Curr. Opin. Immunol , vol.18 , Issue.2 , pp. 214-219
    • Baecher-Allan, C.1    Anderson, D.E.2
  • 82
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science 299, 1033-1036 (2003).
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 83
    • 2442655250 scopus 로고    scopus 로고
    • Yang Y, Huang CT, Huang X, Pardoll DM. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat. Immunol. 5, 508-515 (2004). •• Reveals an important mechanism by which DCs can help overcome a tolerant environment.
    • Yang Y, Huang CT, Huang X, Pardoll DM. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat. Immunol. 5, 508-515 (2004). •• Reveals an important mechanism by which DCs can help overcome a tolerant environment.
  • 85
    • 30144444279 scopus 로고    scopus 로고
    • Dannull J, Su Z, Rizzieri D et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J. Clin Invest. 115(12), 3623-3633 (2005). •• Provides a good example of how reducing the levels of regulatory T cells in cancer patients can improve the antitumor effects of immunotherapy.
    • Dannull J, Su Z, Rizzieri D et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J. Clin Invest. 115(12), 3623-3633 (2005). •• Provides a good example of how reducing the levels of regulatory T cells in cancer patients can improve the antitumor effects of immunotherapy.
  • 86
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5(4), 263-274 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.4 , pp. 263-274
    • Zou, W.1


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