Citrate and mineral metabolism: Kidney stones and bone disease

Frontiers in Bioscience

Volumn 8, Issue SUPPL., 2003, Pages

  Renata, Caudarella ^a,b   Fabio, Vescini ^a   Angela, Buffa ^a   Sergio, Stefoni ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Dipto Med Clin Biotecnologia A   (Italy)

Author keywords

Alkali therapy; Bone mass; Dietary Influences; Gastrointestinal Alkali Absorption; Kidney stones; Osteopenia; Review; Urinary citrate excretion; Urolithiasis

Indexed keywords

ACETAZOLAMIDE; ALKALI; CITRATE CALCIUM; CITRATE POTASSIUM; CITRATE POTASSIUM SODIUM; CITRATE SODIUM; CITRIC ACID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MINERAL; POTASSIUM DERIVATIVE; POTASSIUM MAGNESIUM CITRATE; PROTEIN; SODIUM CHLORIDE; THIAZIDE DIURETIC AGENT; UNCLASSIFIED DRUG;

BLOOD LEVEL; BONE DISEASE; BONE MASS; CITRIC ACID CYCLE; CONSERVATIVE TREATMENT; CRYSTALLIZATION; CYTOSOL; DIET; DIFFERENTIAL DIAGNOSIS; DRUG INDICATION; DRUG RESPONSE; GASTROINTESTINAL ABSORPTION; HUMAN; HYPOCITRATURIA; HYPOKALEMIA; INCIDENCE; INTESTINE ABSORPTION; KIDNEY; KIDNEY TUBULE ACIDOSIS; KIDNEY TUBULE CELL; METABOLISM; MODULATION; NEPHROLITHIASIS; NONHUMAN; OSTEOPENIA; PATHOPHYSIOLOGY; REVIEW; STONE FORMATION; SUPPLEMENTATION; URINARY EXCRETION; UROLITHIASIS; ANIMAL;

ANIMALS; BONE DISEASES; CITRIC ACID; HUMANS; KIDNEY CALCULI; MINERALS;

EID: 3142723570     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1119     Document Type: Review

References (241)

1. Hamm LL: Citrate handling by the kidney. Kidney Int 38, 728-735 (1990)
2. Walser M: Ion association. VI. Interactions between calcium, magnesium, inorganic phosphate, citrate and protein in normal human plasma. J Clin Invest 40, 723-730 (1961)
3. M Walser: Divalent cations: physiochemical state in glomerular filtrate and urine and renal excretion. In: Handbook of physiology. Eds: Orloff J, Berliner RW, American Physiology Society, Washington DC 909-1001 (1973)
4. Simpson DP & S. R. Hager: pH and bicarbonate effects on mitochondrial anion accumulation. Proposed mechanism for changes in renal metabolite levels in acute acid-base disturbances. J Clin Invest 63, 704-712 (1979)
5. Srere PA: The molecular physiology of citrate. Curr Top Cell Regul 33, 261-275 (1992)
6. Melnick JZ, P. A. Srere, N. A. Elshourbagy, O. W. Moe, P. A. Preisig & R. J. Alpern: Adenosine triphosphate citrate lyase mediates hypocitraturia in rats. J Clin Invest 98, 2381-2387 (1996)
7. Elshourbagy NA, J. C. Near, P. J. Kmetz, G. M. Sathe, C. Southan, J. E. Strickler, M. Gross, J. F. Young, T. N. Wells & P. H. Groot: Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age. J Biol Chem 265, 1430-1435 (1990)
8. Kim KS, J. G. Kang, Y. A. Moon, S. W. Park & Y. S. Kim: Regulation of ATP-citrate lyase gene transcription. Yonsei Med J 37, 214-224 (1996)
9. Potapova IA, M. R. El-Maghrabi, S. V. Doronin & W. B. Benjamin: Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars. Biochemistry 39, 1169-1179 (2000)
10. LL Hamm & RJ Alpern: Regulation of Acid-Base Balance, Citrate, and Urine pH. In: Kidney Stones: Medical and Surgical Management. Eds: Coe FL., Favus MJ, Pak CYC, Park JH, Preminger GM, Lippincott-Raven, Philadelphia 1, 289-302 (1996)
11. Cooke RE, W. E. Segar & C. Reed: The role of potassium in the prevention of alkaloses. Am J Med 17, 180-195 (1954)
12. Kaufman AM, C. Brod-Miller & T. Kahn: Role of citrate excretion in acid-base balance in diuretic-induced alkalosis in the rat. Am J Physiol 248, F796-803 (1985)
13. Hamm LL & E. E. Simon: Roles and mechanisms of urinary buffer excretion. Am J Physiol 253, F595-605 (1987)
14. Kaufman AM & T. Kahn: Complementary role of citrate and bicarbonate excretion in acid-base balance in the rat. Am J Physiol 255, F182-187 (1988)
15. Brown JC, R. K. Packer & M. A. Knepper: Role of organic anions in renal response to dietary acid and base loads. Am J Physiol 257, F170-176 (1989)
16. Brennan S, S. Klahr & L. L. Hamm: Citrate transport in rabbit nephron. Am J Physiol 251, F683-689 (1986)
17. Baruch SB, R. L. Burich, C. K. Eun & V. F. King: Renal metabolism of citrate. Med Clin North Am 59, 569-582 (1975)
18. Simpson DP: Citrate excretion: a window on renal metabolism. Am J Physiol 244, F223-234 (1983)
19. Minisola S, W. Rossi, M. T. Pacitti, L. Scarnecchia, F. Bigi, V. Carnevale & G. Mazzuoli: Studies on citrate metabolism in normal subjects and kidney stone patients. Miner Electrolyte Metab 15, 303-308 (1989)
20. Pajor AM: Citrate transport by the kidney and intestine. Semin Nephrol 19, 195-200 (1999)
21. Wright SH, I. Kippen & E. M. Wright: Effect of pH on the transport of Krebs cycle intermediates in renal brush border membranes. Biochim Biophys Acta 684, 287-290 (1982)
22. Grassl SM, E. Heinz & R. Kinne: Effect of K+ and H+ on sodium/citrate cotransport in renal brush-border vesicles. Biochim Biophys Acta 736, 178-188 (1983)
23. Brennan S, K. Hering-Smith & L. L. Hamm: Effect of pH on citrate reabsorption in the proximal convoluted tubule. Am J Physiol 255, F301-306 (1988)
24. Barac-Nieto M: Effects of pH, calcium, and succinate on sodium citrate cotransport in renal microvilli. Am J Physiol 247, F282-290 (1984)
25. Rudman D, J. L. Dedonis, M. T. Fountain, J. B. Chandler, G. G. Gerron, G. A. Fleming & M. H. Kutner: Hypocitraturia in patients with gastrointestinal malabsorption. N Engl J Med 303, 657-661 (1980)
26. Klein KL, M. S. Wang, S. Torikai, W. D. Davidson & K. Kurokawa: Substrate oxidation by isolated single nephron segments of the rat. Kidney Int 20, 29-35 (1981)
