Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway

Microbiology and Immunology

Volumn 50, Issue 12, 2006, Pages 979-987

  Nagafuchi, Seiho ^a   Katsuta, Hitoshi ^a   Koyanagi Katsuta, Rimiko ^a   Yamasaki, Satoshi ^a   Inoue, Yasushi ^a   Shimoda, Kazuya ^a   Ikeda, Yukari ^a   Shindo, Mieko ^a   Yoshida, Eiko ^a   Matsuo, Tomohito ^a   Ohno, Yuju ^a   Kogawa, Kazuhiko ^b   Anzai, Keizo ^b   Kurisaki, Hironori ^a   Kudoh, Jun ^c   Harada, Mine ^a   Shimizu, Nobuyoshi ^c  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED); Autoimmune regulator (AIRE); Autoimmunity; Interleukin 2; T lymphocytes

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AUTOIMMUNE REGULATOR PROTEIN; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 33845777193     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2006.tb03876.x     Document Type: Article

References (31)

1. Anderson, M.S., Venanzi, E.S., Klein, L., Chen, Z., Berzins, S.P., Turley, S.J., Boehmer, H., Bronson, R., Dierich, A., Benoist, C., and Mathis, D. 2000. Projection of an immunological self shadow within the thymus by the Aire protein. Science 298: 1395-1401.
2. Cavadini, P., Vermi, W., Facchetti, F., Fontana, S., Nagafuchi, S., Mazzolari, E., Sediva, A., Marrella, V., Villa, A., Fischer, A., Notarangelo, L.D., and Badolato, R. 2005. AIRE deficiency in thymus of 2 patients with Omenn syndrome. J. Clin. Invest. 115: 728-732.
3. Cenci, E., Mencacci, A., Spaccapelo, R., Tonnetti, L., Mosci, P., Enssle, K.H., Puccetti, P., Romani, I., and Bistoni, F. 1995. T helper cell type 1 (Th1)- and Th2-like responses are present in mice with gastric Candidiasis but protective immunity is associated with Th1 development. J. Infect. Dis. 171: 1279-1288.
4. Chin, R.K., Lo, J.C., Kim, O., Blink, S.E., Christiansen, P.A., Peterson, P., Wang, Y., Ware, C., and Fu, Y.-X. 2003. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 11: 1121-1127.
5. Eisenbarth, G.S., and Gottlieb, P.A. 2004. Autoimmune polyendocrine syndromes. N. Engl. J. Med. 350: 2068-2079.
6. Fidel, P.L. 2002. Immunity to candida. Oral. Dis. 8 (Suppl. 2): 69-75.
7. Gesbert, F., Delespine-Carmagnat, M., and Bertoglio, J. 1998. Recent advances in the understanding of interleukin-2 signal transduction. J. Clin. Immunol. 18: 307-320.
8. Gillis, S., and Watson, J. 1980. Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line. J. Exp. Med. 152: 1709-1719.
9. Hauman, C.H., Thompson, I.O., Theunissen, F., and Wolfaart, P. 1993. Oral carriage of candida in healthy and HIV-seropositive persons. Oral Surg. Oral Med. Pathol. 76: 570-572.
10. Heino, M., Peterson, P., Kudoh, J., Nagamine, K., Kagerstedt, A., Ovod, V., Ranki, A.-M., Rantala, I., Nieminen, M., Tuukkanen, J., Scott, H.S., Antonarakis, S.E., Shimizu, N., and Krohn, K. 1999. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res. Commun. 257: 821-825.
11. Herlaar, E., and Brown, Z. 1999. P38 MAPK signaling cascades in inflammatory disease. Mol. Med. Today 5: 439-442.
12. Klein, E., Klein, G., Nadkarni, J.S., Nadkarni, J.J., Wigzell, H., and Clifford, P. 1968. Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines. Cancer Res. 28: 1300-1310.
13. Kogawa, K., Nagafuchi, S., Katsuta, H., Kudoh, J., Tamiya, S., Sakai, Y., Shimizu, N., and Harada, M. 2002. Expression of AIRE gene in peripheral monocyte/dendritic cell lineage. Immunol. Lett. 80: 195-198.
14. Kogawa, K., Kudoh, J., Nagafuchi, S., Ohga, S., Katsuta, H., Ishibashi, H., Harada, M., and Shimizu, N. 2002. Distinct clinical phenotype and immunoreactivity in Japanese siblings with autoimmune polyglandular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutations. Clin. Immunol. 103: 277-283.