27. Greger R, C. Weidtke, E. Schlatter, M. Wittner & B. Gebler: Potassium activity in cells of isolated perfused cortical thick ascending limbs of rabbit kidney. Pflugers Arch 401, 52-57 (1984)
28. Wittner M, C. Weidtke, E. Schlatter, A. Di Stefano & R. Greger: Substrate utilization in the isolated perfused cortical thick ascending limb of rabbit nephron. Pflugers Arch 402, 52-62 (1984)
29. Anaizi NH, J. J. Cohen, A. J. Black & S. J. Wertheim: Renal tissue citrate: independence from citrate utilization, reabsorption, and pH. Am J Physiol 251, F547-561 (1986)
30. Melnick JZ, O. W. Moe & P. A. Srere: Chronic metabolic acidosis causes an adaptive increase in renal ATP citrate lyase activity. J Am Soc Nephrol 5, 870 (1994)
31. MABridges & MR Mattice: Food and Beverage Analysis. Lea and Febiger, Philadelphia (1942)
32. Sakhaee K, R. Alpern, J. Poindexter & C. Y. C. Pak: Citraturic response to oral citric acid load. J Urol 147, 975-976 (1992)
33. Piper DW, B. H. Fenton & L. R. Goodman: Lactic, pyruvic, citric, and uric acid and urea content of human gastric juice. Gastroenterology 53, 42-48 (1967)
34. Lohse J, H. J. Verine, J. J. Charbit & H. Sarles: Studies on pancreatic stones. II. Citrate secretion in the canine pancreatic juice. Digestion 21, 198-204 (1981)
35. Browne JL, P. A. Sanford & D. H. Smyth: Transfer and metabolism of citrate, succinate, alpha-ketoglutarate and pyruvate by hamster small intestine. Proc R Soc Lond B Biol Sci 200, 117-135 (1978)
36. Wolffram S, R. Unternahrer, B. Grenacher & E. Scharrer: Transport of citrate across the brush border and basolateral membrane of rat small intestine. Comp Biochem Physiol Physiol 109, 39-52 (1994)
37. Fegan J, R. Khan, J. Poindexter & C. Y. C. Pak: Gastrointestinal citrate absorption in nephrolithiasis. J Urol 147, 1212-1214 (1992)
38. Sakhaee K, R. Alpern, H. R. Jacobson & C. Y. C. Pak: Contrasting effects of various potassium salts on renal citrate excretion. J Clin Endocrinol Metab 72, 396-400 (1991)
39. Sakhaee K, R. H. Williams, M. S. Oh, P. Padalino, B. Adams-Huet, P. Whitson & C. Y. C. Pak: Alkali absorption and citrate excretion in calcium nephrolithiasis. J Bone Miner Res 8, 789-794 (1993)
40. Molitoris BA, D. H. Froment, T. A. Mackenzie, W. H. Huffer & A. C. Alfrey: Citrate: a major factor in the toxicity of orally administered aluminum compounds. Kidney Int 36, 949-953 (1989)
41. Wright EM: Transport of carboxylic acids by renal membrane vesicles. Annu Rev Physiol 47, 127-141 (1985)
42. Wright SH, B. Hirayama, J. D. Kaunitz, I. Kippen & E. M. Wright: Kinetics of sodium succinate cotransport across renal brush-border membranes. J Biol Chem 258, 5456-5462 (1983)
43. Hirayama B & E. M. Wright: Coupling between sodium and succinate transport across renal brush border membrane vesicles. Pflugers Arch 407 Suppl 2, S174-179 (1986)
44. Wright EM, S. H. Wright, B. Hirayama & I. Kippen: Interactions between lithium and renal transport of Krebs cycle intermediates. Proc Natl Acad Sci U S A 79, 7514-7517 (1982)
45. Jorgensen KE, U. Kragh-Hansen, H. Roigaard-Petersen & M. I. Sheikh: Citrate uptake by basolateral and luminal membrane vesicles from rabbit kidney cortex. Am J Physiol 244, F686-695 (1983)
46. Law D, K. S. Hering-Smith & L. L. Hamm: Citrate transport in proximal cell line. Am J Physiol 263, C220-225 (1992)
47. Kippen I, J. R. Klinenberg & E. M. Wright: Effects of metabolic intermediates on sugar and amino acid uptake in rabbit renal tubules and brush border membranes. J Physiol 304, 373-387 (1980)
48. Scharer K & F. Manz: Renal handling of citrate in children with various kidney disorders. Int J Pediatr Nephrol 6, 79-88 (1985)
49. Nielsen TT & N. S. Sorensen: Citrate in plasma and urine during total fasting. Acta Med Scand 205, 303-307 (1979)
50. Lemann J Jr, W. F. Piering & E. J. Lennon: Possible role of carbohydrate-induced calciuria in calcium oxalate kidney-stone formation. N Engl J Med 280, 232-237 (1969)
51. Adler S, B. Zett, B. Anderson & D. S. Fraley: Effect of volume expansion on renal citrate and ammonia metabolism in KCl-deficient rats. J Clin Invest 56, 391-400 (1975)
52. Adam WR, A. P. Koretsky & M. W. Weiner: 31P-NMR in vivo measurement of renal intracellular pH: effects of acidosis and K+ depletion in rats. Am J Physiol 251, F904-910 (1986)
53. Shorr E, A. R. Berscheim & H. Taussky: The relation between the urinary citric acid excretion to the menstrual cycle and the steroidal reproductive hormones. Science 95, 606-607 (1942)
54. De Luca HF, F. C. Gran & H. Steenbock: Vitamin D and citrate oxidation. J Biol Chem 224, 201-208 (1957)
55. Karam J, M. T. Harrison, M. Hartog & R. Fraser: Renal citrate and urinary calcium excretion. Effects of growth hormone contrasted with those of sodium fluoracetate. Clin Sci 21, 265-272 (1961)
56. Hodgkinson A: Citric acid excretion in normal adults and in patients with renal calculi. Clin Sci 23, 203-212 (1962)
57. Hodgkinson A: The relation between citric acid and calcium metabolism with particular reference to primary hyperparathyroidism and idiopathic hypercalciuria. Clin Sci 24, 167-178 (1963)
58. Pak CYC, H. F. DeLuca, F. C. Bartter, D. H. Henneman, B. Frame, A. Simopoulos & C. S. Delea: Treatment of vitamin D-resistant rickets with 25-hydroxycholecalciferol. Arch Intern Med 129, 894-899 (1972)
59. Schwille PO, D. Scholz, K. Schwille, R. Leutschaft, I. Goldberg & A. Sigel: Citrate in urine and serum and associated variables in subgroups of urolithiasis. Results from an outpatient stone clinic. Nephron 31, 194-202 (1982)
60. Lichtwitz A, D. Mioco, R. Parlier & S. De Seze: Acide citrique et métabolisme cardiaque. Presse Méd 59, 5-8 and 51-54 (1961)
61. Canary JJ, C. R. Meloni, D. Clive & E. Grossmann: The renal clearance of citrate in men. Metabolism 13, 356-360 (1964)
62. Harrison C, H. E. Harrison & E. A. Park: Vitamin D and citrate metabolism. Am J Physiol 192, 432-436 (1958)
63. Menon M & C. J. Mahle: Urinary citrate excretion in patients with renal calculi. J Urol 129, 1158-1160 (1983)
64. Gordon EE: The metabolism of citrate-C14 in normal and in fluoroinhibitor-poisoned rats. J Clin Invest 40, 1719-1726 (1961)
65. Jenkins AD, T. P. Dousa & L. H. Smith: Transport of citrate across renal brush border membrane: effects of dietary acid and alkali loading. Am J Physiol 249, F590-595 (1985)
66. Windus DW, D. E. Cohn & M. Heifets: Effects of fasting on citrate transport by the brush-border membrane of rat kidney. Am J Physiol 251, F678-682 (1986)
67. Sato K, S. Nishibuchi & K. Okada: [Effect of high-dose thiazide treatment and low-K diet on citrate uptake by rat renal brush border membrane vesicles (BBMV)]. Nippon Jinzo Gakkai Shi 35, 1115-1121 (1993)
68. Chan YL, B. Biagi & G. Giebisch: Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule. Am J Physiol 242, F532-543 (1982)
69. Levi M, L. A. McDonald, P. A. Preisig & R. J. Alpern: Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter. Am J Physiol 261, F767-773 (1991)
70. Parfitt AM: Acetazolamide and sodium bicarbonate induced nephrocalcinosis and nephrolithiasis; relationship to citrate and calcium excretion. Arch Intern Med 124, 736-740 (1969)
71. Nicar MJ, R. Peterson & C. Y. C. Pak: Use of potassium citrate as potassium supplement during thiazide therapy of calcium nephrolithiasis. J Urol 131, 430-433 (1984)
72. Melnick JZ, P. A. Preisig, S. Haynes, C. Y. C. Pak, K. Sakhaee & R. J. Alpern: Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia. Kidney Int 54, 1670-1674 (1998)
73. Bomsztyk K, J. P. George & F. S. Wright: Effects of luminal fluid anions on calcium transport by proximal tubule. Am J Physiol 246, F600-608 (1984)
74. Borensztein P, P. Patron, M. Bichara, J. P. Gardin & M. Paillard: Effects of citrate on urinary calcium excretion. Miner Electrolyte Melab 15, 353-358 (1989)
75. Bond PA & F. A. Jenner: The effect of lithium and related metal ions on the urinary excretion of 2-oxoglutarate and citrate in the rat. Br J Pharmacol 50, 283-289 (1974)
76. Ullrich KJ, H. Fasold, G. Rumrich & S. Kloss: Secretion and contraluminal uptake of dicarboxylic acids in the proximal convolution of rat kidney. Pflugers Arch 400, 241-249 (1984)
77. Burckhardt G: Sodium-dependent dicarboxylate transport in rat renal basolateral membrane vesicles. Pflugers Arch 401, 254-261 (1984)
78. Bond PA, F. A. Jenner, C. R. Lee, E. Lenton, R. J. Pollitt & G. A. Sampson: The effect of lithium salts on the urinary excretion of -oxoglutarate in man. Br J Pharmacol 46, 116-123 (1972)
79. Yusufi AN, S. Christensen & T. P. Dousa: Effect of chronic lithium treatment upon the Na-coupled transporters in renal brush border membranes. Kidney Int 43, 1047-1080 (1993)
80. Caudarella R, R. Miniero, E. Rizzoli, N. Copertari, A. Buffa, C. Perna & N. Malavolta: Urinary citrate excretion in healthy women before and after menopause. Ital J Mineral Electrolyte Metab 9, 31-38 (1995)
81. Luben RA & D. V. Cohn: Effects of parathormone and calcitonin on citrate and hyaluronate metabolism in cultured bone. Endocrinology 98, 413-419 (1976)
82. Price PA, M. K. Williamson & S. A. Sloper: 1,25-Dihydroxyvitamin D3 increases citrate secretion from osteosarcoma cells. J Biol Chem 259, 2537-2540 (1984)
83. Morikawa M, M. Okuyama, H. Yoshihara, S. Yamaguchi & S. Yachiku: [A study of the differences between the sexes in epidemiology of urolithiasis]. Nippon Hinyokika Gakkai Zasshi 89, 538-545 (1998)
84. Pyrah LN: Renal calculus. Berlin Heidelberg (1979)
85. Ljuchall S: Incidence of renal stones in western countries. In: Urolithiasis and related clinical research. Eds: Schwuille PO, Robertson WG, Vahlensieck W, Plenum Press, New York 31-37 (1985)
86. Williams RE: The natural history of renal lithiasis. In: Proceedings of the renal stone research symposium Eds: Hodgkinson A, Nordin BE, Churchill, London 65 (1969)
87. Tawashi R, M. Cousineau & G. Denis: Calcium oxalate crystal growth in normal urine: role of contraceptive hormones. Urol Res 12, 7-9 (1984)
88. Dey J, A. Creighton, J. S. Lindberg, H. A. Fuselier, D. J. Kok, F. E. Cole & L. L. Hamm: Estrogen replacement increased the citrate and calcium excretion rates in postmenopausal women with recurrent urolithiasis. J Urol 167, 169-171 (2002)
89. Caudarella R, F. Stefani, E. Rizzoli, R. Miniero, N. Malavolta & G. Sprovieri: Urinary citrate excretion in postmenopausal women. Fourth International Symposium on Osteoporosis & Consensus Conference, Hong Kong, 27 March-2 April. 1, 151 (1993)
90. Schwille PO, D. Scholz, M. Paulus, W. Engelhardt & A. Sigel: Citrate in daily and fasting urine: results of controls, patients with recurrent idiopathic calcium urolithiasis, and primary hyperparathyroidism. Invest Urol 16, 457-462 (1979)
91. Hosking DH, J. W. Wilson, R. R. Liedtke, L. H. Smith & D. M. Wilson: Urinary citrate excretion in normal persons and patients with idiopathic calcium urolithiasis. J Lab Clin Med 106, 682-689 (1985)