15. Liston, A., Lesage, S., Wilson, J., Peltonen, L., and Goodnow, C.C. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4: 350-354.
16. Lozzio, C.B., and Lozzio, B.B. 1975. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 45: 321-324.
17. Miyoshi, I., Hiraki, S., Tsubota, T., Kubonishi, I., Matsuda, Y., Nakayama, T., Kishimoto, H., Kimura, I., and Masuji, H. 1977. Human B cell, T cell and null cell leukaemic cell lines derived from acute lymphoblastic leukaemias. Nature 267: 843-844.
18. Nagafuchi, S., Katsuta, H., Ohno, Y., Inoue, Y., Shimoda, K., Kogawa, K., Ikeda, Y., Koyanagi-Katsuta, R., Yamasaki, S., Tominaga, H., Tamiya, S., Umemura, T., Otsuka, T., Miyamoto, T., Otsuka, T., Harada, M., Kudoh, J., and Shimizu, N. 2005. Mitogen-activated protein kinase pathway controls autoimmune regulator (AIRE) gene expression in granulo-monocyte colony stimulating factor (GMCSF)-stimulated myelomonocytic leukemia OTC-4 cells. Immunol. Lett. 99: 130-135.
19. Nagamine, K., Peterson, P., Scott, H.D., Kudoh, J., Minoshima, S., Heino, M., Krohn, K.J., Lalioti, M.D., Mullis, P.E., Antonarakis, S.E., Kawasaki, K., Asakawa, S., Ito, F., and Shimizu, N. 1997. Positional cloning of the APECED gene. Nat. Genet. 17: 393-398.
20. Naoe, T., Akao, Y., Yamada, K., Utsumi, R., Koike, K., Shamoto, M., Koie, K., Kurosawa, Y., Kato, K., and Abe, M. 1988. Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells. Cancer Genet. Cytogenet. 34: 77-88.
21. Neufeld, M., Maclaren, N.K., and Blizzard, R.M. 1981. Two types of autoimmune Addison's disease associated with different polyglandular autoimmune (PGA) syndrome. Medicine 60: 355-362.
22. Ohno, Y., Iwasaki, H., Otsuka, T., Shimoda, K., Harada, N., Arima, F., Shigematsu, H., Ohshima, K., Harada, M., and Niho, Y. 1994. Establishment and characterization of a new myelomonocytic leukemia cell line (OTC-4). Proceedings of the 36th Annual Meeting of Japanese Clinical Hematology. Rinshou-Ketsueki 35: 1171 (Abstr.) (in Japanese).
23. Ramsey, C., Winqvist, O., Puhakka, L., Halonen, M., Moro, A., Klampe, O., Eskelin, P., Peito-Huikko, M., and Peltonen, L. 2002. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11: 397-409.
24. Romani, L., Puccetti, P., and Bistoni, F. 1996. Biological role of Th cell subsets in Candidiasis. In Romagnani, S. (ed), Th1 and Th2 cells in health and disease, Karger, Farmington, Conn., pp. 114-137.
25. Romani, L., Mocci, S., Bietta, C., Lanfaloni, L., Pucetti, P., and Bistoni, F. 1991. Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance. Infect. Immun. 59: 4647-4654.
26. + subset expression in murine candidiasis. J. Immunol. 150: 925-931.
27. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. 2004. Annu. Rev. Immunol. 22: 531-562.
28. Samaranayake, L.P. 1992. Oral mycoses in HIV infection. Oral Surg. Oral Med. Pathol. 73: 171-180.
29. Shimoda, K., Feng, J., Nagata, H.S., Watling, D., Rogers, N.C., Stark, G.R., Kerr, I.M., and Ihle, J.N. 1997. Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor. Blood 90: 597-604.
30. The Finnish-German APECED Consortium. 1997. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17: 399-403.
31. Yazaki, M., Takahashi, T., Andoh, M., Akatsuka, Y., Ito, T., Miyake, Y., Ito, Y., Nakamura, S., and Wada, Y. 1999. A novel minor histocompatibility antigen recognized by HLA-A31 restricted cytotoxic T lymphocytes generated from HLA-identical bone marrow donor lymphocytes. Bone Marrow Transplant. 24: 129-137.