92. Garcia DA & E. R. Yendt: The effects of probenecid and thiazides and their combination on the urinary excretion of electrolytes and on acid-base equilibrium. Can Med Assoc J 103, 473-483 (1970)
93. Pak CYC: Citrate and renal calculi: new insights and future directions. Am J Kidney Dis 17, 420-425 (1991)
94. Dickens F: The citric acid content of animal tissues, with reference to its occurrence in bone and tumor. Biochem J 35, 1011-1023 (1941)
95. Pak CYC & E. C. Diller: Ionic interaction with bone mineral. V. Effect of Mg2+, Citrate3-, F- and SO4 negative 2 ion on the solubility, dissolution and growth of bone mineral. Calcif Tissue Res 4, 69-77 (1969)
96. Heaney RP, R. R. Recker & P. D. Saville: Menopausal changes in calcium balance performance. J Lab Clin Med 92, 953-963 (1978)
97. Barcelo P, O. Wuhl, E. Servitge, A. Rousaud & C. Y. Pak: Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol 150, 1761-1764 (1993)
98. Hofbauer J, K. Hobarth, N. Szabo & M. Marberger: Alkali citrate prophylaxis in idiopathic recurrent calcium oxalate urolithiasis - a prospective randomized study. Br J Urol 73, 362-365 (1994)
99. Ettinger B, C. Y. C. Pak, J. T. Citron, C. Thomas, B. Adams-Huet & A. Vangessel: Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. J Urol 158, 2069-2073 (1997)
100. Pak CYC, R. D. Peterson & J. Poindexter: Prevention of spinal bone loss by potassium citrate in cases of calcium urolithiasis. J Urol 168, 31-34 (2002)
101. Martini LA, L. Cuppari, F. A. Colugnati, D. M. Sigulem, V. L. Szejnfeld, N. Schor & I. P. Heilberg: High sodium chloride intake is associated with low bone density in calcium stone-forming patients. Clin Nephrol 54, 85-93 (2000)
102. Muhlbauer RC, A. Lozano & A. Reinli: Onion and a mixture of vegetables, salads, and herbs affect bone resorption in the rat by a mechanism independent of their base excess. J Bone Miner Res 17, 1230-1236 (2002)
103. Sellmeyer DE, M. Schloetter & A. Sebastian: Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab 87, 2008-2012 (2002)
104. Nordin BE, A. G. Need, H. A. Morris & M. Horowitz: The nature and significance of the relationship between urinary sodium and urinary calcium in women. J Nutr 123, 1615-1622 (1993)
105. Barzel US: The skeleton as an ion exchange system: implications for the role of acid-base imbalance in the genesis of osteoporosis. J Bone Miner Res 10, 1431-1436 (1995)
106. Osther PJ, J. Bollerslev, A. B. Hansen, K. Engel & P. Kildeberg: Pathophysiology of incomplete renal tubular acidosis in recurrent renal stone formers: evidence of disturbed calcium, bone and citrate metabolism. Urol Res 21, 169-173 (1993)
107. A Fournier, A Ghazali, P Bataille, M Cohen Solal, A Marie, M Brazier, JL Sebert & L Prin: Bone involvement in idiopathic calcium-stone formers. In: Kidney stones: medical and surgical management. Eds: Coe FL, Favus MJ, Pak CYC, Parks JH, Preminger GM, Lippincot-Raven, Philadelphia 921-938 (1996)
108. Caudarella R, A. Buffa, E. Rizzoli, G. P. Bianchi & F. Vescini: Is there a link between low urinary citrate excretion and vertebral fractures in postmenopausal females? Ital J Mineral Electrolyte Metab 14, 11 (2000)
109. Sebastian A, S. T. Harris, J. H. Ottaway, K. M. Todd & R. C. Morris, Jr.: Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 330, 1776-1781 (1994)
110. FL Coe, JH Parks & Y Nakagawa: Inhibitors and Promoters of Calcium Oxalate Crystallization. In: Disorders of Bone and Mineral Metabolism. Eds: Coe FL, Favus MJ, Raven Press, New York 757-799 (1992)
111. Tiselius HG, A. M. Fornander & M. A. Nilsson: The effects of citrate and urine on calcium oxalate crystal aggregation. Urol Res 21, 363- (1993)
112. Meyer J & L. H. Smith: Growth of calcium oxalate crystals. II. Inhibition by natural urinary crystal growth inhibitors. Invest Urol 13, 36-39 (1975)
113. Smith LH: Calcium containing renal stones. Kidney Int 13, 383-389 (1978)
114. Kok DJ, S. E. Papapoulos & O. L. Bijvoet: Crystal agglomeration is a major element in calcium oxalate urinary stone formation. Kidney Int 37, 51-56 (1990)
115. Kok DJ, S. E. Papapoulos, L. J. Blomen & O. L. Bijvoet: Modulation of calcium oxalate monohydrate crystallization kinetics in vitro. Kidney Int 34, 346-350 (1988)
116. JC Lieske & FL Coe: Urinary inhibitors and renal stone formation. In: Kidney stones: Medical and Surgical Management. Eds: Preminger GM, Lippincott-Raven, Philadelphia 1, 65-113 (1996)
117. Bisaz S, R. Felix, W. F. Neuman & H. Fleisch: quantitative determination of inhibitors of calcium phosphate precipitation in whole urine. Miner Electrolyte Metab 1, 74-83 (1978)
118. JH Parks, LA Ruml & CYC Pak: Hypocitraturia. In: Kidney Stones: Medical and Surgical Management. Eds: Preminger GM, Lippiconcott-Raven, Philadelphia 1, 905-920 (1996)
119. Erwin DT, D. J. Kok, J. Alam, J. Vaughn, O. Coker, B. T. Carriere, J. Lindberg, F. E. Husserl, H. Jr. Fuselier & F. E. Cole: calcium oxalate stone agglomeration reflects stone forming activity: citrate inhibition depends on macromolecules larger than 30 kilodalton. Am J Kidney Dis 24, 893-900 (1994)
120. Rose GA, & S. Sulaiman: Tamm-Horsfall mucoproteins promote calcium oxalate crystal formation in urine: quantitatives studies. J Urol 127, 177-179 (1980)
121. Hesse B, Y. Nakagawa, & F. L. Coe: Inhibition of calcium oxalate monohydrate crystal aggregation by urine proteines. Am J Physiol 257, F569-F578 (1989)
122. Scurr DS & W. G. Robertson: Modifiers of calcium oxalate crystallization found in urine: II. Studies on their mode of action in an artificial urine. J Urol 136, 128-131 (1986)
123. Hoyer JR, & M. W. Seiler: Pathophysiology of Tamm-Horsfall protein. Kidney Int 16, 279-289 (1979)
124. Nakagawa Y: urinary Tamm-Horsfall glycoprotein in patients with various renal diseases. Jpn J Nephrol 29, 31-36 (1987)
125. Ganter K, D. Bongartz & A. Hesse: Tamm-Horsfall protein excretion and its relation to citrate in urine of stone-forming patients. Urology 53, 492-495 (1999)
126. Hess B: Tamm-Horsfall Glycoprotein - Inhibitor or promoter of calcium oxalate monohydrate crystallization processes? Urol Res 20, 83-86 (1992)
127. Hess B, L. Zipperle & P. Jaeger: Citrate and calcium oxalate effects on Tamm-Horsfall glycoprotein as a modifier of crystal aggregation. Am J Physiol 265, F784-F791 (1993)
128. Nicar MJ, C. Skurla, K. Sakhaee & C. Y. C. Pak: Low urinary citrate excretion in nephrolithiasis. Urology 21, 8-14 (1983)
129. Smith LH, P. G. Werness & D. M. Wilson: Metabolic and clinical disturbances in patients with calcium urolithiasis. Scand J Urol Nephrol Suppl 53, 213-220 (1980)
130. Boothby WM & M. Adams: Occurrence of citric acid in urine and body fluids. Am J Physiol 107, 471-479 (1934)
131. Kissin B & M. O. Locks: Urinary citrates in calcium urolithiasis. Proc Soc Exp Biol Med 46, 216-218 (1941)
132. Conway NW, A. T. K. Maitland & J. B. Rennie: The urinary citrate excretion in patients with renal calculi. Br J Urol 21, 30-38 (1949)
133. Scott WW, C. Huggins & B. C. Selman: Metabolism of citric acid in urolithiasis. J Urol 50, 202-209 (1943)
134. Hosking DH, Wilson, J.W.L., Liedtke, R.R., Smith, L.H., Wilson, D.M.: Urinary citrate excretion in normal persons and patients with idiopathic calcium urolithiasis. J Lab Clin Med 106, 682-689 (1985)
135. Baggio B, G. Gambaro, O. Oliva S. Favaro & A. Borsatti: Calcium oxalate nephrolithiasis: an easy way to detect an imbalance between promoting and inhibiting factors. Clin Chim Acta 124, 149-155 (1982)
136. Gambaro G, E. Cicerello, G. Marzaro, F. Marchini, A. Piccoli, C. Paleari & B. Baggio: A critical evaluation of the urinary inhibiting activity in idiopathic calcium oxalate nephrolithiasis. Urol Int 41, 418-421 (1986)
137. Welshman SG & M. G. McGeown: Urinary citrate excretion in stone-formers and normal controls. Br J Urol 48, 7-11 (1976)
138. B Wikstrom, U Backman, BG Danielson, B Fellstrom, G Johansson & S Ljunghall: Urinary citrate excretion and acidification defects in renal calcium stone formers. In: Urolithiasis Clinical and Basic Research. Eds: Finlayson B, Plenum Press, New York - London 757-762 (1981)
139. HG Tiselius: Urinary excretion of citrate in normal subjects and patients with urolithiasis. In: Urolithiasis Clinical and Basic Research. Eds: Smith LH, Robertson WG, Finlayson B, Plenum Press, New York 1, 39-44 (1981)
140. Rudman D, M. H. Kutner, S. C. Redd, 2nd, W. C. t. Waters, G. G. Gerron & J. Bleier: Hypocitraturia in calcium nephrolithiasis. J Clin Endocrinol Metab 55, 1052-1057 (1982)
141. Caudarella R, N. Malavolta, E. Rizzoli, F. Stefani & G. D'Antuono: [Evaluation of citrates in a group of patients with idiopathic calcium calculi]. G Clin Med 66, 126-134 (1986)
142. Parks JH & F. L. Coe: Urine citrate and calcium in calcium nephrolithiasis. Adv Exp Med Biol 208, 445-449 (1986)
143. N Malavolta, F Stefani, E Rizzoli, F Berveglieri, G Martelli, A Bottura & R Caudarella: The hypocitraturia incidence in normal subjects and in calcium stone formers. In: Inhibitors of crystallization in renal lithiasis and their clinical application. Eds: Martelli A, Buli P, Marchesini B, Acta Medica Edizioni e Congressi, Roma 1, 287-289 (1987)
144. Hobarth K & J. Hofbauer: Value of routine citrate analysis and calcium/citrate ratio in calcium urolithiasis. Eur Urol 19, 165-168 (1991)
145. JH Parks, LA Ruml & CYC Pak: Hypocitraturia. In: Kidney Stones: Medical and Surgical Management. Eds: Coe FL, Favus MJ, Pak CYC, Parks JH, Preminger GM, Lippincott-Raven, Philadelphia 1, 905-920 (1996)
146. Minisola S, W. Rossi, M. T. Pacitti, L. Scarnecchia, F. Bigi, V. Carnevale & G. Mazzuoli: Studies on citrate metabolism in normal subjects and kidney stone patients. Miner Electrolyte Metab 15, 303-308 (1989)
147. Nikkila M, T. Koivula & H. Jokela: Urinary citrate excretion in patients with urolithiasis and normal subjects. Eur Urol 16, 382-385 (1989)
148. Curhan GC, W. C. Willett, F. E. Speizer & M. J. Stampfer: Twenty-four-hour urine chemistries and the risk of kidney stones among women and men. Kidney Int 59, 2290-2298 (2001)
149. Asplin JR, J. H. Parks, Y. Nakagawa & F. L. Coe: Reduced crystallization inhibition by urine from women with nephrolithiasis. Kidney Int 61, 1821-1829 (2002)
150. Nikkila MT: Urinary glycosaminoglycan excretion in normal and stone-forming subjects: significant disturbance in recurrent stone formers. Urol Int 44, 157-159 (1989)
151. Scharer K & F. Manz: Renal handling of citrate in children with various kidney disorders. Internat Pediatr Nephrol 6, 79-88 (1985)
152. Schwille PO, D. Scholz & K. Schwille: Ultrafiltrable serum citrate and the relationship between serum and urinary citrate results in controls and renal calcium stone formers. J Clin Chem Clin Biochem 20, 169-173 (1982)
153. Trinchieri A, A. Mandressi, P. Luongo, F. Rovera & G. Longo: Urinary excretion of citrate, glycosaminoglycans, magnesium and zinc in relation to age and sex in normal subjects and in patients who form calcium stones. Scand J Urol Nephrol 26, 379-386 (1992)
154. W Vahlensieck, A Hesse, K Klocke & WD Miersch: Excretion of citric acid in healthy as well as in stone forming men and women. In: Inhibitors of crystallization in renal lithiasis and their clinical application Eds: Martelli A, Buli P, Marchesini B, Acta Medica Edizioni e Congressi, Roma 1, 151-158 (1987)
155. Westbury EJ: Some observations on the quantitative analysis of over 1000 urinary calculi. Br J Urol 46, 215-227 (1974)
156. Hodgkinson A & R. W. Marshall: Changes in the composition of urinary tract stones. Invest Urol 13, 131-135 (1975)
157. Yoshida O & Y. Okada: Epidemiology of urolithiasis in Japan: a chronological and geographical study. Urol Int 45, 104-111 (1990)
158. Kohri K. Y. Ishikawa, Y. Katoh, K. Kataoka, M. Iguchi, S. Yachiku & T. Kurita: Epidemiology of urolithiasis in the elderly. Int Urol Nephrol 23, 413-421 (1991)
159. Kohri K, M. Kodama, Y. Ishikawa, Y. Katayama, M. Takada, Y. Katoh, K. Kataoka, M. Iguchi & T. Kurita: Relationship between metabolic acidosis and calcium phosphate urinary stone formation in women. Int Urol Nephrol 23, 307-316 (1991)
160. Otnes B: Sex differences in the crystalline composition of stones from the upper urinary tract. Scand J Urol Nephrol 14, 51-56 (1980)
161. Iguchi M, C. Takamura, T. Umekawa, T. Kurita & K. Kohri: Inhibitory effects of female sex hormones on urinary stone formation in rats. Kidney Int 56, 479-485 (1999)
162. Hess B, U. Hasler-Strub, D. Ackermann & P. Jaeger: Metabolic evaluation of patients with recurrent idiopathic calcium nephrolithiasis. Nephrol Dial Transplant 12, 1362-1368 (1997)
163. Jaeger P, L. Portmann, A. F. Jacquet & P. Burckhardt: [Indication of the urinary citrate levels in idiopathic renal calculosis]. Schweiz Med Wochenschr 116, 371-373 (1986)
164. Caudarella R, T. Fabris, P. Bernich, A. Novarini, L. Borghi, T. Meschi, N. Malavolta, E. Rizzoli, T. Lusenti & G. Maschio: Effect of potassium citrate therapy on some urinary risk factors promoting renal stone formation. Ital J Mineral Electrolyte Metab 8, 31-35 (1994)
165. Pak CYC: Citrate and renal calculi: an update. Miner Electrolyte Metab 20, 371-377 (1994)
166. Laminski NA, A. M. Meyers, M. I. Sonnekus & A. E. Smyth: Prevalence of hypocitraturia and hypopyrophosphaturia in recurrent calcium stone formers: As isolated defects or associated with other metabolic abnormalities. Nephron 56, 379-386 (1990)
167. Pattaras JG & R. G. Moore: Citrate in the management of urolithiasis. J Endourol 13, 687-692 (1999)
168. Conte A, P. Roca, M. Gianotti & F. Grases: On the relation between citrate and calcium in normal and stone former subjects. Int Urol Nephrol 21, 369-373 (1989)
169. Cupisti A, E. Morelli, S. Lupetti, M. Meola & G. Barsotti: Low urine citrate excretions as a main risk factor for recurrent calcium oxalate nephrolithiasis in males. Nephron 61, 73-76 (1992)
170. Vogel E, P. Leskovar & W. Schutz Some acid-base balance-dependent urinary parameters and calcium-binding anions in stone formers. Eur Urol 10, 254-259 (1984)
171. Nieth H & P. Schollmeyer: Citratstoffwechsel der menschlichen Niere. Verh Ttsch Ges Inn Med 71, 693- (1965)
172. Norman ME, N. I. Feldman, R. M. Cohn, K. S. Roth & D. K. McCurdy: Urinary citrate excretion in the diagnosis of distal renal tubular acidosis. J Pediatr 92, 394-400 (1978)
173. Caudarella R, E. Rizzoli, L. Pironi, N. Malavolta, G. Martelli, G. Poggioli, G. Gozzetti & M. Miglioli: Renal stone formation in patients with inflammatory bowel disease. Scanning Microsc 7, 371-379; discussion 379-380 (1993)
174. Sakhaee K, J. A. Harvey, P. K. Padalino, P. Whitson & C. Y. C. Pak: The potential role of salt abuse on the risk for kidney stone formation. J Urol 150, 310-312 (1993)
175. E Benazzi, G Colussi, G Rombolà, M Surian, F Malberti, F Zoppi, M Giachetti & L Minetti: Urine Citrate excretion and dietary sodium intake in recurrent calcium stone former patients. In: Proceedings of the 6th Meeting of the Italian Society of Mineral Metabolism. Eds: Wichtig, Arezzo 5, 97-100 (1984)
176. Breslau NA, L. Brinkley & K. D. Hill: Relationship role of animal protein-rich diet to kidney stone formation and calcium metabolism. J Clin Endocrinol Metab 66, 140-146 (1988)
177. Oh MS: A new method for estimating G-I absorption of alkali. Kidney Int 36, 915-917 (1989)
178. Caudarella R, A. Buffa, C. Perna, S. Moretti, E. Rizzoli & N. Malavolta: Factors affecting urinary citrate excretion in stone formers and normal subjects. Scanning Microscopy International Meeting, May, 6-11, Houston-Texas (1995) Oral Presentation
179. Cowley DM, B. C. McWhinney, J. M. Brown & A. H. Chalmers: Chemical factors important to calcium nephrolithiasis: evidence for impaired hydroxycarboxylic acid absorption causing hyperoxaluria. Clin Chem 33, 243-247 (1987)
180. Preminger GM, J. A. Harvey & C. Y. C. Pak: Comparative efficacy of "specific" potassium citrate therapy versus conservative management in nephrolithiasis of mild to moderate severity. J Urol 134, 658-661 (1985)
181. Berg C: Alkaline citrate in prevention of recurrent calcium oxalate stones. Scand J Urol Nephrol Suppl 130, 1-83 (1990)
182. Butz M: Zur bedeutung von Zitrat fur die Entstehung und Prophylaxe von Kalziumha. Extracta Urologica 8, 61-73 (1985)
183. M Butz, HH Kinispel & HJ Dulce: Seven years' experience with citrate therapy in recurrent oxalate stone formers. In: Inhibitors of crystallization in renal lithiasis and their clinical application. Eds: Martelli A, Buli P, Marchesini B, Acta Medica Edizioni e Congressi, Roma 1, 159-164 (1988)
184. Tiselius HG, C. Berg, A. M. Fornander & M. A. Nilsson: Effects of citrate on the different phases of calcium oxalate crystallization. Scanning Microsc 7, 381-389; discussion 389-390 (1993)
185. Pak CYC & R. Peterson: Successful treatment of hyperuricosuric calcium oxalate nephrolithiasis with potassium citrate. Arch Intern Med 146, 863-867 (1986)
186. Pak CYC, K. Sakhaee & C. J. Fuller: Physiological and physiochemical correction and prevention of calcium stone formation by potassium citrate therapy. Trans Assoc Am Physicians 96, 294-305 (1983)
187. Pak CYC & C. Fuller: Idiopathic hypocitraturic calcium-oxalate nephrolithiasis successfully treated with potassium citrate. Ann Intern Med 104, 33-37 (1986)
188. Nicar MJ, R. Peterson & C. Y. C. Pak: Use of potassium citrate as potassium supplement during thiazide therapy of calcium nephrolithiasis. J Urol 131, 430-433 (1984)
189. Pak CYC & C. Fuller: Idiopathic hypocitraturic calcium-oxalate nephrolithiasis succesfully treated with potassium citrate. Ann Intern Med 104, (1986)
190. Pak CYC, C. Fuller, K. Sakhaee, G. Preminger & F. Britton: Long-term treatment of calcium nephrolithiasis with potassium citrate. J Urol 134, 11-19 (1985)
191. Sakhaee K, M. Nicar, K. Hill & C. Y. C. Pak: Contrasting effects of potassium citrate and sodium citrate therapies on urinary chemistries and crystallization of stone-forming salts. Kidney Int 24, 348-352 (1983)
192. R Caudarella, A Dormi, E Rizzoli, A Buffa, N Malavolta & S Stefoni: Chronic treatment with potassium citrate in recurrent calcium urolithiasis. In: Urolithiasis 1996. Eds: Pak CYC, Resnick MI, Preminger G, Millet the Printer Inc, 1, 496-497 (1996). VIII International Symposium On Urolithiasis, Dallas, Texas, September 29th- October 2nd
193. Fuselier HA, K. Moore, J. Lindberg, F. E. Husserl, F. E. Cole, D. J. Kok, D. Whitehead, D. J. Galliano & D. T. Erwin: Agglomeration inhibition reflected stone-forming activity during long-term potassium citrate therapy in calcium stone formers. Urology 52, 988-994 (1998)
194. Pak CYC., K. Koenig, R. Khan, S. Haynes & P. Padalino: Physicochemical action of potassium-magnesium citrate in nephrolithiasis. J Bone Miner Res 7, 281-285 (1992)
195. Sakhaee K, T. Bhuket, B. Adams-Huet & D. S. Rao: Meta-analysis of calcium bioavailability: a comparison of calcium citrate with calcium carbonate. Am J Ther 6, 313-321 (1999)
196. Wood RJ & C. Serfaty-Lacrosniere: Gastric acidity, atrophic gastritis, and calcium absorption. Nutr Rev 50, 33-40 (1992)
197. Borghi L, T. Meschi & A. Novarini: Ruolo dei citrati nella terapia della nefrolitiasi. Urologia Pratica 1, 11-18 (1998)
198. Levine BS, J. S. Rodman, S. Wienerman, R. S. Bockman, J. M. Lane & D. S. Chapman: Effect of calcium citrate supplementation on urinary calcium oxalate saturation in female stone formers: implications for prevention of osteoporosis. Am J Clin Nutr 60, 592-596 (1994)
199. Sakhaee K, S. Baker, J. Zerwekh, J. Poindexter, P. A. Garcia-Hernandez & C. Y. C. Pak: Limited risk of kidney stone formation during long-term calcium citrate supplementation in nonstone forming subjects. J Urol 152, 324-327 (1994)
200. Pak CYC, K. Koenig, R. Khan, S. Haynes & P. Padalino: Physicochemical action of potassium-magnesium citrate in nephrolithiasis. J Bone Miner Res 7, 281-285 (1992)
201. Ettinger B, Pak, C.Y.C., Citron, J.T., Thomas, C., Adams-Huet, B., Van Gessel, A.: Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. J Urol 158, 2069-2073 (1997)
202. Herrmann U, P. O. Schwille, A. Schmiedl, J. Fan & M. Manoharan: Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans - preliminary results in patients with idiopathic calcium urolithiasis. Biomed Pharmacother 53, 264-273 (1999)
203. Desmars JF & R. Tawashi: Dissolution and growth of calcium oxalate monohydrate. I. Effect of magnesium and pH. Biochim Biophys Acta 313, 256-267 (1973)
204. Elliot JS & M. E. Ribeiro: The effect of varying concentrations of calcium and magnesium upon calcium oxalate solubility. Invest Urol 10, 295-297 (1973)
205. Curreri PA, G. Onoda & B. Finlayson: A comparative appraisal of adsorption of citrate on whewellite seed crystals. Cryst Growth 53, 209-214 (1981)
206. Schwille PO, A. Schmiedl, U. Herrmann, J. Fan, D. Gottlieb, M. Manoharan & J. Wipplinger: Magnesium, citrate, magnesium citrate and magnesium-alkali citrate as modulators of calcium oxalate crystallization in urine: observations in patients with recurrent idiopathic calcium urolithiasis. Urol Res 27, 117-126 (1999)
207. Nicar MJ, K. Hill & C. Y. C. Pak: Inhibition by citrate of spontaneous precipitation of calcium oxalate in vitro. J Bone Miner Res 2, 215-220 (1987)
208. Meyer JL & L. H. Smith: Growth of calcium oxalate crystals. II. Inhibition by natural urinary crystal growth inhibitors. Invest Urol 13, 36-39 (1975)
209. Bek-Jensen H, A. M. Fornander, M. A. Nilsson & H. G. Tiselius: Is citrate an inhibitor of calcium oxalate crystal growth in high concentrations of urine? Urol Res 24, 67-71 (1996)
210. Kok DJ, S. E. Papapoulos & O. L. Bijvoet: Excessive crystal agglomeration with low citrate excretion in recurrent stone-formers. Lancet 1, 1056-1058 (1986)
211. Fuselier HA, D. M. Ward, J. S. Lindberg, J. M. Allen, F. E. Husserl, P. A. Marcucci, F. E. Cole, J. Turnipseed, J. Alam, D. J. Kok & et al.: Urinary Tamm-Horsfall protein increased after potassium citrate therapy in calcium stone formers. Urology 45, 942-946 (1995)
212. Nicar MJ, R. Peterson & C. Y. C. Pak: Use of potassium citrate as potassium supplement during thiazide therapy of calcium nephrolithiasis. J Urol 131, 430-433 (1984)
213. Pak CYC, C. Skurla, L. Brinkley & K. Sakhaee: Augmentation of renal citrate excretion by oral potassium citrate administration: time course, dose frequency, and dose-response relationship. J Clin Pharmacol 24, 19-26 (1984)
214. Sakhaee K, R. Alpern, H. R. Jacobson & C. Y. Pak: Contrasting effects of various potassium salts on renal citrate excretion. J Clin Endocrinol Metab 72, 396-400 (1991)
215. Pak CYC & C. Fuller: Idiopathic hypocitraturic calcium-oxalate nephrolithiasis successfully treated with potassium citrate. Ann Intern Med 104, 33-37 (1986)
216. Pak CYC, C. Fuller, K. Sakhaee, G. M. Preminger & F. Britton: Long-term treatment of calcium nephrolithiasis with potassium citrate. J Urol 134, 11-19 (1985)
217. Pak CYC, K. Sakhaee & C. J. Fuller: Physiological and physiochemical correction and prevention of calcium stone formation by potassium citrate therapy. Trans Assoc Am Physicians 96, 294-305 (1983)
218. Pak CYC & R. Peterson: Successful treatment of hyperuricosuric calcium oxalate nephrolithiasis with potassium citrate. Arch Intern Med 146, 863-867 (1986)
219. Lemann J Jr, R. W. Gray & J. A. Pleuss: Potassium bicarbonate, but not sodium bicarbonate, reduces urinary calcium excretion and improves calcium balance in healthy men. Kidney Int 35, 688-695 (1989)
220. Sutton RA, N. L. Wong & J. H. Dirks: Effects of metabolic acidosis and alkalosis on sodium and calcium transport in the dog kidney. Kidney Int 15, 520-533 (1979)
221. Miyakawa S & K. Bomsztyk: Increased perfusate pH stimulates active calcium absorption in the distal tubule (DT). Clin Res 36, 523 (1988)
222. Pak CYC: Physicochemical action and extrarenal manifestations of alkali therapy. In: Urological Research. Eds: Robertson WG, Plenum Press, New York 1, 511-516 (1989)
223. Hedelin H, L. Grenabo, J. Hugosson & S. Pettersson: The influence of zinc and citrate on urease-induced urine crystallisation. Urol Res 17, 177-180 (1989)
224. McLean RJ, J. Downey, L. Clapham & J. C. Nickel: Influence of chondroitin sulfate, heparin sulfate, and citrate on Proteus mirabilis-induced struvite crystallization in vitro. J Urol 144, 1267-1271 (1990)
225. Wang YH, L. Grenabo, H. Hedelin, R. J. McLean, J. C. Nickel & S. Pettersson: Citrate and urease-induced crystallization in synthetic and human urine. Urol Res 21, 109-115 (1993)
226. Wang YH, L. Grenabo, H. Hedelin & S. Pettersson: The effects of sodium citrate and oral potassium citrate on urease-induced crystallization. Br J Urol 74, 409-415 (1994)
227. T Esen, M Akinci & A Tellaloglin: Sodium potassium citrate in the medical management of urolithiasis, In: Proceedings of the VII International Symposium on Urolithiaisis 104 (1992)
228. Cicerello E, F. Merlo, G. Gambaro, L. Maccatrozzo, A. Fandella, B. Baggio & G. Anselmo: Effect of alkaline citrate therapy on clearance of residual renal stone fragments after extracorporeal shock wave lithotripsy in sterile calcium and infection nephrolithiasis patients. J Urol 151, 5-9 (1994)
229. Fine JK, C. Y. C. Pak & G. M. Preminger: Effect of medical management and residual fragments on recurrent stone formation following shock wave lithotripsy. J Urol 153, 27-32; discussion 32-23 (1995)
230. Robertson WG, M. Peacock & B. E. Nordin: Calcium oxalate crystalluria and urine saturation in recurrent renal stone-formers. Clin Sci 40, 365-374 (1971)
231. Akinci M, T. Esen, T. Kocak, C. Ozsoy & S. Tellaloglu: Role of inhibitor deficiency in urolithiasis. I. Rationale of urinary magnesium, citrate, pyrophosphate and glycosaminoglycan determinations. Eur Urol 19, 240-243 (1991)
232. Fardella C, M. Lastra, A. Rojas, M. Toro, C. Pinochet, R. Rosales, F. Retamal, Y. Mellado, F. Lopez & E. Saa: [Importance of the deficit of crystallization inhibitors in the etiopathogenesis of urolithiasis]. Rev Med Chil 122, 873-879 (1994)
233. Khand FD, A. F. Ansari, T. U. Khand & J. M. Memon: Is hypocitraturia associated with phosphaturia - a potential cause of calcium urolithiasis in first-time stone formers. J Pak Med Assoc 44, 179-181 (1994)
234. Hauser W, J. Frick & G. Kunit: Alkali citrate for preventing recurrence of calcium oxalate stones. Eur Urol 17, 248-251 (1990)
235. Pak CYC: Citrate and renal calculi. Miner Electrolyte Metab 13, 257-261 (1987)
236. Butz M & H. J. Dulce: Enhencement of urinary citrate stone formers by the intake of alkaline salts. In: Urolithiasis, Clinical and Basic Research. Eds: Smith LU, Robertson WG, Finlayson BS, Plenum Press, New York 881-885 (1981)
237. Butz M, G. Karadzic & H. J. Dulce: Prevention of calcium oxalate stones by alkaline treatment. Urol Res 12, 40-46 (1984)
238. Pak CYC, R. Peterson, K. Sakhaee, C. Fuller, G. Preminger & J. Reisch: Correction of hypocitraturia and prevention of stone formation by combined thiazide and potassium citrate therapy in thiazide-unresponsive hypercalciuric nephrolithiasis. Am J Med 79, 284-288 (1985)
239. Tiselius HG: Urine composition in calcium oxalate stone formers during treatment with alkali. In: Urolithiasis and related clinical research. Eds: Schwille PO, Robertson WG, Vahlensieck W, Plenum Press, New York 533-536 (1985)
240. Nicar MJ, M. C. Hsu & C. Fetner: Urinary response to oral potassium citrate therapy for urolithiasis in a private practice setting. Clin Ther 8, 219-225 (1986)
241. Abdulhadi MH, P. M. Hall & S. B. Streem: Can citrate therapy prevent nephrolithiasis? Urology 41, 221-224 (1993)